Academic Reference Archive：SDT fatty/Jcl

2026/01/20

SDT Fatty Rat Academic Reference List

Research Use Snapshot

Model: SDT fatty/Jcl (spontaneous obese type 2 diabetes model with leptin receptor mutation)
Best suited for: Long-term studies of metabolic syndrome–driven multi-organ complications (kidney, eye, neuropathy/muscle, systemic decline).
Key characteristics on this page: Spontaneous obesity/hyperglycemia/insulin resistance; progressive DKD and CKM-related pathophysiology; natural ocular complications (retinopathy, macular edema–like lesions, cataract); neuropathy and muscle dysfunction; genetic background and time-dependent disease progression.
How to browse: Use the topic sections below or the original year-based list.

🩺 Metabolic Syndrome & Type 2 Diabetes

Why use SDT fatty/Jcl for metabolic syndrome and type 2 diabetes research? This model spontaneously develops obesity, hyperglycemia, and insulin resistance, providing a robust platform to study disease onset, metabolic dysregulation, and intervention effects over time.

A novel model of obesity-related diabetes: introgression of the Lepr (fa) allele… (2005) — see 2005
Diabetes-associated complications in SDT fatty rats. (2008) — see 2008
Effects of preventing hyperphagia on glycolipid metabolic abnormalities… (2008) — see 2008
Effect of food restriction on adipose tissue… (2009) — see 2009
Pathophysiological analysis of female SDT fatty rats. (2010) — see 2010
Effects of food restriction on pancreatic islets… (2011) — see 2011
SDT Fatty Rat: A Novel Model of Obese Type 2 Diabetes. (2011) — see 2011
Elevated GLP-1 on high-fat diet feeding prevents incidence of diabetes… (2012) — see 2012
Increased production of active ghrelin is relevant to hyperphagia… (2012) — see 2012
Metabolic Disorders and Diabetic Complications… (2013) — see 2013
Gender Differences in Metabolic Disorders and Related Diseases… (2014) — see 2014

🫀 Diabetic Kidney Disease & CKM Progression

A model for diabetic kidney disease and CKM progression. SDT fatty/Jcl rats exhibit progressive renal dysfunction associated with metabolic abnormalities, enabling longitudinal evaluation of diabetic kidney disease within a cardio–kidney–metabolic (CKM) framework.

Effects of unilateral nephrectomy on renal function… (2014) — see 2014
Urinary L-FABP as a biomarker of renal hypoxia… (2019) — see 2019
Acute and direct effects of SGLT2 inhibition on GFR… (2019) — see 2019
Glomerular hyperfiltration associated with hyperglycemia… (2021) — see 2021
Salt loading with unilateral nephrectomy accelerates decline in GFR… (2022) — see 2022
Restoration of BCAA catabolism improves kidney function in CKM models… (2025) — see 2025

👁️ Ocular Complications (Retinopathy & Cataract)

Natural development of diabetic ocular complications. This model develops diabetic retinopathy and cataracts without artificial induction, supporting mechanistic and translational studies of diabetes-related eye disorders.

Ocular inflammation in uveal tract in aged obese type 2 diabetic rats… (2014) — see 2014
Involvement of polyol pathway and oxidative stress in cataract formation… (2020) — see 2020
Diabetic Cataract in SDT fatty rats. (2020) — see 2020
Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy… (2024) — see 2024
Early stage diabetic retinopathy characterized by capillary changes and inflammation… (2025) — see 2025

🧠 Neuropathy, Muscle & Systemic Complications

Systemic complications beyond glycemic control. Publications in this section highlight neuropathy, muscle dysfunction, and systemic impairments, allowing comprehensive assessment of multi-organ complications associated with progressive type 2 diabetes.

Diabetic peripheral neuropathy in SDT fatty rats. (2012) — see 2012
Pharmacological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model. (2017) — see 2017
Depression-related behavioural and neuroendocrine changes… (2018) — see 2018
Pathophysiological analyses of skeletal muscle… (2018) — see 2018
Analysis of haemodynamics and angiogenic response to ischaemia… (2020) — see 2020
Relationship between urinary L-FABP and sarcopenia… (2020) — see 2020

🧬 Genetic Background & Disease Progression

Understanding disease progression and model characteristics. Studies here focus on the genetic background, sex differences, aging effects, and pathological progression of SDT fatty/Jcl rats, providing essential context for experimental design and data interpretation.

Introgression of Lepr (fa)… into SDT rats. (2005) — see 2005
Evaluation of blood pressure in SDT-Lepr(fa) rats. (2010) — see 2010
Blood pressure characteristics of female SDT-Lepr(fa) rats. (2011) — see 2011
Effects of ovariectomy on bone metabolism and BMD… (2011) — see 2011
Characteristics of bone turnover, bone mass and bone strength… (2012) — see 2012
Physiological changes induced by salt intake in female SDT fatty rats… (2014) — see 2014

📚 Key Publications (Timeline)

If you read only these publications, you will quickly understand SDT fatty/Jcl. This short timeline highlights foundational and representative studies listed on this page.

