Academic Reference Archive (参考文献アーカイブ)：KK/TaJcl・KK-Ay/TaJcl

 

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1957

Kondo K, Nozawa K, Tomita T, Ezaki K
Inbred strains resulting from Japanese mice.
Bull Exp Animals. 1957; 6: 107-12. (Japanese)

 

1962

Nakamura M
A diabetic strains of the mouse.
Proc Japan Acad. 1962; 38(7): 348-52.

 

1969

Nishimura M
Breeding of mice strains for diabetes mellitus.
Exp Animals. 1969; 18(4): 147-7.

 

1970

Iwatsuka H, Shino A, Suzuoki Z.
General survey of diabetic features of yellow KK mice.
Endocrinol Jpn. 1970 Feb; 17(1): 23-35.

 

Shino A, Iwatsuka H.
Morphological observations on pancreatic islets of spontaneous diabetic mice, "Yellow KK".
Endocrinol Jpn. 1970; 17(6): 459-76. [PMID: 4932863]

 

1971

Matsuo T, Furumo K, Shimakawa K.
Factors affecting development of hyperglycemia in KK mice.
J Takeda Res Lab. 1971; 30(2): 307-13.

 

小林 孝好, 坂口 弘
KKマウスにおける腎糸球体早期変化の電子顕微鏡的研究
糖尿病 Vol. 14 (1971) No. 4, 223-236

 

1972

Wehner H, Höhn D, Faix-Schade U, Huber H, Walzer P.
Glomerular changes in mice with spontaneous hereditary diabetes.
Lab Invest. 1972; 27(3): 331-40. [PMID: 4115812]

 

1973

Taketomi S, Tsuda M, Matsuo T, Iwatsuka H, Suzuoki Z.
Alterations of hepatic enzyme activities in KK and yellow KK mice with various diabetic states.
Horm Metab Res. 1973; 5(5): 333-9. [PMID: 4148927]

 

1974

Iwatsuka H, Taketomi S, Matsuo T, Suzuoki Z.
Congenitally impaired hormone sensitivity of the adipose tissue of spontaneously diabetic mice, KK: Validity of thrifty genotype in KK mice.
Diabetologia. 1974; 10: 611-6.

 

Iwatsuka H, Ishikaw E, Shimakawa K, Shino A.
The Role of Genetic Background of KK Strain in Pathogenesis of Diabetes: Polygenic Inheritance of a Sensitivity to a Diabetogenic Action of Obesity in the Mouse.
J Takeda Res Lab. 1974; 33(4): 248-51.

 

Iwatsukae H, Ishikawa E, Shino A.
Remission of Diabetic Syndromes in Advanced Age of Genetically Obese and Diabetic Mice, Yellow KK.
J Takeda Res Lab. 1974; 33(3): 203-12.

 

Iwatsuka H, Taketomi S, Matsuo T, Suzuoki Z.
Congenitally impaired hormone sensitivity of the adipose tissue of spontaneously diabetic mice, KK. Validity of thrifty genotype in KK mice.
Diabetologia. 1974; 10 Suppl: 611-6. [PMID: 4375059]

 

小林 孝好
KKマウス肝の病理組織学的研究
糖尿病 Vol. 17 (1974) No. 5, 427-432

 

1975

Taketomi S, Ishikawa E, Iwatsuka H
Lipogenic enzymes in two types of genetically obese animals, fatty rats and yellow KK mice.
Horm Metab Res. 1975; 7: 242-6.

 

Furuno K, Arakawa M, Shino A, Suzuoki Z
Induction of fatty liver by ethanol drinking in KK and KK-Ay mice.
J Nutr. 1975; 105(10): 1253-62. [PMID: 1159519]

 

Furuno K, Shimakawa K, Suzuoki Z
Effects of nutritional factors on the development of ethanol-induced fatty liver in KK and KK-Ay mice.
J Nutr. 1975; 105(10): 1263-8. [PMID: 51081]

 

Arakawa M, Taketomi S, Furuno K, Matsuo T, Iwatsuka H
Metabolic studies on the development of ethanol-induced fatty liver in KK-Ay mice.
J Nutr. 1975; 105(12): 1500-8. [PMID: 477]

 

Lemberg A, Oppermann W, Reddi AS, Camerini-Davalos RA
Pre- and postnatal distribution of lipids in the liver of genetic diabetic mice.
Experientia. 1975;31 (7): 860-2. [PMID: 1140334]

 

1978

Kitahara A, Toyota T, Kakizaki M, Goto Y
Activities of hepatic enzymes in spontaneous diabetes rats produced by selective breeding of normal Wistar rats.
Tohoku J Exp Med. 1978; 126(1): 7-11. [PMID: 151947]

 

1979

Kimura M, Suzuki J, Amemiya K
A genetically diabetic model "KK-CAy mice" for a pharmacological assay.
Endocrinol Jpn. 1979; 26(2): 185-95. [PMID: 383473]

 

Appel MC, Schibly BA, Kamara JA, Sorenson RL
Adrenal gland involvement in mice with hereditary obesity and diabetes mellitus. Morphological studies.
Diabetologia. 1979; 16(6): 391-8. [PMID: 467849]

 

1980

Kawamatsu Y, Saraie T, Imamiya E, Nishikawa K, Hamuro Y
Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives.
Arzneimittelforschung. 1980; 30(3): 454-9. [PMID: 7387754]

 

1981

Kimura M, Suzuki J
The pattern of action of blended Chinese traditional medicines to glucose tolerance curves in genetically diabetic KK-CAy mice.
J Pharmacobiodyn. 1981; 4(12): 907-15. [MID: 7341746]

 

1982

江本正直ら
KKマウスの腎糸球体病変 －制限食飼育による影響－.
糖尿病. 1982; 25(11): 1211-19.

 

Waki I, Kyo H, Yasuda M, Kimura M
Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals.
J Pharmacobiodyn. 1982; 5(8): 547-54. [PMID: 6759629]

 

1983

Fujita T, Sugiyama Y, Taketomi S, Sohda T, Kawamatsu Y, Iwatsuka H, Suzuoki Z
Reduction of insulin resistance in obese and/or diabetic animals by 5 - [4 - (1-methylcyclohexylmethoxy) benzyl] - thiazolidine - 2, 4 - dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent.
Diabetes. 1983; 32(9): 804-10. [PMID: 6354788]

 

1984

鈴木 潤，木村 正康
漢方方剤による糖尿病病態マウスの血糖下降作用.
日薬理誌(Folia Pharmacol Jpn). 1984; 83: 1-10. [PMID: 6425156]

 

1985

小林 総一郎, 田村 禎通
自然発症糖尿病動物(KKマウス)の心筋エネルギー代謝に関する研究.
糖尿病. 1985; 28(9): 1019-27.

 

小林 孝好
給餌制限により糖尿病状態をコントロールしたKKマウスにおける病理組織学的研究.
糖尿病. 1985; 28(1): 33-43.

 

松尾 隆夫
Ⅱ型糖尿病モデル動物.
実験医学. 1985; 3(2): 47-52.

 

1986

Ooshima Y, Ihara T
Embryopathy in Genetically Diabetic Mice, Yellow KK，and Its Prevention by Maternal Therapy.
Cong Anom. 1986; 26(3): 169-77.

 

Kimura M, Fujihara M, Nojima H, Kimura I
Hypersensitivity of acetylcholine receptor in diabetic skeletal muscle to neuromuscular blockers: the effect of myotubes cultured with spinal cord or its extract.
J Pharmacobiodyn. 1986; 9(1): 29-38. [PMID: 2423670]

 

Kimura M, Kimura I, Nojima H, Muroi M
Diabetes mellitus-induced hypersensitivity of mouse skeletal muscles to acetylcholine and succinylcholine.
Jpn J Pharmacol. 1986; 40(2): 251-6. [PMID: 3702147]

 

Fujihara M, Kimura I, Nakamura T, Kimura M
Developmentally delayed sensitivity of acetylcholine receptor in myotubes of nerve-muscle cocultures from genetically diabetic mouse embryos.
J Pharmacobio Dyn. 1986; 9(4): 402-8. [PMID: 3735061]

 

1987

Diani AR, Sawada GA, Zhang NY, Wyse BM, Connell CL, Vidmar TJ, Connell MA
The KKAy mouse: a model for the rapid development of glomerular capillary basement membrane thickening.
Blood Vessels. 1987; 24(6): 297-303. [PMID: 3651618]

 

Diani AR, Sawada GA, Hannah BA, Jodelis KS, Connell MA, Connell CL, Vidmar TJ, Wyse BM
Analysis of pancreatic islet cells and hormone content in the spontaneously diabetic KKAy mouse by morphometry, immunocytochemistry and radioimmunoassay.
Virchows Arch A Pathol Anat Histopathol. 1987; 412(1): 53-61. [PMID: 2446417]

 

Nishioka H, Yoshida T, Yoshioka K, Kondo M
Hyperinsulinemic yellow KK mice and norepinephrine turnover.
Endocrinol Jpn. 1987; 34(4): 489-95. [PMID: 3678150]

 

Nonaka T, Oki Y
Obese Diabetes Induced by Over-dose of Monosodium-L-Glutamate and/or Monosodium-L-Aspartate in KK Mice.
Bull Nippon Vet Zootech Coll. 1987; 36: 8-15.

 

Kimura M, Suzuki J, Amemiya K, Mimura Y
Insulin resistance of adjuvant-induced granuloma pouch formation in genetically diabetic KK-CAy mice.
Endocrinol Jpn. 1987; 34(3): 347-55. [PMID: 3308441]

 

1988

Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I, Horikoshi H
Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats.
Diabetes. 1988; 37(11): 1549-58. [PMID: 3053303]

 

新井敏郎ら
KKマウスの代謝特性と肥満性糖尿病の誘発.
Proc Jpn Soc Anim Biochem. 1988; 21: 40-50.

 

藤原俊彦ら
KKマウスの加齢に伴う糖尿病病態の解析.
三共研究年報. 1988; 40: 73-82.

 

Reddi A, DeAngelis B, Frank O, Lasker N, Baker H
Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice.
Life Sci. 1988; 42(13): 1323-30. [PMID: 3280936]

 

M Tsukada et al.
Studies on a clinical marker of diabetes mellitus. (4). Detection of liver membrane anti bodies and islet cell surface antibodies in patients with non-insulin-dependent diabetes mellitus and in KK mice.
J Meikai Univ Sch Dent. 1988; 17(3): 353-60.

 

Reddi AS, Camerini-Davalos RA
Hereditary diabetes in the KK mouse: an overview.
Adv Exp Med Biol. 1988; 246:7-15. [PMID: 3074669]

 

Camerini-Davalos RA, Reddi AS, Wehner H, Velasco C
Kidney disease in KK mice: effect of insulin.
Adv Exp Med Biol. 1988; 246:333-7. [PMID: 3074664]

 

Reddi AS, Velasco CA, Khan MY, Bloodworth JM Jr, Camerini-Davalos RA
Kidney disease in KK mice: effect of glipizide.
Adv Exp Med Biol. 1988; 246:305-12. [PMID: 3250259]

 

Camerini-Davalos RA, Reddi AS
Kidney disease in KK mice: effect of glyburide.
Adv Exp Med Biol. 1988; 246: 297-303. [PMID: 2977928]

 

Wehner H
Sequence of changes in KK mouse nephropathy.
Adv Exp Med Biol. 1988; 246:147-56. [PMID: 3250252]

 

Reddi AS, Wehner H, Khan MY, Camerini-Davalos RA
Kidney disease in KK mice: structural, biochemical and functional relationships.
Adv Exp Med Biol. 1988; 246: 135-45. [PMID: 2854953]

 

Taketomi S, Fujita T, Yokono K
Insulin receptor and postbinding defects in KK mouse adipocytes and improvement by ciglitazone.
Diabetes Res Clin Pract. 1988; 5(2): 125-34. [PMID: 3416709]

 

Sugiyama Y, Taketomi S, Tawada H, Meguro K, Ikeda H, Fujita T.
Selective potentiation of 5-methyl-2-(1-methylcyclohexyl)-4-oxazoleacetic acid (AD-4610) on glucose-induced insulin secretion.
Horm Metab Res. 1988; 20(3): 145-9. [PMID: 3290076]

 

Kimura M, Kimura I, Fujihara M, Hoshino N.
Diabetic state-induced modifications of succinylcholine binding mode in the microsomal fractions of mouse skeletal muscles.
Life Sci. 1988; 42(9): 1029-36. [PMID: 3343894]

 

Kimura I, Matsui T, Kimura M.
Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.
Jpn J Pharmacol. 1988; 46(1): 93-6. [PMID: 3367550]

 

Kimura M, Kimura I, Nakamura T, Nojima H.
Diabetic state-induced modification of resting membrane potential and conductance in diaphragm muscle of alloxan and diabetic KK-CAy mice.
Diabetologia. 1988; 31(2): 103-7. [PMID: 3360221]

 

Ohta Y, Kitazaki T, Tsuda M.
Thermogenesis in brown adipose tissue of genetically obese, diabetic (KKAY) mice.
Endocrinol Jpn. 1988; 35(1): 83-92. [PMID: 3396515]

 

1989

松尾隆夫.
シンポジウム2. KKマウス抗糖尿病薬開発における利用.
日本疾患モデル動物研究会記録. 1989; 5, 18-23.

 

樋口直子ら.
MSA処理KKマウスの糖尿病発症に及ぼす雄性ホルモンの影響.
Exp Anim. 1989; 38(1): 25-9.

 

松尾隆夫, 小高裕之.
特集 糖尿病 - 糖尿病の病態モデル.
代謝. 1989; 26(7): 641-8.

 

Y Ooshima et al.
Lung maturation of fetuses in yellow KK mice .
Teratology. 1989; 40(6): 659.

