Academic Reference Archive：High Fat Diet 32

2005

• Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T.
  Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
  Nat Med. 2005; 11(4): 400-8. [PMID: 15778720]

2007

• Nasu R, Seki K, Nara M, Murakami M, Kohama T.
  Effect of a high-fat diet on diabetic mother rats and their offspring through three generations.
  Endocr J. 2007; 54(4): 563-9. [PMID: 17603226]

• Yamato M, Shiba T, Yoshida M, Ide T, Seri N, Kudou W, Kinugawa S, Tsutsui H.
  Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin.
  FEBS J. 2007; 274(15): 3855-63. [PMID: 17617229]

• Nishikawa S, Yasoshima A, Doi K, Nakayama H, Uetsuka K.
  Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice.
  Exp Anim. 2007; 56(4): 263-72. [PMID: 17660680]

• Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y.
  Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
  FEBS Lett. 2007; 581(1): 91-6. [PMID: 17182038]

• Aoyagi T, Birumachi J, Hiroyama M, Fujiwara Y, Sanbe A, Yamauchi J, Tanoue A.
  Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice.
  Endocrinology. 2007; 148(5): 2075-84. [PMID: 17303660]

• Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T.
  Disruption of CXC Motif Chemokine Ligand-14 in Mice Ameliorates Obesity-induced Insulin Resistance.
  J Biol Chem. 2007; 282(42): 30794-803. [PMID: 17724031]

2008

• Sakurai T, Nishioka H, Fujii H, Nakano N, Kizaki T, Radak Z, Izawa T, Haga S, Ohno H.
  Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes.
  Biosci Biotechnol Biochem. 2008; 72(2): 463-76. [PMID: 18256485]

• Nishikawa S, Doi K, Nakayama H, Uetsuka K.
  The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet.
  Toxicol Pathol. 2008; 36(6): 850-7. [PMID: 18812581]

• Kobayashi M, Ohnishi H, Okazawa H, Murata Y, Hayashi Y, Kobayashi H, Kitamura T, Matozaki T.
  Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.
  Endocrinology. 2008; 149(11): 5662-9. [PMID: 18635660]

2009

• Horii T, Morita S, Kimura M, Hatada I.
  Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
  PLoS One. 2009; 4(6): e5809. [PMID: 19503838]

• Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S.
  Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice.
  PLoS One. 2009; 4(1): e4240. [PMID: 19156225]

• Kubo M, Ijichi N, Ikeda K, Horie-Inoue K, Takeda S, Inoue S.
  Modulation of adipogenesis-related gene expression by estrogen-related receptor gamma during adipocytic differentiation.
  Biochim Biophys Acta. 2009; 1789(2): 71-7. [PMID: 18809516]

• Tozuka Y, Wada E, Wada K.
  Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring.
  FASEB J. 2009; 23(6): 1920-34. [PMID: 19158155]

• Nakamura K, Aoyagi T, Hiroyama M, Kusakawa S, Mizutani R, Sanbe A, Yamauchi J, Kamohara M, Momose K, Tanoue A.
  Both V(1A) and V(1B) vasopressin receptors deficiency result in impaired glucose tolerance.
  Eur J Pharmacol. 2009; 613(1-3): 182-8. [PMID: 19375419]

• Matsushima S, Kinugawa S, Yokota T, Inoue N, Ohta Y, Hamaguchi S, Tsutsui H.
  Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes.
  Am J Physiol Heart Circ Physiol. 2009; 297(1): H409-16. [PMID: 19465539]

• Nozaki Y, Fujita K, Yoneda M, Wada K, Shinohara Y, Takahashi H, Kirikoshi H, Inamori M, Kubota K, Saito S, Mizoue T, Masaki N, Nagashima Y, Terauchi Y, Nakajima A.
  Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease.
  J Hepatol. 2009; 51(3): 548-56. [PMID: 19596472]

• Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H.
  Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice.
  Am J Physiol Heart Circ Physiol. 2009; 297(3): H1069-77. [PMID: 19617406]

• Matsubara Y, Kano K, Kondo D, Mugishima H, Matsumoto T.
  Differences in Adipocytokines and Fatty Acid Composition between Two Adipocyte Fractions of Small and Large Cells in High-Fat Diet-Induced Obese Mice.
  Ann Nutr Metab 2009; 54: 258-267 [PMID: 19641303]

• Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
  Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions.
  Gut. 2009; 58(12): 1637-43. [PMID: 19570763]

• Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K.
  Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
  FASEB J. 2009; 23(12): 4148-57. [PMID: 19671667]

• Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
  Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
  Cell Metab. 2009; 10(3): 178-88. [PMID: 19723494]

• Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T.
  Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver.
  J Agric Food Chem. 2009; 57(5): 1786-92. [PMID: 19256553]

2010

• Hasegawa G, Yamasaki M, Kadono M, Tanaka M, Asano M, Senmaru T, Kondo Y, Fukui M, Obayashi H, Maruyama N, Nakamura N, Ishigami A.
  Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.
  Endocrinology. 2010; 151(2): 529-36. [PMID: 19934374]

• Tanegashima K, Suzuki K, Nakayama Y, Hara T.
  Antibody-assisted enhancement of biological activities of CXCL14 in human monocytic leukemia-derived THP-1 cells and high fat diet-induced obese mice.
  Exp Cell Res. 2010; 316(7): 1263-70. [PMID: 20083103]

• Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K.
  Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring.
  Neurochem Int. 2010;57(3):235-47. [PMID: 20538025]

• Miyagi T, Takehara T, Uemura A, Nishio K, Shimizu S, Kodama T, Hikita H, Li W, Sasakawa A, Tatsumi T, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
  Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet.
  J Gastroenterol. 2010; 45(12): 1247-54. [PMID: 20596733]

2011

• Oiso H, Furukawa N, Suefuji M, Shimoda S, Ito A, Furumai R, Nakagawa J, Yoshida M, Nishino N, Araki E.
  The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver.
  Biochem Biophys Res Commun. 2011; 404(1): 166-72. [PMID: 21108932]

• Nakatani M, Kokubo M, Ohsawa Y, Sunada Y, Tsuchida K.
  Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis.
  Am J Physiol Endocrinol Metab. 2011; 300(3): E543-53. [PMID: 21205933]

• Kuwashiro S, Terai S, Oishi T, Fujisawa K, Matsumoto T, Nishina H, Sakaida I.
  Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation.
  Cell Tissue Res. 2011; 344(1): 125-34. [PMID: 21327395]

• Tominaga K, Yamauchi A, Egawa T, Tanaka R, Kawahara S, Shuto H, Kataoka Y.
  Vascular dysfunction and impaired insulin signaling in high-fat diet fed ovariectomized mice.
  Microvasc Res. 2011; 82(2): 171-6. [PMID: 21723877]

• Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T.
  Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass.
  Aging. 2011; 3(12): 1169-77. [PMID: 22184277]

• Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T.
  Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.
  EMBO J. 2011; 30(22): 4678-91. [PMID: 2189736]

• 大友 理宣,高嶋 亜希子,菊池 継夫,高橋 純一郎,戸枝 一喜,畠 恵司.
  米糠乳酸発酵抽出物の高脂肪食負荷ラットにおける脂質異常改善作用.
  生薬学雑誌. 2011; 65: 33-8.

• Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y.
  Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
  J Biol Chem. 2011; 86(29):25467-76. [PMID: 21613229]

• Tajima A, Hirata T, Taniguchi K, Kondo Y, Kato S, Saito-Hori M, Ishimoto T, Yamamoto K.
  Combination of TS-021 with metformin improves hyperglycemia and synergistically increases pancreatic β-cell mass in a mouse model of type 2 diabetes.
  Life Sci. 2011; 89(17-18): 662-70. [PMID: 21872612]

2012

• Yamato M, Shiba T, Ide T, Seri N, Kudo W, Ando M, Yamada K, Kinugawa S, Tsutsui H.
  High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice.
  Mol Cell Biochem. 2012; 359(1-2): 161-7. [PMID: 21850461]

• Febriza Dwiranti, Masanori Hiraoka, Takahiro Taguchi, Yuko Konishi, Mari Tominaga, Akira Tominaga.
  Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice.
  Int J B Sci. 2012; 8(1): 64-75.

• Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, Nakayama T, Taniguchi M, Hirata N, Ishimori N, Tsutsui H, Onoé K, Iwabuchi K.
  Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance.
  PLoS One. 2012; 7(2): e30568. [PMID: 22383967]

• Inazuka F, Sugiyama N, Tomita M, Abe T, Shioi G, Esumi H.
  Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance.
  J Biol Chem. 2012; 287(20): 16379-89. [PMID: 22418434]

• Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami KI, Hayata-Takano A, Baba A, Hashimoto H.
  Compensatory Recovery of Blood Glucose Levels in KKA(y) Mice Fed a High-Fat Diet: Insulin-Sparing Effects of PACAP Overexpression in β Cells.
  J Mol Neurosci. 2012; 48(3): 647-53. [PMID: 22477644]

• Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K.
  Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice.
  Hepatology. 2012; 56(3): 912-21. [PMID: 22505328]

• Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
  Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
  Hepatol Res. 2012 Jul 19. [Epub ahead of print] [PMID: 22834991]

• Nishikawa S, Sugimoto J, Okada M, Sakairi T, Takagi S.
  Gene expression in livers of BALB/C and C57BL/6J mice fed a high-fat diet.
  Toxicol Pathol. 2012; 40(1): 71-82. [PMID: 22105644]

• Aizawa N, Homma Y, Igawa Y.
  Influence of High Fat Diet Feeding for 20 Weeks on Lower Urinary Tract Function in Mice.
  LUTS: Lower Urinary Tract Symptoms Early View, Article first published online: 21 SEP 2012.

• Takahashi A, Morita M, Yokoyama K, Suzuki T, Yamamoto T.
  Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
  Mol Cell Biol. 2012; 32(24): 5067-77. [PMID: 23071089]

2013

• Ito M, Yamanashi Y, Toyoda Y, Izumi-Nakaseko H, Oda S, Sugiyama A, Kuroda M, Suzuki H, Takada T, Adachi-Akahane S.
  Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
  Biochim Biophys Acta. 2013; 1831(2):459-68. [PMID: 23200860]

• Yamashita-Sugahara Y, Tokuzawa Y, Nakachi Y, Kanesaki-Yatsuka Y, Matsumoto M, Mizuno Y, Okazaki Y.
  Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.
  J Biol Chem. 2013; 288(7): 4522-37. [PMID: 23275342]

• Takada S, Kinugawa S, Hirabayashi K, Suga T, Yokota T, Takahashi M, Fukushima A, Homma T, Ono T, Sobirin MA, Masaki Y, Mizushima W, Kadoguchi T, Okita K, Tsutsui H.
  Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.
  J Appl Physiol. 2013; 114(7):844-57. [PMID: 23329824]

• Senmaru T, Fukui M, Okada H, Mineoka Y, Yamazaki M, Tsujikawa M, Hasegawa G, Kitawaki J, Obayashi H, Nakamura N.
  Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet.
  Metabolism. 2013 (Article in Press). [PMID: 23332447]

• Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y,Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T.
  Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.
  Biochem Biophys Res Commun. 2013; 431(4):712-7. [PMID: 23353086]

• Fujii M, Shibazaki Y, Wakamatsu K, Honda Y, Kawauchi Y, Suzuki K, Arumugam S, Watanabe K, Ichida T, Asakura H, Yoneyama H.
  A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma.
  Med Mol Morphol. 2013 (Article in Press). [PMID: 23430399]

• Takata S, Sawa Y, Uchiyama T, Ishikawa H.
  Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.
  Acta Histochem Cytochem. 2013; 46(1): 35-42. [PMID: 23554538]

• Arai S, Maehara N, Iwamura Y, Honda SI, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura KI, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T.
  Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells.
  Cell Rep. 2013; 3, 1–12. [PMID: 23562157]

• Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
  Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain.
  PLoS One. 2013; 8(4): e60706. [PMID: 23593289]

• Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
  Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
  Hepatol Res. 2013 Mar;43(3):276-88. [PMID: 22834991]

• Aibara D, Matsusue K, Matsuo K, Takiguchi S, Gonzalez FJ, Yamano S.
  Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
  Biol Pharm Bull. 2013;36(11):1766-72.

• Aizawa N, Homma Y, Igawa Y.
  Influence of High Fat Diet Feeding for 20 Weeks on Lower Urinary Tract Function in Mice.
  Low Urin Tract Symptoms. 2013 May;5(2):101-8. [PMID: 26663378]

• Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H.
  PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.
  Front Endocrinol (Lausanne). 2013 Mar 11;4:27 [PMID: 23483824]

• Hashimoto T, Igarashi J, Hasan AU, Ohmori K, Kohno M, Nagai Y, Yamashita T, Kosaka H.
  Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity.
  PLoS One. 2013 Nov 6;8(11) [PMID: 24223187]

• Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H.
  The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
  FASEB J. 2013 Jun;27(6):2301-15. [PMID: 23430976]

• Traber PG, Zomer E.
  Therapy of experimental NASH and fibrosis with galectin inhibitors.
  PLoS One. 2013 Dec 18;8(12):e83481 [PMID: 24367597]

• Uchiyama T, Takata S, Ishikawa H, Sawa Y.
  Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.
  Acta Histochem Cytochem. 2013 Apr 30;46(2):97-104. [PMID: 23720608]

• Arai C, Miyake M, Matsumoto Y, Mizote A, Yoshizane C, Hanaya Y, Koide K, Yamada M, Hanaya T, Arai S, Fukuda S.
  Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in mice with established obesity.
  J Nutr Sci Vitaminol (Tokyo). 2013;59(5):393-401. [PMID: 24418873]

• Shimamura Y, Yoda M, Sakakibara H, Matsunaga K, Masuda S.
  Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules.
  Biosci Biotechnol Biochem. 2013;77(7):1455-60. [PMID: 23832364]

• Tanno S, Terao A, Okamatsu-Ogura Y, Kimura K.
  Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice.
  Obes Res Clin Pract. 2013 Jul-Aug;7(4):e251-7 [PMID: 24306152]

