Academic Reference Archive：SDT fatty/Jcl

2005

• Masuyama T, Katsuda Y, Shinohara M.
  A novel model of obesity-related diabetes: introgression of the Lepr (fa) allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats.
  Exp Anim. 2005; 54(1): 13-20. [PMID: 15725677]

2008

• Matsui K, Ohta T, Oda T, Sasase T, Ueda N, Miyajima K, Masuyama T, Shinohara M, Matsushita M.
  Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats.
  Exp Anim. 2008; 57(2): 111-21. [PMID: 18421173]

• Kenichi MATSUI, Takeshi OHTA, Hisayo MORINAGA, Tomohiko SASASE, Sumiaki FUKUDA, Makoto ITO, Masatoshi UEDA, Naoto OGAWA, Katsuhiro MIYAJIMA, Mutsuyoshi MATSUSHITA.
  Effects of preventing hyperphagia on glycolipid metabolic abnormalities in Spontaneously Diabetic Torii fatty rats.
  Anim Sci J. 2008; 79(5): 605–13.

2009

• Morinaga H, Ohta T, Matsui K, Sasase T, Fukuda S, Ito M, Ueda M, Ishii Y, Miyajima K, Matsushita M.
  Effect of food restriction on adipose tissue in spontaneously diabetic Torii
  fatty rats. Exp Diabetes Res. 2009; 2009:715057. [PMID: 19696902]

2010

• Ishii Y, Ohta T, Sasase T, Morinaga H, Ueda N, Hata T, Kakutani M, Miyajima K, Katsuda Y, Masuyama T, Shinohara M, Matsushita M.
  Pathophysiological analysis of female spontaneously diabetic Torii fatty rats.
  Exp Anim. 2010; 59(1): 73-84. [PMID: 20224171]

• Ishii Y, Maki M, Yamamoto H, Sasase T, Kakutani M, Ohta T.
  Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats.
  Exp Anim. 2010; 59(4): 525-9. [PMID: 20661000]

2011

• Ishii Y, Ohta T, Sasase T, Morinag H, Miyajima K, Kakutani M.
  Effects of food restriction on pancreatic islets in Spontaneously Diabetic Torii fatty rats.
  J Vet Med Sci. 2011; 73(2): 169-75. [PMID: 20877155]

• Ishii Y, Maki M, Yamamoto H, Sasase T, Kakutani M, Ohta T.
  Blood Pressure Characteristics of Female Spontaneously Diabetic Torii-Lepr(fa) Rats.
  J Vet Med Sci. 2011; 73(4): 501–5. [PMID: 21127391]

• Fukuda S, Miyajima K, Sasase T, Ohta T.
  Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rat: A Novel Model of Obese Type 2 Diabetes.
  Open Diabetes J. 2011; 4: 30-6.

• Kimura S, Sasase T, Ohta T, Matsushita M.
  Effects of Ovariectomy on Bone Metabolism and Bone Mineral Density in Spontaneously Diabetic Torii-Lepr fa Rats.
  J Vet Med Sci. 2011; 73(8): 1025-9. [PMID: 21490414]

• 龍門 徳彦, 稲葉 信博, 中村 早苗, 平尾 直啓, 前野 孝之, 千葉 薫, 笹瀬 智彦, 太田 毅.
  簡易ガラス化法を用いたSpontaneously Diabetic Torii-Leprfa (SDT-fa/fa) ratの2細胞期胚の凍結保存.
  実験動物技術. 2011; 46(1): 3-9.

2012

• Kimura S, Sasase T, Ohta T, Sato E, Matsushita M.
  Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Leprfa rats.
  J Bone Miner Metab. 2012; 30(3): 312-20. [PMID: 22038286]

• Kimura S, Sasase T, Ohta T, Sato E, Matsushita M.
  Parathyroid hormone (1-34) improves bone mineral density and glucose metabolism in Spontaneously Diabetic Torii-Leprfa rats.
  J Vet Med Sci. 2012; 74(1): 103-5. [PMID: 21869570]

• Hata T, Ohta T, Ishii Y, Sasase T, Yamaguchi T, Mera Y, Miyajima K, Tanoue G, Sato E, Matsushita M.
  Elevated glucagon-like peptide-1 on a high-fat diet feeding prevents the incidence of diabetes mellitus in Spontaneously Diabetic Torii Leprfa rats.
  J D M. 2012; 2(2): 170-8.

• Yamaguchi T, Sasase T, Mera Y, Tomimoto D, Tadaki H, Kemmichi Y, Ohta T, Sato E, Matsushita M.
  Diabetic peripheral neuropathy in Spontaneously Diabetic Tprii-Lepr (fa) (SDT Fatty) rats.
  J Vet Med Sci. 2012; 74(12): 1669-73.［PMID: 22850562］

• 稲葉 信博, 中村 早苗, 平尾 直啓, 龍門 徳彦, 千葉 薫, 美谷島 克宏, 太田 毅.
  雌性Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) ラットの生殖学的基礎検討.
  実験動物技術. 2012; 47(1): 3-9.

