Academic Reference Archive：High Fat Diet 32

2005

• Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T.
  Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
  Nat Med. 2005; 11(4): 400-8. [PMID: 15778720]

2006

• Ohori H, Yamakoshi H, Tomizawa M, Shibuya M, Kakudo Y, Takahashi A, Takahashi S, Kato S, Suzuki T, Ishioka C, Iwabuchi Y, Shibata H.
  Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer.
  Mol Cancer Ther. 2006; 5(10): 2563-71. [PMID: 17041101]

2007

• Nasu R, Seki K, Nara M, Murakami M, Kohama T.
  Effect of a high-fat diet on diabetic mother rats and their offspring through three generations.
  Endocr J. 2007; 54(4): 563-9. [PMID: 17603226]

• Yamato M, Shiba T, Yoshida M, Ide T, Seri N, Kudou W, Kinugawa S, Tsutsui H.
  Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin.
  FEBS J. 2007; 274(15): 3855-63. [PMID: 17617229]

• Nishikawa S, Yasoshima A, Doi K, Nakayama H, Uetsuka K.
  Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice.
  Exp Anim. 2007; 56(4): 263-72. [PMID: 17660680]

• Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y.
  Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
  FEBS Lett. 2007; 581(1): 91-6. [PMID: 17182038]

• Aoyagi T, Birumachi J, Hiroyama M, Fujiwara Y, Sanbe A, Yamauchi J, Tanoue A.
  Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice.
  Endocrinology. 2007; 148(5): 2075-84. [PMID: 17303660]

• Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T.
  Disruption of CXC Motif Chemokine Ligand-14 in Mice Ameliorates Obesity-induced Insulin Resistance.
  J Biol Chem. 2007; 282(42): 30794-803. [PMID: 17724031]

2008

• Sakurai T, Nishioka H, Fujii H, Nakano N, Kizaki T, Radak Z, Izawa T, Haga S, Ohno H.
  Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes.
  Biosci Biotechnol Biochem. 2008; 72(2): 463-76. [PMID: 18256485]

• Nishikawa S, Doi K, Nakayama H, Uetsuka K.
  The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet.
  Toxicol Pathol. 2008; 36(6): 850-7. [PMID: 18812581]

• Kobayashi M, Ohnishi H, Okazawa H, Murata Y, Hayashi Y, Kobayashi H, Kitamura T, Matozaki T.
  Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.
  Endocrinology. 2008; 149(11): 5662-9. [PMID: 18635660]

2009

• Horii T, Morita S, Kimura M, Hatada I.
  Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
  PLoS One. 2009; 4(6): e5809. [PMID: 19503838]

• Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S.
  Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice.
  PLoS One. 2009; 4(1): e4240. [PMID: 19156225]

• Kubo M, Ijichi N, Ikeda K, Horie-Inoue K, Takeda S, Inoue S.
  Modulation of adipogenesis-related gene expression by estrogen-related receptor gamma during adipocytic differentiation.
  Biochim Biophys Acta. 2009; 1789(2): 71-7. [PMID: 18809516]

• Tozuka Y, Wada E, Wada K.
  Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring.
  FASEB J. 2009; 23(6): 1920-34. [PMID: 19158155]

• Nakamura K, Aoyagi T, Hiroyama M, Kusakawa S, Mizutani R, Sanbe A, Yamauchi J, Kamohara M, Momose K, Tanoue A.
  Both V(1A) and V(1B) vasopressin receptors deficiency result in impaired glucose tolerance.
  Eur J Pharmacol. 2009; 613(1-3): 182-8. [PMID: 19375419]

• Matsushima S, Kinugawa S, Yokota T, Inoue N, Ohta Y, Hamaguchi S, Tsutsui H.
  Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes.
  Am J Physiol Heart Circ Physiol. 2009; 297(1): H409-16. [PMID: 19465539]

• Nozaki Y, Fujita K, Yoneda M, Wada K, Shinohara Y, Takahashi H, Kirikoshi H, Inamori M, Kubota K, Saito S, Mizoue T, Masaki N, Nagashima Y, Terauchi Y, Nakajima A.
  Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease.
  J Hepatol. 2009; 51(3): 548-56. [PMID: 19596472]

• Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H.
  Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice.
  Am J Physiol Heart Circ Physiol. 2009; 297(3): H1069-77. [PMID: 19617406]

• Matsubara Y, Kano K, Kondo D, Mugishima H, Matsumoto T.
  Differences in Adipocytokines and Fatty Acid Composition between Two Adipocyte Fractions of Small and Large Cells in High-Fat Diet-Induced Obese Mice.
  Ann Nutr Metab 2009; 54: 258-267 [PMID: 19641303]

• Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
  Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions.
  Gut. 2009; 58(12): 1637-43. [PMID: 19570763]

• Shibata H, Yamakoshi H, Sato A, Ohori H, Kakudo Y, Kudo C, Takahashi Y, Watanabe M, Takano H, Ishioka C, Noda T, Iwabuchi Y.
  Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.
  Cancer Sci. 2009; 100(5): 956-60. [PMID: 19445025]

• Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K.
  Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
  FASEB J. 2009; 23(12): 4148-57. [PMID: 19671667]

• Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
  Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
  Cell Metab. 2009; 10(3): 178-88. [PMID: 19723494]

• Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T.
  Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver.
  J Agric Food Chem. 2009; 57(5): 1786-92. [PMID: 19256553]

2010

• Hasegawa G, Yamasaki M, Kadono M, Tanaka M, Asano M, Senmaru T, Kondo Y, Fukui M, Obayashi H, Maruyama N, Nakamura N, Ishigami A.
  Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.
  Endocrinology. 2010; 151(2): 529-36. [PMID: 19934374]