2014

• Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Tanaka S, Okita K, Tsutsui H.
  Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice.
  Endocrinology. 2014 Jan;155(1):68-80. [PMID: 24189138]

• Takakura K, Koido S, Fujii M, Hashiguchi T, Shibazaki Y, Yoneyama H, Katagi H, Kajihara M, Misawa T, Homma S, Ohkusa T, Tajiri H.
  Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice.
  Anticancer Res. 2014 Sep;34(9):4849-55. [PMID: 25202066]

• Ishikawa H, Takaki A, Tsuzaki R, Yasunaka T, Koike K, Shimomura Y, Seki H, Matsushita H, Miyake Y, Ikeda F, Shiraha H, Nouso K, Yamamoto K.
  L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
  PLoS One. 2014 Jul 1;9(7) [PMID: 24983359]

• Kuramoto K, Sakai F, Yoshinori N, Nakamura TY, Wakabayashi S, Kojidani T, Haraguchi T, Hirose F, Osumi T.
  Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction.
  Mol Cell Biol. 2014 Jul;34(14):2721-31. [PMID: 24820416]

• Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T.
  AMPD1: a novel therapeutic target for reversing insulin resistance.
  BMC Endocr Disord. 2014 Dec 15;14:96. [PMID: 25511531]

• Naka S, Nomura R, Takashima Y, Okawa R, Ooshima T, Nakano K.
  A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease.
  Oral Dis. 2014 Oct;20(7):700-6.[PMID: 25360469]

• Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Suzuki H, Arai E, Ojima H, Kanai Y, Saito H.
  Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.
  Cancer Sci. 2014 Oct;105(10):1254-60. [PMID: 25117675]

• Sawa Y, Takata S, Hatakeyama Y, Ishikawa H, Tsuruga E.
  Expression of toll-like receptor 2 in glomerular endothelial cells and promotion of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide.
  PLoS One. 2014 May 16;9(5):e97165 [PMID: 24835775]

• Yang W, Tanaka Y, Bundo M, Hirokawa N.
  Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
  Dev Cell. 2014 Oct 27;31(2):202-14. [PMID: 25373778]

2015

• Niwa M, Numaguchi Y, Ishii M, Kuwahata T, Kondo M, Shibata R, Miyata K, Oike Y, Murohara T.
  IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.
  Biochem Biophys Res Commun. 2015 Jan 30;457(1):12-8. [PMID: 25534853]

• Nakano S, Katsuno K, Isaji M, Nagasawa T, Buehrer B, Walker S, Wilkison WO, Cheatham B.
  Remogliflozin Etabonate Improves Fatty Liver Disease in Diet-Induced Obese Male Mice.
  J Clin Exp Hepatol. 2015 Sep;5(3):190-8. [PMID: 26628836]

• Tandelilin AA, Hirase T, Hudoyo AW, Cheng J, Toyama K, Morisaki H, Morisaki T.
  AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
  BMC Endocr Disord. 2015;15:11. [PMID: 25887856]. *Erratum in: BMC Endocr Disord. 2015;8;15:80 [PMID: 26645205]

• Nishimura W, Takahashi S, Yasuda K.
  MafA is critical for maintenance of the mature beta cell phenotype in mice.
  Diabetologia. 2015 Mar;58(3):566-74 [PMID: 25500951]

• Konishi H, Shirabe K, Nakagawara H, Harimoto N, Yamashita Y, Ikegami T, Yoshizumi T, Soejima Y, Oda Y, Maehara Y.
  Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis.
  Cancer Sci. 2015 May;106(5):542-9.[PMID:25736100]

• Fushimi S, Myazawa F, Nakagawa K, Burdeos GC, Miyazawa T.
  Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats.
  J Nutr Sci Vitaminol (Tokyo). 2015;61(1):90-5. [PMID: 25994144]

• Saito M, Kaneda A, Sugiyama T, Iida R, Otokuni K, Kaburagi M, Matsuoka H.
  Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model.
  Exp Anim. 2015;64(3):231-9. [PMID: 25765873]

• Wang B, Tanaka K, Katsube T, Maruyama K, Ninomiya Y and Nenoi M.
  Dietary Modification of Mouse Response to Total-Body-Irradiation.
  Evolution of Ionizing Radiation Research September 17, 2015

• Saito K, Uebanso T, Maekawa K, Ishikawa M, Taguchi R, Nammo T, Nishimaki-Mogami T, Udagawa H, Fujii M, Shibazaki Y, Yoneyama H, Yasuda K, Saito Y.
  Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis.
  Sci Rep. 2015 Aug 20;5:12466. [PMID: 26289793]

• Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.
  Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.
  PLoS One. 2015 Sep 17;10(9):e0138322. [PMID: 26378455]

• Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, Yada T, Amano N, Kitamura T.
  N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food.
  Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R561-75. [PMID: 26157056]

• Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, Yamamoto T.
  Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.
  Cell Rep. 2015 Dec 29;13(12):2756-67. [PMID: 26711342]

• Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H.
  Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.
  Gastric Cancer. 2015 Oct;18(4):774-83. [PMID: 25331984]

• Ailixiding M, Aibibula Z, Iwata M, Piao J, Hara Y, Koga D, Okawa A, Morita S1, Asou Y.
  Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.
  Biochem Biophys Res Commun. 2015 Oct 23;466(3):319-26 [PMID: 26362183]

• Fujita T, Yamashita D, Uehara N, Inokuchi G, Hasegawa S, Otsuki N1, Nibu K.
  A high-fat diet delays age-related hearing loss progression in C57BL/6J mice.
  PLoS One. 2015 Jan 27;10(1):e0117547 [PMID: 25625852]

2016

• Higashimura Y, Naito Y, Takagi T, Uchiyama K, Mizushima K, Ushiroda C, Ohnogi H, Kudo Y, Yasui M, Inui S, Hisada T, Honda A, Matsuzaki Y, Yoshikawa T.
  Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice.
  Am J Physiol Gastrointest Liver Physiol. 2016 Jan 14. [PMID: 26767984]

• Noble EE, Kanoski SE.
  Early life exposure to obesogenic diets and learning and memory dysfunction.
  Curr Opin Behav Sci. 2016 Jun;9:7-14.[PMID: 26858972]

• Yamato M, Kawano K, Yamanaka Y, Saiga M, Yamada K.
  TEMPOL increases NAD(+) and improves redox imbalance in obese mice.
  Redox Biol. 2016 Aug;8:316-22.[PMID: 26942863]

• Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, and Ichikawa S.
  Evidence-Based Complementary and Alternative Medicine Volume 2016 (2016).
  Article ID 4282758, 9.[PMID: None]

• Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
  L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.
  Hepatol Res. 2016 Apr 7.[PMID: 27062266]

• Hatanaka Y, Wada K, Kabuta T.
  Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation.
  Neurochem Int. 2016 Jul;97:99-108.[PMID: 26970392]

• Peñaa L, Meanaa, C, Astudilloa AM, Lordéna G, Valdearcosa M, Sato H, Murakamic M, Balsindea J, Balboaa MA.
  Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume 1861, Issue 9, Part A, September 2016, Pages 1083–1095. [PMID: 27317983]

• Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.
  Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice.
  Endocrinology. 2016 May;157(5):1839-51.[PMID: 26943364]

• Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T.
  High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b.
  J Mol Cell Cardiol. 2016 Jan;90:38-46.[PMID: 26654778]

• Xie G, Wang X, Liu P, Wei R, Chen W, Rajani C, Hernandez BY, Alegado R, Dong B, Li D, Jia W.
  Distinctly altered gut microbiota in the progression of liver disease.
  Oncotarget. 2016 Mar 29. [PMID: 27036035]

• Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H.
  The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.
  EBioMedicine. 2016 Jan 29;5:82-92.[PMID: 27077115]

• Aoki K, Tajima K, Taguri M, Terauchi Y.
  Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet.
  J Steroid Biochem Mol Biol. 2016 May;159:110-20.[PMID: 26976654]

• Aibibula Z, Ailixiding M, Iwata M, Piao J, Hara Y, Okawa A, Asou Y.
  Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis.
  Biochem Biophys Res Commun. 2016 Mar 25;472(1):26-32.[PMID: 26903297]

• Fukuda K, Uehara Y, Nakata E, Inoue M, Shimazu K, Yoshida T, Kanda H, Nanjo H, Hosoi Y, Yamakoshi H, Iwabuchi Y, Shibata H.
  A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa.
  Int J Radiat Biol. 2016 Jul;92(7):388-94.[PMID: 27043482]

• Shirai M, Arakawa S, Teranishi M, Kai K.
  Decreased hepatic phosphorylated p38 mitogen-activated protein kinase contributes to attenuation of thioacetamide-induced hepatic necrosis in diet-induced obese mice.
  J Toxicol Sci. 2016;41(2):245-53.[PMID: 26961609]

• Nakazono S, Cho K, Isaka S, Abu R, Yokose T, Murata M, Ueno M, Tachibana K, Hirasaka K, Kim D, Oda T.
  Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet.
  Bioactive Carbohydrates and Dietary Fibre Vol7,2, April 2016, 1–8 [PMID: none]

• Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, Ichikawa S.
  Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells.
  Evid Based Complement Alternat Med. 2016;2016:4282758.[PMID: 27429636]

• Toita R, Kawano T, Murata M, Kang JH.
  Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice.
  Biomaterials. 2016 Dec;110:81-88.[PMID: 27716475]

• Yamamoto S, Oshima Y, Saitou T, Watanabe T, Miyake T, Yoshida O, Tokumoto Y, Abe M, Matsuura B, Hiasa Y, Imamura T.
  Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM)
  Biochemistry and Biophysics Reports 8 (2016) 277–283 [PMID: none]

• Nagaishi K, Mizue Y, Chikenji T, Otani M, Nakano M, Konari N, Fujimiya M.
  Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.
  Sci Rep. 2016 Oct 10;6:34842.[PMID: 27721418]

• Ijuin T, Hosooka T, Takenawa T.
  Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.
  Mol Cell Biol. 2015 Oct 19;36(1):108-18.[PMID: 26483413]

• Akiko Takashima, Kimihiko Sano, Shiho Nakagawa, Gen Toshima, Junichiro Takahashi, Fumika Kurosaki, Akira Sasaki, Kazuyuki Hiwatashi, Keishi Hata.
  In vitro and in vivo antidiabetic effects of the ethanol extract from Lentinula edodes (Shiitake).
  Nutrafoods (2016) 15:279-284 [PMID: None]

2017

• Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, Shigehara K, Nishikawa T, Kosaka K, Hosoi H.
  Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice.
  PLoS One. 2017 Mar 13;12(3):e0173661. [PMID: 28288167]

• Tomiga Y, Yoshimura S, Ito A, Nakashima S, Kawanaka K, Uehara Y, Tanaka H, Higaki Y.
  Exercise training rescues high fat diet-induced neuronal nitric oxide synthase expression in the hippocampus and cerebral cortex of mice.
  Nitric Oxide. 2017 Jun 1;66:71–77. [PMID: 28302517]

• Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
  L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.
  Hepatol Res. 2017 Mar;47(3):E44–E54. [PMID: 27062266]

• Yamamoto R, Iida A, Tanikawa K, Shiratsuchi H, Tokuda M, Matsui T, Nakamura T.
  Dietary D-Allose Ameliorates Hepatic Inflammation in Mice with Non-alcoholic Steatohepatitis.
  Food Sci Technol Res. 2017;23(2):319–327. [PMID: None]

• Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K.
  Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity.
  Int J Obes (Lond). 2017 Apr;41(4):483–488.

• Afrin MR, Arumugam S, Rahman MA, Karuppagounder V, Harima M, Suzuki H, Miyashita S, Suzuki K, Ueno K, Yoneyama H, Watanabe K.
  Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling.
  Int Immunopharmacol. 2017 Jun 5;49:161–167. [PMID: 28595079]

• Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M.
  Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.
  Oncotarget. 2017 Mar 14;8(11):18280–18295. [PMID: 28407685]

• Takemoto M, Takemoto H, Kouno H, Soeda T, Moriya T.
  A Simple, Enzymatic Biotransformation Method Using Fresh Green Tea Leaves Efficiently Generates Theaflavin-Containing Fermentation Water That Has Potent Physiological Functions in Mice and Humans.
  Biol Pharm Bull. 2017 Jun 1;40(6):860–866. [PMID: 28381812]

• Sreedhar R, Arumugam S, Thandavarayan RA, Karuppagounder V, Koga Y, Nakamura T, Harima M, Watanabe K.
  Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus.
  [PMID: 28483670]

• Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K.
  Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
  Lipids Health Dis. 2017 Jun 3;16(1):106. [PMID: 28578672]

• Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K.
  Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.
  Sci Rep. 2017 Aug 29;7(1):9807. [PMID: 28852070]

• Komori T, Morikawa Y.
  Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target.
  Anat Sci Int. 2017 Nov 4. [PMID: 29103176]

• Saito T, Muramatsu M, Ishii Y, Saigo Y, Konuma T, Toriniwa Y, Miyajima K, Ohta T.
  Pathophysiological analysis of the progression of hepatic lesions in STAM mice.
  Physiol Res. 2017 Nov 24;66(5):791–799. [PMID: 28730823]

• Sasaki T, Yasoshima Y, Matsui S, Yokota-Hashimoto H, Kobayashi M, Kitamura T.
  Intraperitoneal injection of d-serine inhibits high-fat diet intake and preference in male mice.
  Appetite. 2017 Nov 1;118:120–128. [PMID: 28803978]

• Hirose S, Asano K, Nakane A.
  Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.
  Biochem Biophys Res Commun. 2017 Mar 11;484(3):480–485. [PMID: 28089867]

• Hirotani Y, Fukamachi J, Ueyama R, Urashima Y, Ikeda K.
  Effects of Capsaicin Coadministered with Eicosapentaenoic Acid on Obesity-Related Dysregulation in High-Fat-Fed Mice.
  Biol Pharm Bull. 2017;40(9):1581–1585. [PMID: 28867743]

• Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA.
  Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
  FASEB J. 2017 Nov 10;201700866R. [PMID: 29127188]