• 平尾 直啓, 竜門 徳彦, 稲葉 信博, 千葉 薫, 笹瀬 智彦, 太田 毅.
  SDT-fa/fa および SDT- +/+ラットの糖尿病発症・進展に２種の基礎資料が及ぼす影響.
  実験動物技術. 2012; 47(2): 55-56.

• Hata M, Nishi Y, Tajiri Y, Masuyama T, Hosoda H, Kangawa K, Kojima M.
  Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats.
  MET CLI EXP Vol.61(2012): 491-495

• Masuda T, Muto S, Fujisawa G, Iwazu Y, Kimura M, Kobayashi T, Sarukawa M, Sasaki N, Watanabe Y, Shinohara M, Murakami T, Shimada K, Kobayashi E, Kusano E.
  Heart angiotensin Ⅱ-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progresses diabetic cardiomyopathy.
  Am J Physiol Heart Circ Physiol. 2012; 302.

• Hiroharu Mifune, Yoshihiro Nishi, Yuji Tajiri, Taku Masuyama, Hiroshi Hosoda, Kenji Kangawa, Masayasu Kojima.
  Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats
  Metabolism. 2012 Apr;61(4):491-5. doi: 10.1016/j.metabol.2011.09.001. Epub 2011 Oct 14. PMID: 22001335

2013

• Yusuke Kenmochi, Kenji Fukui, Mimi Maki, Shuichi Kimura, Yukihito Ishii, Tomohiko Sasase, Katsuhiro Miyajima, and Takeshi Ohta.
  Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Leprfa Rat: A New Obese Type 2 Diabetic Model.
  J Diabetes Res. 2013; 2013: 948257. [PMID: 23691524]

• Islam MS.
  Animal models of diabetic neuropathy: progress since 1960s.
  J Diabetes Res. 2013; 2013:149452. [PMID: 23984428]

• Wang Y, Sun G, Sun J, Liu S, Wang J, Xu X, Miao L.
  Spontaneous Type2 Diabetic Rodent Models.
  J Diabetes Res. 2013; 2013:401723

• Sasase T, Ohta T, Masuyama T, Yokoi N, Kakehashi A, Shinohara M.
  The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications
  J Diabetes Res. 2013;2013:976209. doi: 10.1155/2013/976209. Epub 2013 Feb 26.PMID: 23691526

2014

• 太田 毅、勝田 佳朋、槇 美実、篠原 雅巳、Tong Bin、山田 宣永.
  食塩負荷がSDT fattyラットの血圧、腎機能に及ぼす影響.
  北信越畜産学会報. 2014; 108: 9-14.

• Katsuda Y, Kenmochi Y, Maki M, Sano R, Ishii Y, Miyajima K, Kakimoto K, Ohta T.
  Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Leprfa (SDT fatty) rat, a novel obese type 2 diabetic model.
  Anim Sci J. 2014; 85(5): 588-94. [PMID: 24571912]

• Katsuda Y, Ohta T, Miyajima K, Kenmochi Y, Sasase T, Tong B, Shinohara M, Yamada T.
  Diabetic complications in obese type 2 diabetic rat models.
  Exp Anim. 2014; 63(2): 121-32. [PMID: 24770637]

• Takeshi Ohta, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong, and Takahisa Yamada.
  Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-Leprfa Rats.
  J Diabetes Res. 2014; 2014:841957. [PMID: 24892034]

• Katsuda Y, Kenmochi Y, Maki M, Sano R, Toriniwa Y, Ishii Y, Miyajima K, Kakimoto K, Ohta T.
  Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model.
  J Diabetes Res. 2014; 2014:363126. doi: 10.1155/2014/363126. Epub 2014 Aug 10. [PMID: 25177706]

• Kenmochi Y, Miyajima K, Ohta T, Sasase T, Yasui Y, Toyoda K, Kakimoto K, Shoda T, Kakehashi A.
  Ocular inflammation in uveal tract in aged obese type 2 diabetic rats (Spontaneously Diabetic Torii fatty rats).
  J Diabetes Res. 2014; 2014:629016. doi: 10.1155/2014/629016. Epub 2014 Sep 14. [PMID: 25295283]

• Ohta T, Kenmochi Y, Miyajima K, Shinohara M, and Yamada T.
  Pharmacological Effect of α-Glucosidase Inhibitor Voglibose in a Novel Obese Diabetic Model.
  Br J Pharm Res. 2014; 4(23): 2622-2630.