• Tanegashima K, Suzuki K, Nakayama Y, Hara T.
  Antibody-assisted enhancement of biological activities of CXCL14 in human monocytic leukemia-derived THP-1 cells and high fat diet-induced obese mice.
  Exp Cell Res. 2010; 316(7): 1263-70. [PMID: 20083103]

• Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K.
  Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring.
  Neurochem Int. 2010;57(3):235-47. [PMID: 20538025]

• Miyagi T, Takehara T, Uemura A, Nishio K, Shimizu S, Kodama T, Hikita H, Li W, Sasakawa A, Tatsumi T, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
  Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet.
  J Gastroenterol. 2010; 45(12): 1247-54. [PMID: 20596733]

2011

• Oiso H, Furukawa N, Suefuji M, Shimoda S, Ito A, Furumai R, Nakagawa J, Yoshida M, Nishino N, Araki E.
  The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver.
  Biochem Biophys Res Commun. 2011; 404(1): 166-72. [PMID: 21108932]

• Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K.
  Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis.
  Am J Physiol Endocrinol Metab. 2011; 300(3): E543-53. [PMID: 21205933]

• Kuwashiro S, Terai S, Oishi T, Fujisawa K, Matsumoto T, Nishina H, Sakaida I.
  Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation.
  Cell Tissue Res. 2011; 344(1): 125-34. [PMID: 21327395]

• Tominaga K, Yamauchi A, Egawa T, Tanaka R, Kawahara S, Shuto H, Kataoka Y.
  Vascular dysfunction and impaired insulin signaling in high-fat diet fed ovariectomized mice.
  Microvasc Res. 2011; 82(2): 171-6. [PMID: 21723877]

• Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T.
  Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass.
  Aging. 2011; 3(12): 1169-77. [PMID: 22184277]

• Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T.
  Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.
  EMBO J. 2011; 30(22): 4678-91. [PMID: 2189736]

• 大友 理宣,高嶋 亜希子,菊池 継夫,高橋 純一郎,戸枝 一喜,畠 恵司.
  米糠乳酸発酵抽出物の高脂肪食負荷ラットにおける脂質異常改善作用.
  生薬学雑誌. 2011; 65: 33-8.

• Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y.
  Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
  J Biol Chem. 2011; 86(29):25467-76. [PMID: 21613229]

• Tajima A, Hirata T, Taniguchi K, Kondo Y, Kato S, Saito-Hori M, Ishimoto T, Yamamoto K.
  Combination of TS-021 with metformin improves hyperglycemia and synergistically increases pancreatic β-cell mass in a mouse model of type 2 diabetes.
  Life Sci. 2011; 89(17-18): 662-70. [PMID: 21872612]

• Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T.
  Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.
  EMBO J. 2011; 30(22):4678-91. [PMID: 21897366]

2012

• Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada K, Kinugawa S, Tsutsui H.
  High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice.
  Mol Cell Biochem. 2012; 359(1-2): 161-7. [PMID: 21850461]

• Febriza Dwiranti, Masanori Hiraoka, Takahiro Taguchi, Yuko Konishi, Mari Tominaga, Akira Tominaga.
  Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice.
  Int J B Sci. 2012; 8(1): 64-75.

• Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, Nakayama T, Taniguchi M, Hirata N, Ishimori N, Tsutsui H, Onoé K, Iwabuchi K.
  Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance.
  PLoS One. 2012; 7(2): e30568. [PMID: 22383967]

• Inazuka F, Sugiyama N, Tomita M, Abe T, Shioi G, Esumi H.
  Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance.
  J Biol Chem. 2012; 287(20): 16379-89. [PMID: 22418434]

• Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami KI, Hayata-Takano A, Baba A, Hashimoto H.
  Compensatory Recovery of Blood Glucose Levels in KKA(y) Mice Fed a High-Fat Diet: Insulin-Sparing Effects of PACAP Overexpression in β Cells.
  J Mol Neurosci. 2012; 48(3): 647-53. [PMID: 22477644]

• Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K.
  Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.
  Hepatology. 2012; 56(3): 912-21. [PMID: 22505328]

• Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
  Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
  Hepatol Res. 2012 Jul 19. [Epub ahead of print] [PMID: 22834991]

• Nishikawa S, Sugimoto J, Okada M, Sakairi T, Takagi S.
  Gene expression in livers of BALB/C and C57BL/6J mice fed a high-fat diet.
  Toxicol Pathol. 2012; 40(1): 71-82. [PMID: 22105644]

• Aizawa N, Homma Y, Igawa Y.
  Influence of High Fat Diet Feeding for 20 Weeks on Lower Urinary Tract Function in Mice.
  LUTS: Lower Urinary Tract Symptoms Early View, Article first published online: 21 SEP 2012.