• Afrin R, Arumugam S, Rahman A, Wahed MI, Karuppagounder V, Harima M, Suzuki H, Miyashita S, Suzuki K, Yoneyama H, Ueno K, Watanabe K.
  Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation.
  Int Immunopharmacol. 2017 Mar;44:174–182. [PMID: 28110063]

• Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K.
  Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
  Peptides. 2017 Oct 7. [PMID: 29017855]

• Takahashi Y, Matsunaga Y, Tamura Y, Terada S, Hatta H.
  Pre-Exercise High-Fat Diet for 3 Days Affects Post-Exercise Skeletal Muscle Glycogen Repletion.
  J Nutr Sci Vitaminol (Tokyo). 2017;63(5):323–330. [PMID: 29225317]

• Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T.
  Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway.
  PLoS One. 2017 Aug 3;12(8):e0182422. [PMID: 28771625]

• de Conti A, Ortega JF, Tryndyak V, Dreval K, Moreno FS, Rusyn I, Beland FA, Pogribny IP.
  MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.
  Oncotarget. 2017 Aug 1;8(51):88517–88528. [PMID: 29179453]

• Ideta T, Shirakami Y, Ohnishi M, Maruta A, Obara K, Miyazaki T, Kochi T, Sakai H, Tomita H, Tanaka T, Blaner WS, Shimizu M.
  Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.
  Oncotarget. 2017 Aug 7;8(41):70695–70706. [PMID: 29050312]

• Sugizaki T, Zhu S, Guo G, Matsumoto A, Zhao J, Endo M, Horiguchi H, Morinaga J, Tian Z, Kadomatsu T, Miyata K, Itoh H, Oike Y.
  Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.
  NPJ Aging Mech Dis. 2017 Sep 8;3:12. [PMID: 28900540]

• Shimizu T, Sato T, Tsukiyama K, Fujita H, Kato S, Hoizumi M, Shirasawa H, Narita T, Terada Y, Seino Y, Yamada Y.
  Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice.
  Endocrinology. 2017 Jul 1;158(7):2134–2144. [PMID: 28430907]

2018

• Higashi Y, Yamakuchi M, Fukushige T, Ibusuki A, Hashiguchi T, Kanekura T.
  High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice.
  Exp Dermatol. 2018 Feb;27(2):178-184. [PMID: 29247486]

• Al-Fayoumi S, Hashiguchi T, Shirakata Y, Mascarenhas J, Singer JW.
  Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
  J Exp Pharmacol. 2018 May 9;10:9-17. [PMID: 29785143]

• Yoshida Y, Furukawa JI, Naito S, Higashino K, Numata Y, Shinohara Y.
  Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.
  Glycoconj J. 2018 Sep 8. [PMID: 30194503]

• Maejima Y, Yokota S, O'Hashi R, Aoyama M, Shimomura K.
  The effect of avertin anesthesia and a mixture of three types of anesthetic agents on food intake and body weight in high fat-induced obese male and female mice.
  Exp Anim. 2018 Sep 13. [PMID: 30210091]

• Lo Re O, Panebianco C, Porto S, Cervi C, Rappa F, Di Biase S, Caraglia M, Pazienza V, Vinciguerra M.
  Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells.
  J Cell Physiol. 2018 Feb;233(2):1202-1212. [PMID: 28471474]

• Fujisawa K, Takami T, Fukui Y, Nagatomo T, Saeki I, Matsumoto T, Hidaka I, Yamamoto N, Okamoto T, Furutani-Seiki M, Sakaida I.
  Assessment of high fat diet-induced fatty liver in medaka.
  Biol Open. 2018 Aug 20. [PMID: 30127096]

• Akaki J, Tachi S, Nakamura N, Arai T, Yamasaki H, Inoue M, Makino T.
  Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet.
  J Ethnopharmacol. 2018 Jun 28;220:1-8. [PMID: 29588201]

• Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.
  A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.
  Mol Brain. 2018 May 24;11(1):28. [PMID: 29793524]

• Mori T, Suzuki-Yamazaki N, Takaki S.
  Lnk/Sh2b3 Regulates Adipose Inflammation and Glucose Tolerance through Group 1 ILCs.
  Cell Rep. 2018 Aug 14;24(7):1830-1841. [PMID: 30110639]

• Oishi K, Ohyama S, Higo-Yamamoto S.
  Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
  Biochem Biophys Res Commun. 2018 Jan 22;495(4):2616-2621. [PMID: 29288667]

• Homeyer A, Hammad S, Schwen LO, Dahmen U, Höfener H, Gao Y, Dooley S, Schenk A.
  Focused scores enable reliable discrimination of small differences in steatosis.
  Diagn Pathol. 2018 Sep 20;13(1):76. [PMID: 30231920]

• Yoshida K, Kita Y, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T.
  Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice.
  FASEB J. 2018 Sep 28:fj201801203R. [PMID: 30265576]

• Nakashima A, Sugimoto R, Suzuki K, Shirakata Y, Hashiguchi T, Yoshida C, Nakano Y.
  Anti‐fibrotic activity of Euglena gracilis and paramylon in a mouse model of non‐ alcoholic steatohepatitis.
  Food Sci Nutr. 2018 Nov 8;7(1):139-147. [PMID: 30680167]

• Ardiansyah, Inagawa Y, Koseki T, Agista AZ, Ikeda I, Goto T, Komai M, Shirakawa H.
  Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet.
  BMC Complement Altern Med. 2018 Nov 14;18(1):304. [PMID: 30428888]

• Naka S, Wato K, Hatakeyama R, Okawa R, Nomura R, Nakano K.
  Longitudinal comparison of Streptococcus mutans-induced aggravation of non-alcoholic steatohepatitis in mice.
  J Oral Microbiol. 2018 Jan 22;10(1):1428005. [PMID: 29503703]

• Dechassa ML, Tryndyak V, de Conti A, Xiao W, Beland FA, Pogribny IP.
  Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
  Mol Carcinog. 2018 Aug;57(8):978-987. [PMID: 29603380]

• Kawaguchi T, Nakano D, Koga H, Torimura T.
  Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.
  Liver Cancer. 2018; DOI_10.1159_000491763. [PMID: None]

• Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, Hara Y, Tomiyama Y, Kuribayashi F, Torimura T, Hino K.
  Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice.
  Cell Mol Gastroenterol Hepatol. 2018 Sep 11;7(1):115-134. [PMID: 30510994]

• Wakabayashi C, Kunugi H.
  Involvement of IL-6 and GSK3β in impaired sensorimotor gating induced by high-fat diet.
  Neurosci Res. 2018 Oct 13. pii: S0168-0102(18)30328-6. [PMID: 30326250]

• Yoshida T, MaruyamaT, Miura M, Inoue M, Fukuda K, Shimazu K, Taguchi D, Kanda H, Oshima M, Iwabuchi Y, Shibata H.
  Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis.
  Journal of Functional Foods. 2018 Nov;50:192-200. [PMID: None]

2019

• Komatsu G, Nonomura T, Sasaki M, Ishida Y, Arai S, Miyazaki T.
  AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease.
  Exp Anim. 2019;68(2):147–158. [PMID: 30487357]