2015

• Katsuda Y, Sasase T, Tadaki H, Mera Y, Motohashi Y, Kenmochi Y, Toyoda K, Kakimoto K, Kume S, Ohta T.
  Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
  Exp Anim. 2015; 64(2): 161-169. [PMID: 25736710]

• Sasase T, Yokoi N, Pezzolesi M.G, and Shinohara M.
  Animal Models of Diabetes and Metabolic Disease 2014.
  J Diabetes Res. 2015; 2015:571809. [PMID: 25973428]

• Ohta T, Motohashi Y, Miyajima K, Kenmochi Y, Ishii Y, Shinohara M, Yamada T.
  Diet-induced fatty hepatic steatosis in male Spontaneously Diabetic Torii (SDT) fatty rats, a genetic model for obese type 2 diabetes.
  Br J Med Med Res. 2015; 7(5): 398-404.

• 太田 毅、本橋 雄、大熊 千尋、勝田 佳朋、石井 幸仁、美谷島 克宏、篠原 雅巳、Tong Bin、山田 宜永.
  フェノフィブラート投与が雌性 SDT fattyラットの糖及び脂質代謝に及ぼす影響
  北信越畜産学会報. 2015; 110: 19-25.

• 平尾 直啓、前野 孝之、龍門 徳彦、稲葉 信博、千葉 薫、笹瀬 智彦、太田 毅、篠原 雅巳、Tong Bin、山田 宜永.
  Amp-FTA法の導入に伴う遺伝子型診断の作業効率化およびコスト削減Amp-FTA法の導入に伴う遺伝子型診断の作業効率化およびコスト削減
  北信越畜産学会報. 2015; 110: 47-51.

• Miyajima K, Toriniwa Y, Motohashi Y, Ishii Y, Shinohara M, Yamashiro H, Yamada T, Ohta T.
  Effects of isolation stress on glucose/lipid metabolism in Spontaneously Diabetic Torii (SDT) fatty rats.
  Br J Med Med Res. 2015; 8(7): 588-594.

• Ohta T, Kimura S, Hirata M, Yamada T, Sugiyama T.
  Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats.
  J Vet Med Sci. 2015; 77(10): 1327-30. [PMID: 26004433]

• Ishii Y, Motohashi Y, Muramatsu M, Katsuda Y, Miyajima K, Sasase T, Yamada T, Matsui T, Kume S, Ohta T.
  Female SDT fatty rats develop Non-Alcoholic Steatohepatitis (NASH)-like hepatic lesions.
  World J Gastroenterol. 2015; 21(30): 9067-9078. [PMID: 26290633]

• 石井 幸仁、本橋 雄、村松 真、勝田 佳朋、美谷島 克宏、笹瀬 智彦、久米 新一、山田 宜永、太田 毅.
  SDT fattyラットを用いた脂肪性肝疾患に関する研究－新規NASHモデルの確立に向けて－．
  栄養生理研究会報. 2015; 59(2): 97-107.

2016

• 稲葉 信博、龍門 徳彦、平尾 直啓、山中 沙織、前野 孝之、安里 千秋、高橋 明之、千葉 薫、笹瀬 智彦、山田 宜永、太田 毅.
  新規肥満2型糖尿病モデル雄性SDT fattyラットの維持・繁殖生産技術の向上と課題について.
  北信越畜産学会報(技術報告). (112):2016.3.

• Takakura S, Toyoshi T, Hayashizaki Y, Takasu T.
  Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats.
  Life Sci. 2016 Feb 15; 147: 125-31. [PMID: 26829386]

• Ohta T, Shinohara M, Gotoh T, Yamada T, Miyajima K.
  Pathophysiological Changes With Aging in a Novel Obese Diabetic Rat.
  M J Nutr. 2016; 1(1): 004. [PMID: None]

• François Briand, Masami Shinohara, Emmanuel Brousseau, Katsuhiro Miyajima, Takeshi Ohta, Yasushi Kageyama, Thierry Sulpice
  Unilateral Nephrectomy and Salt Supplementation in Spontaneously Diabetic Torii Fatty Rat Expedite Renal Complications and Glomerular Filtration Rate Decline within 10 weeks Pathophysiological Changes With Aging in a Novel Obese Diabetic Rat[PDF].
  NYAS CKD conference 2016

• François Briand, Masami Shinohara, Emmanuel Brousseau, Yasushi Kageyama, Thierry Sulpice
  Dapagliflozin Improves Glycemic Control, Hypertension and is Neutral on Severe Renal Impairment in Uni-nephrectomized SDT fatty rat, a 10-week Model of Advanced Renal Complications and Glomerular Filtration Rate Decline. Pathophysiological Changes With Aging in a Novel Obese Diabetic Rat[PDF].
  Kidney week 2016

2017

• Murai Y, Miyajima K, Shinohara M, Yamada T, Ohta T.
  Investigation of Pharmacological responses to an anti-diabetic drug pioglitazone in female Spontaneously Diabetic Torii (SDT) Fatty Rats, a new obese type 2 diabetic rat.
  Scientific J Diabetol. 2017; 1(1): 8-13. [PMID: None]

• 本橋 雄、太田 毅、谷合 枝里子、鳥庭 靖文、剣持 佑介、石井 幸仁、篠原 雅巳、山田 宜永、美谷島 克宏.
  雌性SDT fattyラットの非アルコール性脂肪肝炎(NASH)様病変に対するピオグリタゾンの治療効果の検討.
  北信越畜産学会報 = Hokushinetsu journal of animal science. (114): 1-7, 2017-03.