2005 — A novel model of obesity-related diabetes: introgression of the Lepr (fa) allele…
2008 — Diabetes-associated complications in SDT fatty rats.
2010 — Pathophysiological analysis of female SDT fatty rats.
2013 — Metabolic Disorders and Diabetic Complications… (J Diabetes Res.)
2014 — Effects of unilateral nephrectomy on renal function… (J Diabetes Res.)
2018 — Pharmacological responses… a new NASH model. (J Vet Med Sci.)
2019 — Urinary L-FABP as a biomarker of renal hypoxia…
2020 — Diabetic Cataract in SDT fatty rats. (J Diabetes Res.)
2024 — Pemafibrate protective effect against diabetic retinopathy…
2025 — Restoration of BCAA catabolism improves kidney function in CKM models…

Related CLEA Japan product: SDT fatty/Jcl

References by Year

2005
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025

Inquiry:

If you have any question, please feel free to contact us from here .

2005

Masuyama T, Katsuda Y, Shinohara M.
A novel model of obesity-related diabetes: introgression of the Lepr (fa) allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats.
Exp Anim. 2005; 54(1): 13-20. [PMID: 15725677]

2008

Matsui K, Ohta T, Oda T, Sasase T, Ueda N, Miyajima K, Masuyama T, Shinohara M, Matsushita M.
Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats.
Exp Anim. 2008; 57(2): 111-21. [PMID: 18421173]

Kenichi MATSUI, Takeshi OHTA, Hisayo MORINAGA, Tomohiko SASASE, Sumiaki FUKUDA, Makoto ITO, Masatoshi UEDA, Naoto OGAWA, Katsuhiro MIYAJIMA, Mutsuyoshi MATSUSHITA.
Effects of preventing hyperphagia on glycolipid metabolic abnormalities in Spontaneously Diabetic Torii fatty rats.
Anim Sci J. 2008; 79(5): 605–13.

2009

Morinaga H, Ohta T, Matsui K, Sasase T, Fukuda S, Ito M, Ueda M, Ishii Y, Miyajima K, Matsushita M.
Effect of food restriction on adipose tissue in spontaneously diabetic Torii
fatty rats. Exp Diabetes Res. 2009; 2009:715057. [PMID: 19696902]

2010

Ishii Y, Ohta T, Sasase T, Morinaga H, Ueda N, Hata T, Kakutani M, Miyajima K, Katsuda Y, Masuyama T, Shinohara M, Matsushita M.
Pathophysiological analysis of female spontaneously diabetic Torii fatty rats.
Exp Anim. 2010; 59(1): 73-84. [PMID: 20224171]

Ishii Y, Maki M, Yamamoto H, Sasase T, Kakutani M, Ohta T.
Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats.
Exp Anim. 2010; 59(4): 525-9. [PMID: 20661000]

2011

Ishii Y, Ohta T, Sasase T, Morinag H, Miyajima K, Kakutani M.
Effects of food restriction on pancreatic islets in Spontaneously Diabetic Torii fatty rats.
J Vet Med Sci. 2011; 73(2): 169-75. [PMID: 20877155]

Ishii Y, Maki M, Yamamoto H, Sasase T, Kakutani M, Ohta T.
Blood Pressure Characteristics of Female Spontaneously Diabetic Torii-Lepr(fa) Rats.
J Vet Med Sci. 2011; 73(4): 501–5. [PMID: 21127391]

Fukuda S, Miyajima K, Sasase T, Ohta T.
Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rat: A Novel Model of Obese Type 2 Diabetes.
Open Diabetes J. 2011; 4: 30-6.

Kimura S, Sasase T, Ohta T, Matsushita M.
Effects of Ovariectomy on Bone Metabolism and Bone Mineral Density in Spontaneously Diabetic Torii-Lepr fa Rats.
J Vet Med Sci. 2011; 73(8): 1025-9. [PMID: 21490414]

龍門徳彦, 稲葉信博, 中村早苗, 平尾直啓, 前野孝之, 千葉薫, 笹瀬智彦, 太田毅.
簡易ガラス化法を用いたSpontaneously Diabetic Torii-Leprfa (SDT-fa/fa) ratの2細胞期胚の凍結保存.
実験動物技術. 2011; 46(1): 3-9.

2012

Kimura S, Sasase T, Ohta T, Sato E, Matsushita M.
Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Leprfa rats.
J Bone Miner Metab. 2012; 30(3): 312-20. [PMID: 22038286]

Kimura S, Sasase T, Ohta T, Sato E, Matsushita M.
Parathyroid hormone (1-34) improves bone mineral density and glucose metabolism in Spontaneously Diabetic Torii-Leprfa rats.
J Vet Med Sci. 2012; 74(1): 103-5. [PMID: 21869570]

Hata T, Ohta T, Ishii Y, Sasase T, Yamaguchi T, Mera Y, Miyajima K, Tanoue G, Sato E, Matsushita M.
Elevated glucagon-like peptide-1 on a high-fat diet feeding prevents the incidence of diabetes mellitus in Spontaneously Diabetic Torii Leprfa rats.
J D M. 2012; 2(2): 170-8.

Yamaguchi T, Sasase T, Mera Y, Tomimoto D, Tadaki H, Kemmichi Y, Ohta T, Sato E, Matsushita M.
Diabetic peripheral neuropathy in Spontaneously Diabetic Tprii-Lepr (fa) (SDT Fatty) rats.
J Vet Med Sci. 2012; 74(12): 1669-73.［PMID: 22850562］

稲葉信博, 中村早苗, 平尾直啓, 龍門徳彦, 千葉薫, 美谷島克宏, 太田毅.
雌性Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) ラットの生殖学的基礎検討.
実験動物技術. 2012; 47(1): 3-9.

平尾直啓, 竜門徳彦, 稲葉信博, 千葉薫, 笹瀬智彦, 太田毅.
SDT-fa/fa および SDT- +/+ラットの糖尿病発症・進展に２種の基礎資料が及ぼす影響.
実験動物技術. 2012; 47(2): 55-56.

Hata M, Nishi Y, Tajiri Y, Masuyama T, Hosoda H, Kangawa K, Kojima M.
Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats.
MET CLI EXP Vol.61(2012): 491-495

Masuda T, Muto S, Fujisawa G, Iwazu Y, Kimura M, Kobayashi T, Sarukawa M, Sasaki N, Watanabe Y, Shinohara M, Murakami T, Shimada K, Kobayashi E, Kusano E.
Heart angiotensin Ⅱ-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progresses diabetic cardiomyopathy.
Am J Physiol Heart Circ Physiol. 2012; 302.

Hiroharu Mifune, Yoshihiro Nishi, Yuji Tajiri, Taku Masuyama, Hiroshi Hosoda, Kenji Kangawa, Masayasu Kojima.
Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats
Metabolism. 2012 Apr;61(4):491-5. doi: 10.1016/j.metabol.2011.09.001. Epub 2011 Oct 14. PMID: 22001335

2013

Yusuke Kenmochi, Kenji Fukui, Mimi Maki, Shuichi Kimura, Yukihito Ishii, Tomohiko Sasase, Katsuhiro Miyajima, and Takeshi Ohta.
Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Leprfa Rat: A New Obese Type 2 Diabetic Model.
J Diabetes Res. 2013; 2013: 948257. [PMID: 23691524]

Islam MS.
Animal models of diabetic neuropathy: progress since 1960s.
J Diabetes Res. 2013; 2013:149452. [PMID: 23984428]

Wang Y, Sun G, Sun J, Liu S, Wang J, Xu X, Miao L.
Spontaneous Type2 Diabetic Rodent Models.
J Diabetes Res. 2013; 2013:401723

Sasase T, Ohta T, Masuyama T, Yokoi N, Kakehashi A, Shinohara M.
The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications
J Diabetes Res. 2013;2013:976209. doi: 10.1155/2013/976209. Epub 2013 Feb 26.PMID: 23691526

2014

太田毅、勝田佳朋、槇美実、篠原雅巳、Tong Bin、山田宣永.
食塩負荷がSDT fattyラットの血圧、腎機能に及ぼす影響.
北信越畜産学会報. 2014; 108: 9-14.

Katsuda Y, Kenmochi Y, Maki M, Sano R, Ishii Y, Miyajima K, Kakimoto K, Ohta T.
Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Leprfa (SDT fatty) rat, a novel obese type 2 diabetic model.
Anim Sci J. 2014; 85(5): 588-94. [PMID: 24571912]

Katsuda Y, Ohta T, Miyajima K, Kenmochi Y, Sasase T, Tong B, Shinohara M, Yamada T.
Diabetic complications in obese type 2 diabetic rat models.
Exp Anim. 2014; 63(2): 121-32. [PMID: 24770637]

Takeshi Ohta, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong, and Takahisa Yamada.
Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-Leprfa Rats.
J Diabetes Res. 2014; 2014:841957. [PMID: 24892034]

Katsuda Y, Kenmochi Y, Maki M, Sano R, Toriniwa Y, Ishii Y, Miyajima K, Kakimoto K, Ohta T.
Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model.
J Diabetes Res. 2014; 2014:363126. doi: 10.1155/2014/363126. Epub 2014 Aug 10. [PMID: 25177706]