• Tsuma Y, Mori J, Ota T, Kawabe Y, Morimoto H, Fukuhara S, Kodo K, Umemura A, Nakajima H, Hosoi H.
  Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway.
  Biochem Biophys Res Commun. 2019 Jan 29;509(1):306-313. [PMID: 30583863]

• Borowa-Mazgaj B, de Conti A, Tryndyak V, Steward CR, Jimenez L, Melnyk S, Seneshaw M, Mirshahi F, Rusyn I, Beland FA, Sanyal AJ, Pogribny IP.
  Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis.
  Toxicol Sci. 2019 May 14. [PMID: 31086990]

• Yoshida Y, Shimizu I, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagami H, Morishita R, Minamino T.
  Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity.
  Sci Rep. 2019 Mar 7;9(1):3858. [PMID: 30846754]

• Hye Khan MA, Schmidt J, Stavniichuk A, Imig JD, Merk D.
  A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice.
  Biochem Pharmacol. 2019 Aug;166:212-221. [PMID: 31129048]

• Kawakami T, Takasaki S, Kadota Y, Fukuoka D, Sato M, Suzuki S.
  Regulatory role of metallothionein-1/2 on development of sex differences in a high-fat diet-induced obesity.
  Life Sci. 2019 Jun 1;226:12-21. [PMID: 30954474]

• Ushiroda C, Naito Y, Takagi T, Uchiyama K, Mizushima K, Higashimura Y, Yasukawa Z, Okubo T, Inoue R, Honda A, Matsuzaki Y, Itoh Y.
  Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice.
  J Clin Biochem Nutr. 2019 Apr. [PMID: None]

• Shimoda H, Tanaka J, Zaiki K, Nakaoji K.
  Tiliroside, a Constituent of Strawberry Seeds, Slightly Enhances Hyaluronan Production via Hyaluronan Synthase 2 Expression in Mouse Skin and Human Fibroblasts.
  Int J Biomedical Science. 2019;15(1):24-31. [PMID: None]

• Iida A, Kuranuki S, Yamamoto R, Uchida M, Ohta M, Ichimura M, Tsuneyama K, Masaki T, Seike M, Nakamura T.
  Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice.
  Exp Anim. 2019 Jun 1. [PMID: 31155606]

• Zhu S, Tian Z, Torigoe D, Zhao J, Xie P, Sugizaki T, Sato M, Horiguchi H, Terada K, Kadomatsu T, Miyata K, Oike Y.
  Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.
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• Shikama Y, Kurosawa M, Furukawa M, Ishimaru N, Matsushita K.
  Involvement of adiponectin in age-related increases in tear production in mice.
  Aging (Albany NY). 2019 Oct 8;11(19):8329-8346. [PMID: 31596727]

• Kawaguchi T, Nakano D, Koga H, Torimura T.
  Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.
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• Wakabayashi C, Kunugi H.
  Involvement of IL-6 and GSK3β in impaired sensorimotor gating induced by high-fat diet.
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2020

• Watanabe K, Afrin MR, Sreedhar R, Karuppagounder V, Harima M, Alexander X, Velayutham R, Arumugam S.
  Pharmacological Investigation of Ceraceomyces tessulatus (Agaricomycetes) in Mice with Non-Alcoholic Steatohepatitis.
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• Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.
  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.
  Free Radic Biol Med. 2020 Jun 15;156:45-56. [PMID: 32553752]

• Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T.
  Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.
  Sci Rep. 2020 May 8;10(1):7818. [PMID: 32385406]

• Maejima Y, Yokota S, Horita S, Shimomura K.
  Early life high-fat diet exposure evokes normal weight obesity.
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• Morikawa S, Oshima S, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Stutte S, Watanabe M.
  High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage.
  Biochem Biophys Res Commun. 2020 Feb 19;522(4):971-977. [PMID: 31810607]

• Sato H, Taketomi Y, Miki Y, Murase R, Yamamoto K, Murakami M.
  Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.
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• Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T.
  Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass.
  PLoS Genet. 2020 May;16(5):e1008586. [PMID: 32463816]

• Nishimura M, Nomura Y, Egi M, Obata N, Tsunoda M, Mizobuchi S.
  Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice.
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• Arai C, Suyama A, Arai S, Arai N, Yoshizane C, Koya-Miyata S, Mizote A, Endo S, Ariyasu T, Mitsuzumi H, Ushio S.
  Trehalose itself plays a critical role on lipid metabolism.
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2021

• Afrin MR, Arumugam S, Pitchaimani V, Karuppagounder V, Thandavarayan RA, Harima M, Hossain CF, Suzuki K, Sone H, Matsubayashi Y, Watanabe K.
  Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation.
  Heliyon. 2021 Jan 5;7(1):e05888.

• Toru Miwa
  Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein
  Front Cell Neurosci. 2021 Apr 6:15:634868. doi: 10.3389/fncel.2021.634868. eCollection 2021.

2022

• Suzuki H, Watanabe K, Arumugam S, Yellurkar ML, Sreedhar R, Afrin R, Sone H.
  Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice.
  Int J Med Mushrooms. 2022;24(1):41-52.

• Yoshikazu Sawaguchi, Keiichi Hirata, Ryo Suzuki, Kazuo Maruyama, Naoki Utoguchi
  Anti-Obesity Dendritic Cell Vaccine Therapy Targeting Neovascular Vessels in High-Fat-Diet-Fed Mice
  September 2022 BPB Reports 5(5):95-98 DOI: 10.1248/bpbreports.5.5_95

• Jianbo Wu, Kenchi Miyasaka, Wakana Yamada, Shogo Takeda, Norihito Shimizu, Hiroshi Shimoda
  The anti-adiposity mechanisms of ampelopsin and vine tea extract in high fat diet and alcohol-induced fatty liver mouse models
  Molecules. 2022 Jan 18;27(3):607. doi: 10.3390/molecules27030607

• S Nemoto, T Kubota, H Ohno
  Abundance of Ruminococcaceae is Associated with Claudin 22 Gene Expression and Body Weight in Mice
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• Eri Nanizawa Ph.D., Shun Otsuka Ph.D., Naoyuki Hatayama Ph.D., Yuki Tamaki M.S. b, Yumi Hayashi Ph.D. b, Tetsuya Ishikawa M.D., Ph.D., Shuichi Hirai M.D., Ph.D., Munekazu Naito M.D., Ph.D.
  Short-term high-fat and high-carbohydrate diets both increase susceptibility to liver injury by inducing hepatic procoagulant and proinflammatory conditions with different balances
  Nutrition. 2022 Sep:101:111710. doi: 10.1016/j.nut.2022.111710. Epub 2022 May 6.

• Kentaro Murakami, Yusuke Sasaki, Masato Asahiyama, Wataru Yano, Toshiaki Takizawa, Wakana Kamiya, Yoshihiro Matsumura, Motonobu Anai, Tsuyoshi Osawa, Jean-Charles Fruchart, Jamila Fruchart-Najib, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama, Toshiya Tanaka
  Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis
  Cells. 2022 Feb 18;11(4):720. doi: 10.3390/cells11040720.