• Murai Y, Ohta T, Tadaki H, Miyajima K, Shinohara M, Fatchiyah F, Yamada T.
  Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.
  Med Arch. 2017 Dec; 71(6): 380-384. [PMID: 29416195]

• Maekawa T, Tadaki H, Sasase T, Motohashi Y, Miyajima K, Ohta T, Kume S.
  Pharmacological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model.
  J Pharm Toxic Method. 2017; 88: 160-166.

• 美谷島 克宏、太田 毅、村井 康高、石井 幸仁、篠原 雅巳、山田 宜永.
  雌性SDT fattyラットすい臓における摂餌制限の影響.
  北信越畜産学会報. (114): 2017, 27-33.

• François Briand, Masami Shinohara, Emmanuel Brousseau, Takeshi Ohta, Yasushi Kageyama, Thierry Sulpice
  Dapagliflozin Alone or Combined with Ramipril Improves Hyperglycemia, Hypertension, and Prevents Kidney Complications and GFR Decline in the Nephrectomized SDT Fatty Rat Model of Diabetic Nephropathy[PDF].
  Kidney week 2017

2018

• Katsuhiro M, Hui Teoh S, Yamashiro H, Shinohara M, Fatchiyah F, Ohta T, Yamada T.
  Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats.
  Med Arch. 2018 Feb; 72(1): 4-8.

• Toriniwa Y, Saito T, Miyajima K, Ishii Y, Uno K, Maekawa T, Matsui T, Kume S, Yamada T, Ohta T.
  Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.
  J Vet Med Sci. 2018 Jun 6; 80(6): 878-885. [PMID: 29643297]

• Sakimura K, Maekawa T, Sasagawa K, Ishii Y, Kume S, Ohta T.
  Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus.
  Clin Exp Pharmacol Physiol. 2018; 45: 927-933. [PMID: 29757463]

• Kenmochi Y, Ohta T, Motohashi Y, Kaneshige A, Katsumi S, Kakimoto K, Yasui Y, Anagawa-Nakamura A, Toyoda K, Taniai-Riya E, Takahashi A, Shoda T, Yamada T.
  Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.
  J Toxicol Pathol. 2018 Apr; 31(2): 113-123. [PMID: 29750000]

• Motohashi Y, Kenmochi Y, Maekawa T, Tadaki H, Sasase T, Tanaka Y, Kakehashi A, Yamada T, Ohta T.
  Diabetic Macular Edema-like Ocular Lesions in Male Spontaneously Diabetic Torii Fatty Rats.
  Physiol Res. 2018 Jul 17; 67(3): 423-432. [PMID: 29527913]

• Sakimura K, Maekawa T, Kume S, Ohta T.
  Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion.
  Int J Endocrinol. 2018 Sep 23. [PMID: 30344606]

• Takakura S, Takasu T.
  First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats. Clin Exp Pharmacol Physiol.
  2018 Nov 28. [PMID: 30485488]

• Maekawa T, Ohta T, Kume S.
  Pathophysiological abnormalities in the brains of Spontaneous Diabetes Torii-Leprfa (SDT fatty) rats, a novel type2 diabetic model.
  J Vet Med Sci. 2018; 80(9): 1385-1391.

• Toriniwa Y, Muramatsu M, Ishii Y, Riya E, Miyajima K, Ohshida S, Kitatani K, Takekoshi S, Matsui T, Kume S, Yamada T, Ohta T.
  Pathophysiological Characteristics of Non-Alcoholic Steatohepatitis-Like Chages in Cholesterol-Loaded Type 2 Diabetic Rats.
  Physiol Res. 2018; 67: 601-612.

• 美谷島 克宏、剣持 佑介、本橋 雄、鳥庭 靖文、村井 康高、篠原 雅巳、山城 秀昭、山田 宜永、太田 毅.
  雄性 SDT fattyラットにおけるアンジオテンシンⅡ受容体拮抗薬ロサルタンの薬理作用に関する検討.
  北信越畜産学会報. (116): 2018, 1-8.

• 美谷島 克宏、村井 康高、石井 幸仁、笹瀬 智彦、篠原 雅巳、山城 秀昭、山田 宜永、太田 毅.
  肥満2型糖尿病モデル雌雄SDT fatty ラットにおける摂餌制限による内臓脂肪および皮下脂肪の量的変動.
  北信越畜産学会報. (116): 2018, 15-22.