 

Arai T, Tomioka R, Oki Y.
Effect of estrogen administration on diabetic KK mice.
Nippon Juigaku Zasshi. 1989; 51(4): 823-6. [PMID: 2685438]

 

浜田 久, 飯田竜一, 石村勝正, 山下悟, 牧平富義, 小林紀彦.
KKマウスの糖尿病病態に及ぼすAcarbose長期投与の影響.
薬理と治療. 1989; 17(9): 4195-206.

 

Aoyagi T, Akanuma H, Wada T, Sakaguchi T, Kobayashi T, Umezawa H.
Changes in relationship between blood glucose level and plasma 1,5-anhydroglucitol level in KK mice.
Biochem Int. 1989; 18(3): 599-603. [PMID: 2764965]

 

Nagase N, Saijo Y, Nitta H, Tamura Y, Orino S, Akaike Y, Mori H.
Myocardial disorders caused by magnesium deficiency in diabetic KK mice.
Magnesium. 1989; 8(5-6): 307-15. [PMID: 2615521]

 

Asselot C, Labat-Robert J, Kern P.
Heparin fragments regulate collagen phenotype and fibronectin synthesis in the skin of genetically diabetic mice.
Biochem Pharmacol. 1989; 38(6): 895-9. [PMID: 2539162]

 

Kobayashi S, Fujihara M, Hoshino N, Kimura I, Kimura M.
Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.
Endocrinol Jpn. 1989; 36(6): 833-44. [PMID: 2561275]

 

Kimura I, Pancho LR, Isoi Y, Kimura M.
Diabetes-induced enhancement of prostanoid-stimulated contraction in mesenteric veins of mice.
Jpn J Pharmacol. 1989; 51(3): 403-10. [PMID: 2622093]

 

Nakagawa M, Kobayashi S, Kimura I, Kimura M.
Diabetic state-induced modification of Ca, Mg, Fe and Zn content of skeletal, cardiac and smooth muscles.
Endocrinol Jpn. 1989; 36(6): 795-807. [PMID: 2633909]

 

1990

Sohda T, Momose Y, Meguro K, Kawamatsu Y, Sugiyama Y, Ikeda H.
Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones.
Arzneimittelforschung. 1990; 40(1): 37-42. [PMID: 2339998]

 

田中裕幸.
自然発病糖尿病マウス(KKマウス)の心筋病変の成因 -心筋内ノルエピネフリンおよびβアドレナリン作動性受容体の変化について-.
久留米医学会誌. 1990; 53(12): 1320-31.

 

小野信悦.
くすりの開発と病態モデル12; 肥満・糖尿病.
Med.Pharm. 1990; 24(3): 1316.

 

吉田俊秀ら.
新β3受容体作働薬BRL26830Aの抗肥満・抗糖尿病作用 - Yellow KKマウスを用いての検討.
医学のあゆみ. 1990; 154(1): 85-6.

 

Iijima T, Thukada M, Sugiura M, Ishi K, Nambu M.
Detection of liver membrane antibodies in patients with non-insulin-dependent diabetes mellitus.
Trop Gastroenterol. 1990; 11(1): 34-8. [PMID: 2356576]

 

Reddi AS, Velasco CA, Reddy PR, Khan MY, Camerini-Davalos RA.
Diabetic microangiopathy in KK mice. VI. Effect of glycemic control on renal glycoprotein metabolism and established glomerulosclerosis.
Exp Mol Pathol. 1990; 53(2): 140-51. [PMID: 2148155]

 

Ikeda H, Taketomi S, Sugiyama Y, Shimura Y, Sohda T, Meguro K, Fujita T.
Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.
Arzneimittelforschung. 1990; 40(2 Pt 1): 156-62. [PMID: 2334455]

 

Matsui T, Kimura I, Kimura M.
Increase in the activities of plasma pseudocholinesterase dependent on the blood glucose level and its relation to the hypersensitivity to acetylcholine in striated muscles of KK-CAy mice with diabetes.
Jpn J Pharmacol. 1990; 54(2): 97-103. [PMID: 2150210

 

1991

Ooshima Y.
Growth Retardation during Organogenesis in Genetically Diabetic Mice, Yellow KK.
Cong Anom. 1991; 31: 13-21.

 

Ooshima Y, Shiota K, Ihara T.
Delayed Maturation of Fetal Lung in Yellow KK Mice.
Cong Anom. 1991; 31: 33-40.

 

盧 国強, 宇賀茂三, 宮田幹夫, 石川 哲.
自然発症糖尿病Yellow KKマウス水晶体の病理組織学的研究.
あたらしい眼科. 1991; 8(8): 1337-41.

 

Momose Y, Meguro K, Ikeda H, Hatanaka C, Oi S, Sohda T.
Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds.
Chem Pharm Bull (Tokyo). 1991; 39(6): 1440-5. [PMID: 1934164]

 

Sato Y, Nishikawa M, Shinkai H, Sukegawa E.
Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals.
Diabetes Res Clin Pract. 1991; 12(1): 53-9. [PMID: 1906797]

 

1992

Reddi AS, Jyothirmayi GN.
Effect of chronic metformin treatment of hepatic and muscle glycogen metabolism in KK mice.
Biochem Med Metab Biol. 1992; 47(2): 124-32. [PMID: 1515171]

 

Jyothirmayi GN, Jayasundaramma B, Reddi AS.
In vivo glycogen and lipid synthesis by various tissues from normal and metformin-treated KK mice.
Res Commun Chem Pathol Pharmacol. 1992; 78(1): 113-6. [PMID: 1462045]

 

Than S, Ishida H, Inaba M, Fukuba Y, Seino Y, Adachi M, Imura H, Ikehara S.
Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.
J Exp Med. 1992; 176(4): 1233-8. [PMID: 1402665]

 

池原 進.
特集：糖尿病と免疫) 糖尿病の病因の解析 －骨髄移植を用いるアプローチ－.
Diabetes Frontier. 1992; 3(1): 22-5.

 

Odaka H, Shino A, Ikeda H, Matsuo T.
Antiobesity and antidiabetic actions of a new potent disaccharidase inhibitor in genetically obese-diabetic mice, KKA(y).
J Nutr Sci Vitaminol (Tokyo). 1992; 38(1): 27-37. [PMID: 1629784]

 

1993

Shimada T.
Correlation between metabolic and histopathological changes in the myocardium of the KK mouse. Effect of diltiazem on the diabetic heart.
Jpn Heart J. 1993 Sep;34(5):617-26. [PMID: 8301847]

 

1994

Takahashi H, Nakano K, Yasuda T, Komiyama Y, Murakami T, Nishimura M, Nakanishi T, Sakamoto M, Nanbu A, Yoshimura M.
Anti-obesity and anti-diabetic effects of carteolol in non-insulin-dependent diabetic mice.
Clin Exp Pharmacol Physiol. 1994; 21(6): 477-83. [PMID: 7982278]

 

山田 勉, 生沼 利倫, 劉 勝彦
中国茶の肥満マウス (KK-Ay) に及ぼす影響
日本東洋医学雑誌 Vol. 45 (1994) No. 2, 291-297

 

1995

Hioki Y, Itoh Y, Nakajima A, Fukuroda T, Ohasi H, Kamei T, Yano M.
A novel adrenaline derivative, AZ002, and its hypoglycemic action in yellow KK mice.
Jpn J Pharmacol. 1995; 69(3): 251-8. [PMID: 8699633]

 

Suzufuji Katsumi.
Osteopenia in KK-Ay mice with non-insulin-dependent diabetes mellitus.
Tohoku Univ Dent J. 1995; 14(2): 167-83. (Japanese)

 

1996

Takada Y, Takata Y, Iwanishi M, Imamura T, Sawa T, Morioka H, Ishihara H, Ishiki M, Usui I, Temaru R, Urakaze M, Satoh Y, Inami T, Tsuda S, Kobayashi M.
Effect of glimepiride (HOE 490) on insulin receptors of skeletal muscles from genetically diabetic KK-Ay mouse.
Eur J Pharmacol. 1996; 308(2): 205-10. [PMID: 8840133]

 

Zhu XP, Satoh J, Muto G, Muto Y, Sagara M, Takahashi K, Seino H, Hirai S, Masuda T, Tanaka S, Ishida H, Seino Y, Toyota T.
Improvement of glucose tolerance with immunomodulators on type 2 diabetic animals.
Biotherapy. 1996; 9(4): 189-97. [PMID: 9012538]

 

Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M.
Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice.
Biosci Biotechnol Biochem. 1996; 60(2): 204-8. [PMID: 9063966]

 

1997

Shimokawa T, Kato M, Shioduka K, Irie J, Ezaki O.
Effect of triiodothyronine on muscle cell differentiation and blood glucose level in hyperglycemic KK mice.
Biochem Biophys Res Commun. 1997; 235(3): 790-3. [PMID: 9207240]

 

Morimoto Y, Nishikawa K, Ohashi M.
KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production.
Life Sci. 1997; 61(8): 795-803. [PMID: 9275009]

 

Muto Y, Satoh J, Muto G, Masuda T, Sagara M, Fukuzawa M, Miyaguchi S, Qiang XL, Sakata Y, Nakazawa T, Ikehata F, Toyota T.
Effect of long-term treatment with complete Freund's adjuvant on KK-Ay mouse, a model of non-insulin-dependent diabetes mellitus.
Clin Immunol Immunopathol. 1997; 83(1): 53-9. [PMID: 9073536]

 

Shimura T, Miura T, Usami M, Ishihara E, Tanigawa K, Ishida H, Seino Y.
Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM).
Biol Pharm Bull. 1997; 20(5): 507-10. [PMID: 9178930]

 

Kako M, Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, Kato A.
Hypoglycemic activity of some triterpenoid glycosides.
J Nat Prod. 1997; 60(6): 604-5. [PMID: 9214731]

 

1998

Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K.
Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation.
Mamm Genome. 1998; 9(7): 506-10. [PMID: 9657845]

 

Matsuda H, Koyama H, Sato H, Sawada J, Itakura A, Tanaka A, Matsumoto M, Konno K, Ushio H, Matsuda K.
Role of nerve growth factor in cutaneous wound healing: accelerating effects in normal and healing-impaired diabetic mice.
J Exp Med. 1998; 187(3): 297-306. [PMID: 9449710]

 

Ninomiya H, Inomata T, Ogihara K.
Glomerular vascular changes in KK-Ay mice with early diabetes: scanning electron microscopy of vascular resin casts.
J Vet Med Sci. 1998; 60(1): 103-6. [PMID: 9492368]

 

Kume E, Yamada T, Iwasaki H.
A rhino mutant originating in KK mice.
Exp Anim. 1998; 47(1): 11-21. [PMID: 9498108]

 

Nishimura M.
KK and KK-Ay strains of mice.
Nippon Rinsho. 1998; 56 Suppl 3: 708-13. (Review. Japanese) [PMID: 9513501]

 

Shinkai H, Onogi S, Tanaka M, Shibata T, Iwao M, Wakitani K, Uchida I.
Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.
J Med Chem. 1998; 41(11): 1927-33. [PMID: 9599241]

 

Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N.
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.
J Biol Chem. 1998; 273(27): 16710-4. [PMID: 9642225]

 

Funabiki K, Makita Y, Yamamoto M, Shike T, Fukui M, Sumiyoshi Y, Tomino Y.
Dissociated expression of collagen type IV subchains in diabetic kidneys of KKAy mice.
Nephron. 1998; 80(2): 208-13. [PMID: 9736822]

 

Miura T, Koide T, Ohichi R, Kako M, Usami M, Ishihara E, Yasuda N, Ishida H, Seino Y, Tanigawa K.
Effect of acarbose (alpha-glucosidase inhibitor) on disaccharase activity in small intestine in KK-Ay and ddY mice.
J Nutr Sci Vitaminol (Tokyo). 1998; 44(3): 371-9. [PMID: 9742458]

 

Ishikawa Y, Saito MN, Ikemoto T, Takeno H, Watanabe K, Tani T.
Actions of the novel oral antidiabetic agent HQL-975 in insulin-resistant non-insulin-dependent diabetes mellitus model animals.
Diabetes Res Clin Pract. 1998; 41(2): 101-11. [PMID: 9789716]

 

Shimokawa T, Kato M, Watanabe Y, Hirayama R, Kurosaki E, Shikama H, Hashimoto S.
In vivo effects of pioglitazone on uncoupling protein-2 and -3 mRNA levels in skeletal muscle of hyperglycemic KK mice.
Biochem Biophys Res Commun. 1998; 251(1): 374-8. [PMID: 9790963]

 

Arakawa K, Ishihara T, Aoto M, Inamasu M, Saito A, Ikezawa K.
Actions of novel antidiabetic thiazolidinedione, T-174, in animal models of non-insulin-dependent diabetes mellitus (NIDDM) and in cultured muscle cells.
Br J Pharmacol. 1998; 125(3): 429-36. [PMID: 9806323]

 

Reginato MJ, Bailey ST, Krakow SL, Minami C, Ishii S, Tanaka H, Lazar MA.
A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties.
J Biol Chem. 1998; 273(49): 32679-84. [PMID: 9830009]

 

Yuan Z, He P, Cui J, Takeuchi H.
Hypoglycemic effect of water-soluble polysaccharide from Auricularia auricula-judae Quel. on genetically diabetic KK-Ay mice.
Biosci Biotechnol Biochem. 1998; 62(10): 1898-903. [PMID: 9836425]

 

Yoshitomi H, Yamazaki K, Abe S, Tanaka I.
Differential regulation of mouse uncoupling proteins among brown adipose tissue, white adipose tissue, and skeletal muscle in chronic beta 3 adrenergic receptor agonist treatment.
Biochem Biophys Res Commun. 1998; 253(1): 85-91. [PMID: 9875224]

 

Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K.
Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice.
Eur J Endocrinol. 1998; 139(6): 654-61. [PMID: 9916873]

 

西村正彦.
糖尿病(3) 糖尿病の実験モデル 遺伝性糖尿病モデル動物/肥満 KK系およびKK‐Ay系マウス.
日本臨床. 1998,56,708-13.