• Burdeos GC, Nakagawa K, Kimura F, Miyazawa T.
  Tocotrienol attenuates triglyceride accumulation in HepG2 cells and F344 rats.
  Lipids. 2012; 47(5): 471-81. [PMID: 22367056]

• Takahashi A, Morita M, Yokoyama K, Suzuki T, Yamamoto T.
  Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
  Mol Cell Biol. 2012; 32(24): 5067-77. [PMID: 23071089]

2013

• Ito M, Yamanashi Y, Toyoda Y, Izumi-Nakaseko H, Oda S, Sugiyama A, Kuroda M, Suzuki H, Takada T, Adachi-Akahane S.
  Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
  Biochim Biophys Acta. 2013; 1831(2):459-68. [PMID: 23200860]

• Yamashita-Sugahara Y, Tokuzawa Y, Nakachi Y, Kanesaki-Yatsuka Y, Matsumoto M, Mizuno Y, Okazaki Y.
  Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.
  J Biol Chem. 2013; 288(7): 4522-37. [PMID: 23275342]

• Takada S, Kinugawa S, Hirabayashi K, Suga T, Yokota T, Takahashi M, Fukushima A, Homma T, Ono T, Sobirin MA, Masaki Y, Mizushima W, Kadoguchi T, Okita K, Tsutsui H.
  Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.
  J Appl Physiol. 2013; 114(7):844-57. [PMID: 23329824]

• Senmaru T, Fukui M, Okada H, Mineoka Y, Yamazaki M, Tsujikawa M, Hasegawa G, Kitawaki J, Obayashi H, Nakamura N.
  Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet.
  Metabolism. 2013 (Article in Press). [PMID: 23332447]

• Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y,Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T.
  Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.
  Biochem Biophys Res Commun. 2013; 431(4):712-7. [PMID: 23353086]

• Fujii M, Shibazaki Y, Wakamatsu K, Honda Y, Kawauchi Y, Suzuki K, Arumugam S, Watanabe K, Ichida T, Asakura H, Yoneyama H.
  A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma.
  Med Mol Morphol. 2013 (Article in Press). [PMID: 23430399]

• Takata S, Sawa Y, Uchiyama T, Ishikawa H.
  Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.
  Acta Histochem Cytochem. 2013; 46(1): 35-42. [PMID: 23554538]

• Arai S, Maehara N, Iwamura Y, Honda SI, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura KI, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T.
  Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells.
  Cell Rep. 2013; 3, 1–12. [PMID: 23562157]

• Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
  Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain.
  PLoS One. 2013; 8(4): e60706. [PMID: 23593289]

• Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
  Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
  Hepatol Res. 2013 Mar;43(3):276-88. [PMID: 22834991]

• Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S.
  Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
  Biol Pharm Bull. 2013;36(11):1766-72.

• Aizawa N, Homma Y, Igawa Y.
  Influence of High Fat Diet Feeding for 20 Weeks on Lower Urinary Tract Function in Mice.
  Low Urin Tract Symptoms. 2013 May;5(2):101-8. [PMID: 26663378]

• Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H.
  PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.
  Front Endocrinol (Lausanne). 2013 Mar 11;4:27 [PMID: 23483824]

• Hashimoto T, Igarashi J, Hasan AU, Ohmori K, Kohno M, Nagai Y, Yamashita T, Kosaka H.
  Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity.
  PLoS One. 2013 Nov 6;8(11) [PMID: 24223187]

• Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H.
  The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
  FASEB J. 2013 Jun;27(6):2301-15. [PMID: 23430976]

• Traber PG, Zomer E.
  Therapy of experimental NASH and fibrosis with galectin inhibitors.
  PLoS One. 2013 Dec 18;8(12):e83481 [PMID: 24367597]

• Uchiyama T, Takata S, Ishikawa H, Sawa Y.
  Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.
  Acta Histochem Cytochem. 2013 Apr 30;46(2):97-104. [PMID: 23720608]

• Arai C, Miyake M, Matsumoto Y, Mizote A, Yoshizane C, Hanaya Y, Koide K, Yamada M, Hanaya T, Arai S, Fukuda S.
  Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in mice with established obesity.
  J Nutr Sci Vitaminol (Tokyo). 2013;59(5):393-401. [PMID: 24418873]

• Shimamura Y, Yoda M, Sakakibara H, Matsunaga K, Masuda S.
  Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules.
  Biosci Biotechnol Biochem. 2013;77(7):1455-60. [PMID: 23832364]

• Tanno S, Terao A, Okamatsu-Ogura Y, Kimura K.
  Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice.
  Obes Res Clin Pract. 2013 Jul-Aug;7(4):e251-7 [PMID: 24306152]

2014

• Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Tanaka S, Okita K, Tsutsui H.
  Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice.
  Endocrinology. 2014 Jan;155(1):68-80. [PMID: 24189138]

• Takakura K, Koido S, Fujii M, Hashiguchi T, Shibazaki Y, Yoneyama H, Katagi H, Kajihara M, Misawa T, Homma S, Ohkusa T, Tajiri H.
  Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice.
  Anticancer Res. 2014 Sep;34(9):4849-55. [PMID: 25202066]

• Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.
  Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system.
  J Mol Cell Cardiol. 2014 Dec;77:73-85. [PMID: 25264174]

• Ishikawa H, Takaki A, Tsuzaki R, Yasunaka T, Koike K, Shimomura Y, Seki H, Matsushita H, Miyake Y, Ikeda F, Shiraha H, Nouso K, Yamamoto K.
  L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
  PLoS One. 2014 Jul 1;9(7) [PMID: 24983359]

• Kuramoto K, Sakai F, Yoshinori N, Nakamura TY, Wakabayashi S, Kojidani T, Haraguchi T, Hirose F, Osumi T.
  Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction.
  Mol Cell Biol. 2014 Jul;34(14):2721-31. [PMID: 24820416]

• Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T.
  AMPD1: a novel therapeutic target for reversing insulin resistance.
  BMC Endocr Disord. 2014 Dec 15;14:96. [PMID: 25511531]

• Naka S, Nomura R, Takashima Y, Okawa R, Ooshima T, Nakano K.
  A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease.
  Oral Dis. 2014 Oct;20(7):700-6.[PMID: 25360469]

• Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Suzuki H, Arai E, Ojima H, Kanai Y, Saito H.
  Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.
  Cancer Sci. 2014 Oct;105(10):1254-60. [PMID: 25117675]

• Sawa Y, Takata S, Hatakeyama Y, Ishikawa H, Tsuruga E.
  Expression of toll-like receptor 2 in glomerular endothelial cells and promotion of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide.
  PLoS One. 2014 May 16;9(5):e97165 [PMID: 24835775]

• Yang W, Tanaka Y, Bundo M, Hirokawa N.
  Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
  Dev Cell. 2014 Oct 27;31(2):202-14. [PMID: 25373778]

2015

• Niwa M, Numaguchi Y, Ishii M, Kuwahata T, Kondo M, Shibata R, Miyata K, Oike Y, Murohara T.
  IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.
  Biochem Biophys Res Commun. 2015 Jan 30;457(1):12-8. [PMID: 25534853]

• Nakano S, Katsuno K, Isaji M, Nagasawa T, Buehrer B, Walker S, Wilkison WO, Cheatham B.
  Remogliflozin Etabonate Improves Fatty Liver Disease in Diet-Induced Obese Male Mice.
  J Clin Exp Hepatol. 2015 Sep;5(3):190-8. [PMID: 26628836]

• Tandelilin AA, Hirase T, Hudoyo AW, Cheng J, Toyama K, Morisaki H, Morisaki T.
  AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
  BMC Endocr Disord. 2015;15:11. [PMID: 25887856]. *Erratum in: BMC Endocr Disord. 2015;8;15:80 [PMID: 26645205]

• Nishimura W, Takahashi S, Yasuda K.
  MafA is critical for maintenance of the mature beta cell phenotype in mice.
  Diabetologia. 2015 Mar;58(3):566-74 [PMID: 25500951]

• Konishi H, Shirabe K, Nakagawara H, Harimoto N, Yamashita Y, Ikegami T, Yoshizumi T, Soejima Y, Oda Y, Maehara Y.
  Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis.
  Cancer Sci. 2015 May;106(5):542-9.[PMID:25736100]

• Fushimi S, Myazawa F, Nakagawa K, Burdeos GC, Miyazawa T.
  Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats.
  J Nutr Sci Vitaminol (Tokyo). 2015;61(1):90-5. [PMID: 25994144]

• Saito M, Kaneda A, Sugiyama T, Iida R, Otokuni K, Kaburagi M, Matsuoka H.
  Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model.
  Exp Anim. 2015;64(3):231-9. [PMID: 25765873]

• Wang B, Tanaka K, Katsube T, Maruyama K, Ninomiya Y and Nenoi M.
  Dietary Modification of Mouse Response to Total-Body-Irradiation.
  Evolution of Ionizing Radiation Research September 17, 2015

• Saito K, Uebanso T, Maekawa K, Ishikawa M, Taguchi R, Nammo T, Nishimaki-Mogami T, Udagawa H, Fujii M, Shibazaki Y, Yoneyama H, Yasuda K, Saito Y.
  Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis.
  Sci Rep. 2015 Aug 20;5:12466. [PMID: 26289793]

• Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.
  Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.
  PLoS One. 2015 Sep 17;10(9):e0138322. [PMID: 26378455]

• Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T.
  N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food.
  Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R561-75. [PMID: 26157056]

• Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, Yamamoto T.
  Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.
  Cell Rep. 2015 Dec 29;13(12):2756-67. [PMID: 26711342]

• Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H.
  Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.
  Gastric Cancer. 2015 Oct;18(4):774-83. [PMID: 25331984]

• Ailixiding M, Aibibula Z, Iwata M, Piao J, Hara Y, Koga D, Okawa A, Morita S1, Asou Y.
  Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
  Biochem Biophys Res Commun. 2015 Oct 23;466(3):319-26 [PMID: 26362183]

• Fujita T, Yamashita D, Uehara N, Inokuchi G, Hasegawa S, Otsuki N1, Nibu K.
  A high-fat diet delays age-related hearing loss progression in C57BL/6J mice.
  PLoS One. 2015 Jan 27;10(1):e0117547 [PMID: 25625852]

2016

• Higashimura Y, Naito Y, Takagi T, Uchiyama K, Mizushima K, Ushiroda C, Ohnogi H, Kudo Y, Yasui M, Inui S, Hisada T, Honda A, Matsuzaki Y, Yoshikawa T.
  Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice.
  Am J Physiol Gastrointest Liver Physiol. 2016 Jan 14. [PMID: 26767984]

• Noble EE, Kanoski SE.
  Early life exposure to obesogenic diets and learning and memory dysfunction.
  Curr Opin Behav Sci. 2016 Jun;9:7-14.[PMID: 26858972]

• Yamato M, Kawano K, Yamanaka Y, Saiga M, Yamada K.
  TEMPOL increases NAD(+) and improves redox imbalance in obese mice.
  Redox Biol. 2016 Aug;8:316-22.[PMID: 26942863]

• Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, and Ichikawa S.
  Evidence-Based Complementary and Alternative Medicine Volume 2016 (2016).
  Article ID 4282758, 9.[PMID: None]

• Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
  L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.
  Hepatol Res. 2016 Apr 7.[PMID: 27062266]

• Hatanaka Y, Wada K, Kabuta T.
  Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation.
  Neurochem Int. 2016 Jul;97:99-108.[PMID: 26970392]

• Peñaa L, Meanaa, C, Astudilloa AM, Lordéna G, Valdearcosa M, Sato H, Murakamic M, Balsindea J, Balboaa MA.
  Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume 1861, Issue 9, Part A, September 2016, Pages 1083–1095. [PMID: 27317983]

• Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.
  Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice.
  Endocrinology. 2016 May;157(5):1839-51.[PMID: 26943364]

• Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T.
  High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b.
  J Mol Cell Cardiol. 2016 Jan;90:38-46.[PMID: 26654778]

• Xie G, Wang X, Liu P, Wei R, Chen W, Rajani C, Hernandez BY, Alegado R, Dong B, Li D, Jia W.
  Distinctly altered gut microbiota in the progression of liver disease.
  Oncotarget. 2016 Mar 29. [PMID: 27036035]

• Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H.
  The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.
  EBioMedicine. 2016 Jan 29;5:82-92.[PMID: 27077115]

• Aoki K, Tajima K, Taguri M, Terauchi Y.
  Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet.
  J Steroid Biochem Mol Biol. 2016 May;159:110-20.[PMID: 26976654]

• Aibibula Z, Ailixiding M, Iwata M, Piao J, Hara Y, Okawa A, Asou Y.
  Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis.
  Biochem Biophys Res Commun. 2016 Mar 25;472(1):26-32.[PMID: 26903297]

• Fukuda K, Uehara Y, Nakata E, Inoue M, Shimazu K, Yoshida T, Kanda H, Nanjo H, Hosoi Y, Yamakoshi H, Iwabuchi Y, Shibata H.
  A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa.
  Int J Radiat Biol. 2016 Jul;92(7):388-94.[PMID: 27043482]

• Shirai M, Arakawa S, Teranishi M, Kai K.
  Decreased hepatic phosphorylated p38 mitogen-activated protein kinase contributes to attenuation of thioacetamide-induced hepatic necrosis in diet-induced obese mice.
  J Toxicol Sci. 2016;41(2):245-53.[PMID: 26961609]

• H, Abe Y, Hibi T, Masugi Y, Aiura K, Sakamoto M, Kitagawa Y.
  Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
  BMC Gastroenterol. 2016 Jun 13;16(1):61.[PMID: 27296438]

• Nakazono S, Cho K, Isaka S, Abu R, Yokose T, Murata M, Ueno M, Tachibana K, Hirasaka K, Kim D, Oda T.
  Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet.
  Bioactive Carbohydrates and Dietary Fibre Vol7,2, April 2016, 1–8 [PMID: none]

• Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, Ichikawa S.
  Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells.
  Evid Based Complement Alternat Med. 2016;2016:4282758.[PMID: 27429636]

• Toita R, Kawano T, Murata M, Kang JH.
  Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice.
  Biomaterials. 2016 Dec;110:81-88.[PMID: 27716475]

• Yamamoto S, Oshima Y, Saitou T, Watanabe T, Miyake T, Yoshida O, Tokumoto Y, Abe M, Matsuura B, Hiasa Y, Imamura T.
  Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM)
  Biochemistry and Biophysics Reports 8 (2016) 277–283 [PMID: none]

• Nagaishi K, Mizue Y, Chikenji T, Otani M, Nakano M, Konari N, Fujimiya M.
  Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.
  Sci Rep. 2016 Oct 10;6:34842.[PMID: 27721418]

• Ijuin T, Hosooka T, Takenawa T.
  Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.
  Mol Cell Biol. 2015 Oct 19;36(1):108-18.[PMID: 26483413]

• Akiko Takashima, Kimihiko Sano, Shiho Nakagawa, Gen Toshima, Junichiro Takahashi, Fumika Kurosaki, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata.
  In vitro and in vivo antidiabetic effects of the ethanol extract from Lentinula edodes (Shiitake).
  Nutrafoods (2016) 15:279-284 [PMID: None]

2017

• Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, Shigehara K, Nishikawa T, Kosaka K, Hosoi H.
  Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice.
  PLoS One. 2017 Mar 13;12(3):e0173661. [PMID: 28288167]

• Tomiga Y, Yoshimura S, Ito A, Nakashima S, Kawanaka K, Uehara Y, Tanaka H, Higaki Y.
  Exercise training rescues high fat diet-induced neuronal nitric oxide synthase expression in the hippocampus and cerebral cortex of mice.
  Nitric Oxide. 2017 Jun 1;66:71–77. [PMID: 28302517]

• Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
  L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.
  Hepatol Res. 2017 Mar;47(3):E44–E54. [PMID: 27062266]

• Yamamoto R, Iida A, Tanikawa K, Shiratsuchi H, Tokuda M, Matsui T, Nakamura T.
  Dietary D-Allose Ameliorates Hepatic Inflammation in Mice with Non-alcoholic Steatohepatitis.
  Food Sci Technol Res. 2017;23(2):319–327. [PMID: None]

• Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K.
  Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity.
  Int J Obes (Lond). 2017 Apr;41(4):483–488.