• 剣持 佑介、村井 康高、竹内 里美、山城 秀昭、篠原 雅巳、山田 宜永、太田 毅.
  2型糖尿病モデル動物における血液凝固能の変化の検討
  北信越畜産学会報. (116): 2018, 37-42.

• François Briand, Sophie Antonelli, Virginie Mauro, Nicolas Cimbolini, Masami Shinohara, Emmanuel Brousseau, Takeshi Ohta, Yasushi Kageyama, Laurence Feraille, Thierry Sulpice.
  The Uni-Nephrectomized SDT Fatty Rat, a novel Type 2 diabetic model of Diabetic Nephropathy, develops features of diabetic retinopathy over 10 weeksAcute and Direct Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glomerular Filtaration Rate in Spontaneously Diabetic Torii Fatty Rats.
  ARVO 2018

• François Briand, Fuminari Yamaguchi, Yuko Katayama, Tomohisa Suzuki, Masami Shinohara
  Unilateral nephrectomy and salt loading differentially alter glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic nephropathy
  Kidney Week 2018

2019

• Murai Y, Sasase T, Tadaki H, Heitaku S, Imagawa N, Yamada T, Ohta T.
  Analysis of hemodynamics and angiogenic response to ischemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats.
  Clin Exp Pharmacol Physiol. 2019 Dec 23. [PMID: 31868944]

• Takahashi T, Matsuura C, Toyoda K, Suzuki Y, Yamada N, Kobayashi A, Sugai S, Shimoi K.
  Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human type 2 diabetes.
  Fundamental Toxicological Sciences. 2019; 6(8): 287-297. [PMID: none]

• Takahashi T, Matsuura C, Toyoda K, Suzuki Y, Yamada N, Kobayashi A, Sugai S, Shimoi K.
  Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats.
  J Toxicol Sci. 2019; 44(11): 759-776. [PMID: 31708533]

• Tanaka Y, Takagi R, Ohta T, Sasase T, Kobayashi M, Toyoda F, Shimmura M, Kinoshita N, Takano H, Kakehashi A.
  Pathological Features of Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats.
  J Diabetes Res. 2019 Sep 15; 2019: 8724818. [PMID: 31637263]

• Takakura S, Takasu T.
  First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats.
  Clin Exp Pharmacol Physiol. 2019 Mar; 46(3): 266-273. [PMID: 30485488]

• Tanabe J, Ogura Y, Nakabayashi M, Nagai Y, Watanabe S, Sugaya T, Ohata K, Ichikawa D, Inoue K, Hoshino S, Kimura K, Shibagaki Y, Ono Y, Kamijo-Ikemori A.
  The Possibility of Urinary Liver-Type Fatty Acid-Binding Protein as a Biomarker of Renal Hypoxia in Spontaneously Diabetic Torii Fatty Rats.
  Kidney Blood Press Res. 2019; 44(6): 1476-1492. [PMID: 31734667]

• Nomura S, Kitami A, Kawabata R, Kawabata, Takakura A, Nakatsugawa M, Kono R, Maeno A, Tokuda A, Isogai Y, Ishizuya T, Utsunomiya H, Nakamura M.
  Teripartide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 diabetes Mellitus.
  Endocrinology Asahi Kasei Pharma.

• Shoji Takakura, Toshiyuki Takasu.
  Acute and Direct Effects of Sodium-Glucose Cotransporter 2 Inhibition on Glomerular Filtaration Rate in Spontaneously Diabetic Torii Fatty Rats.
  Biol Pharm Bull. 2019; 42: 1707-1712.

2020

• Kasumi Kikuchi, Kousuke Noda, Miyuki Murata, Atsuhiro Kanda, Satoru Kase, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida.
  Involvement of polyol pathway and oxidative stress in cataract formation in Spontaneously Diabetic Torii fatty rats.
  IOVS. 2020 Jun; 61(7): 1019. [PMID: none]

• Yasutaka Murai, Tomohiko Sasase, Hironobu Tadaki, Shiro Heitaku, Naoya Imagawa, Takahisa Yamada, Takeshi Ohta.
  Analysis of Haemodynamics and Angiogenic Response to Ischaemia in the Obese Type 2 Diabetic Model Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rats.
  Clin Exp Pharmacol Physiol. 2020 Apr; 47(4): 583-590. [PMID: 31868944]

• Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi.
  Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats.
  Fundam Toxicol Sci. 2020; 7(1): 41-54. [PMID: none]

• Jun Tanabe, Yuji Ogura, Keisei Kosaki, Yoshio Nagai, Takeshi Sugaya, Keiichi Ohata, Shiika Watanabe, Daisuke Ichikawa, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Seiji Maeda, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
  Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.
  J Diabetes Res. 2020; 2020: 7614035. [PMID: 32405506]

• Kikuchi K, Murata M, Noda K, Kase S, Tagawa Y, Kageyama Y, Shinohara M, Sasase T, Ishida S.
  Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats.
  J Diabetes Res. 2020; 2020: 3058547: 1-9.