 

藤野 正行, 何 普明
タモギタケ熱水抽出物によるII型糖尿病モデルマウスの血糖値抑制
日本食品科学工学会誌 Vol. 45 (1998) No. 10, 618-623

 

草野 崇一, 阿部 浩之, 岡田 篤典
白甘藷 (Ipomoea batatas L.) の抗糖尿病作用
日本農芸化学会誌 Vol. 72 (1998) No. 9, 1045-1052

 

1999

Shibata T, Matsui K, Nagao K, Shinkai H, Yonemori F, Wakitani K.
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Eur J Pharmacol. 1999; 364(2-3): 211-9. [PMID: 9932726]

 

Ninomiya H, Inomata T, Ogihara K.
Obstructive uropathy and hydronephrosis in male KK-Ay mice: a report of cases.
J Vet Med Sci. 1999; 61(1): 53-7. [PMID: 10027165]

 

Suto J, Matsuura S, Yamanaka H, Sekikawa K.
Quantitative trait loci that regulate plasma lipid concentration in hereditary obese KK and KK-Ay mice.
Biochim Biophys Acta. 1999; 1453(3): 385-95. [PMID: 10101257]

 

Masuzaki H, Ogawa Y, Aizawa-Abe M, Hosoda K, Suga J, Ebihara K, Satoh N, Iwai H, Inoue G, Nishimura H, Yoshimasa Y, Nakao K.
Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.
Diabetes. 1999; 48(8): 1615-22. [PMID: 10426381]

 

Oku A, Ueta K, Arakawa K, Ishihara T, Nawano M, Kuronuma Y, Matsumoto M, Saito A, Tsujihara K, Anai M, Asano T, Kanai Y, Endou H.
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
Diabetes. 1999; 48(9): 1794-800. [PMID: 10480610]

 

Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Makino H.
Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.
Diabetes. 1999; 48(9): 1830-5. [PMID: 10480615]

 

Ebihara K, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Satoh N, Tamaki M, Yoshioka T, Hayase M, Matsuoka N, Aizawa-Abe M, Yoshimasa Y, Nakao K.
Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.
Diabetes. 1999; 48(10): 2028-33. [PMID: 10512369]

 

Furuya Y, Kawakita T, Tajima S.
Effect of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on insulin resistance in non-insulin dependent diabetes mellitus model mice.
J Trad Med. 1999; 16(3): 123-8. (Japanese)

 

2000

Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, Matsuoka N, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Nakao K.
Pathophysiological role of leptin in obesity-related hypertension.
J Clin Invest. 2000; 105(9): 1243-52. [PMID: 10791999]

 

Aoyama T, Fukui K, Takamatsu K, Hashimoto Y, Yamamoto T.
Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK).
Nutrition. 2000; 16(5): 349-54. [PMID: 10793303]

 

Sigrist S, Bedoucha M, Boelsterli UA.
Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes.
Biochem Pharmacol. 2000; 60(1): 67-75. [PMID: 10807946]

 

Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, Inoue T, Nakayama C, Taiji M, Noguchi H.
Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.
Diabetes. 2000; 49(3): 436-44. [PMID: 10868966]

 

Ninomiya H, Inomata T, Ogihara K.
Microvasculature of hydronephrotic kidneys in KK-A(Y) mice.
J Vet Med Sci. 2000; 62(10): 1093-8. [PMID: 11073081]

 

Muto G, Satoh J, Muto Y, Takahashi K, Nakazawa T, Sagara M, Miyaguchi S, Fukuzawa M, Qiang X, Sakata Y, Takizawa Y, Li Y, Bando S, Housai T, Tamagawa A, Toyota T.
Adjuvant-induced improvement of glucose intolerance in type 2 diabetic KK-Ay mice through interleukin-1 and tumor necrosis factor-alpha.
Clin Immunol. 2000; 97(3): 259-65. [PMID: 11112365]

 

Aoyama T, Fukui K, Nakamori T, Hashimoto Y, Yamamoto T, Takamatsu K, Sugano M.
Effect of soy and milk whey protein isolates and their hydrolysates on weight reduction in genetically obese mice.
Biosci Biotechnol Biochem. 2000; 64(12): 2594-600. [PMID: 11210122]

 

2001

Okumura Masae , Suzuki Kunihiko , Yamaura Keisuke , Uchiyama Masao , Nakayama Sadao , Oguchi Katsuji.
Antidiabetic effects of Kampo medicines in a non-insulin-dependent diabetes mellitus model using KK-Ay mice.
J Trad Med. 2001; 18: 81-8.

 

Nakamura Y, Nagase I, Asano A, Sasaki N, Yoshida T, Umekawa T, Sakane N, Saito M.
Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse.
J Vet Med Sci. 2001; 63(3): 309-14. [PMID: 11307932]

 

Takii H, Kometani T, Nishimura T, Nakae T, Okada S, Fushiki T.
Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice.
Biol Pharm Bull. 2001; 24(5): 484-7. [PMID: 11379765]

 

Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y.
Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model.
Diabetes. 2001; 50(8): 1943-8. [PMID: 11473059]

 

Takeuchi H, Mooi LY, Inagaki Y, He P.
Hypoglycemic effect of a hot-water extract from defatted sesame (Sesamum indicum L.) seed on the blood glucose level in genetically diabetic KK-Ay mice.
Biosci Biotechnol Biochem. 2001; 65(10): 2318-21. [PMID: 11758931]

 

Kiho T, Kochi M, Usui S, Hirano K, Aizawa K, Inakuma T.
Antidiabetic effect of an acidic polysaccharide (TAP) from Tremella aurantia and its degradation product (TAP-H).
Biol Pharm Bull. 2001; 24(12): 1400-3.[ PMID: 11767110]

 

Suzuki T, Hiroki A, Watanabe T, Yamashita T, Takei I, Umezawa K.
Potentiation of insulin-related signal transduction by a novel protein-tyrosine phosphatase inhibitor, Et-3,4-dephostatin, on cultured 3T3-L1 adipocytes.
J Biol Chem. 2001; 276(29): 27511-8. [PMID: 11342532]

 

森 強士, 西川 泰, 高田 曜子, 樫内 賀子, 石原 伸浩
インスリーナ葉の抗糖尿病作用
日本栄養・食糧学会誌 Vol. 54 (2001) No. 4, 197-203

 

2002

Hayashi K, Ito M.
Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice.
Biol Pharm Bull. 2002; 25(2): 188-92. [PMID: 11853163]

 

Ueda E, Yoshikawa Y, Ishino Y, Sakurai H, Kojima Y.
Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies.
Chem Pharm Bull (Tokyo). 2002; 50(3): 337-40. [PMID: 11911195]

 

Komatsu S, Kiyosawa H, Yoshiki A, Okazaki Y, Yoshino M, Tomaru Y, Watanabe S, Muramatsu M, Kusakabe M, Hayashizaki Y.
Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice.
Mamm Genome. 2002; 13(6): 293-8. [PMID: 12115031]

 

Murai A, Iwamura K, Takada M, Ogawa K, Usui T, Okumura J.
Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice.
Life Sci. 2002; 71(12): 1405-15. [PMID: 12127161]

 

Shiuchi T, Cui TX, Wu L, Nakagami H, Takeda-Matsubara Y, Iwai M, Horiuchi M.
ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO.
Hypertension. 2002; 40(3): 329-34. [PMID: 12215475]

 

Miura T, Kubo M, Itoh Y, Iwamoto N, Kato M, Park SR, Ukawa Y, Kita Y, Suzuki I.
Antidiabetic activity of Lyophyllum decastes in genetically type 2 diabetic mice.
Biol Pharm Bull. 2002; 25(9): 1234-7. [PMID: 12230127]

 

Okazaki M, Saito Y, Udaka Y, Maruyama M, Murakami H, Ota S, Kikuchi T, Oguchi K.
Diabetic nephropathy in KK and KK-Ay mice.
Exp Anim. 2002; 51(2): 191-6. [PMID: 12012732]

 

Morimoto Y, Sakata M, Ohno A, Maegawa T, Tajima S.
Effects of Byakko-ka-ninjin-to, Bofu-tsusho-san and Gorei-san on blood glucose level, water intake and urine volume in KKAy mice.
Yakugaku Zasshi. 2002; 122(2): 163-8. [PMID: 11857957] (Japanese)

 

Sasagawa T, Yoshikawa Y, Kawabe K, Sakurai H, Kojima Y.
Bis(6-ethylpicolinato)oxovanadium(IV) complex with normoglycemic activity in KK-A(y) mice.
J Inorg Biochem. 2002 Jan 1;88(1):108-12.[PMID: 11750032]

 

Yoshikawa Y, Ueda E, Kawabe K, Miyake H, Takino T, Sakurai H, Kojima Y.
Development of new insulinomimetic zinc(II) picolinate complexes with a Zn(N2O2) coordination mode: structure characterization, in vitro, and in vivo studies.
J Biol Inorg Chem. 2002 Jan;7(1-2):68-73.[ PMID: 11862542]

 

2003

Yoshikawa Y, Ueda E, Sakurai H, Kojima Y.
Anti-diabetes effect of Zn(II)/carnitine complex by oral administration.
Chem Pharm Bull (Tokyo). 2003; 51(2): 230-1. [PMID: 12576666]

 

Kobayashi M, Kimura H, Liao J, Abe M, Hirose S, Tomino Y.
Measurement of mouse urinary type IV collagen using time-resolved fluoroimmunoassay.
Anal Sci. 2003; 19(2): 205-10. [PMID: 12608746]

 

Ishihara K, Oyaizu S, Fukuchi Y, Mizunoya W, Segawa K, Takahashi M, Mita Y, Fukuya Y, Fushiki T, Yasumoto K.
A soybean peptide isolate diet promotes postprandial carbohydrate oxidation and energy expenditure in type II diabetic mice.
J Nutr. 2003; 133(3): 752-7. [PMID: 12612148]

 

Kurihara H, Fukami H, Kusumoto A, Toyoda Y, Shibata H, Matsui Y, Asami S, Tanaka T.
Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice.
Biosci Biotechnol Biochem. 2003; 67(4): 877-80. [PMID: 12784631]

 

Matsumoto K, Iijima H.
Sibutramine sensitivity assay revealed a unique phenotype of bombesin BB3 receptor-deficient mice.
Eur J Pharmacol. 2003; 473(1): 41-6. [PMID: 12877936]

 

Gohda T, Makita Y, Shike T, Tanimoto M, Funabiki K, Horikoshi S, Tomino Y.
Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a Type 2 diabetes model: is Zn-alpha2 glycoprotein-1 a candidate gene for obesity
Diabetes. 2003; 52(8): 2175-81. [PMID: 12882938]

 

Kojima Y, Yoshikawa Y, Ueda E, Ueda R, Yamamoto S, Kumekawa K, Yanagihara N, Sakurai H.
Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus.
Chem Pharm Bull (Tokyo). 2003; 51(8): 1006-8. [PMID: 12913247]

 

Mae T, Kishida H, Nishiyama T, Tsukagawa M, Konishi E, Kuroda M, Mimaki Y, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara M.
A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats.
J Nutr. 2003; 133(11): 3369-77. [PMID: 14608046]

 

Fan Q, Shike T, Shigihara T, Tanimoto M, Gohda T, Makita Y, Wang LN, Horikoshi S, Tomino Y.
Gene expression profile in diabetic KK/Ta mice.
Kidney Int. 2003; 64(6): 1978-85. [PMID: 14633120]

 

Kuroda M, Mimaki Y, Sashida Y, Mae T, Kishida H, Nishiyama T, Tsukagawa M, Konishi E, Takahashi K, Kawada T, Nakagawa K, Kitahara M.
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
Bioorg Med Chem Lett. 2003; 13(24): 4267-72. [PMID: 14643306]

 

Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingström G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Björkstrand E, Abrahmsen LB.
Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains.
Endocrinology. 2003; 144(11): 4755-62. [PMID: 12960099]

 

2004

Miura T, Tsuchiya M, Itoh Y, Okamoto H, Noji M, Suzuki I.
Antidiabetic activity of Fuscoporia oblique in KK-Ay mice.
J Trad Med. 2004; 21(1): 39-41.

 

Toshihiro Miura, Yasushi Itoh, Torao Ishida.
Hypoglycemic and hypolipidemic activity of the leaf of Samallanthus sonchifolius in genetically type 2 diabetic mice.
J Trad Med. 2004; 21(6): 275-7.