Kenmochi Y, Miyajima K, Ohta T, Sasase T, Yasui Y, Toyoda K, Kakimoto K, Shoda T, Kakehashi A.
Ocular inflammation in uveal tract in aged obese type 2 diabetic rats (Spontaneously Diabetic Torii fatty rats).
J Diabetes Res. 2014; 2014:629016. doi: 10.1155/2014/629016. Epub 2014 Sep 14. [PMID: 25295283]

Ohta T, Kenmochi Y, Miyajima K, Shinohara M, and Yamada T.
Pharmacological Effect of α-Glucosidase Inhibitor Voglibose in a Novel Obese Diabetic Model.
Br J Pharm Res. 2014; 4(23): 2622-2630.

2015

Katsuda Y, Sasase T, Tadaki H, Mera Y, Motohashi Y, Kenmochi Y, Toyoda K, Kakimoto K, Kume S, Ohta T.
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
Exp Anim. 2015; 64(2): 161-169. [PMID: 25736710]

Sasase T, Yokoi N, Pezzolesi M.G, and Shinohara M.
Animal Models of Diabetes and Metabolic Disease 2014.
J Diabetes Res. 2015; 2015:571809. [PMID: 25973428]

Ohta T, Motohashi Y, Miyajima K, Kenmochi Y, Ishii Y, Shinohara M, Yamada T.
Diet-induced fatty hepatic steatosis in male Spontaneously Diabetic Torii (SDT) fatty rats, a genetic model for obese type 2 diabetes.
Br J Med Med Res. 2015; 7(5): 398-404.

太田毅、本橋雄、大熊千尋、勝田佳朋、石井幸仁、美谷島克宏、篠原雅巳、Tong Bin、山田宜永.
フェノフィブラート投与が雌性 SDT fattyラットの糖及び脂質代謝に及ぼす影響
北信越畜産学会報. 2015; 110: 19-25.

平尾直啓、前野孝之、龍門徳彦、稲葉信博、千葉薫、笹瀬智彦、太田毅、篠原雅巳、Tong Bin、山田宜永.
Amp-FTA法の導入に伴う遺伝子型診断の作業効率化およびコスト削減Amp-FTA法の導入に伴う遺伝子型診断の作業効率化およびコスト削減
北信越畜産学会報. 2015; 110: 47-51.

Miyajima K, Toriniwa Y, Motohashi Y, Ishii Y, Shinohara M, Yamashiro H, Yamada T, Ohta T.
Effects of isolation stress on glucose/lipid metabolism in Spontaneously Diabetic Torii (SDT) fatty rats.
Br J Med Med Res. 2015; 8(7): 588-594.

Ohta T, Kimura S, Hirata M, Yamada T, Sugiyama T.
Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats.
J Vet Med Sci. 2015; 77(10): 1327-30. [PMID: 26004433]

Ishii Y, Motohashi Y, Muramatsu M, Katsuda Y, Miyajima K, Sasase T, Yamada T, Matsui T, Kume S, Ohta T.
Female SDT fatty rats develop Non-Alcoholic Steatohepatitis (NASH)-like hepatic lesions.
World J Gastroenterol. 2015; 21(30): 9067-9078. [PMID: 26290633]

石井幸仁、本橋雄、村松真、勝田佳朋、美谷島克宏、笹瀬智彦、久米新一、山田宜永、太田毅.
SDT fattyラットを用いた脂肪性肝疾患に関する研究－新規NASHモデルの確立に向けて－．
栄養生理研究会報. 2015; 59(2): 97-107.

2016

稲葉信博、龍門徳彦、平尾直啓、山中沙織、前野孝之、安里千秋、高橋明之、千葉薫、笹瀬智彦、山田宜永、太田毅.
新規肥満2型糖尿病モデル雄性SDT fattyラットの維持・繁殖生産技術の向上と課題について.
北信越畜産学会報(技術報告). (112):2016.3.

Takakura S, Toyoshi T, Hayashizaki Y, Takasu T.
Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats.
Life Sci. 2016 Feb 15; 147: 125-31. [PMID: 26829386]

Ohta T, Shinohara M, Gotoh T, Yamada T, Miyajima K.
Pathophysiological Changes With Aging in a Novel Obese Diabetic Rat.
M J Nutr. 2016; 1(1): 004. [PMID: None]

2017

Murai Y, Miyajima K, Shinohara M, Yamada T, Ohta T.
Investigation of Pharmacological responses to an anti-diabetic drug pioglitazone in female Spontaneously Diabetic Torii (SDT) Fatty Rats, a new obese type 2 diabetic rat.
Scientific J Diabetol. 2017; 1(1): 8-13. [PMID: None]

本橋雄、太田毅、谷合枝里子、鳥庭靖文、剣持佑介、石井幸仁、篠原雅巳、山田宜永、美谷島克宏.
雌性SDT fattyラットの非アルコール性脂肪肝炎(NASH)様病変に対するピオグリタゾンの治療効果の検討.
北信越畜産学会報 = Hokushinetsu journal of animal science. (114): 1-7, 2017-03.

