Kras301/Jcl Academic Reference List
The Kras301/Jcl Academic Reference Archive provides a curated collection of scientific publications featuring the Kras301/Jcl transgenic rat supplied by CLEA Japan.
Carrying the human K-ras oncogene, this genetically modified rat has been developed as a valuable model for pancreatic ductal adenocarcinoma (PDAC) research. It has been widely used to investigate pancreatic tumor development, biomarker discovery, molecular mechanisms of carcinogenesis, and translational approaches for early cancer detection.
The references collected on this page include studies on pancreatic cancer initiation and progression, serum microRNA and protein biomarkers, metabolomic and transcriptomic profiling, and oncogenic Ras signaling. Publications are organized chronologically, allowing researchers to follow the development and expanding applications of this model in pancreatic cancer research.
For detailed information on the biological characteristics, availability, and ordering information for Kras301/Jcl, please visit the corresponding product page.
Research Use Snapshot
- Product type: Human K-ras oncogene transgenic rat model for pancreatic ductal adenocarcinoma research.
- Typical applications: Pancreatic cancer initiation and progression studies, early diagnosis research, biomarker discovery, oncogenic signaling analysis, and translational evaluation of pancreatic ductal adenocarcinoma.
- Evidence on this page: Publications include studies on pancreatic tumor development, circulating microRNAs, protein biomarkers, metabolomic and transcriptomic profiling, acinar cell susceptibility, and Ras-related molecular mechanisms.
- How to browse: Explore representative publications by research purpose or browse the complete reference list organized by publication year.
🧬 PDAC Model Development & Disease Progression
How is Kras301/Jcl used to study pancreatic ductal adenocarcinoma? The publications on this page describe the development and characterization of a transgenic rat model that reproduces pancreatic tumor formation and supports preclinical investigation of pancreatic ductal adenocarcinoma.
🔬 Molecular Mechanisms & Ras Signaling
Investigation of oncogenic pathways in pancreatic cancer. These studies use Kras301/Jcl-related pancreatic tumors to examine Ras-driven carcinogenesis and downstream molecular changes associated with tumor development.
🩸 Biomarker Discovery & Early Diagnosis
Applications in early detection and circulating biomarker research. The reference list includes studies evaluating serum microRNAs and tumor-associated proteins as potential indicators of pancreatic ductal adenocarcinoma.
🧪 Omics & Translational Profiling
Integrated molecular profiling of pancreatic tumors. These publications apply metabolomic, transcriptomic, and proteomic approaches to identify disease-associated pathways and molecular features with relevance to human pancreatic cancer.
📚 Key Publications (Timeline)
Representative studies using Kras301/Jcl. These publications highlight the establishment of the model, investigation of Ras-driven pancreatic carcinogenesis, and the development of circulating and tissue-based biomarkers.
- An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas (2009) — see 2009
- Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats (2010) — see 2010
- Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas (2012) — see 2012
- RAS oncogenic signal upregulates EZH2 in pancreatic cancer (2012) — see 2012
- Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas (2013) — see 2013
Related CLEA Japan product: Kras301/Jcl
For the animal, please click here↓
: https://www.clea-japan.com/en/products/genetically_modified/item_a0206
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2009
- Fukamachi K, Tanaka H, Hagiwara Y, Ohara H, Joh T, Iigo M, Alexander DB, Xu J, Long N, Takigahira M, Yanagihara K, Hino O, Saito I, Tsuda H.
An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.
Biochem Biophys Res Commun. 2009 Dec 18;390(3):636-41. [PMID: 19818733]
2010
- Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H.
Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.
Cancer Sci. 2010 Feb;101(2):341-6. [PMID: 19917056]
2012
- Yabushita S, Fukamachi K, Tanaka H, Sumida K, Deguchi Y, Sukata T, Kawamura S, Uwagawa S, Suzui M, Tsuda H.
Circulating microRNAs in serum of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
Pancreas. 2012 Oct;41(7):1013-8. [PMID: 22513294]
- Fujii S, Fukamachi K, Tsuda H, Ito K, Ito Y, Ochiai A.
RAS oncogenic signal upregulates EZH2 in pancreatic cancer.
Biochem Biophys Res Commun. 2012 Jan 20;417(3):1074-9. [PMID: 22222375]
2013
- Yabushita S, Fukamachi K, Tanaka H, Fukuda T, Sumida K, Deguchi Y, Mikata K, Nishioka K, Kawamura S, Uwagawa S, Suzui M, Alexander DB, Tsuda H.
Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
Carcinogenesis. 2013 Jun;34(6):1251-9. [PMID: 23393225]
- Yabushita S, Fukamachi K, Kikuchi F, Ozaki M, Miyata K, Sukata T, Deguchi Y, Tanaka H, Kakehashi A, Kawamura S, Uwagawa S, Wanibuchi H, Suzui M, Alexander DB, Tsuda H.
Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.
Pancreas. 2013 Aug;42(6):1034-9. [PMID: 23648844]
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for Kras301/Jcl, along with a related product link and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Which years are included in the reference list on this page?- A: The reference list on this page includes publications from 2009, 2010, 2012, and 2013.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to the same publications listed in the year-based archive.
Q: Where can I find the product page for Kras301/Jcl?- A: The product link is provided in the "Related CLEA Japan product: Kras301/Jcl" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about Kras301/Jcl.