 

Miura T, Itoh Y, Iwamoto N, Kato M, Ishida T.
Suppressive activity of the fruit of Momordica charantia with exercise on blood glucose in type 2 diabetic mice.
Biol Pharm Bull. 2004; 27(2): 248-50. [PMID: 14758046]

 

Kuwabara K, Murakami K, Todo M, Aoki T, Asaki T, Murai M, Yano J.
A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4- oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.
J Pharmacol Exp Ther. 2004; 309(3): 970-7. [PMID: 14982965]

 

Shiuchi T, Iwai M, Li HS, Wu L, Min LJ, Li JM, Okumura M, Cui TX, Horiuchi M.
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.
Hypertension. 2004; 43(5): 1003-10. [PMID: 15037562]

 

Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J.
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
J Clin Invest. 2004; 113(10): 1408-18. [PMID: 15146238]

 

Sasaki M, Uehara S, Ohta H, Taguchi K, Kemi M, Nishikibe M, Matsumoto H.
Losartan ameliorates progression of glomerular structural changes in diabetic KKAy mice.
Life Sci. 2004; 75(7): 869-80. [PMID: 15183078]

 

Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, Yoshimatsu H.
Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice.
Hepatology. 2004; 40(1): 177-84. [PMID: 15239101]

 

Miura T, Itoh Y, Kaneko T, Ueda N, Ishida T, Fukushima M, Matsuyama F, Seino Y.
Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice.
Biol Pharm Bull. 2004; 27(7): 1103-5. [PMID: 15256748]

 

Suto J, Sekikawa K.
Confirmation and characterization of murine body weight QTLs, Bwq1 and Bwq2, identified in C57BL/6J x KK-Ay/a F2-Ay/a mice.
J Vet Med Sci. 2004; 66(9): 1039-45. [PMID: 15472465]

 

Nakagawa K, Kishida H, Arai N, Nishiyama T, Mae T.
Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice.
Biol Pharm Bull. 2004; 27(11): 1775-8. [PMID: 15516721]

 

Tanimoto M, Fan Q, Gohda T, Shike T, Makita Y, Tomino Y.
Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice.
Metabolism. 2004; 53(11): 1473-9. [PMID: 15536604]

 

Fan Q, Liao J, Kobayashi M, Yamashita M, Gu L, Gohda T, Suzuki Y, Wang LN, Horikoshi S, Tomino Y.
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice.
Nephrol Dial Transplant. 2004; 19(12): 3012-20. [PMID: 15574998]

 

Tsukahara C, Sugiyama F, Paigen B, Kunita S, Yagami K.
Blood pressure in 15 inbred mouse strains and its lack of relation with obesity and insulin resistance in the progeny of an NZO/HILtJ x C3H/HeJ intercross.
Mamm Genome. 2004; 15(12): 943-50. [PMID: 15599552]

 

Sakuramata Y, Oe H, Kusano S, Aki O.
Effects of combination of Caiapo with other plant-derived substance on anti-diabetic efficacy in KK-Ay mice.
Biofactors. 2004; 22(1-4): 149-52. [PMID: 15630271]

 

Yoshiko Fukuchi, Yoji Kato, Isao Okunishi, Yasuko Matsutani, Toshihiko Osawa, Michitaka Naito.
6-Methylsulfinylhexyl Isothiocyanate, an Antioxidant Derived from Wasabia japonica MATUM, Ameliorates Diabetic Nephropathy in Type 2 Diabetic Mice.
Food Sci Technol Res. 2004; 10(3); 290-5.

 

Yu PH, Wang M, Fan H, Deng Y, Gubisne-Haberle D.
Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice.
Am J Physiol Endocrinol Metab. 2004; 286(4): E634-41. [PMID: 14656718]

 

Ohnishi M, Matuo T, Tsuno T, Hosoda A, Nomura E, Taniguchi H, Sasaki H, Morishita H.
Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice.
Biofactors. 2004; 21(1-4): 315-9. [PMID: 15630218]

 

Moriyama T, Kishimoto K, Nagai K, Urade R, Ogawa T, Utsumi S, Maruyama N, Maebuchi M.
Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption.
Biosci Biotechnol Biochem. 2004; 68(2): 352-9. [PMID: 14981298]

 

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I.
Increased oxidative stress in obesity and its impact on metabolic syndrome.
J Clin Invest. 2004; 114(12): 1752-61. [PMID: 15599400]

 

Yajima H, Ikeshima E, Shiraki M, Kanaya T, Fujiwara D, Odai H, Tsuboyama-Kasaoka N, Ezaki O, Oikawa S, Kondo K.
Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance.
J Biol Chem. 2004; 279(32): 33456-62. [PMID: 15178687]

 

水谷 伸, 泉 哲郎
2 型糖尿病動物モデル. 別冊「医学のあゆみ」糖尿病・代謝症候群
state of arts 2004-2006; 207-10.

 

2005

Toshihiro Miura, Tomoko Koike, Torao Ishida.
Antidiabetic Activity of Green Tea (Thea sinensis L.) in Genetically Type 2 Diabetic Mice.
J Health Sci. 2005; 51(6): 708-10.

 

Shuichi Kusano, Shogo Tamasu, Shigekazu Nakatsugawa.
Effects of the White-Skinned Sweet Potato (Ipomoea batata L.) on the Expression of Adipocytokine in Adipose Tissue of Genetic Type 2 Diabetic Mice.
Food Sci Technol Res. 2005; 11(4): 369-72.

 

Harada H, Hirokawa Y, Suzuki K, Hiyama Y, Oue M, Kawashima H, Kato H, Yoshida N, Furutani Y, Kato S.
Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid.
Chem Pharm Bull (Tokyo). 2005; 53(2): 184-98. [PMID: 15684518]

 

Shike T, Gohda T, Tanimoto M, Kobayashi M, Makita Y, Funabiki K, Horikoshi S, Hirose S, Shirai T, Tomino Y.
Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice.
Nephrol Dial Transplant. 2005; 20(5): 879-85. [PMID: 15769825]

 

Yajima H, Noguchi T, Ikeshima E, Shiraki M, Kanaya T, Tsuboyama-Kasaoka N, Ezaki O, Oikawa S, Kondo K.
Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents.
Int J Obes (Lond). 2005; 29(8): 991-7. [PMID: 15852044]

 

Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, Kawada T, Nakagawa K, Kitahara M.
Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.
Biol Pharm Bull. 2005; 28(5): 937-9. [PMID: 15863912]

 

Yotsumoto T, Naitoh T, Kanaki T, Tsuruzoe N.
A retinoid X receptor antagonist, HX531, improves leptin resistance without increasing plasma leptin level in KK-Ay mice under normal dietary conditions.
Metabolism. 2005; 54(5): 573-8. [PMID: 15877285]

 

Suzuki M, Kakuta H, Takahashi A, Shimano H, Tada-Iida K, Yokoo T, Kihara R, Yamada N.
Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice.
J Atheroscler Thromb. 2005; 12(2): 77-84. [PMID: 15942117]

 

Suto J.
Apolipoprotein gene polymorphisms as cause of cholesterol QTLs in mice.
J Vet Med Sci. 2005; 67(6): 583-9. [PMID: 15997185]

 

Nozawa H.
Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.
Biochem Biophys Res Commun. 2005; 336(3): 754-61. [PMID: 16140264]

 

Ando H, Yanagihara H, Hayashi Y, Obi Y, Tsuruoka S, Takamura T, Kaneko S, Fujimura A.
Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.
Endocrinology. 2005; 146(12): 5631-6. [PMID: 16166217]

 

Miura T, Nosaka K, Ishii H, Ishida T.
Antidiabetic effect of Nitobegiku, the herb Tithonia diversifolia, in KK-Ay diabetic mice.
Biol Pharm Bull. 2005; 28(11): 2152-4. [PMID: 16272709]

 

Nagamatsu T, Hirasawa Y, Matsui Y, Ohtsu S, Yamane K, Toyoshi T, Kyuki K, Suzuki Y.
Increase in the deposition of aggregated protein in the glomeruli of spontaneously diabetic mice.
J Pharmacol Sci. 2005; 99(3): 287-93. [PMID: 16276036]

 

Sudo T, Ishii A, Asami J, Uematsu Y, Saitoh M, Nakamura A, Tada N, Ohnuki T, Komurasaki T, Nakagawa J.
Transgenic mice over-expressing dicarbonyl/L-xylulose reductase gene crossed with KK-Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds.
Exp Anim. 2005; 54(5): 385-94. [PMID: 16365515]

 

Choi YY, Osada K, Ito Y, Nagasawa T, Choi MR, Nishizawa N.
Effects of dietary protein of Korean foxtail millet on plasma adiponectin, HDL-cholesterol, and insulin levels in genetically type 2 diabetic mice.
Biosci Biotechnol Biochem. 2005; 69(1): 31-7. [PMID: 15665464]

 

Yoshikawa Y, Kondo M, Sakurai H, Kojima Y.
A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes.
J Inorg Biochem. 2005 Jul;99(7):1497-503.[PMID: 15921760]

 

2006

T Miura, Y Mizutani, T Ishida.
Antidiabetic effect of the herb Myrcia speciosa in KK-Ay diabetic mice.
J Trad Med. 2006; 23(1): 16-8.

 

Toshihiro Miura, Chika Shindou, Wen-Ping Zhang, Ikukatsu Suzuki, Torao Ishida.
Antidiabetic activity of Cissus sicyoides in KK-Ay mice.
J Trad Med. 2006; 23(3): 89-91.

 

Hagiwara S, Makita Y, Gu L, Tanimoto M, Zhang M, Nakamura S, Kaneko S, Itoh T, Gohda T, Horikoshi S, Tomino Y.
Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation.
Nephrol Dial Transplant. 2006; 21(3): 605-15. [PMID: 16282336]

 

Miura T, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T, Matsuyama F, Seino Y.
Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.
Biol Pharm Bull. 2006; 29(3): 585-7. [PMID: 16508174]

 

Suto J.
Characterization of Cq3, a quantitative trait locus that controls plasma cholesterol and phospholipid levels in mice.
J Vet Med Sci. 2006; 68(4): 303-9. [PMID: 16679719]

 

Nishiu J, Ito M, Ishida Y, Kakutani M, Shibata T, Matsushita M, Shindo M.
JTP-426467 acts as a selective antagonist for peroxisome proliferator-activated receptor gamma in vitro and in vivo.
Diabetes Obes Metab. 2006; 8(5): 508-16. [PMID: 16918585]

 

Iwai M, Li HS, Chen R, Shiuchi T, Wu L, Min LJ, Li JM, Tsuda M, Suzuki J, Tomono Y, Tomochika H, Mogi M, Horiuchi M.
Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan.
J Pharmacol Exp Ther. 2006; 319(3): 1081-7. [PMID: 16990512]

 

Shoji Y, Nakashima H.
Glucose-lowering effect of powder formulation of African black tea extract in KK-A(y)/TaJcl diabetic mouse.
Arch Pharm Res. 2006; 29(9): 786-94. [PMID: 17024853]

 

Iida T, Kuyama H, Watanabe M, Toda C, Matsuo E, Kido A, Ando E, Tsunasawa S, Nishimura O.
Rapid and efficient MALDI-TOF MS peak detection of 2-nitrobenzenesulfenyl-labeled peptides using the combination of HPLC and an automatic spotting apparatus.
J Biomol Tech. 2006; 17(5): 333-41. [PMID: 17122066]

 

Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I.
Adiponectin replenishment ameliorates obesity-related hypertension.
Hypertension. 2006; 47(6): 1108-16.[ PMID: 16651465]

 

武内浩二, 鈴木伸宏, 小高裕之.
糖尿病治療薬の基礎 ―糖尿病モデル動物と糖尿病治療薬の開発―.
日薬理誌(Folia Pharmacol Jpn). 2006; 128: 37-41. [PMID: 16940698]

 

Honda S, Aoki F, Tanaka H, Kishida H, Nishiyama T, Okada S, Matsumoto I, Abe K, Mae T.
Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study.
J Agric Food Chem. 2006; 54(24): 9055-62. [PMID: 17117790]

 

田中 真実, 渡辺 毅, 打田 悌治, 金澤 武道, 長内 智宏, 奥村 謙
ソヤサポニンBの血糖上昇抑制効果
日本未病システム学会雑誌 Vol. 12 (2006) No. 1, 1-8

 

2007

Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y.
Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.
Diabetes. 2007; 56(1): 24-33. [PMID: 17192461]

 

Tanimoto M, Gohda T, Kaneko S, Hagiwara S, Murakoshi M, Aoki T, Yamada K, Ito T, Matsumoto M, Horikoshi S, Tomino Y.
Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.
Metabolism. 2007; 56(2): 160-7. [PMID: 17224327]

 

Toshihiro Miura, Manami Kurata, Satoshi Takagi, Chinami Ishibashi, Eriko Ishihara, Torao Ishida.
Effect of Fuscoporia obliqua with exercise on blood glucose and lipid in type 2 diabetic mice.
J Trad Med. 2007; 24(4); 137-9.

 

Shiina K, Gohda T, Murakoshi M, Yamada K, Aoki T, Yamazaki T, Tanimoto M, Tomino Y.
M-cadherin, a candidate gene for type 2 diabetes and related phenotypes in a KK/Ta mouse model.
Acta Diabetol. 2007; 44(1): 6-13. [PMID: 17357879]

 

Nomura M, Nishii H, Ozaki Y, Fujimoto N, Matsumoto T.
An angiotensin II receptor blocker increases sexual behavior in type 2 diabetic mice.
Physiol Behav. 2007; 91(2-3): 223-8. [PMID: 17434545]

 

Suto J.
Quantitative trait locus analysis of plasma cholesterol levels and body weight by controlling the effects of the Apoa2 allele in mice.
J Vet Med Sci. 2007; 69(4): 385-92. [PMID: 17485926]

 

Sim MK, Xu XG, Wong YC, Sim SZ, Lee KO.
Des-aspartate-angiotensin I exerts hypoglycemic action via glucose transporter-4 translocation in type 2 diabetic KKAy mice and GK rats.
Endocrinology. 2007; 148(12): 5925-32. [PMID: 17823251]

 

Yoshikawa M, Wang T, Morikawa T, Xie H, Matsuda H.
Bioactive constituents from chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sugar-loaded rats and genetically diabetic KK-A(y) mice and structures of new acylated flavonol glycosides, sinocrassosides A(1), A(2), B(1), and B(2).
Chem Pharm Bull (Tokyo). 2007; 55(9): 1308-15. [PMID: 17827753]

 

Murosaki S, Lee TR, Muroyama K, Shin ES, Cho SY, Yamamoto Y, Lee SJ.
A combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo.
J Nutr. 2007; 137(10): 2252-7. [PMID: 17885007]

 

Suto J.
The A y allele at the agouti locus enhances sensitivity to endotoxin-induced lethality in mice.
J Vet Med Sci. 2007; 69(9): 931-7. [PMID: 17917378]

 

Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K.
Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin.
J Oleo Sci. 2007; 56(12): 615-21. [PMID: 17992001]

 

Shigehisa Taketomi.
KK and KKAy Mice: Models of Type 2 Diabetes with Obesity. Animal Models of Diabetes: Frontiers in Research, Second Edition, ed by Shafir E.
New York, Taylor and Francis Group, 335-48, 2007.