• Yuka Hayashi, Ippei Shimizu, Yohko Yoshida, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Shinya Fujiki, Kazuyuki Ozaki, Manabu Abe, Kenji Sakimura, Shujiro Okuda, Toshiya Hayano, Kazuhiro Nakamura, Kenneth Walsh, Naja Zenius Jespersen, Søren Nielsen, Camilla Scheele, Tohru Minamino
  Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity
  iScience. 2022 Jun 7;25(7):104547. doi: 10.1016/j.isci.2022.104547

• Masashi Satoh, Misao Iizuka, Masataka Majima, Chizuru Ohwa, Akito Hattori, Luc Van Kaer, Kazuya Iwabuchi
  Adipose invariant NKT cells interact with CD1d‐expressing macrophages to regulate obesity‐related inflammation
  Immunology. 2022 Apr;165(4):414-427. doi: 10.1111/imm.13447. Epub 2022 Feb 28.

• Toshinori Yasuzawa, Ryota Nishi, Satono Ishitani, Osamu Matsuo, Shigeru Ueshima
  Effects of Enzamin, a microbial product, on alterations of intestinal microbiota induced by a high-fat diet
  Nutrients. 2022 Nov 10;14(22):4743. doi: 10.3390/nu14224743

• Koji Wakame, Keisuke Sato, Masafumi Kasai, Emi Kikuchi, Kihiro Shimizu, Ako Kudo, Ken-Ichi Komatsu, Akifumi Nakata
  Oral administration of Mulberry (morus alba L.) Leaf powder prevents the development of hepatocellular carcinoma in stelic animal model (STAM) mice
  Anticancer Research August 2022, 42 (8) 4055-4062; DOI: https://doi.org/10.21873/anticanres.15902

• Masakazu Fujii, Daiki Setoyama, Kazuhito Gotoh, Yushi Dozono, Mikako Yagi, Masataka Ikeda, Tomomi Ide, Takeshi Uchiumi, Dongchon Kang
  TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation
  iScience. 2022 Aug 10;25(9):104889. doi: 10.1016/j.isci.2022.104889

• Kenta Ikeda, Shin Morizane, Takahiko Akagi, Sumie Hiramatsu-Asano, Kota Tachibana, Ayano Yahagi, Masanori Iseki, Hideaki Kaneto, Jun Wada, Katsuhiko Ishihara, Yoshitaka Morita, Tomoyuki Mukai
  Obesity and dyslipidemia synergistically exacerbate psoriatic skin inflammation
  Int. J. Mol. Sci. 2022, 23(8), 4312; https://doi.org/10.3390/ijms23084312

• Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa, Michiko Shirane
  PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy
  Mol Brain. 2023 Jan 19; 16:11. doi: 10.1186/s13041-023-01002-4

• Asahiro Morishita, Tomoko Tadokoro, Shintaro Fujihara, Hisakazu Iwama, Kyoko Oura, Koji Fujita, Joji Tani, Kei Takuma, Mai Nakahara, Tingting Shi, Reiji Haba, Keiichi Okano, Akira Nishiyama, Masafumi Ono, Takashi Himoto, Tsutomu Masaki
  Ipragliflozin attenuates non-alcoholic steatohepatitis development in an animal model
  PLoS One. 2022 Feb 22;17(2): e0261310. doi: 10.1371/journal.pone.0261310

• D. Cheng, B. Zinker, Yi Luo, P. Shipkova, Claudia H De Oliveira, G. Krishna, E. A. Brown, Stephanie Boehm, G. Tirucherai, Huidong Gu, Zhengping Ma, C. Chu, J. Onorato, L. Kopcho, R. Ammar, Julia Smith, P. Devasthale, R. Lawrence, Steven A Stryker, E. Dierks, Anthony V. Azzara, Leon Carayannopoulos, E. Charles, K. Lentz, D. Gordon
  MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity
  November 2022 Cell Metabolism 34(11):1732-1748.e5 DOI: 10.1016/j.cmet.2022.10.007

• Atsushi Kimura, Kenya Kamimura, Marina Ohkoshi-Yamada, Yoko Shinagawa-Kobayashi, Ryo Goto, Takashi Owaki, Chiyumi Oda, Osamu Shibata, Shinichi Morita, Norihiro Sakai, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai
  Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model
  Biochemical and Biophysical Research Communications, 28 Jan 2022, 596:76-82 PMID: 35121372

• Nobunao Ikewaki, Gary A Levy, Gene Kurosawa, Masaru Iwasaki, Vidyasagar D Dedeepiya, Suryaprakash Vaddi, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel JK Abraham
  Hepatoprotective effects of Aureobasidium pullulans derived β 1, 3–1, 6 glucans in a murine model of non-alcoholic steatohepatitis
  J Clin Exp Hepatol. 2022 Jun 27;12(6):1428–1437. doi: 10.1016/j.jceh.2022.06.008

• Yusuke Hoshino, Taro Sakamoto, Naoki Sudo, Masahiro Ito, Takeshi Haneda, Nobuhiko Okada, Tsuyoshi Miki
  Fatty acid homeostasis tunes flagellar motility by activating phase 2 flagellin expression, contributing to Salmonella gut colonization
  Infect Immun. 2022 Jun 2;90(7): e00184-22. doi: 10.1128/iai.00184-22

• Mustapha Najimi, Sébastien Michel, Maria M. Binda, Kris Gellynck, Nathalie Belmonte, Giuseppe Mazza, Noelia Gordillo, Yelena Vainilovich, Etienne Sokal
  Human Allogeneic Liver-Derived Progenitor Cells Significantly Improve NAFLD Activity Score and Fibrosis in Late-Stage NASH Animal Model.
  Cells 2022, 11(18), 2854; https://doi.org/10.3390/cells11182854

• 末松保憲
  アテローム性動脈硬化症の新規診断, 治療薬の開発
  ueharazaidan.or.jp

2023

• Saranya Serirukchutarungsee, Ippei Watari, Pornchanok Sangsuriyothai, Masato Akakura, Takashi Ono
  The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats
  J Clin Med. 2023 Feb 28;12(5):1903. doi: 10.3390/jcm12051903

• Yuya Takahashi, Hiroki Fujita, Yusuke Seino, Satoko Hattori, Shihomi Hidaka, Tsuyoshi Miyakawa, Atsushi Suzuki, Hironori Waki, Daisuke Yabe, Yutaka Seino, Yuichiro Yamada
  Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia
  J Cachexia Sarcopenia Muscle. 2023 Oct 27;14(6):2703–2718. doi: 10.1002/jcsm.13346

• Nanaho Kasahara, Yukiko Imi, Reina Amano, Masakazu Shinohara, Kumiko Okada, Yusei Hosokawa, Makoto Imamori, Chiaki Tomimoto, Jun Kunisawa, Shigenobu Kishino, Jun Ogawa, Wataru Ogawa, Tetsuya Hosooka
  A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells
  Springer Science and Business Media LLC PMID: 37923895 PMCID: PMC10624680

• Yukiko Imi, Reina Amano, Nanaho Kasahara, Yuichiro Obana, Tetsuya Hosooka
  Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes
  Biochem Biophys Rep. 2023 Apr 25; 34:101476. doi: 10.1016/j.bbrep.2023.101476