Murai Y, Ohta T, Tadaki H, Miyajima K, Shinohara M, Fatchiyah F, Yamada T.
Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.
Med Arch. 2017 Dec; 71(6): 380-384. [PMID: 29416195]

Maekawa T, Tadaki H, Sasase T, Motohashi Y, Miyajima K, Ohta T, Kume S.
Pharmacological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model.
J Pharm Toxic Method. 2017; 88: 160-166.

美谷島克宏、太田毅、村井康高、石井幸仁、篠原雅巳、山田宜永.
雌性SDT fattyラットすい臓における摂餌制限の影響.
北信越畜産学会報. (114): 2017, 27-33.

2018

Katsuhiro M, Hui Teoh S, Yamashiro H, Shinohara M, Fatchiyah F, Ohta T, Yamada T.
Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats.
Med Arch. 2018 Feb; 72(1): 4-8.

Toriniwa Y, Saito T, Miyajima K, Ishii Y, Uno K, Maekawa T, Matsui T, Kume S, Yamada T, Ohta T.
Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.
J Vet Med Sci. 2018 Jun 6; 80(6): 878-885. [PMID: 29643297]

Sakimura K, Maekawa T, Sasagawa K, Ishii Y, Kume S, Ohta T.
Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus.
Clin Exp Pharmacol Physiol. 2018; 45: 927-933. [PMID: 29757463]

Kenmochi Y, Ohta T, Motohashi Y, Kaneshige A, Katsumi S, Kakimoto K, Yasui Y, Anagawa-Nakamura A, Toyoda K, Taniai-Riya E, Takahashi A, Shoda T, Yamada T.
Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.
J Toxicol Pathol. 2018 Apr; 31(2): 113-123. [PMID: 29750000]

Motohashi Y, Kenmochi Y, Maekawa T, Tadaki H, Sasase T, Tanaka Y, Kakehashi A, Yamada T, Ohta T.
Diabetic Macular Edema-like Ocular Lesions in Male Spontaneously Diabetic Torii Fatty Rats.
Physiol Res. 2018 Jul 17; 67(3): 423-432. [PMID: 29527913]

Sakimura K, Maekawa T, Kume S, Ohta T.
Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion.
Int J Endocrinol. 2018 Sep 23. [PMID: 30344606]

Takakura S, Takasu T.
First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats. Clin Exp Pharmacol Physiol.
2018 Nov 28. [PMID: 30485488]

Maekawa T, Ohta T, Kume S.
Pathophysiological abnormalities in the brains of Spontaneous Diabetes Torii-Leprfa (SDT fatty) rats, a novel type2 diabetic model.
J Vet Med Sci. 2018; 80(9): 1385-1391.

Toriniwa Y, Muramatsu M, Ishii Y, Riya E, Miyajima K, Ohshida S, Kitatani K, Takekoshi S, Matsui T, Kume S, Yamada T, Ohta T.
Pathophysiological Characteristics of Non-Alcoholic Steatohepatitis-Like Chages in Cholesterol-Loaded Type 2 Diabetic Rats.
Physiol Res. 2018; 67: 601-612.

美谷島克宏、剣持佑介、本橋雄、鳥庭靖文、村井康高、篠原雅巳、山城秀昭、山田宜永、太田毅.
雄性 SDT fattyラットにおけるアンジオテンシンⅡ受容体拮抗薬ロサルタンの薬理作用に関する検討.
北信越畜産学会報. (116): 2018, 1-8.

美谷島克宏、村井康高、石井幸仁、笹瀬智彦、篠原雅巳、山城秀昭、山田宜永、太田毅.
肥満2型糖尿病モデル雌雄SDT fatty ラットにおける摂餌制限による内臓脂肪および皮下脂肪の量的変動.
北信越畜産学会報. (116): 2018, 15-22.

剣持佑介、村井康高、竹内里美、山城秀昭、篠原雅巳、山田宜永、太田毅.
2型糖尿病モデル動物における血液凝固能の変化の検討
北信越畜産学会報. (116): 2018, 37-42.