 

新井 千加子, 竹井 恭彦, 國方 敏夫, 宮田 聡美, 岩城 完三, 福田 恵温.
KK-Ayマウスにおけるコタラヒムブツ，アンマロクおよびすいおうの糖尿病改善作用.
食科工. 2007; 54: 539-45.

 

西村正彦.
肥満・痩せを呈するモデル動物1. KK-Ayマウス.
Adiposcience. 2007; 3(4), 459-63.

 

Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I.
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation.
Diabetes. 2007; 56(4): 901-11. [PMID: 17395738]

 

Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.
Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.
Diabetes. 2007; 56(9): 2235-41. [PMID: 17596404]

 

Maeda H, Hosokawa M, Sashima T, Miyashita K.
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice.
J Agric Food Chem. 2007 Sep 19;55(19):7701-6.[PMID: 17715888]

 

Nonogaki K, Nozue K, Oka Y.
Social isolation affects the development of obesity and type 2 diabetes in mice.
Endocrinology. 2007; 148(10): 4658-66. [PMID: 17640995]

 

佐子田嘉明，武石 勝，高橋康久，渋井仁志，影山 靖，田口福志，遊佐寿恵，片平清昭.
麻酔がマウスの血糖値に及ぼす影響.
実験動物技術. 2007; 42(2): 23-28.

 

堀尾文彦.
抗糖尿病ならびに抗動脈硬化因子であるアディポネクチンの産生に対する大豆たん白質の促進作用.
大豆たん白質研究. 2007; 10: 63-6.

 

新井 千加子, 竹井 恭彦, 國方 敏夫, 宮田 聡美, 岩城 完三, 福田 恵温
KK-Ayマウスにおけるコタラヒムブツ，アンマロクおよびすいおうの糖尿病改善作用
日本食品科学工学会誌 Vol. 54 (2007) No. 12, 539-545

 

2008

Tomono Y, Iwai M, Inaba S, Mogi M, Horiuchi M.
Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models.
Am J Hypertens. 2008; 21(2): 206-12. [PMID: 18188158]

 

Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M.
Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine.
Hypertension. 2008; 51(2): 528-33. [PMID: 18195165]

 

Fu L, Isobe K, Zeng Q, Suzukawa K, Takekoshi K, Kawakami Y.
The effects of beta(3)-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice.
Eur J Pharmacol. 2008; 584(1): 202-6. [PMID: 18304529]

 

Azukizawa S, Kasai M, Takahashi K, Miike T, Kunishiro K, Kanda M, Mukai C, Shirahase H.
Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.
Chem Pharm Bull (Tokyo). 2008; 56(3): 335-45. [PMID: 18310946]

 

Abe M, Matsuda M, Kobayashi H, Miyata Y, Nakayama Y, Komuro R, Fukuhara A, Shimomura I.
Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.
Arterioscler Thromb Vasc Biol. 2008; 28(5): 871-7. [PMID: 18323514]

 

Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N.
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
Biol Pharm Bull. 2008; 31(4): 651-5. [PMID: 18379057]

 

Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O, Kokura S, Yoshikawa T.
A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice.
J Clin Biochem Nutr. 2008; 42(2): 150-7. [PMID: 18385833]

 

Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O, Kokura S, Yoshikawa T.
Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice.
J Clin Biochem Nutr. 2008; 42(2): 158-66. [PMID: 18385834]

 

Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
Diabetes. 2008; 57(9): 2382-92. [PMID: 18458149]

 

Yamamoto Y, Ishino F, Kaneko-Ishino T, Shiura H, Uchio-Yamada K, Matsuda J, Suzuki O, Sato K.
Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression.
Exp Anim. 2008; 57(4): 385-95. [PMID: 18633161]

 

Kubohara Y, Kikuchi H, Oshima Y.
Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells.
Life Sci. 2008; 83(17-18): 608-12. [PMID: 18812178]

 

Hirasawa Y, Matsui Y, Ohtsu S, Yamane K, Toyoshi T, Kyuki K, Sakai T, Feng Y, Nagamatsu T.
Involvement of hyperglycemia in deposition of aggregated protein in glomeruli of diabetic mice.
Eur J Pharmacol. 2008; 601(1-3): 129-35. [PMID: 18950619]

 

Park KO, Ito Y, Nagasawa T, Choi MR, Nishizawa N.
Effects of dietary Korean proso-millet protein on plasma adiponectin, HDL cholesterol, insulin levels, and gene expression in obese type 2 diabetic mice.
Biosci Biotechnol Biochem. 2008; 72(11): 2918-25. [PMID: 18997420]

 

Wei Wang, Toshihiro Miura, Hong Shi, Dong-Ming Ma, Qi-Duo Zhao, Wen-Ping Zhang, Eriko Ishihara, Kanehara Masayuki, Bo Li Zhang, Xiu Mei Gao, De Qin Zhang, Torao Ishida.
Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice.
J. Health Sci. 2008; 54(2); 203-6.

 

Suto J.
Genetic dissection of testis weight in a mouse strain having an extremely large testis: major testis weight determinants are autosomal rather than Y-linked on the basis of comprehensive analyses in Y-chromosome consomic strains.
Proc Jpn Acad Ser B. 2008; 84(9): 393-406. [PMID: 18997451]

 

Suto J.
Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice.
Med Sci Monit. 2008; 14(2): CR65-74. [PMID: 18227763]

 

武内浩二.
肥満2型糖尿病モデル動物.
日本臨牀. 2008; 66巻(増刊号3): 616-20.

 

中村二郎.
糖尿病合併症のモデル動物.
日本臨牀. 2008; 66巻(増刊号3): 623-7.

 

松本 昌和, 谷本 光生, 合田 朋仁, 堀越 哲, 富野 康日己
自然発症2型糖尿病腎症モデルマウスにおけるpitavastatin投与による腎症進展抑制効果の検討
順天堂医学 Vol. 54 (2008) No. 1, 52-60

 

堀尾 文彦, 小林 美里
2型糖尿病自然発症モデル動物と糖尿病原因遺伝子の解析の現状
伝子の解析の現状 化

 

2009

Im R, Mano H, Matsuura T, Nakatani S, Shimizu J, Wada M.
Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse.
J Ethnopharmacol. 2009;121(2): 234-40. [19028559]

 

Aoyama T, Ikejima K, Kon K, Okumura K, Arai K, Watanabe S.
Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-A(y) mice.
Hepatology. 2009; 49(5): 1636-44. [PMID: 19205029]

 

Suto J.
Metabolic consequence of congenital asplenia caused by the Dominant hemimelia mutation in mice.
J Vet Med Sci. 2009; 71(2): 177-82. [PMID: 19262028]

 

Zhang H, Matsuda H, Yamashita C, Nakamura S, Yoshikawa M.
Hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii as a new type of anti-diabetic compound.
Eur J Pharmacol. 2009; 606(1-3): 255-61. [PMID: 19374876]

 

Kato R, Tachibe M, Sugano S, Kishida T, Ebihara K.
High-hydroxypropylated tapioca starch improves insulin resistance in genetically diabetic KKAy mice.
J Food Sci. 2009; 74(3): H89-96. [PMID: 19397723]

 

Yamazaki T, Tanimoto M, Gohda T, Ohara I, Hagiwara S, Murakoshi M, Matsumoto M, Kaneko S, Aoki T, Toyoda H, Ishikawa Y, Funabiki K, Horikoshi S, Tomino Y.
Combination Effects of Enalapril and Losartan on Lipid Peroxidation in the Kidneys of KK-A/Ta Mice.
Nephron Exp Nephrol. 2009; 113(2): e66-e76. [PMID: 19609084]

 

Rippmann JF, Schoelch C, Nolte T, Pavliska H, van Marle A, van Es H, Prestle J.
Improved lipid profile through liver-specific knockdown of liver X receptor alpha in KKAy diabetic mice.
J Lipid Res. 2009; 50(1): 22-31. [PMID: 18769020]

 

Katsuno K, Fujimori Y, Ishikawa-Takemura Y, Isaji M.
Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.
Eur J Pharmacol. 2009; 618(1-3): 98-104. [PMID: 19615995]

 

Phichitrasilp T, Hondo E, Rerkamnuaychoke W, Wakitani S, Sugiyama M, Terakawa J, Kiso Y.
Reproductive performance in diabetes mice with a special reference to uterine natural killer cells and placental growth factor.
J Vet Med Sci. 2009 Apr;71(4):519-23. [PMID: 19420861]

 

Tanabe A, Matsuda M, Fukuhara A, Miyata Y, Komuro R, Shimomura I, Tojo H.
Obesity causes a shift in metabolic flow of gangliosides in adipose tissues.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):547-52. [PMID: 19116132]

 

Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Ohara I, Toyoda H, Ishikawa Y, Horikoshi S, Tomino Y.
Pleiotropic effect of pyridoxamine on diabetic complications via CD36 expression in KK-Ay/Ta mice.
Diabetes Res Clin Pract. 2009 Feb;83(2):183-9. [PMID: 19144436]

 

Itoh T, Kobayashi M, Horio F, Furuichi Y.
Hypoglycemic effect of hot-water extract of adzuki (Vigna angularis) in spontaneously diabetic KK-A(y) mice.
Nutrition. 2009 Feb;25(2):134-41. [PMID: 18929464]

 

Kang MS, Hirai S, Goto T, Kuroyanagi K, Kim YI, Ohyama K, Uemura T, Lee JY, Sakamoto T, Ezaki Y, Yu R, Takahashi N, Kawada T.
Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.
Biofactors. 2009 Sep-Oct;35(5):442-8. [PMID: 19753653]

 

Tachibe M, Kato R, Sugano S, Kishida T, Ebihara K.
Hydroxypropylated tapioca starch retards the development of insulin resistance in KKAy mice, a type 2 diabetes model, fed a high-fat diet.
J Food Sci. 2009 Sep;74(7):H232-6. [PMID: 19895475]

 

Suto J.
Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice.
Mamm Genome. 2009 Jan;20(1):1-13. [PMID: 19067046]

 

Nishihara R, Sugano N, Takano M, Shimada T, Tanaka H, Oka S, Ito K.
The effect of Porphyromonas gingivalis infection on cytokine levels in type 2 diabetic mice.
J Periodontal Res. 2009 Jun;44(3):305-10.

 

Sim MK, Wong YC, Xu XG, Sim SZ, Tsi D.
Hypoglycemic action of chicken meat extract in type-2 diabetic KKAy mice and GK rats.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2583-8. [PMID: 19966489]

 

Ohnishi T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T, Matsuguchi T.
Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes.
J Periodontal Res. 2009 Feb;44(1):43-51. [PMID: 18973548]

 

2010

Takagi S, Miura T, Ishihara E, Ishida T, Chinzei Y.
Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice.
Biomed Res. 2010 Aug;31(4):213-8. [PMID: 20834178]

 

Hioki C, Yoshida T, Kogure A, Yoshimoto K and Shimatsu A.
Growth Hormone Administration Controls Body Composition Associated with Changes of Thermogenesis in Obese KK-Ay Mice.
The Open Endocrinology Journal, 2010, 4, 3-8. [PMID: None]

 

Mikami N, Hosokawa M, Miyashita K.
Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-Ay mice.
Mol Med Rep. 2010 May-Jun;3(3):449-53. [PMID: 21472260]

 

Yamamoto K., Kimura T.
Dietary Sparassis crispa (Hanabiratake) ameliorates plasma levels of adiponectin and glucose in type 2 diabetic mice.
Journal of Health Science 2010 Vol. 56 No. 5 pp. 541-546 [PMID: None]

 

Jinno Y, Nakakuki M, Kawano H, Notsu T, Mizuguchi K, and Shimano H
Cide-a and Cide-c are induced in the progression of hepatic steatosis and inhibited by eicosapentaenoic acid.
Prostaglandins Leukot Essent Fatty Acids. 2010 Aug;83(2):75-81. [PMID: 21472260]

 

Iwanami J, Mogi M, Tsukuda K, Min LJ, Sakata A, Jing F, Iwai M, Horiuchi M.
Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice.
J Hypertens. 2010 Aug;28(8):1730-7. [PMID: 20498620]

 

Kon K, Ikejima K, Okumura K, Arai K, Aoyama T, Watanabe S.
Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen.
Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G329-37. [PMID: 20539006]

 

Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, Narukami T, Takahashi N, Kawada T.
Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
Mol Nutr Food Res. 2010 Nov;54(11):1596-608. [PMID: 20540147]

 

Shimamura M, Karasawa H, Sakakibara S, Shinagawa A.
Raldh3 expression in diabetic islets reciprocally regulates secretion of insulin and glucagon from pancreatic islets.
Biochem Biophys Res Commun. 2010 Oct 8;401(1):79-84. [PMID: 20833146]

 

Lim SI.
Food Science/Microbiology : Article ; Anti-diabetic Effect of Material Fermented Using Rice Bran and Soybean as the Main Ingredient by Bacillus sp.
Journal of Applied Biological Chemistry 2010, （韓国語）[PMID: None]

 

Unoki-Kubota H, Yamagishi S, Takeuchi M, Bujo H, Saito Y.
Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice.
Protein Pept Lett. 2010 Sep;17(9):1177-81. [PMID: 20441560]

 

Yoshinari O, Igarashi K.
Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice.
Curr Med Chem. 2010;17(20):2196-202. [PMID: 20423301]

 

Lim SI, Lee.
BY Anti-diabetic effect of material fermented using rice bran and soybean as the main ingredient by Bacillus sp.
Journal of the Korean Society for Applied Biological Chemistry April 2010, Volume 53, Issue 2, pp 222-229 [PMID: None]

 

Suwa A, Yoshino M, Yamazaki C, Naitou M, Fujikawa R, Matsumoto S, Kurama T, Shimokawa T, Aramori I.
RMI1 deficiency in mice protects from diet and genetic-induced obesity.
FEBS J. 2010 Feb;277(3):677-86. [PMID: 20050919]

 

Minich DM, Lerman RH, Darland G, Babish JG, Pacioretty LM, Bland JS, Tripp ML.
Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome.
J Nutr Metab. 2010;2010. pii: 467316. [PMID: 20721358]

 

Takano M, Nishihara R, Sugano N, Matsumoto K, Yamada Y, Takane M, Fujisaki Y, Ito K.
The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice.
Arch Oral Biol. 2010 May;55(5):379-84. [PMID: 20381011]

 

Yamauchi R, Kobayashi M, Matsuda Y, Ojika M, Shigeoka S, Yamamoto Y, Tou Y, Inoue T, Katagiri T, Murai A, Horio F.
Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice.
J Agric Food Chem. 2010 May 12;58(9):5597-603. [PMID: 20405946]

 

Takikawa M, Inoue S, Horio F, Tsuda T.
Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice.
J Nutr. 2010 Mar;140(3):527-33.[PMID: 20089785]

 

Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K.
Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.
Arch Biochem Biophys. 2010 Dec 1;504(1):17-25.[ PMID: 20515643]

 

青木 竜弥, 金子 滋, 谷本 光生, 萩原 晋二, 村越 真紀, 石川 祐史, 古川 雅子, 合田 朋仁, 堀越 哲, 富野 康日己
2型糖尿病腎症モデルマウス (KK-Ay/Taマウス) におけるQTL解析による腎症疾患感受性遺伝子座の検討
順天堂医学 Vol. 56 (2010) No.2,107-115

 

本 三保子, 内田 菜穂子, 倉兼 静江, 山田 則子
ヒメウコギ葉茶の2型糖尿病モデルマウスに対する抗糖尿病作用
日本家政学会誌 Vol. 61 (2010) No. 10, 647-653

 

長野 正信, 上野 知子, 藤井 暁, 侯 徳興, 藤井 信
黒酢もろみ末のII型糖尿病モデルマウスKK-Ayに対する高血糖抑制効果
日本食品科学工学会誌 Vol. 57 (2010) No. 8, 346-354

 

餅 康樹, 角田 伸代, 柴 祥子, 村木 悦子, 加園 恵三
マウスにおいて魚油はウェイトリバウンドによる体重増加および肝臓への脂肪蓄積を抑制する
日本栄養・食糧学会誌 Vol. 63 (2010) No. 2, 69-77

 

2011

Ohara I, Tanimoto M, Gohda T, Yamazaki T, Hagiwara S, Murakoshi M, Aoki T, Toyoda H, Ishikawa Y, Funabiki K, Horikoshi S, Tomino Y.
Effect of combination therapy with angiotensin receptor blocker and 1,25-dihydroxyvitamin D(3) in type 2 diabetic nephropathy in KK-A(y)/Ta mice.
Nephron Exp Nephrol. 2011;117(4):e124-32.[PMID: 20948237]

 

Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Takagi M, Horikoshi S, Tomino Y.
Mindin: a novel marker for podocyte injury in diabetic nephropathy.
Nephrol Dial Transplant. 2011 Jul;26(7):2153-60. [PMID: 21098016]

 

Teraoka N, Mutoh M, Takasu S, Ueno T, Nakano K, Takahashi M, Imai T, Masuda S, Sugimura T, Wakabayashi K.
High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice.
Int J Cancer. 2011 Aug 1;129(3):528-35. [PMID: 20886595]

 

Kurakane S, Yamada N, Sato H, Igarashi K.
Anti-diabetic effects of Actinidia arguta polyphenols on rats and KK-Ay mice.
Food Sci. Technol. Res., 17 (2), 93 – 102, 2011 [PMID: None]

 

Yoshikawa Y, Adachi Y, Yasui H, Hattori M, Sakurai H.
Oral administration of Bis(aspirinato)zinc(II) complex ameliorates hyperglycemia and metabolic syndrome-like disorders in spontaneously diabetic KK-A(y) mice: structure-activity relationship on zinc-salicylate complexes.
Chem Pharm Bull (Tokyo). 2011;59(8):972-7. [PMID: 21804241]

 

Zang Y, Sato H, Igarashi K.
Anti-diabetic effects of a kaempferol glycoside-rich fraction from unripe soybean (Edamame, Glycine max L. Merrill. 'Jindai') leaves on KK-A(y) mice.
Biosci Biotechnol Biochem. 2011;75(9):1677-84. [PMID: 21897048]

 

Takahashi N, Senda M, Lin S, Goto T, Yano M, Sasaki T, Murakami S, Kawada T.
Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice.
Mol Nutr Food Res. 2011 Dec;55(12):1791-7 [PMID: 22038981]

 

Morimoto Y, Bando YK, Shigeta T, Monji A, Murohara T.
Atorvastatin prevents ischemic limb loss in type 2 diabetes: role of p53.
J Atheroscler Thromb. 2011;18(3):200-8. [PMID: 21123956]

 

Tanabe K, Nakamura S, Omagari K, Oku T.
Repeated ingestion of the leaf extract from Morus alba reduces insulin resistance in KK-Ay mice.
Nutr Res. 2011 Nov;31(11):848-54. [PMID: 22118756]

 

Goto T, Kim YI, Funakoshi K, Teraminami A, Uemura T, Hirai S, Lee JY, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Takahashi N, Kawada T.
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E1022-32. [PMID: 21862726]

 

Matsuda Y, Kobayashi M, Yamauchi R, Ojika M, Hiramitsu M, Inoue T, Katagiri T, Murai A, Horio F.
Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet.
Biosci Biotechnol Biochem. 2011;75(12):2309-15. [PMID: 22146708]

 

Yoshikawa Y, Murayama A, Adachi Y, Sakurai H, Yasui H.
Challenge of studies on the development of new Zn complexes (Zn(opt)₂) to treat diabetes mellitus.
Metallomics. 2011 Jul;3(7):686-92 [PMID: 21584335]

 

Otake K, Azukizawa S, Fukui M, Shibabayashi M, Kamemoto H, Miike T, Kunishiro K, Kasai M, Shirahase H.
A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity.
Chem Pharm Bull (Tokyo). 2011;59(10):1233-42. [PMID: 21963632]

 

Uemura T, Goto T, Kang MS, Mizoguchi N, Hirai S, Lee JY, Nakano Y, Shono J, Hoshino S, Taketani K, Tsuge N, Narukami T, Makishima M, Takahashi N, Kawada T.
Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice.
J Nutr. 2011 Jan;141(1):17-23. [PMID: 21106928]

 

Yoshinari O, Igarashi K.
Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice.
Br J Nutr. 2011 Oct;106(7):995-1004. [PMID: 21736843]

 

Goto T, Lee JY, Teraminami A, Kim YI, Hirai S, Uemura T, Inoue H, Takahashi N, Kawada T.
Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.
J Lipid Res. 2011 May;52(5):873-84 [PMID: 21324916]

 

Martinez HG, Quinones MP, Jimenez F, Estrada CA, Clark K, Muscogiuri G, Sorice G, Musi N, Reddick RL, Ahuja SS.
Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome.
Diabetologia. 2011 Oct;54(10):2660-8. [PMID: 21779871]

 

Kang JH, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.
Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
J Med Food. 2011 Mar;14(3):310-5 [PMID: 21332406]

 

Aburada T, Ikarashi N, Kagami M, Ichikawa Y, Sugitani M, Maniwa A, Ueda H, Toda T, Ito K, Ochiai W, Matsushita R, Miyamoto K, Sugiyama K.
Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice.
Phytother Res. 2011 Jun;25(6):897-903. [PMID: 21110398]

 

Ikarashi N, Toda T, Okaniwa T, Ito K, Ochiai W, Sugiyama K.
Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet.
Evid Based Complement Alternat Med. 2011;2011:952031. [PMID: 21799697]

 

Airanthi MK, Sasaki N, Iwasaki S, Baba N, Abe M, Hosokawa M, Miyashita K.
Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver.
J Agric Food Chem. 2011 Apr 27;59(8):4156-63. [PMID: 21405010]

 

Okada T, Mizuno Y, Sibayama S, Hosokawa M, Miyashita K.
Antiobesity effects of Undaria lipid capsules prepared with scallop phospholipids.
J Food Sci. 2011 Jan-Feb;76(1):H2-6. [ PMID: 21535684]

 

Watanabe S, Takahashi T, Tanaka L, Haruta Y, Shiota M, Hosokawa M, Miyashita K
The effect of milk polar lipids separated from butter serum on the lipid levels in the liver and the plasma of obese-model mouse (KK-Ay)
J of Functional Foods Vol3, Issue 4, October 2011, Pages 313–320 [PMID: none]

 

倉兼 静江.
サルナシの抗生活習慣病食品素材・成分としての開発と作用機構.
2011, 岩手大学大学院連合農学研究科-博士論文

 

岩井 邦久, 小野寺 昭夫, 岩井 佳代, 森永 八江, 松江 一.
ガマズミ果実搾汁残渣から分離した果肉皮粉末の血糖上昇抑制および抗酸化作用.
日本食品科学工学会誌 Vol. 58 (2011) No. 9, 413-420.

 

上野 知子.
黒酢および黒酢もろみ末の機能性.
日本醸造協会誌 Vol. 106 (2011) No. 4 , 183-189.

 

堀尾文彦、小林美里.
コーヒーの2型糖尿病抑制効果.
バイオサイエンスとインダストリー , 69巻 6号, 452-457, 2011年.

 

2012

Mikami N, Hosokawa M, Miyashita K.
Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(y) mice.
J Food Sci. 2012 Jun;77(6):H114-20. [PMID: 22582992]

 

Kobayashi M, Matsuda Y, Iwai H, Hiramitsu M, Inoue T, Katagiri T, Yamashita Y, Ashida H, Murai A, Horio F.
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
J Nutr Sci Vitaminol (Tokyo). 2012;58(6):408-14. [PMID: 23419399]

 

Kitano Y, Murazumi K, Duan J, Kurose K, Kobayashi S, Sugawara T, Hirata T.
Effect of dietary porphyran from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice.
J Nutr Sci Vitaminol (Tokyo). 2012;58(1):14-9. [PMID: 23007062]

 

Kuroda M, Mimaki Y, Ohtomo T, Yamada J, Nishiyama T, Mae T, Kishida H, Kawada T.
Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-Ay mice and identification of the active ingredients.
J Nat Med. 2012 Apr;66(2):394-9. [PMID: 21987283]

 

Ishikawa Y, Gohda T, Tanimoto M, Omote K, Furukawa M, Yamaguchi S, Murakoshi M, Hagiwara S, Horikoshi S, Funabiki K, Tomino Y.
Effect of exercise on kidney function, oxidative stress, and inflammation in type 2 diabetic KK-A(y) mice.
Exp Diabetes Res. 2012;2012:702948. [PMID: 22899901]

 

Ohshima K, Mogi M, Jing F, Iwanami J, Tsukuda K, Min LJ, Higaki J, Horiuchi M.
Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistance.
Hypertension. 2012 Feb;59(2):493-9. [PMID: 22184328]

 

Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H.
Hepatic peroxisome proliferator-activated receptor-γ-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals.
Eur Heart J. 2012 May;33(10):1279-89. [PMID: 21825308]

 

Ha BG, Nagaoka M, Yonezawa T, Tanabe R, Woo JT, Kato H, Chung UI, Yagasaki K.
Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo.
J Nutr Biochem. 2012 May;23(5):501-9. [PMID: 21684132]

 

Iba T, Aihara K, Kawasaki S, Yanagawa Y, Niwa K, Ohsaka A.
Formation of the venous thrombus after venous occlusion in the experimental mouse model of metabolic syndrome.
Thromb Res. 2012 May;129(5):e246-50. [PMID: 22459906]

 

Lee SY, Park SL, Hwang JT, Yi SH, Nam YD, Lim SI.
Antidiabetic Effect of Morinda citrifolia (Noni) Fermented by Cheonggukjang in KK-A(y) Diabetic Mice.
Evid Based Complement Alternat Med. 2012;2012:163280. [PMID: 22969823]

 

Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami K, Hayata-Takano A, Baba A, Hashimoto H.
Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells.
J Mol Neurosci. 2012 Nov;48(3):647-53. [PMID: 22477644]

 

Kim YI, Hirai S, Goto T, Ohyane C, Takahashi H, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice.
PLoS One. 2012;7(2):e31317. [PMID: 22347463]

 

Tsuchida T, Shiraishi M, Ohta T, Sakai K, Ishii S.
Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis by inducing the excretion of hepatic lipids in high-fat diet-fed KK-Ay mice.
Metabolism. 2012 Jul;61(7):944-53. [PMID: 22154323]

 

Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, Tamaki T.
Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice.
Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E77-86. [PMID: 21917632]

 

Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada T.
Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
J Nutr Biochem. 2012 Jul;23(7):768-76.[PMID: 21889885]

 

Nishikawa S, Hosokawa M, Miyashita K.
Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice.
Phytomedicine. 2012 Mar 15;19(5):389-94.[PMID: 22305278]

 

Iwasaki S, Widjaja-Adhi MAK, Koide A, Kaga T, Nakano S, Beppu F, Hosokawa M, Miyashita K.
In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-Ay Mice.
Food and Nutrition Sciences, 2012, 3, 1491-1499.[PMID: none]

 

青木 一太, 倉重 圭史, 西村 学子, 山崎 真美, 佐藤 惇, 吉田 光希, 齊藤 正人, 安彦 善裕
糖尿病モデルマウスにおける酸化ストレス阻害剤による口腔粘膜創傷治癒の促進
日本口腔内科学会雑誌 Vol. 18 (2012) No. 1: 1-7 [PMID: None]

 

2013

Yoshiaki Katsuda, Takeshi Ohta, Masami Shinohara, Tong Bin, Takahisa Yamada.
Diabetic mouse models.
OJAS. 2013; 3(4): 334-42.