• Afrin MR, Arumugam S, Rahman MA, Karuppagounder V, Harima M, Suzuki H, Miyashita S, Suzuki K, Ueno K, Yoneyama H, Watanabe K.
  Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling.
  Int Immunopharmacol. 2017 Jun 5;49:161–167. [PMID: 28595079]

• Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M.
  Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.
  Oncotarget. 2017 Mar 14;8(11):18280–18295. [PMID: 28407685]

• Takemoto M, Takemoto H, Kouno H, Soeda T, Moriya T.
  A Simple, Enzymatic Biotransformation Method Using Fresh Green Tea Leaves Efficiently Generates Theaflavin-Containing Fermentation Water That Has Potent Physiological Functions in Mice and Humans.
  Biol Pharm Bull. 2017 Jun 1;40(6):860–866. [PMID: 28381812]

• Sreedhar R, Arumugam S, Thandavarayan RA, Karuppagounder V, Koga Y, Nakamura T, Harima M, Watanabe K.
  Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus.
  [PMID: 28483670]

• Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K.
  Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
  Lipids Health Dis. 2017 Jun 3;16(1):106. [PMID: 28578672]

• Lye HS, Kato T, Low WY, Taylor TD, Prakash T, Lew LC, Ohno H, Liong MT.
  Lactobacillus fermentum FTDC 8312 combats hypercholesterolemia via alteration of gut microbiota.
  J Biotechnol. 2017 Nov 20;262:75–83. [PMID: 28935567]

• Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K.
  Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.
  Sci Rep. 2017 Aug 29;7(1):9807. [PMID: 28852070]

• Kusumoto Y, Irie J, Iwabu K, Tagawa H, Itoh A, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Yamada S, Kawai T, Watanabe M, Oike Y, Itoh H.
  Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice.
  Metabolism. 2017 Jun;71:1–6. [PMID: 28521862]

• Komori T, Morikawa Y.
  Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target.
  Anat Sci Int. 2017 Nov 4. [PMID: 29103176]

• Saito T, Muramatsu M, Ishii Y, Saigo Y, Konuma T, Toriniwa Y, Miyajima K, Ohta T.
  Pathophysiological analysis of the progression of hepatic lesions in STAM mice.
  Physiol Res. 2017 Nov 24;66(5):791–799. [PMID: 28730823]

• Sasaki T, Yasoshima Y, Matsui S, Yokota-Hashimoto H, Kobayashi M, Kitamura T.
  Intraperitoneal injection of d-serine inhibits high-fat diet intake and preference in male mice.
  Appetite. 2017 Nov 1;118:120–128. [PMID: 28803978]

• Hirose S, Asano K, Nakane A.
  Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.
  Biochem Biophys Res Commun. 2017 Mar 11;484(3):480–485. [PMID: 28089867]

• Hirotani Y, Fukamachi J, Ueyama R, Urashima Y, Ikeda K.
  Effects of Capsaicin Coadministered with Eicosapentaenoic Acid on Obesity-Related Dysregulation in High-Fat-Fed Mice.
  Biol Pharm Bull. 2017;40(9):1581–1585. [PMID: 28867743]

• Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA.
  Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
  FASEB J. 2017 Nov 10;201700866R. [PMID: 29127188]

• Afrin R, Arumugam S, Rahman A, Wahed MI, Karuppagounder V, Harima M, Suzuki H, Miyashita S, Suzuki K, Yoneyama H, Ueno K, Watanabe K.
  Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation.
  Int Immunopharmacol. 2017 Mar;44:174–182. [PMID: 28110063]

• Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K.
  Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
  Peptides. 2017 Oct 7. [PMID: 29017855]

• Takahashi Y, Matsunaga Y, Tamura Y, Terada S, Hatta H.
  Pre-Exercise High-Fat Diet for 3 Days Affects Post-Exercise Skeletal Muscle Glycogen Repletion.
  J Nutr Sci Vitaminol (Tokyo). 2017;63(5):323–330. [PMID: 29225317]

• Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T.
  Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway.
  PLoS One. 2017 Aug 3;12(8):e0182422. [PMID: 28771625]

• de Conti A, Ortega JF, Tryndyak V, Dreval K, Moreno FS, Rusyn I, Beland FA, Pogribny IP.
  MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.
  Oncotarget. 2017 Aug 1;8(51):88517–88528. [PMID: 29179453]

• Ideta T, Shirakami Y, Ohnishi M, Maruta A, Obara K, Miyazaki T, Kochi T, Sakai H, Tomita H, Tanaka T, Blaner WS, Shimizu M.
  Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.
  Oncotarget. 2017 Aug 7;8(41):70695–70706. [PMID: 29050312]

• Sugizaki T, Zhu S, Guo G, Matsumoto A, Zhao J, Endo M, Horiguchi H, Morinaga J, Tian Z, Kadomatsu T, Miyata K, Itoh H, Oike Y.
  Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.
  NPJ Aging Mech Dis. 2017 Sep 8;3:12. [PMID: 28900540]

• Shimizu T, Sato T, Tsukiyama K, Fujita H, Kato S, Hoizumi M, Shirasawa H, Narita T, Terada Y, Seino Y, Yamada Y.
  Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice.
  Endocrinology. 2017 Jul 1;158(7):2134–2144. [PMID: 28430907]

2018

• Satoh M, Iwabuchi K.
  Role of Natural Killer T Cells in the Development of Obesity and Insulin Resistance: Insights From Recent Progress.
  Front Immunol. 2018 Jun 11;9:1314. [PMID: 29942311]

• Higashi Y, Yamakuchi M, Fukushige T, Ibusuki A, Hashiguchi T, Kanekura T.
  High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice.
  Exp Dermatol. 2018 Feb;27(2):178-184. [PMID: 29247486]

• Al-Fayoumi S, Hashiguchi T, Shirakata Y, Mascarenhas J, Singer JW.
  Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
  J Exp Pharmacol. 2018 May 9;10:9-17. [PMID: 29785143]

• Yoshida Y, Furukawa JI, Naito S, Higashino K, Numata Y, Shinohara Y.
  Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.
  Glycoconj J. 2018 Sep 8. [PMID: 30194503]

• Maejima Y, Yokota S, O'Hashi R, Aoyama M, Shimomura K.
  The effect of avertin anesthesia and a mixture of three types of anesthetic agents on food intake and body weight in high fat-induced obese male and female mice.
  Exp Anim. 2018 Sep 13. [PMID: 30210091]

