Hras128/Jcl Academic Reference List
The Hras128/Jcl Academic Reference Archive provides a curated collection of scientific publications featuring the Hras128/Jcl transgenic rat supplied by CLEA Japan.
As a cancer-prone model carrying the human c-Ha-ras proto-oncogene, Hras128/Jcl has been used to investigate carcinogen susceptibility, tumor promotion, organ-specific carcinogenesis, and the development of medium-term bioassay systems.
The references collected on this page include studies on tongue, mammary, skin, and lung carcinogenesis, as well as chemoprevention, dietary influence, nanomaterial safety, and tumor-related molecular mechanisms. Publications are organized chronologically, allowing researchers to review the scientific development and expanding applications of this model in experimental carcinogenesis and safety assessment.
For detailed information on the biological characteristics, availability, and ordering information for Hras128/Jcl, please visit the corresponding product page.
Research Use Snapshot
- Product type: Human c-Ha-ras proto-oncogene transgenic rat model for carcinogenesis research.
- Typical applications: Chemical carcinogenesis, cancer susceptibility studies, medium-term carcinogenicity bioassays, chemoprevention research, toxicologic pathology, and cancer risk assessment.
- Evidence on this page: Publications include studies on carcinogen sensitivity, tongue, mammary, skin, and lung carcinogenesis, dietary modulation of tumor development, nanomaterial safety assessment, and medium-term bioassay applications.
- How to browse: Explore representative publications by research purpose or browse the complete reference list organized by publication year.
🧬 Experimental Carcinogenesis
How is Hras128/Jcl used in experimental cancer research? The publications on this page demonstrate the high susceptibility of Hras128/Jcl rats to chemically induced carcinogenesis, making this model valuable for organ-specific cancer research.
- High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis (2005) — see 2005
- An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats (2006) — see 2006
- A high-fat diet increases the incidence of mammary cancer in c-Ha-ras proto-oncogene transgenic rats (2017) — see 2017
🛡️ Chemoprevention & Cancer Prevention
Applications in cancer prevention research. These studies evaluate dietary compounds and chemopreventive approaches using the Hras128/Jcl model.
🧪 Toxicology & Safety Assessment
Evaluation of carcinogenicity and material safety. Hras128/Jcl has been applied to studies assessing chemical, particulate, and nanomaterial-related carcinogenic potential.
🔬 Model Development & Carcinogenicity Bioassays
Development of rapid bioassay systems for carcinogenesis research. These publications describe the establishment and application of Hras128/Jcl as a sensitive transgenic rat model for medium-term carcinogenicity testing.
📚 Key Publications (Timeline)
Representative studies using Hras128/Jcl. These publications highlight the development, validation, and major research applications of this transgenic carcinogenesis model.
- High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis (2005) — see 2005
- An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats (2006) — see 2006
- Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens (2007) — see 2007
- Purple corn color suppresses Ras protein level and inhibits mammary carcinogenesis (2008) — see 2008
- A high-fat diet increases the incidence of mammary cancer in c-Ha-ras proto-oncogene transgenic rats (2017) — see 2017
Related CLEA Japan product: Hras128/Jcl
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: https://www.clea-japan.com/en/products/genetically_modified/item_a0203
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2005
- Tsuda H, Fukamachi K, Ohshima Y, Ueda S, Matsuoka Y, Hamaguchi T, Ohnishi T, Takasuka N, Naito A.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Cancer Sci. 2005 Jun;96(6):309-16. [PMID: 15958052]
- 大嶋 浩, 深町勝巳, 松岡洋一郎, 濱口哲也, 大西隆仁, 高須賀信夫, 飯郷正明, 内藤暁宏, 津田洋幸.
発がん高感受性ヒトc-Ha-rasがん遺伝子トランスジェニックラット ―新規高発がん動物モデルの開発―.
日本疾患モデル学会記録, 21巻, 45-53, 2005年.
2006
- Suzuki R, Kohno H, Suzui M, Yoshimi N, Tsuda H, Wakabayashi K, Tanaka T.
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.
Carcinogenesis. 2006 Mar;27(3):619-30. [PMID: 16219633]
2007
- Ohnishi T, Fukamachi K, Ohshima Y, Jiegou X, Ueda S, Iigo M, Takasuka N, Naito A, Fujita K, Matsuoka Y, Izumi K, Tsuda H.
Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens.
Toxicol Pathol. 2007 Apr;35(3):436-43. [PMID: 17474063]
- Tsuda H, Iigo M, Takasuka N, Ueda S, Ohshima Y, Fukamachi K, Shirai T, Hirano S, Matsuda E, Wakabayashi K.
Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.
Food Chem Toxicol. 2007 Jun;45(6):1013-9. [PMID: 17258375]
- Matsuoka Y, Hamaguchi T, Fukamachi K, Yoshida M, Watanabe G, Taya K, Tsuda H, Tsubura A.
Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention.
Med Mol Morphol. 2007 Dec;40(4):185-90. [PMID: 18085376]
2008
- Fukamachi K, Imada T, Ohshima Y, Xu J, Tsuda H.
Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz [a] anthracene-induced mammary carcinogenesis in the rat.
Cancer Sci. 2008 Sep;99(9):1841-6. [PMID: 18616524]
2011
- Xu J, Sagawa Y, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Ikarashi Y, Uchino T, Nishimura T, Morita A, Suzui M, Tsuda H.
Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats.
Food Chem Toxicol. 2011 Jun;49(6):1298-302. [PMID: 21414375]
2014
- Xu J, Futakuchi M, Alexander DB, Fukamachi K, Numano T, Suzui M, Shimizu H, Omori T, Kanno J, Hirose A, Tsuda H.
Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles.
Arch Toxicol. 2014 Jan;88(1):65-75. [PMID: 23832296]
2017
- Magaki M, Ishii H, Yamasaki A, Kitai Y, Kametani S, Nakai R, Dabid A, Tsuda H, Ohnishi T.
A high-fat diet increases the incidence of mammary cancer in c-Ha-ras proto-oncogene transgenic rats.
J Toxicol Pathol. 2017 Apr;30(2):145-152. [PMID: 28458452]
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for Hras128/Jcl, along with a related product link and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Which years are included in the reference list on this page?- A: The reference list on this page includes publications from 2005, 2006, 2007, 2008, 2011, 2014, and 2017.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to the same publications listed in the year-based archive.
Q: Where can I find the product page for Hras128/Jcl?- A: The product link is provided in the "Related CLEA Japan product: Hras128/Jcl" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about Hras128/Jcl.