 

Furukawa M, Gohda T, Hagiwara S, Tanimoto M, Horikoshi S, Funabiki K, Tomino Y.
Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-A (y) Mouse.
Int J Nephrol. 2013;2013:519130. [PMID: 23819050]

 

Moroki T, Yoshikawa Y, Yoshizawa K, Tsubura A, Yasui H.
Morphological characterization of systemic changes in KK-Ay mice as an animal model of type 2 diabetes.
In Vivo. 2013 Jul-Aug;27(4):465-72. [PMID: 23812216]

 

Arai T, Kim HJ, Hirako S, Nakasatomi M, Chiba H, Matsumoto A.
Effects of dietary fat energy restriction and fish oil feeding on hepatic metabolic abnormalities and insulin resistance in KK mice with high-fat diet-induced obesity.
J Nutr Biochem. 2013 Jan;24(1):267-73. [PMID: 22901684]

 

Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
Hepatol Res. 2013 Mar;43(3):276-88. [PMID: 22834991]

 

Kadowaki S1, Munekane M, Kitamura Y, Hiromura M, Kamino S, Yoshikawa Y, Saji H, Enomoto S.
Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent.
Biol Trace Elem Res. 2013 Jul;154(1):111-9. [PMID: 23712834]

 

2014

Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ, Horiuchi M.
Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice.
Eur J Pharmacol. 2014 Feb 5;724:9-15. [PMID: 24361310]

 

Matsumoto S, Shimabukuro M, Fukuda D, Soeki T, Yamakawa K, Masuzaki H, Sata M.
Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice.
Cardiovasc Diabetol. 2014 Jan 31;13:30. [PMID: 24485356]

 

Ko SH, Lee JK, Lee HJ, Ye SK, Kim HS, Chung MH.
8-Oxo-2'-deoxyguanosine ameliorates features of metabolic syndrome in obese mice.
Biochem Biophys Res Commun. 2014 Jan 10;443(2):610-6. [PMID: 24333420]

 

Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kanaoka T, Kobayashi R, Ohki K, Matsuda M, Tsurumi-Ikeya Y, Yamashita A, Tokita Y, Umemura S.
Effects of the Angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders.
Biomed Res Int. 2014;2014:946492. [PMID: 24991574]

 

Maeda A, Tamura K, Wakui H, Ohsawa M, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Kanaoka T, Dejima T, Ohki K, Haku S, Yamashita A, Umemura S.
Effects of Ang II receptor blocker irbesartan on adipose tissue function in mice with metabolic disorders.
Int J Med Sci. 2014 Apr 27;11(6):646-51. [PMID: 24834011]

 

Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H.
Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
PLoS One. 2014 Aug 29;9(8):e104948. [PMID: 25170869]

 

Tanaka H, Fukahori S, Baba S, Ueno T, Sivakumar R, Yagi M, Asagiri K, Ishii S, Tanaka Y.
Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice.
JPEN J Parenter Enteral Nutr. 2014 Oct 14. [PMID: 25316683]

 

Ishizawa K, Izawa-Ishizawa Y, Yamano N, Urushihara M, Sakurada T, Imanishi M, Fujii S, Nuno A, Miyamoto L, Kihira Y, Ikeda Y, Kagami S, Kobori H, Tsuchiya K, Tamaki T.
Nitrosonifedipine ameliorates the progression of type 2 diabetic nephropathy by exerting antioxidative effects.
PLoS One. 2014 Jan 28;9(1):e86335. [PMID: 24489716]

 

Hayashi Y, Suemitsu E, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Kaji N, Baba Y, Harashima H.
Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.
Mol Ther Nucleic Acids. 2014 Mar 18;3:e154. [PMID: 24643205]

 

Hosaka T, Sasaga S, Yamasaka Y, Nii Y, Edazawa K, Tsutsumi R, Shuto E, Okahisa N, Iwata S, Tomotake H, Sakai T.
Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice.
J Med Invest. 2014;61(3-4):345-52. [PMID: 25264053]

 

Omote K, Gohda T, Murakoshi M, Sasaki Y, Kazuno S, Fujimura T, Ishizaka M, Sonoda Y, Tomino Y.
Role of the TNF pathway in the progression of diabetic nephropathy in KK-A(y) mice.
Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1335-47. [PMID: 24647715]

 

Akiyama N, Akiyama Y, Kato H, Kuroda T, Ono T, Imagawa K, Asakura K, Shinosaki T, Murayama T, Hanasaki K.
Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation.
J Pharmacol Exp Ther. 2014 Apr;349(1):66-74. [PMID: 24511146]

 

Nonogaki K, Hazama M, Satoh N.
Liraglutide suppresses obesity and hyperglycemia associated with increases in hepatic fibroblast growth factor 21 production in KKAy mice.
Biomed Res Int. 2014;2014:751930. [PMID: 24804243]

 

Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, Eto K.
Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice.
J Appl Toxicol. 2014 Aug;34(8):914-23. [PMID: 24243536]

 

Sugizaki T, Watanabe M, Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.
The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice.
Endocrinology. 2014 Aug;155(8):2810-9.[PMID: 24773344]

 

神内 伸也, 新藤 由梨, 内海 有香, 岩田 直洋, 岡﨑 真理, 鈴木 史子, 飯塚 博, 浅野 哲, 松崎 広和, 日比野 康英
2 型糖尿病マウスの肝臓における霊芝菌糸体培養培地抽出物 (WER) の糖質代謝に与える影響
509-515 Vol. 11 (2014) No.1: 57-66 [PMID: None]

 

2015

Ikeda K, Tomimoto S, Tsuchiya S, Hamagami, K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H,
Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice.
Biochemistry and Biophysics Reports Volume 2, July 2015, Pages 179–183. [PMID: None]

 

Horiba T, Katsukawa M, Mita M, Sato R.
Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway.
Biochem Biophys Res Commun. 2015 Aug 7;463(4):846-52. [PMID: 26051277]

 

Nakaoka H, Mogi M, Kan-No H, Tsukuda K, Ohshima K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Horiuchi M.
Angiotensin II type 2 receptor signaling affects dopamine levels in the brain and prevents binge eating disorder.
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):749-57. [PMID: 25757658]

 

Byun SY, Shin YJ, Nam KY, Hong SP, Ahn SK.
A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, UI-1499.
Life Sci. 2015 Jan 1;120:1-7. [PMID: 25447448]

 

Xuan M, Okazaki M, Iwata N, Asano S, Kamiuchi S, Matsuzaki H, Sakamoto T, Miyano Y, Iizuka H, Hibino Y.
Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain.
Evid Based Complement Alternat Med. 2015;2015:865986. [PMID: 25945116]

 

Takahashi H, Goto T, Yamazaki Y, Kamakari K, Hirata M, Suzuki H, Shibata D, Nakata R, Inoue H, Takahashi N, Kawada T.
Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α.
J Lipid Res. 2015 Feb;56(2):254-65. [PMID: 25510248]

 

Morikawa T, Akaki J, Ninomiya K, Kinouchi E, Tanabe G, Pongpiriyadacha Y, Yoshikawa M, Muraoka O.
Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis.
Nutrients. 2015 Feb 27;7(3):1480-93. [PMID: 25734563]

 

Ishihara R, Mizuno Y, Miwa A, Hamada A, Tsuruta T, Wabitsch M, Sonoyama K.
Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes.
Biochem Biophys Res Commun. 2015 Mar 6;458(2):362-8. [PMID: 25656573]

 

Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Kaneko K, Ono H, Asano T, Oka Y, Katagiri H.
A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.
Nat Commun. 2015 Aug 13;6:7940 [PMID: 26268630]

 

Li ZS, Noda K, Fujita E, Manabe Y, Hirata T, Sugawara T.
The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Ay mice.
J Nutr. 2015 Mar;145(3):490-8. [PMID: 25733464]

 

Takasu T, Hayashizaki Y, Tahara A, Kurosaki E, Takakura S.
Antihyperglycemic effect of ipragliflozin, a sodium-glucose co-transporter 2 inhibitor, in combination with oral antidiabetic drugs in mice.
Clin Exp Pharmacol Physiol. 2015 Jan;42(1):87-93. [PMID: 25311502]

 

Maeda H, Hosomi R, Koizumi M, Toda Y, Mitsui M, Fukunaga K.
Dietary cod protein decreases triacylglycerol accumulation and fatty acid desaturase indices in the liver of obese type-2 diabetic KK-Ay mice.
Journal of Functional Foods Volume 14, April 2015, Pages 87–94 [PMID: None]

 

Tomimoto D, Okuma C, Ishii Y, Kobayashi A, Ohta T, Kakutani M, Imanaka T, Ogawa N.
JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice.
J Pharmacol Sci. 2015 Sep;129(1):51-8.[ PMID: 26354408]

 

Taketani K, Hoshino S, Uemura T, Goto T, Takahashi N, Tsuge N, Kawada T.
An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
J Nutr Sci Vitaminol (Tokyo). 2015;61(6):465-70. [PMID: 26875488]

 

2016

Mochizuki S, Takano M, Sugano N, Ohtsu M, Tsunoda K, Koshi R, Yoshinuma N.
The effect of B vitamin supplementation on wound healing in type 2 diabetic mice.
J Clin Biochem Nutr. 2016 Jan;58(1):64-8. [PMID: 26798199]

 

Nakadera E, Yamashina S, Izumi K, Inami Y, Sato T, Fukushima H, Kon K, Ikejima K, Ueno T, Watanabe S.
Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis.
Biochem Biophys Res Commun. 2016 Jan 22;469(4):1104-10. [PMID: 26687947]

 

Ozaki KI, Awazu M, Tamiya M, Iwasaki Y, Harada A, Kugisaki S, Tanimura S, Kohno M.
Targeting the ERK resistance and type 2 diabetes. signaling pathway as a potential treatment for insulin
Am J Physiol Endocrinol Metab. 2016 Feb 9. [PMID: 26860984]

 

Toshimitsu T, Mochizuki J, Ikegami S, Itou H.
Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice.
J Dairy Sci. 2016 Feb;99(2):933-46. [PMID: 26686731]

 

Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice.
Am J Physiol Endocrinol Metab. 2016 Feb 16:ajpendo.00028.2015. [PMID: 26884382]

 

Morimoto K, Watanabe M, Sugizaki 1, Irie J, Itoh H.
Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in Male Mice.
Endocrinology. 2016 Mar;157(3):1071-81. [PMID: 26789236]

 

Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E.
Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.
J Clin Biochem Nutr. 2016 Nov;59(3):207-214. [PMID: 27895388]

 

Yoshida M, Hayashi K, Watadani R, Okano Y, Tanimura K, Kotoh J, Sasaki D, Matsumoto K, Maeda A.
Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice.
J Vet Med Sci. 2016 Nov 26. [PMID: 27890887]

 

Kon K , Ikejima K , Morinaga M , Kusama H , Arai K , Aoyama T , Uchiyama A , Yamashina S , Watanabe S
L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-A(y) mice.
Hepatol Res. 2016 Apr 7. doi: 10.1111/hepr.12720. [Epub ahead of print][PMID: 27062266]

 

Takahashi H, Chi HY, Mohri S, Kamakari K, Nakata K, Ichijo N, Nakata R, Inoue H, Goto T, Kawada T.
Rice Koji Extract Enhances Lipid Metabolism through Proliferator-Activated Receptor Alpha (PPARα) Activation in Mouse Liver.
J Agric Food Chem. 2016 Nov 23;64(46):8848-8856. [PMID: 27934292]

 

Ravi Kumar,S, Yamauchi I, Bhaskar N, Katsuki A, Hosokawa M, Miyashita K
Squalene modulates fatty acid metabolism: Enhanced EPA/DHA in obese/diabetic mice (KK‐Ay) model
European Journal of Lipid Science and Technology, Volume 118, Number 12 [PMID: none]

 

Yamauchi I, Uemura M, Hosokawa M, Iwashima-Suzuki A, Shiota M, Miyashita K.
The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-A(y) mice and wild-type C57BL/6J mice.
Food Funct. 2016 Sep 14;7(9):3854-67.[PMID: 27501823]

 

2017

Hasegawa Y, Nakagawa E, Kadota Y, Kawaminami S.
Lignosulfonic acid promotes hypertrophy in 3T3-L1 cells without increasing lipid content and increases their 2-deoxyglucose uptake.
Asian-Australas J Anim Sci. 2017 Jan;30(1):111-118. [PMID: 27383805]

 

Kitamura K, Takamura Y, Iwamoto T, Nomura M, Iwasaki H, Ohdera M, Murakoshi M, Sugiyama K, Matsuyama K, Manabe Y, Fujii NL, Fushiki T.
Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle.
Biosci Biotechnol Biochem. 2017 Feb;81(2):335-342. [PMID: 27771987]

 

Morimoto M, Azuma N, Kadowaki H, Abe T, Suto Y.
Regulation of type 2 diabetes by helminth-induced Th2 immune response.
J Vet Med Sci. 2017 Jan 10;78(12):1855-1864. [PMID: 27665994]

 

Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.
Hepatol Res. 2017 Mar;47(3):E44-E54. [PMID: 27062266]

 

Naito Y, Yoshikawa Y, Shintani M, Kamoshida S, Kajiwara N, Yasui H.
Anti-hyperglycemic Effect of Long-Term Bis(hinokitiolato)zinc Complex ([Zn(hkt)2]) Ingestion on Insulin Resistance and Pancreatic Islet Cells Protection in Type 2 Diabetic KK-Ay Mice.
Biol Pharm Bull. 2017;40(3):318-326. [PMID: 28250273]

 