2019

Murai Y, Sasase T, Tadaki H, Heitaku S, Imagawa N, Yamada T, Ohta T.
Analysis of hemodynamics and angiogenic response to ischemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats.
Clin Exp Pharmacol Physiol. 2019 Dec 23. [PMID: 31868944]

Takahashi T, Matsuura C, Toyoda K, Suzuki Y, Yamada N, Kobayashi A, Sugai S, Shimoi K.
Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human type 2 diabetes.
Fundamental Toxicological Sciences. 2019; 6(8): 287-297. [PMID: none]

Takahashi T, Matsuura C, Toyoda K, Suzuki Y, Yamada N, Kobayashi A, Sugai S, Shimoi K.
Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats.
J Toxicol Sci. 2019; 44(11): 759-776. [PMID: 31708533]

Tanaka Y, Takagi R, Ohta T, Sasase T, Kobayashi M, Toyoda F, Shimmura M, Kinoshita N, Takano H, Kakehashi A.
Pathological Features of Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats.
J Diabetes Res. 2019 Sep 15; 2019: 8724818. [PMID: 31637263]

Takakura S, Takasu T.
First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats.
Clin Exp Pharmacol Physiol. 2019 Mar; 46(3): 266-273. [PMID: 30485488]

Tanabe J, Ogura Y, Nakabayashi M, Nagai Y, Watanabe S, Sugaya T, Ohata K, Ichikawa D, Inoue K, Hoshino S, Kimura K, Shibagaki Y, Ono Y, Kamijo-Ikemori A.
The Possibility of Urinary Liver-Type Fatty Acid-Binding Protein as a Biomarker of Renal Hypoxia in Spontaneously Diabetic Torii Fatty Rats.
Kidney Blood Press Res. 2019; 44(6): 1476-1492. [PMID: 31734667]

Nomura S, Kitami A, Kawabata R, Kawabata, Takakura A, Nakatsugawa M, Kono R, Maeno A, Tokuda A, Isogai Y, Ishizuya T, Utsunomiya H, Nakamura M.
Teripartide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 diabetes Mellitus.
Endocrinology Asahi Kasei Pharma.

Shoji Takakura, Toshiyuki Takasu.
Acute and Direct Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glomerular Filtaration Rate in Spontaneously Diabetic Torii Fatty Rats.
Biol Pharm Bull. 2019; 42: 1707-1712.

2020

Kasumi Kikuchi, Kousuke Noda, Miyuki Murata, Atsuhiro Kanda, Satoru Kase, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida.
Involvement of polyol pathway and oxidative stress in cataract formation in Spontaneously Diabetic Torii fatty rats.
IOVS. 2020 Jun; 61(7): 1019. [PMID: none]

Yasutaka Murai, Tomohiko Sasase, Hironobu Tadaki, Shiro Heitaku, Naoya Imagawa, Takahisa Yamada, Takeshi Ohta.
Analysis of Haemodynamics and Angiogenic Response to Ischaemia in the Obese Type 2 Diabetic Model Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rats.
Clin Exp Pharmacol Physiol. 2020 Apr; 47(4): 583-590. [PMID: 31868944]

Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi.
Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats.
Fundam Toxicol Sci. 2020; 7(1): 41-54. [PMID: none]

Jun Tanabe, Yuji Ogura, Keisei Kosaki, Yoshio Nagai, Takeshi Sugaya, Keiichi Ohata, Shiika Watanabe, Daisuke Ichikawa, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Seiji Maeda, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.
J Diabetes Res. 2020; 2020: 7614035. [PMID: 32405506]

Kikuchi K, Murata M, Noda K, Kase S, Tagawa Y, Kageyama Y, Shinohara M, Sasase T, Ishida S.
Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats.
J Diabetes Res. 2020; 2020: 3058547: 1-9.

2021

R Sano, Y Ishii, M Yamanaka, Y Yasui, Y Kenmochi, F Kuroki, M Sugimoto, S Fukuda, T Sasase, K Miyajima, D Nakae, T Ohta.
Glomerular hyperfiltration with hyperglycemia in the spontaneously diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model.
Physiol Res. 2021 Mar 17; 70(1): 45-54. [PMID: 33453716]

Shohei Yamada, Jun Tanabe, Yuji Ogura, Yoshio Nagai, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Daisuke Ichikawa, Shiika Watanabe, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
Renoprotective effect of GLP-1 receptor agonist, liraglutide, in early-phase diabetic kidney disease in spontaneously diabetic Torii fatty rats.
Clin Exp Nephrol. 2021 Apr; 25(4): 365-375. [PMID: 33409761]

Maekawa T, Nakamura S, Miyajima K, Uno K, Yamaguchi A, Mandai K, Gotoh T, Shinohara M, Shinozaki Y, Sasase T, Fatchiyah F, Ohta T.
Ocular Changes-Charact And Retinal Lesion-In Spontaneously Diabetic Torii (SDT) Fatty Rats, An Obese Type 2 Diabetic Model.
J Smart Biopro Tech. 2021 Apr; 2(2).