• François Briand, Masami Shinohara, Emmanuel Brousseau, Yasushi Kageyama, Thierry Sulpice
  GLP-1 receptor agonist liraglutide reduces hyperfiltration and prevents glomerular filtration rate decline in the SDT fatty rat modelDiabetic Cataract in Spontaneously Diabetic Torii Fatty Rats.
  Keystone Diabetes 2020

2021

• R Sano, Y Ishii, M Yamanaka, Y Yasui, Y Kenmochi, F Kuroki, M Sugimoto, S Fukuda, T Sasase, K Miyajima, D Nakae, T Ohta.
  Glomerular hyperfiltration with hyperglycemia in the spontaneously diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model.
  Physiol Res. 2021 Mar 17; 70(1): 45-54. [PMID: 33453716]

• Shohei Yamada, Jun Tanabe, Yuji Ogura, Yoshio Nagai, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Daisuke Ichikawa, Shiika Watanabe, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
  Renoprotective effect of GLP-1 receptor agonist, liraglutide, in early-phase diabetic kidney disease in spontaneously diabetic Torii fatty rats.
  Clin Exp Nephrol. 2021 Apr; 25(4): 365-375. [PMID: 33409761]

• Maekawa T, Nakamura S, Miyajima K, Uno K, Yamaguchi A, Mandai K, Gotoh T, Shinohara M, Shinozaki Y, Sasase T, Fatchiyah F, Ohta T.
  Ocular Changes-Charact And Retinal Lesion-In Spontaneously Diabetic Torii (SDT) Fatty Rats, An Obese Type 2 Diabetic Model.
  J Smart Biopro Tech. 2021 Apr; 2(2).

• Teoh SH, Miyajima K, Shinozaki Y, Shinohara M, Ohata K, Briand F, Morimoto R, Nakamura Y, Uno K, Kemuriyama N, Nakae D, Ohta T, Maekawa T.
  Effects of excessive sodium chloride loading in thespontaneously diabetic torii (SDT) fatty rats, a preclinicalmodel of type 2 diabetes mellitus
  J Toxicol Sci. 2021; 46(12): 589-599. doi: 10.2131/jts.46.589. [PMID: 34853244]

• Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
  Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats
  Mol Cell Endocrinol. 2022 Jan 1; 539: 111472. doi: 10.1016/j.mce.2021.111472. Epub 2021 Oct 1. [PMID: 34606964]

2022

• 篠原 雅巳.
  食塩負荷・片腎摘出が肥満2型糖尿病モデルSDT fatty ラットの腎症進展に及ぼす影響.
  Medical Science Digest. 2022; 48(2): 23-25. (2022.2)

• Kotake H, Yamada S, Ogura Y, Watanabe S, Inoue K, Ichikawa D, Sugaya T, Ohata K, Natsuki Y, Hoshino S, Watanabe M, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
  Endurance exercise training-attenuated diabetic kidney disease with muscle weakness in spontaneously diabetic Torii fatty rats.
  Kidney Blood Press Res. 2022; 47(3): 203-218. doi: 10.1159/000521464. Epub 2021 Dec 17. [PMID: 34923497]

• Yoshioka K, Hirakawa Y, Kurano M, Ube Y, Ono Y, Kojima K, Iwama T, Kano K, Hasegawa S, Inoue T, Shimada T, Aoki J, Yatomi Y, Nangaku M, Inagi R.
  Lysophosphatidylcholine mediates fast decline inkidney function in diabetic kidney disease
  Kidney Int. 2022 Mar; 101(3): 510-526. doi: 10.1016/j.kint.2021.10.039. Epub 2021 Nov 29. [PMID: 34856312]

• Shinozaki Y, Katayama Y, Yamaguchi F, Suzuki T, Watanabe K, Uno K, Tsutsui T, Sugimoto M, Shinohara M, Miyajima K, Ohta T.
  Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease
  Clin Exp Pharmacol Physiol. 2022 Apr; 49(4): 492-500. doi: 10.1111/1440-1681.13621. Epub 2022 Feb 4. [PMID: 35066915]

• Maekawa T, Sugimoto M, Kume S, Ohta T.
  Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats
  J Vet Med Sci. 2022 Mar 3; 84(3): 330-337. doi: 10.1292/jvms.21-0654. Epub 2022 Jan 27. [PMID: 35082197]

• Saigo Y, Sasase T, Uno K, Shinozaki Y, Maekawa T, Sano R, Toriniwa Y, Miyajima K, Ohta T.
  Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats
  J Pharmacol Toxicol Methods. 2022 Jul-Aug; 116: 107190. doi: 10.1016/j.vascn.2022.107190. Epub 2022 Jun 7. [PMID: 35688322]