• Lo Re O, Panebianco C, Porto S, Cervi C, Rappa F, Di Biase S, Caraglia M, Pazienza V, Vinciguerra M.
  Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells.
  J Cell Physiol. 2018 Feb;233(2):1202-1212. [PMID: 28471474]

• Fujisawa K, Takami T, Fukui Y, Nagatomo T, Saeki I, Matsumoto T, Hidaka I, Yamamoto N, Okamoto T, Furutani-Seiki M, Sakaida I.
  Assessment of high fat diet-induced fatty liver in medaka.
  Biol Open. 2018 Aug 20. [PMID: 30127096]

• Akaki J, Tachi S, Nakamura N, Arai T, Yamasaki H, Inoue M, Makino T.
  Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet.
  J Ethnopharmacol. 2018 Jun 28;220:1-8. [PMID: 29588201]

• Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.
  A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.
  Mol Brain. 2018 May 24;11(1):28. [PMID: 29793524]

• Mori T, Suzuki-Yamazaki N, Takaki S.
  Lnk/Sh2b3 Regulates Adipose Inflammation and Glucose Tolerance through Group 1 ILCs.
  Cell Rep. 2018 Aug 14;24(7):1830-1841. [PMID: 30110639]

• Oishi K, Ohyama S, Higo-Yamamoto S.
  Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
  Biochem Biophys Res Commun. 2018 Jan 22;495(4):2616-2621. [PMID: 29288667]

• Homeyer A, Hammad S, Schwen LO, Dahmen U, Höfener H, Gao Y, Dooley S, Schenk A.
  Focused scores enable reliable discrimination of small differences in steatosis.
  Diagn Pathol. 2018 Sep 20;13(1):76. [PMID: 30231920]

• Yoshida K, Kita Y, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T.
  Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice.
  FASEB J. 2018 Sep 28:fj201801203R. [PMID: 30265576]

• Nakashima A, Sugimoto R, Suzuki K, Shirakata Y, Hashiguchi T, Yoshida C, Nakano Y.
  Anti‐fibrotic activity of Euglena gracilis and paramylon in a mouse model of non‐ alcoholic steatohepatitis.
  Food Sci Nutr. 2018 Nov 8;7(1):139-147. [PMID: 30680167]

• Ardiansyah, Inagawa Y, Koseki T, Agista AZ, Ikeda I, Goto T, Komai M, Shirakawa H.
  Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet.
  BMC Complement Altern Med. 2018 Nov 14;18(1):304. [PMID: 30428888]

• Naka S, Wato K, Hatakeyama R, Okawa R, Nomura R, Nakano K.
  Longitudinal comparison of Streptococcus mutans-induced aggravation of non-alcoholic steatohepatitis in mice.
  J Oral Microbiol. 2018 Jan 22;10(1):1428005. [PMID: 29503703]

• Dechassa ML, Tryndyak V, de Conti A, Xiao W, Beland FA, Pogribny IP.
  Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
  Mol Carcinog. 2018 Aug;57(8):978-987. [PMID: 29603380]

• Kawaguchi T, Nakano D, Koga H, Torimura T.
  Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.
  Liver Cancer. 2018; DOI_10.1159_000491763. [PMID: None]

• Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, Hara Y, Tomiyama Y, Kuribayashi F, Torimura T, Hino K.
  Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice.
  Cell Mol Gastroenterol Hepatol. 2018 Sep 11;7(1):115-134. [PMID: 30510994]

• Wakabayashi C, Kunugi H.
  Involvement of IL-6 and GSK3β in impaired sensorimotor gating induced by high-fat diet.
  Neurosci Res. 2018 Oct 13. pii: S0168-0102(18)30328-6. [PMID: 30326250]

• Yoshida T, MaruyamaT, Miura M, Inoue M, Fukuda K, Shimazu K, Taguchi D, Kanda H, Oshima M, Iwabuchi Y, Shibata H.
  Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis.
  Journal of Functional Foods. 2018 Nov;50:192-200. [PMID: None]

• Liu T, Kamiyoshi A, Tanaka M, Iida S, Sakurai T, Ichikawa-Shindo Y, Kawate H, Hirabayashi K, Dai K, Cui N, Tanaka M, Wei Y, Nakamura K, Matsui S, Yamauchi A, Shindo T.
  RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders.
  Peptides. 2018 Oct 29;110:10-18. [PMID: 30487357]

2019

• Komatsu G, Nonomura T, Sasaki M, Ishida Y, Arai S, Miyazaki T.
  AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease.
  Exp Anim. 2019;68(2):147–158. [PMID: 30487357]

• Tsuma Y, Mori J, Ota T, Kawabe Y, Morimoto H, Fukuhara S, Kodo K, Umemura A, Nakajima H, Hosoi H.
  Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway.
  Biochem Biophys Res Commun. 2019 Jan 29;509(1):306-313. [PMID: 30583863]

• Murakami-Nishida S, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Morita Y, Nishida S, Motoshima H, Kondo T, Komohara Y, Araki E.
  Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ.
  Atherosclerosis. 2019 Jul;286:30-39. [PMID: 31096071]

• Borowa-Mazgaj B, de Conti A, Tryndyak V, Steward CR, Jimenez L, Melnyk S, Seneshaw M, Mirshahi F, Rusyn I, Beland FA, Sanyal AJ, Pogribny IP.
  Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis.
  Toxicol Sci. 2019 May 14. [PMID: 31086990]