Teoh SH, Miyajima K, Shinozaki Y, Shinohara M, Ohata K, Briand F, Morimoto R, Nakamura Y, Uno K, Kemuriyama N, Nakae D, Ohta T, Maekawa T.
Effects of excessive sodium chloride loading in thespontaneously diabetic torii (SDT) fatty rats, a preclinicalmodel of type 2 diabetes mellitus
J Toxicol Sci. 2021; 46(12): 589-599. doi: 10.2131/jts.46.589. [PMID: 34853244]

Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats
Mol Cell Endocrinol. 2022 Jan 1; 539: 111472. doi: 10.1016/j.mce.2021.111472. Epub 2021 Oct 1. [PMID: 34606964]

2022

篠原雅巳.
食塩負荷・片腎摘出が肥満2型糖尿病モデルSDT fatty ラットの腎症進展に及ぼす影響.
Medical Science Digest. 2022; 48(2): 23-25. (2022.2)

Kotake H, Yamada S, Ogura Y, Watanabe S, Inoue K, Ichikawa D, Sugaya T, Ohata K, Natsuki Y, Hoshino S, Watanabe M, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
Endurance exercise training-attenuated diabetic kidney disease with muscle weakness in spontaneously diabetic Torii fatty rats.
Kidney Blood Press Res. 2022; 47(3): 203-218. doi: 10.1159/000521464. Epub 2021 Dec 17. [PMID: 34923497]

Yoshioka K, Hirakawa Y, Kurano M, Ube Y, Ono Y, Kojima K, Iwama T, Kano K, Hasegawa S, Inoue T, Shimada T, Aoki J, Yatomi Y, Nangaku M, Inagi R.
Lysophosphatidylcholine mediates fast decline inkidney function in diabetic kidney disease
Kidney Int. 2022 Mar; 101(3): 510-526. doi: 10.1016/j.kint.2021.10.039. Epub 2021 Nov 29. [PMID: 34856312]

Shinozaki Y, Katayama Y, Yamaguchi F, Suzuki T, Watanabe K, Uno K, Tsutsui T, Sugimoto M, Shinohara M, Miyajima K, Ohta T.
Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease
Clin Exp Pharmacol Physiol. 2022 Apr; 49(4): 492-500. doi: 10.1111/1440-1681.13621. Epub 2022 Feb 4. [PMID: 35066915]

Maekawa T, Sugimoto M, Kume S, Ohta T.
Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats
J Vet Med Sci. 2022 Mar 3; 84(3): 330-337. doi: 10.1292/jvms.21-0654. Epub 2022 Jan 27. [PMID: 35082197]

Saigo Y, Sasase T, Uno K, Shinozaki Y, Maekawa T, Sano R, Toriniwa Y, Miyajima K, Ohta T.
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats
J Pharmacol Toxicol Methods. 2022 Jul-Aug; 116: 107190. doi: 10.1016/j.vascn.2022.107190. Epub 2022 Jun 7. [PMID: 35688322]

Hasegawa T, Takagi R, Tanaka Y, Ohta T, Shinohara M, Kageyama Y, Sasase T, Muramatsu SI, Kaburaki T, Kakehashi A.
Differences in the Effects of Pentobarbital Anesthetic and Combination of Medetomidine Hydrochloride, Midazolam, and Butorphanol Tartrate Anesthetic on Electroretinogram in Spontaneously Diabetic Torii Fatty Rats
Biomed Hub. 2022 Sep 9; 7(3): 106-114. doi: 10.1159/000526189. eCollection 2022 Sep-Dec. [PMID: 36262406]

Kentaro Yoshioka, Yosuke Hirakawa, Makoto Kurano, Yuko Ube, Yoko Ono, Kensuke Kojima, Taiga Iwama, Kuniyuki Kano, Sho Hasegawa, Tsuyoshi Inoue, Takashi Shimada, Junken Aoki, Yutaka Yatomi, Masaomi Nangaku, Reiko Inagi
Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease
Kidney Int. 2022 Mar;101(3):510-526. doi: 10.1016/j.kint.2021.10.039. Epub 2021 Nov 29.PMID: 34856312

Hara K, Sakai Y, Tajiri Y, Nomura M.
Beneficial effects of SGLT2 inhibitor on metabolic inflexibility and visceral fat amount in animal model of obese type 2 diabetes
Heliyon. 2022 Oct 10;8(10):e11012. doi: 10.1016/j.heliyon.2022.e11012. eCollection 2022 Oct.PMID: 36281369

2023

Taku Yamamoto, Satoru Kase, Akihiro Shinkai, Miyuki Murata, Kasumi Kikuchi, Di Wu, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida.
Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation
Invest Ophthalmol Vis Sci. 2023 Jul 3; 64(10): 20. doi: 10.1167/iovs.64.10.20.