Yoshida M, Hayashi K, Watadani R, Okano Y, Tanimura K, Kotoh J, Sasaki D, Matsumoto K, Maeda A.
Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice.
J Vet Med Sci. 2017 Feb 14;79(2):299-307. [PMID: 27890887]

 

Iwase M, Yamamoto T, Nishimura K, Takahashi H, Mohri S, Li Y, Jheng HF, Nomura W, Takahashi N, Kim CS, Yu R, Taniguchi M, Baba K, Murakami S, Kawada T, Goto T.
Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation.
Lipids. 2017 Jun 10. [PMID: 28601955]

 

Munemasa T, Mukaibo T, Kondo Y, Masaki C, Kusuda Y, Miyagi Y, Tsuka S, Hosokawa R, Nakamoto T.
Salivary ｐgland hypofunction in KK-A y type 2 diabetic mice.
J Diabetes. 2017 Mar 16. [PMID: 28299899]

 

Takagi S, Yamashita T, Miura T.
Does a Treadmill Running Mineral Density and Bone Quality of the Femur in KK-Ay Mice, a Type 2 Diabetic Animal ModelExercise Contribute to Preventing Deterioration of Bone
Calcif Tissue Int. 2017 Dec;101(6):631-640.[PMID: 28779183]

 

Koga T, Aoki W, Fujii M, Satou K, Ikeda Y.
Spontaneous Infection Caused by Streptococcus agalactiae in KK-Ay Mice.
Comp Med. 2017 Oct 1;67(5):416-419.[PMID: 28935003]

 

Felix AD, Takahashi N, Takahashi M, Katsumata-Tsuboi R, Satoh R, Soon Hui T, Miyajima K, Nakae D, Inoue H, Uehara M.
Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice.
Biosci Biotechnol Biochem. 2017 Nov;81(11):2209-2211.[PMID: 28934910]

 

Watadani R, Kotoh J, Sasaki D, Someya A, Matsumoto K, Maeda A.
10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity.
J Vet Med Sci. 2017 Sep 29;79(9):1596-1602.[PMID: 28740028]

 

Adachi SI, Yoshizawa F, Yagasaki K.
Hyperuricemia in type 2 diabetic model KK-Ay/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels.
BMC Res Notes. 2017 Nov 7;10(1):577.[PMID: 29115981]

 

Takamura Y, Nomura M, Uchiyama A, Fujita S.
Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice.
J Nutr Sci Vitaminol (Tokyo). 2017;63(5):339-348.[PMID: 29225319]

 

2018

Moto M, Takamizawa N, Shibuya T, Nakamura A, Katsuraya K, Kazuyasu Iwasaki K, Tanaka K, Murota A.
Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice.
Journal of Functional Foods 40 (2018) 336–340. [PMID: none]

 

Hori M, Mutoh M, Ishigamori R, Imai T, Takahashi M.
Activated Ductal Proliferation Induced by N-Nitrosobis (2-oxopropyl)amine in Fat-infiltrated Pancreas of KK-Ay Mice.
In Vivo. 2018 May-Jun;32(3):499-505. [PMID: 29695552]

 

Tamura M, Hoshi C, Kimura Y, Suzuki T, Yamamoto-Maeda M.
Effects of γ-Polyglutamic Acid on the Cecal Microbiota and Visceral Fat in KK-Ay/TaJcl Male Mice,
Food Science and Technology Research, 2018 Volume 24 Issue 1 Pages 151-157. [PMID: none]

 

Hashim M, Yokoi N, Takahashi H, Gheni G, Okechi OS, Hayami T, Murao N, Hidaka S, Minami K, Mizoguchi A, Seino S.
Inhibition of SNAT5 Induces Incretin Responsive State From Incretin Unresponsive State in Pancreatic β-cells: Study of β-cell Spheroid Clusters as a Model.
Diabetes. 2018 Jun 28. pii: db171486. [PMID: 29954738]

 

Inagawa H, Saika T, Nishiyama N, Nisizawa T, Kohchi C, Uenobe M, Soma GI.
Dewaxed Brown Rice Feed Improves Fatty Liver in Obese and Diabetic Model Mice.
Anticancer Res. 2018 Jul;38(7):4339-4345.[PMID: 29970571]

 

Tian Z, Miyata K, Morinaga J, Horiguchi H, Kadomatsu T, Endo M, Zhao J, Zhu S, Sugizaki T, Sato M, Terada K, Okumura T, Murohara T, Oike Y.
Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction.
Circ J. 2018 Jan 25;82(2):437-447.[ PMID: 28890470]

 

An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Mastuda H, Kawada T, Goto T.
A Phytol-Enriched Diet Activates PPAR-α in the Liver and Brown Adipose Tissue to Ameliorate Obesity-Induced Metabolic Abnormalities.
Mol Nutr Food Res. 2018 Mar;62(6):e1700688.[PMID: 29377597]

 

Ueda T, Tategaki A, Hamada K, Kishida H, Hosoe K, Morikawa H, Nakagawa K.
Effects of Pediococcus acidilactici R037 on Serum Triglyceride Levels in Mice and Rats after Oral Administration.
J Nutr Sci Vitaminol (Tokyo). 2018;64(1):41-47.[PMID: 29491271]

 

Tobita H, Sato S, Yazaki T, Mishiro T, Ishimura N, Ishihara S, Kinoshita Y.
Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver.
Mol Med Rep. 2018 May;17(5):6840-6846.[PMID: 29512720]

 

Sugiyama M, Kikuchi A, Misu H, Igawa H, Ashihara M, Kushima Y, Honda K, Suzuki Y, Kawabe Y, Kaneko S, Takamura T.
Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
PLoS One. 2018 Mar 29;13(3):e0194798.[PMID: 29596463]

 

Yamashita Y, Kishida H, Nakagawa K, Yoshioka Y, Ashida H.
Liquorice flavonoid oil suppresses hyperglycaemia accompanied by skeletal muscle myocellular GLUT4 recruitment to the plasma membrane in KK-Ay mice.
Int J Food Sci Nutr. 2018 Oct 10:1-9. [PMID: 30304967]

 

Sekijima H, Goto K, Hiramoto K, Komori R, Ooi K.
Characterization of dry skin associating with type 2 diabetes mellitus using a KK-Ay/TaJcl mouse model.
Cutan Ocul Toxicol. 2018 Dec;37(4):391-395. [PMID: 30063844]

 

Iizuka Y, Ozeki A, Tani T, Tsuda T.
Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase.
J Nutr Sci Vitaminol (Tokyo). 2018;64(4):258-264. [PMID: 30175788]

 

Ogiwara M , Ota W , Mizushige T , Kanamoto R , Ohinata K .
Enzymatic digest of whey protein and wheylin-1, a dipeptide released in the digest, increase insulin sensitivity in an Akt phosphorylation-dependent manner.
Food Funct. 2018 Sep 19;9(9):4635-4641.[PMID: 30151525]

 

Nishiguchi T, Yoshikawa Y, Yasui H.
Investigating the target organs of novel anti-diabetic zinc complexes with organo‑selenium ligands.
J Inorg Biochem. 2018 Aug;185:103-112. [PMID: 29843022]

 

Horio F.
Studies of Genetic and Nutritional Factors in Disorders of Glucose and Lipid Metabolism.
Nippon Eiyo Shokuryo Gakkaishi 2018 Volume 71 Issue 6 Pages 267-274 [PMID: None]

 

2019

Suzuki M, Kon K, Ikejima K, Arai K, Uchiyama A, Aoyama T, Yamashina S, Ueno T Watanabe S.
The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-Ay Mice.
Alcohol Clin Exp Res. 2019 Apr;43(4):617-627. [PMID: 30748014]

 

Izu H, Okuda M, Shibata S, Fujii T, Matsubara K.
Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice.
Biosci Biotechnol Biochem. 2019 Apr;83(4):747-750. [PMID: 30582404]

 

Ho HJ, Shirakawa H, Hirahara K, Sone H, Kamiyama S, Komai M.
Menaquinone-4 Amplified Glucose-Stimulated Insulin Secretion in Isolated Mouse Pancreatic Islets and INS-1 Rat Insulinoma Cells.
Int J Mol Sci. 2019 Apr 23;20(8). [PMID: 31018587]

 

Sakurai S, Inai Y, Minakata S, Manabe S, Ito Y, Ihara Y.
A novel assay for detection and quantification of C-mannosyl tryptophan in normal or diabetic mice.
Sci Rep. 2019 Mar 18;9(1):4675. [PMID: 30886328]

 

Kimura N, Kikumori A, Kawase D, Okano M, Fukamachi K, Ishida T, Nakajima K, Shiomi M.
Species differences in lipoprotein lipase and hepatic lipase activities: comparative studies of animal models of lifestyle-related diseases.
Exp Anim. 2019 Feb 11. [PMID: 30745527]

 

Kitagawa R, Kon K, Uchiyama A, Arai K, Yamashina S, Kuwahara-Arai K, Kirikae T, Ueno T, Ikejima K.
Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature.
Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G707-G715. [PMID: 31509430]

 

Maekawa M, Tadaki H, Tomimoto D, Okuma C, Sano R, Ishii Y, Katsuda Y, Yoshiuchi H, Kakefuda R, Ohta T, Sasase T.
A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
Biol Pharm Bull. 2019;42(11):1906-1912. [PMID: 31685773]

 

Morishita K, Miike T, Takeda S, Fukui M, Ito Y, Kitao T, Ozawa SI, Hirono S, Shirahase H.
(S)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist.
Chem Pharm Bull (Tokyo). 2019;67(11):1211-1224. [PMID: 31685749]

 

Akutagawa K, Fujita T, Ouhara K, Takemura T, Tari M, Kajiya M, Matsuda S, Kuramitsu S, Mizuno N, Shiba H, Kurihara H.
Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice.
Int Immunopharmacol. 2019 Mar;68:30-38 [PMID: 30599445]

 

Toyoda T, Kamei A, Ishijima T, Abe K, Okada S.
A maple syrup extract alters lipid metabolism in obese type 2 diabetic model mice.
Nutr Metab (Lond). 2019 Dec 4;16:84. [PMID: 31827572]

 

Guan Y, Nakano D, Zhang Y, Li L, Tian Y, Nishiyama A.
A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators.
Sci Rep. 2019 Jul 18;9(1):10435. [PMID: 31320707]

 

2020

Mitsuhiro Kondo, Atsuo Tahara, Kazumi Hayashi, Hiroshi Inami, Takeshi Ishikawa, Yuichi Tomura.
Therapeutic effects of interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 on diabetic nephropathy in type 2 diabetic mice.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul;393(7):1197-1209. [PMID: 31974740]

 

Saki Ichikawa, Tomohito Gohda, Maki Murakoshi, Zi Li, Eri Adachi, Takeo Koshida, Yusuke Suzuki.
Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice.
FEBS Open Bio. 2020 Jun; 10(6): 1122–1134. [PMID: 32301275]

 

Atsuo Tahara, Toshiyuki Takasu.
Therapeutic Effects of SGLT2 Inhibitor Ipragliflozin and Metformin on NASH in Type 2 Diabetic Mice.
Endocr Res. Feb-May 2020;45(2):147-161. [PMID: 31955626]

 

Megumi Yamamoto, Rie Yanagisawa, Atsushi Sakai, Masaki Mogi, Satoshi Shuto, Masachika Shudo, Hazuki Kashiwagi, Megumi Kudo, Masaaki Nakamura, Mineshi Sakamoto.
Toxicokinetics of methylmercury in diabetic KK-Ay mice and C57BL/6 mice.
J Appl Toxicol. 2020 Oct 5. [PMID: 33015845]

 

Koki Sugimoto, Ryota Hosomi, Munehiro Yoshida, Kenji Fukunaga.
Effects of dietary oils prepared from the internal organs of the Japanese giant scallop ( Patinopecten yessoensis) on cholesterol metabolism in obese type-II diabetic KK- A y mice.
Food Sci Nutr. 2020 Oct 26;8(12):6727-6737. [PMID: 33312556]

 

T Ishida, S Morisawa, M Iizuka, H Fujita, K Jobu, Y Morita, M Miyamura.
Juzentaihoto extract suppresses adipocyte hypertrophy and improves hyperglycemia in KKAy mice.
Pharmazie. 2020 May 1;75(5):191-194. [PMID: 32393426]

 

Naoki Takatani, Daisuke Taya, Ami Katsuki, Fumiaki Beppu, Yumiko Yamano, Akimori Wada, Kazuo Miyashita, Masashi Hosokawa.
Identification of Paracentrone in Fucoxanthin-Fed Mice and Anti-Inflammatory Effect against Lipopolysaccharide-Stimulated Macrophages and Adipocytes.
Mol Nutr Food Res. 2020 Nov 20;e2000405. [PMID: 33215789]

 

Katsunori Nonogaki, Takao Kaji.
Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KK-A y mice.
Heliyon. 2020 Dec 19;6(12):e05774.[PMID: 33364514]

 

2021

Tsuneki Horikawa, Keiichi Hiramoto, Kenji Goto, Hidehisa Sekijima, Kazuya Ooi .
Differences in the mechanism of type 1 and type 2 diabetes-induced skin dryness by using model mice.
Int J Med Sci. 2021 Jan 1;18(2):474-481. [PMID: 33390816]

 

2023

Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Ooi
Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice
Life (Basel). 2023 Jul 11;13(7):1540. doi: 10.3390/life13071540.

 

Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Ooi
Changes in the AGE/Macrophage/TNF-α Pathway Affect Skin Dryness during KK-Ay/Tajcl Mice Aging
Life (Basel). 2023 Jun 7;13(6):1339. doi: 10.3390/life13061339.

 

2024

Masashi Imai, Keiichi Hiramoto, Shota Tanaka, Kazuya Ooi
Interactions between Age-Related Type 2 Diabetes and the Small Intestine
Biol Pharm Bull. 2024;47(4):791-795. doi: 10.1248/bpb.b24-00065.