SDT fatty/Jcl
Animals/Diabetes Models/
Ordering name: SDT fatty/Jcl
Nomenclature: SDT.Cg-Leprfa/JttJcl
Availability: Live colony
Not genetically modified animal
Origin
In 2004, Dr. Masuyama and Dr. Shinohara (Research Laboratories of Torii Pharmaceutical Co., Ltd., Japan) established the congenic type 2 diabetes model Spontaneously Diabetic Torii fatty (SDT fatty) rat by introducing the fa allele of the Zucker Fatty rat into the genome of the original SDT rat 1). SDT fatty rats were introduced to Central Pharmaceutical Research Institute, Japan Tobacco Inc. (Japan) and were characterized in detail by Dr. Ohta and Dr. Sasase. CLEA Japan has received right of production and sales from Japan Tobacco Inc., and has distributed the animals as SDT fatty rats from 2012.
Background Data (weight, blood property, blood biochemistry, organ weight)
◆ SDT fatty/Jcl 10 weeks of age data (*Japanese) 
◆References (*Japanese)
Characteristics/Usage
*We have excerpted and included a portion of the document in the PDF.
【Diabetic Nephropathy Model】
▼ 10-week 0.3% salt load Unilateral nephrectomy SDT fatty rats showed a decrease in creatinine clearance and a >50% decrease in GFR.
▼Diabetic Nephropaty Model (Japanese)▼
【NASH Model】
▼ Jcl:SD cholesterol-added diet (Cho)
▼ SDT fatty/Jcl cholesterol-added diet (Cho)
▼NASH Model (Japanese)▼
PDF Catalog
*We have excerpted and included a portion of the document in the PDF.
▽ Pathology of SDT fatty rat
▽ English version ▽
Additional Data 2023
Reference
▼ Introduction of Various Diabetic Complications model(Nephrology, Retinopathy, and Cardiovascular)
▼ Secondary Sarcopenia: SDT fatty rat, spontaneous type 2 diabetic animal model
▼ Cholesterol-Loaded NASH: SDT fatty rats, type 2 diabetes and obesity model
▼ High-sucrose/high-fat diet promotes nephropathy: Introduction of obese type 2 diabetes model SDT fatty rats 
▼ Diabetic peripheral neuropathy in SDT fatty rat, a new animal model of obese type 2 diabetes
▼ The results of research on Diabetic Retinopathy in SDT fatty rats
Cautions for the Breeding and Experimentation of Diabetic Model Animals
- Acclimation: Please take 3-5 days of acclimation after transportation to avoid hypoglycemia caused by stress.
- Frequent Bedding Changes: Due to polyuria associated with diabetes, please increase the frequency and amount of bedding changes.
- Consistent Measurement: Blood glucose levels can fluctuate based on diet, measurement methods, and sample type (blood, serum, plasma). Please ensure consistent procedures.
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .