*C57BL/6J mice cannot be shipped outside of Japan due to licensing agreements. Please consider using our contract research services if you need to use this strain.
Histopathological Analysis Results
|
Animal/Age |
C57BL/6J mice / 24 weeks old |
|
Necropsy Location |
Ishibe Breeding Farm |
|
Necropsy Date |
2024/12/10-13 |
|
Sex |
♂♀ |
|
Dietary Conditions |
CE-2, HFD32, QF |
|
n Number |
5 animals per group / Total 30 |
|
Organs for Histopathological Analysis |
Liver, Kidney |
|
Statistical Analysis |
Difference between diets: Kruskal-Wallis / |
Summary of Histopathological Evaluation
Liver:
• Both HFD32 and QF induced hepatic steatosis (fatty change of hepatocytes), but it was more pronounced in HFD32 for both males and females.
• Deposited lipid droplets were of larger size in females.
• Inflammatory cell infiltration was induced to a very mild degree in males.
Kidney:
• Vacuolar degeneration of tubular epithelial cells was observed in males with both HFD32 and QF.
• Inflammation in the renal pelvis region was observed more frequently in the female HFD32 group.
• Glomerular lesions tended to increase slightly with both HFD32 and QF.
Liver
*: vs control within each sex
#: HFD32 vs QF within each sex
†: between sexes within the same diet
ND: Not detected
HFD32
• Severe; especially macrovesicular steatosis in females (♀)
QF
• Low to moderate; less severe in females (♀) than in males (♂)
Inflammatory Cell Infiltration
• Extremely mild in all groups
Kidney / Males (♂)
*: vs control within each sex
#: HFD32 vs QF within each sex
†: between sexes within the same diet
ND: Not detected
HFD32・QF
• Vacuolar degeneration of tubular epithelial cells
• Observed with HFD32 and QF; prominent in males (♂)
Inflammation in the renal pelvis region
• →2 cases in HFD32 males (♂)
Kidney / Females (♀)
*: vs control within each sex
#: HFD32 vs QF within each sex
†: between sexes within the same diet
ND: Not detected
HFD32
• Vacuolar degeneration of tubular epithelial cells
• Observed with HFD32; degree was very mild
Inflammation in the renal pelvis region
• →HFD32 females (♀): 2 cases (very mild to moderate)
• QF females (♀): 2 cases (very mild)
Urinary casts
• Extremely mild in all groups
Regarding Inflammation in the Renal Pelvis Region
• Higher frequency and degree in females (♀).
• Potentially more easily induced by HFD32.
Kidney / GlomeruliKidney / Glomeruli
ND: Not detected
HFD32・QF
•HFD32 and QF: Glomerular lesions were very mild.
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