• Hasegawa T, Takagi R, Tanaka Y, Ohta T, Shinohara M, Kageyama Y, Sasase T, Muramatsu SI, Kaburaki T, Kakehashi A.
  Differences in the Effects of Pentobarbital Anesthetic and Combination of Medetomidine Hydrochloride, Midazolam, and Butorphanol Tartrate Anesthetic on Electroretinogram in Spontaneously Diabetic Torii Fatty Rats
  Biomed Hub. 2022 Sep 9; 7(3): 106-114. doi: 10.1159/000526189. eCollection 2022 Sep-Dec. [PMID: 36262406]

• Kentaro Yoshioka, Yosuke Hirakawa, Makoto Kurano, Yuko Ube, Yoko Ono, Kensuke Kojima, Taiga Iwama, Kuniyuki Kano, Sho Hasegawa, Tsuyoshi Inoue, Takashi Shimada, Junken Aoki, Yutaka Yatomi, Masaomi Nangaku, Reiko Inagi
  Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease
  Kidney Int. 2022 Mar;101(3):510-526. doi: 10.1016/j.kint.2021.10.039. Epub 2021 Nov 29.PMID: 34856312

• Hara K, Sakai Y, Tajiri Y, Nomura M.
  Beneficial effects of SGLT2 inhibitor on metabolic inflexibility and visceral fat amount in animal model of obese type 2 diabetes
  Heliyon. 2022 Oct 10;8(10):e11012. doi: 10.1016/j.heliyon.2022.e11012. eCollection 2022 Oct.PMID: 36281369

• François Briand, Masami Shinohara, Emmanuel Brousseau, Julie Maupoint, Caroline Dubroca, Yasushi Kageyama, Thierry Sulpice
  Liraglutide Improves Both Diabetic Nephropathy and Cardiomyopathy in the SDT Fatty Rat, a Cardiorenal Model of Type 2 DiabetesBeneficial effects of SGLT2 inhibitor on metabolic inflexibility and visceral fat amount in animal model of obese type 2 diabetes
  ERA 2022

2023

• Taku Yamamoto, Satoru Kase, Akihiro Shinkai, Miyuki Murata, Kasumi Kikuchi, Di Wu, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida.
  Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation
  Invest Ophthalmol Vis Sci. 2023 Jul 3; 64(10): 20. doi: 10.1167/iovs.64.10.20.

• Hitoshi Kotake, Yuji Ogura, Shohei Yamada, Kazuho Inoue, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Yasunori Natsuki, Seiko Hoshino, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori.
  Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats
  J Physiol Sci. 2023 Apr 4; 73(1): 5. doi: 10.1186/s12576-023-00865-5.

• François Briand, Masami Shinohara, Emmanuel Brousseau, Julie Maupoint, Caroline Dubroca, Yasushi Kageyama, Thierry Sulpice
  Liraglutide improves both diabetic nephropathy and cardiomyopathy in the SDT Fatty rat, a cardiorenal model of Type 2 diabetesMechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats
  WCN23

• François Briand, Kana Watanabe, Katsuhiro Miyajima, Masami Shinohara, Takeshi Ohta, Yasushi Kageyama
  High fat/high sucrose feeding aggravates kidney lesions in the spontaneously diabetic torii fatty rat, an obese type 2 diabetic model of nephropathy
  WCN23

2024

• Yoshiaki Tanaka, Rina Takagi, Shingen Mitou, Machiko Shimmura, Tetsuya Hasegawa, Jota Amarume, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Takeshi Ohta, Shin-Ichi Muramatsu, Akihiro Kakehashi, Toshikatsu Kaburaki.
  Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
  Biol Pharm Bull. 2024 Mar 27; 47(3): 713-722. doi: 10.1248/bpb.b23-00872. Epub 2024 Mar 1.

• Takashima A, Miura J, Sugiyama K, Shimizu M, Okada M, Otani T, Nagashima T, Tsuda T, Araki T.
  Glycation promotes pulp calcification in Type 2 Diabetes rat model
  Oral Dis. 2024 Mar; 30(2): 593-603. doi: 10.1111/odi.14529. Epub 2023 Mar 13. [PMID: 36843542]

• Tanaka Y, Takagi R, Mitou S, Shimmura M, Hasegawa T, Amarume J, Shinohara M, Kageyama Y, Sasase T, Ohta T, Muramatsu SI, Kakehashi A, Kaburaki T.
  Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
  Biol Pharm Bull. 2024 Mar 27; 47(3): 713-722. doi: 10.1248/bpb.b23-00872. Epub 2024 Mar 1. [PMID: 38432946]

• Rina Takagi, Yoshiaki Tanaka, Tetsuya Hasegawa, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Machiko Shimmura-Tomita, Akihiro Kakehashi, Toshikatsu Kaburaki.
  Prophylactic Pattern Scanning LaserRetinal Photocoagulation for DiabeticRetinopathy in Spontaneously DiabeticTorii Fatty Rats: PreliminaryExperimental Results
  Journal of Diabetes Mellitus. 2024; 14: 153-165.