• Yoshida Y, Shimizu I, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagami H, Morishita R, Minamino T.
  Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity.
  Sci Rep. 2019 Mar 7;9(1):3858. [PMID: 30846754]

• Hye Khan MA, Schmidt J, Stavniichuk A, Imig JD, Merk D.
  A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice.
  Biochem Pharmacol. 2019 Aug;166:212-221. [PMID: 31129048]

• Kawakami T, Takasaki S, Kadota Y, Fukuoka D, Sato M, Suzuki S.
  Regulatory role of metallothionein-1/2 on development of sex differences in a high-fat diet-induced obesity.
  Life Sci. 2019 Jun 1;226:12-21. [PMID: 30954474]

• Ushiroda C, Naito Y, Takagi T, Uchiyama K, Mizushima K, Higashimura Y, Yasukawa Z, Okubo T, Inoue R, Honda A, Matsuzaki Y, Itoh Y.
  Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice.
  J Clin Biochem Nutr. 2019 Apr. [PMID: None]

• Shimoda H, Tanaka J, Zaiki K, Nakaoji K.
  Tiliroside, a Constituent of Strawberry Seeds, Slightly Enhances Hyaluronan Production via Hyaluronan Synthase 2 Expression in Mouse Skin and Human Fibroblasts.
  Int J Biomedical Science. 2019;15(1):24-31. [PMID: None]

• Matsumoto K, Shimada H, Morishima H, Akahori R, Kida N.
  Resistant Starch‐Supplemented Udon Noodles Prevent Impaired Glucose Tolerance and Induce Intestinal Immunoglobulin‐A Secretion in Mice.
  Starch. 2019 Jun 5. [PMID: None]

• Iida A, Kuranuki S, Yamamoto R, Uchida M, Ohta M, Ichimura M, Tsuneyama K, Masaki T, Seike M, Nakamura T.
  Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice.
  Exp Anim. 2019 Jun 1. [PMID: 31155606]

• Zhu S, Tian Z, Torigoe D, Zhao J, Xie P, Sugizaki T, Sato M, Horiguchi H, Terada K, Kadomatsu T, Miyata K, Oike Y.
  Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.
  PLoS One. 2019 Aug 23;14(8):e0221366. [PMID: 31442231]

• Shikama Y, Kurosawa M, Furukawa M, Ishimaru N, Matsushita K.
  Involvement of adiponectin in age-related increases in tear production in mice.
  Aging (Albany NY). 2019 Oct 8;11(19):8329-8346. [PMID: 31596727]

• Kawaguchi T, Nakano D, Koga H, Torimura T.
  Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.
  Liver Cancer. 2019 Oct;8(5):359-372. [PMID: 31768345]

• Wakabayashi C, Kunugi H.
  Involvement of IL-6 and GSK3β in impaired sensorimotor gating induced by high-fat diet.
  Neurosci Res. 2019 Oct;147:33-38. [PMID: 30326250]

2020

• Watanabe K, Afrin MR, Sreedhar R, Karuppagounder V, Harima M, Alexander X, Velayutham R, Arumugam S.
  Pharmacological Investigation of Ceraceomyces tessulatus (Agaricomycetes) in Mice with Non-Alcoholic Steatohepatitis.
  [Forthcoming]

• Nishida S, Matsumura T, Senokuchi T, Murakami-Nishida S, Ishii N, Morita Y, Yagi Y, Motoshima H, Kondo T, Araki E.
  Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.
  Biochem Biophys Res Commun. 2020 Mar 26;524(1):8-15. [PMID: 31964532]

• Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.
  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.
  Free Radic Biol Med. 2020 Jun 15;156:45-56. [PMID: 32553752]

• Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T.
  Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.
  Sci Rep. 2020 May 8;10(1):7818. [PMID: 32385406]

• Maejima Y, Yokota S, Horita S, Shimomura K.
  Early life high-fat diet exposure evokes normal weight obesity.
  Nutr Metab (Lond). 2020 Jun 24;17:48. [PMID: 32595758]

• Morikawa S, Oshima S, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Stutte S, Watanabe M.
  High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage.
  Biochem Biophys Res Commun. 2020 Feb 19;522(4):971-977. [PMID: 31810607]

• Sato H, Taketomi Y, Miki Y, Murase R, Yamamoto K, Murakami M.
  Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.
  Cell Rep. 2020 May 5;31(5):107579. [PMID: 32375030]

• Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T.
  Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass.
  PLoS Genet. 2020 May;16(5):e1008586. [PMID: 32463816]

• Nishimura M, Nomura Y, Egi M, Obata N, Tsunoda M, Mizobuchi S.
  Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice.
  BMC Neurosci. 2020 Feb 17;21(1):8. [PMID: 32066381]

• Arai C, Suyama A, Arai S, Arai N, Yoshizane C, Koya-Miyata S, Mizote A, Endo S, Ariyasu T, Mitsuzumi H, Ushio S.
  Trehalose itself plays a critical role on lipid metabolism.
  Nutr Metab (Lond). 2020 Mar 18. [PMID: 32206077]

2021

• Afrin MR, Arumugam S, Pitchaimani V, Karuppagounder V, Thandavarayan RA, Harima M, Hossain CF, Suzuki K, Sone H, Matsubayashi Y, Watanabe K.
  Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation.
  Heliyon. 2021 Jan 5;7(1):e05888.

2022

• Suzuki H, Watanabe K, Arumugam S, Yellurkar ML, Sreedhar R, Afrin R, Sone H.
  Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice.
  Int J Med Mushrooms. 2022;24(1):41-52.