Hitoshi Kotake, Yuji Ogura, Shohei Yamada, Kazuho Inoue, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Seiko Hoshino, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats
J Physiol Sci. 2023 Apr 4; 73(1): 5. doi: 10.1186/s12576-023-00865-5.

2024

Yoshiaki Tanaka, Rina Takagi, Shingen Mitou, Machiko Shimmura, Tetsuya Hasegawa, Jota Amarume, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Takeshi Ohta, Shin-Ichi Muramatsu, Akihiro Kakehashi, Toshikatsu Kaburaki.
Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
Biol Pharm Bull. 2024 Mar 27; 47(3): 713-722. doi: 10.1248/bpb.b23-00872. Epub 2024 Mar 1.

Takashima A, Miura J, Sugiyama K, Shimizu M, Okada M, Otani T, Nagashima T, Tsuda T, Araki T.
Glycation promotes pulp calcification in Type 2 Diabetes rat model
Oral Dis. 2024 Mar; 30(2): 593-603. doi: 10.1111/odi.14529. Epub 2023 Mar 13. [PMID: 36843542]

Tanaka Y, Takagi R, Mitou S, Shimmura M, Hasegawa T, Amarume J, Shinohara M, Kageyama Y, Sasase T, Ohta T, Muramatsu SI, Kakehashi A, Kaburaki T.
Protective Eﬀect of Pemaﬁbrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
Biol Pharm Bull. 2024 Mar 27; 47(3): 713-722. doi: 10.1248/bpb.b23-00872. Epub 2024 Mar 1. [PMID: 38432946]

Rina Takagi, Yoshiaki Tanaka, Tetsuya Hasegawa, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Machiko Shimmura-Tomita, Akihiro Kakehashi, Toshikatsu Kaburaki.
Prophylactic Pattern Scanning LaserRetinal Photocoagulation for DiabeticRetinopathy in Spontaneously DiabeticTorii Fatty Rats: PreliminaryExperimental Results
Journal of Diabetes Mellitus. 2024; 14: 153-165.

2025

Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X, Marshall M, Jagarlapudi S, Jami-Alahmadi Y, Jean-Beltran PM, Song L, Chiou J, Geoly F, Vargas SR, Zhang Y, Kuang E, Callahan D, Stansfield JC, Russo M, Griffin J, Sun Z, Miller MR, Hyde CL, Clasquin MF, Hales K, Daurio NA, Crane JD, Hirenallur-Shanthappa D, Groarke J, Zhang BB, Roth Flach RJ.
Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models
Kidney Int. 2025 May 21; S0085-2538(25)00408-9. doi: 10.1016/j.kint.2025.04.025. Online ahead of print. [PMID: 40409667]

Ito S, Taguchi K, Kodama G, Kubo S, Moriyama T, Yamashita Y, Yokota Y, Nakayama Y, Kaida Y, Shinohara M, Tashiro K, Ohta K, Yamagishi SI, Fukami K.
Involvement of impaired carnitine-induced fatty acid oxidation inexperimental and human diabetic kidney disease
JCI Insight. 2025 May 22; 10(13): e179362. doi: 10.1172/jci.insight.179362. eCollection 2025 Jul 8. [PMID: 40402578]

Kikuchi K, Murata M, Kageyama Y, Shinohara M, Sasase T, Noda K, Ishida S.
Spontaneously Diabetic Torii Fatty Rat Shows Early Stage ofDiabetic Retinopathy Characterized by Capillary Changesand Inflammation
J Diabetes Res. 2025 Apr 21; 2025: 3800292. doi: 10.1155/jdr/3800292. eCollection 2025. [PMID: 40297222]

Fukasawa, Motoaki; Nagao, Shizuko; Takahashi, Kazuo
Impaired Brain Tissue Clearance in Diabetic Nephropathy
Journal of the American Society of Nephrology 36(10S):10.1681/ASN.2025f7nxk2mh, October 2025. | DOI: 10.1681/ASN.2025f7nxk2mh

FAQ

Q:What is included on this page?: A:This page provides an academic reference list for SDT fatty/Jcl, including a related product link and publications organized by year.
Q:How are the references organized?: A:References are presented in the original "References by Year" list, and you can jump to each year using the year index at the top of the page.
Q:Where can I find the product page for SDT fatty/Jcl?: A:The product link is provided in the "Related CLEA Japan product: SDT fatty/Jcl" section on this page.
Q:What years are covered in the reference list?: A:The year index at the top of the page shows coverage from 2005 through 2025.
Q:How can I contact CLEA Japan about this model?: A:The "Inquiry" section on this page includes a link to the contact form for questions about SDT fatty/Jcl.