Profile of BALB/cAJcl・BALB/cByJJcl Mice

References

Foster et al eds., The Mouse in Biomedical Research, Volume I: 1981; Volume II: 1982; Volume III: 1983; Volume IV: 1982, Academic Press Inc. New York.

 

Biochemical and Immunological Loci

 

 

Lifespan

• Conventional environment:

• S.P.F. environment:

 

Naturally Occurring Tumors and Lesions

• Amyloidosis incidence: 40%, reticular neoplasms: 23% in females, 3% in males (Ebbesen, 1971)

• Lymphatic leukemia incidence: 0% (Hoag, 1963)

• Mammary tumor incidence: 0% overall, 5% in multiparous females, and 1% in nulliparous females (Hoag, 1963)

• Low incidence of fibromas (Storer, 1966)

• Lung tumor incidence: 26-29% (Heston, 1968)

• No incidence of congenital malformations (Kalter, 1968)

• Leukemia incidence: 5% (Myers, 1970)

• Mammary tumor incidence at 2 years of age: 30% (Bentvelzen, 1970)

• Incidence of heart damage due to calcium deposition: 17-62% (Festing, 1971)

• Mammary tumor incidence at 14 months of age: 10% (Schlom, 1973)

• Various tumor incidences: kidney tumors 25-48%, mammary tumors 3-13%, reticuloendothelial tumors 11-20%, lung tumors 10-16%, synovial tumors 2-8% (Sass, 1976)

• Myocarditis with right ventricular cardiomyopathy in 60% of males and 30% of females. Fibrosis is a late-stage symptom of myocarditis and is occasionally seen in general mouse strains (Bellini, 1976)

 

Immunological Characteristics

• Good immune response to Vi antigen (Gaines, 1965)

• Susceptible to BALB/Tennant leukemia virus (Tennant, 1965)

• Low concentration of anti-DNP antibody (Paul, 1970)

• Good immune response to Type III pneumococcal polysaccharide (Brala, 1971)

• Very good immune response to Cholera A and B antigens (Cerny, 1971)

• Resistant to experimental immune thyroiditis (Vladutiu, 1971)

• Resistant to anaphylactic shock induced by ovalbumin (Tanioka, 1971)

• Poor immune response to bacteriophage fd (Kolsch, 1971)

• Progression of leukemia is highly influenced by sensitization with Friend virus (Dietz, 1972)

• Good PCF immune response of the spleen to pneumococcal polysaccharide (Amsbaugh, 1972)

• Relatively resistant to intestinal helminths (Eaton, 1972)

• Low erythrocyte agglutinability (Blomberg, 1972)

• Good immune response to Salmonella anatum and S. senftenberg lipopolysaccharides, but poor response to S. strasbourg lipopolysaccharide (Dipanli, 1972)

• Good immune response to dextran-1,3 glucosyl linkages and dextran (Blomberg, 1972)

• Young lymphocytes show high sensitivity to PHA sensitization (Hellman, 1972)

• Resistant to infection with Salmonella typhimurium strain C5 (Pobson, 1972)

• Resistant to induction of experimental allergic encephalomyelitis (Levine, 1973)

• Good primary immune response to haemolysin and haemagglutinin (Ghaffar, 1973)

• Susceptible to synthetic polypeptides and Gla 60, Ala 80, Tyr 10 (Dorf, 1974)

• High sensitivity of lymphocytes to phytohaemagglutinin (Heiniger, 1975)

• Susceptible to MHV type III (Leprevost, 1975)

• Resistant to induction of diabetes mellitus by encephalomyelitis virus (Boucher, 1975)

• 100% vertical transmission of leukemia virus for up to three generations (Jenson, 1976)

 

Physiological and Biochemical Characteristics

• High β-glucuronidase activity in seminal fluid (Erickson, 1967)

• Low serum cholinesterase activity in females (Angel, 1967)

• Low serum haptoglobin levels (Peacock, 1967)

• High systolic blood pressure in the heart (Schlager, 1967)

• Low serum ceruloplasmin in males (Meler, 1968)

• High brain hypoxanthine-guanine phosphoribosyl transferase activity but low N-methyl nicotinamide oxidase activity (Haff, 1969)

• High erythrocyte catalase activity (Huffman, 1971)

• Fast peripheral nerve conduction velocity (Hegmann, 1972)

• Low brain tyrosin hydroxylase activity (Ciranello, 1972)

• High brain L-glutamic acid decarboxylase, choline acetyltransferase, and catechol-O-methyl transferase activities, but low acetylcholinesterase and monoamine oxidase activities (Tunnicliff, 1973)

• High kidney arylsulfatase activity (Damiel, 1976)

 

Pharmacological Characteristics

• Susceptible to chloroform toxicity (Christensen, 1963)

• Susceptible to leukemia induction but resistant to liver cancer induction by neonatal DMBA administration (Flaks, 1968)

• Highly susceptible to tumor induction by 3-methylcholanthrene (Whithmire, 1971)

• Low ovarian sensitivity to PMS 3 IU and 7 IU, but increased sensitivity with male cohabitation (Zarrow, 1971)

• High incidence of myeloma induced by intraperitoneal injection of mineral oil (Potter, 1972)

• Susceptible to skin tumor formation by DMBA (Thomas, 1973)

• Low excitatory behavior after D-amphetamine treatment (Babbini, 1974)

• High incidence of lung cancer induced by inhalation of methylcholanthrene (Akamatsu, 1974)

• Resistant to isoniazid toxicity (Taylor, 1976)

 

Anatomical Characteristics

• Incidence of accessory spleens is 21% (Hummel, 1966), and the spleen is large at all ages (Albert, 1966)

• Brain weight is heavy (Storer, 1967)

• The volume of the cerebral hippocampus is large (Wimer, 1968)

• The relative weight of the kidney is heavy (Schlager, 1968)

• The pituitary gland is small (Sinha, 1975)

• The brain-to-body weight ratio is large, and the spinal cord is also large (Roderick, 1973) The incidence of corpus callosum agenesis is 39% (Wahlsten, 1974)

※Quoted and modified from Jcl NEWS No.1, issued October 1, 1989, by CLEA Japan, Inc., Development Division.

 

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