• François Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenić, Li Chen, Mathieu Petitjean, Blazej Dolicki, Thomas de Bel, Yasushi Kageyama, Thierry Sulpice
  Quantitative Image Analysis Reveals the Benefits of Dapagliflozin on Glomerulosclerosis,Podocytes Effacement and Kidney Fibrosis in the SDT Fatty Rat Model of Diabetic Nephropathy
  CKD Summit 2024

• François Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenić, Li Chen, Mathieu Petitjean, Yasushi Kageyama, Thierry Sulpice
  Quantitative image analysis reveals podocytes effacement and kidney fibrosis in SDT fatty rats with impaired renal function by unilateral nephrectomy and salt supplemented diet
  WCN24

• Rana Assaly, Caroline Dubroca, Yosra Doghri, Aurélie Waget, François Briand, Masami Shinohara, Yasushi Kageyama,Thierry Sulpice
  Characterization and progression of heart failure with preserved ejection fraction in SDT fatty rats.
  ESC London 2024

• François Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenić, Li Chen, Mathieu Petitjean, Blazej Dolicki, Thomas de Bel, Yasushi Kageyama, Thierry Sulpice
  Quantitative Image Analysis Reveals the Benefits of Dapagliflozin on Glomerulosclerosis, Podocytes Effacement and Kidney Fibrosis in the SDT Fatty Rat Model of Diabetic Nephropathy
  Kidney Week 2024

2025

• Bollinger E, Williams G, Piper ME, Steen K, Neale KT, Chen X, Marshall M, Jagarlapudi S, Jami-Alahmadi Y, Jean-Beltran PM, Song L, Chiou J, Geoly F, Vargas SR, Zhang Y, Kuang E, Callahan D, Stansfield JC, Russo M, Griffin J, Sun Z, Miller MR, Hyde CL, Clasquin MF, Hales K, Daurio NA, Crane JD, Hirenallur-Shanthappa D, Groarke J, Zhang BB, Roth Flach RJ.
  Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome models
  Kidney Int. 2025 May 21; S0085-2538(25)00408-9. doi: 10.1016/j.kint.2025.04.025. Online ahead of print. [PMID: 40409667]

• Ito S, Taguchi K, Kodama G, Kubo S, Moriyama T, Yamashita Y, Yokota Y, Nakayama Y, Kaida Y, Shinohara M, Tashiro K, Ohta K, Yamagishi SI, Fukami K.
  Involvement of impaired carnitine-induced fatty acid oxidation inexperimental and human diabetic kidney disease
  JCI Insight. 2025 May 22; 10(13): e179362. doi: 10.1172/jci.insight.179362. eCollection 2025 Jul 8. [PMID: 40402578]

• Kikuchi K, Murata M, Kageyama Y, Shinohara M, Sasase T, Noda K, Ishida S.
  Spontaneously Diabetic Torii Fatty Rat Shows Early Stage ofDiabetic Retinopathy Characterized by Capillary Changesand Inflammation
  J Diabetes Res. 2025 Apr 21; 2025: 3800292. doi: 10.1155/jdr/3800292. eCollection 2025. [PMID: 40297222]

• Fukasawa, Motoaki; Nagao, Shizuko; Takahashi, Kazuo
  Impaired Brain Tissue Clearance in Diabetic Nephropathy
  Journal of the American Society of Nephrology 36(10S):10.1681/ASN.2025f7nxk2mh, October 2025. | DOI: 10.1681/ASN.2025f7nxk2mh

• François Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenić, Li Chen, Mathieu Petitjean, Thomas de Bel, Yasushi Kageyama, Thierry Sulpice
  QUANTITATIVE IMAGE ANALYSIS REVEALS THE BENEFITS OF DRUGS IN ANIMAL MODELS OF CHRONIC KIDNEY DISEASE
  CKD Summit 2025

• François Briand, Estelle Grasset, Takeshi Ohta, Masami Shinohara, Caroline Dubroca, Thierry Sulpice
  QSGLT2 INHIBITION IMPROVES GLYCEMIC CONTROL, DIABETIC NEPHROPATHY AND NEUROPATHY IN THE SPONTANEOUSLY DIABETIC TORII FATTY RAT, A TRANSLATIONAL MODEL OF TYPE 2 DIABETES
  ATTD Asia 2025

2026

• François Briand, Guillaume Bourdier, Estelle Grasset, Rana Assaly, Caroline Dubroca, Masami Shinohara, Thierry Sulpice
  A 6-WEEK TREATMENT WITH SEMAGLUTIDE IMPROVES BOTH KIDNEY DYSFUNCTION AND HEART FAILURE WITH PRESERVED EJECTION FRACTION IN THE SDT FATTY RAT MODEL
  WCN 2026