• Natsuko Hada, Asao Katsume, Kawasaki Kenichi, Chihiro Endo, Naoshi Horiba, Masayuki Sudoh
  Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non‐alcoholic steatohepatitis (NASH)
  Pharmacol Res Perspect. 2023 May 19;11(3): e01094. doi: 10.1002/prp2.1094

• Yvonne Burmeister, Kathrin Weyer, Achim Dörre, Bernd Seilheimer
  The Multicomponent Medicinal Product Hepar Compositum Reduces Hepatic Inflammation and Fibrosis in a Streptozotocin- and High-Fat Diet-Induced Model of Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis
  Biomedicines 2023, 11(12), 3216; https://doi.org/10.3390/biomedicines11123216

• P Sangsuriyothai
  The expression of incretin hormones and their receptors in the submandibular glands of offspring from high fat diet-fed mother rats
  DOI 10.58837/CHULA.THE.2023.571

• Takezaki D, Morizane S, Ikeda K, Iseki M, Sakamoto Y, Kawakami Y, Hashiguchi T, Shirakata Y, Nishina S and Mukai T
  Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model
  Front. Immunol. 14:1214623. doi: 10.3389/fimmu.2023.1214623

• Bin Zhang, Biyan Zhang, Ruenn Chai Lai, Wei Kian Sim, Kong Peng Lam, Sai Kiang Lim
  MSC− sEV treatment polarizes pro− fibrotic M2 macrophages without exacerbating liver fibrosis in NASH
  Int J Mol Sci. 2023 Apr 30;24(9):8092. doi: 10.3390/ijms24098092

• Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, Akiho Nishimura, Luke Bu, Lingfeng Fu, Feng Wei, Jun Zhang, Yilin Tong, Huaitao Wang, Kazuya Iwamoto, Takaichi Fukuda, Hayato Nakagawa, Koji Taniguchi, Yuji Miyamoto, Hideo Baba, Takatsugu Ishimoto
  Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion
  August 2023 JHEP Reports 5(12):100892 DOI: 10.1016/j.jhepr.2023.100892

• Julien Guillarda, Valérie Untereinerb, Roselyne Garnotela,c, Camille Boulagnon-Rombid, Cyril Gobineta, Isabelle Proulte, Ganesh Dhruvananda Sockalinguma, Gérard Thiéfin
  Longitudinal Study of Cirrhosis Development in STAM and carbon tetrachloride Mouse Models Using Fourier Transform Infrared Spectral Imaging
  August 2023 Laboratory Investigation 103(1Suppl):100231 DOI: 10.1016/j.labinv.2023.100231

• Pradeep Kumar Rajan, Utibe-Abasi S Udoh, Yuto Nakafuku, Sandrine V Pierre, Juan Sanabria
  Normalization of the ATP1A1 signalosome rescinds epigenetic modifications and induces cell autophagy in hepatocellular carcinoma
  Cells. 2023 Sep 27;12(19):2367. doi: 10.3390/cells12192367

2024

• Koki Nishida, Shinji Ueno, Yusuke Seino, Shihomi Hidaka, Naoya Murao, Yuki Asano, Haruki Fujisawa, Megumi Shibata, Takeshi Takayanagi, Kento Ohbayashi, Yusaku Iwasaki, Katsumi Iizuka, Shoei Okuda, Mamoru Tanaka, Tadashi Fujii, Takumi Tochio, Daisuke Yabe, Yuuichiro Yamada, Yoshihisa Sugimura, Yoshiki Hirooka, Yoshitaka Hayashi, Atsushi Suzuki
  Impaired fat absorption from intestinal tract in high-fat diet fed male mice deficient in proglucagon-derived peptides
  Nutrients. 2024 Jul 14;16(14):2270. doi: 10.3390/nu16142270.

• Hiroshi Suzuki, Kenichi Watanabe, Somasundaram Arumugam, Rejina Afrin, Masahiko Yamamoto, Y. Matsubayashi, Hirohito Sone
  Lactic acid-fermented Sake lees protect against nonalcoholic steatohepatitis in mice
  Functional Foods in Health and Disease 18 May 2024

• Kenya Honda, Takeshi Tanoue, Manabu Nagayama, Ayumi Roochana, Samuel Zimmerman, Orr Ashenberg, Tanvi Jain, Satoshi Sasajima, Kozue Takeshita, Nicola Hetherington, Nobuyuki Okahashi, Masahiro Ueda, Morichika Konishi, Yoshiaki Nakayama, Aki Minoda, Ashwin Skelly, Yasuhiko Minokoshi, Nicholas Pucci, Daniel Mende, Makoto Arita, Hironori Yamamoto, Shunji Watanabe, Kouichi Miura, Wataru Suda, Koji Atarashi, Mami Matsushita, Shingo Kajimura, Damian Plichta, Masayuki Saito, Ramnik Xavier
  Identification of specific microbiota members that induce beige fat biogenesis in response to dietary cues
  Res Sq [Preprint]. 2024 Dec 3: rs.3.rs-5454144. [Version 1] doi: 0.21203/rs.3.rs-5454144/v1

• Maya Kudo, Ming Gao, Misa Hayashi, Yukiko Kobayashi, Jinwei Yang, Tonghua Liu
  Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways
  Food Nutr Res. 2024 Jan 22:68. doi: 10.29219/fnr.v68.10307. eCollection 2024.

• Jumpei Ogura, Koji Yamanoi, Kentaro Ishida, Eijiro Nakamura, Shinji Ito, Naoki Aoyama, Yuki Nakanishi, Toshi Menju, Kosuke Kawaguchi, Yuko Hosoe, Mana Taki, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai
  A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response
  Exp Mol Med. 2024 Dec 2;56(12):2659–2672. doi: 10.1038/s12276-024-01356-2

• Hiroyasu Sato, Yoshitaka Taketomi, Remi Murase, Jonguk Park, Koji Hosomi, Takayuki Jujo Sanada, Kenji Mizuguchi, Makoto Arita, Jun Kunisawa, Makoto Murakami
  Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction
  Cell Rep. 2024 Oct 22;43(10):114752. doi: 10.1016/j.celrep.2024.114752. Epub 2024 Sep 17.

• Jiratchaya Srisutha, Ippei Watari, Masato Akakura, Minami Watanabe, Chidsanu Changsiripun, Takashi Ono
  P2X7R and P2X4R expression of mice submandibular gland in high-fat diet/streptozotocin-induced type 2 diabetes
  Sci Rep. 2024 May 13; 14:10855. doi: 10.1038/s41598-024-60519-3

• Takafumi Saeki, Saya Yamamoto, Junji Akaki, Takahiro Tanaka, Misaki Nakasone, Hidemasa Ikeda, Wei Wang, Makoto Inoue, Yoshiaki Manse, Kiyofumi Ninomiya, Toshio Morikawa
  Ameliorative effect of bofutsushosan (fangfengtongshengsan) extract on the progression of aging-induced obesity
  J Nat Med. 2024 Apr 25;78(3):576–589. doi: 10.1007/s11418-024-01803-4

• Yusuke Inoue, Manatsu Fukushima, Go Hirasawa, Fumiya Furukawa, Hiroyuki Takeda, Chie Umatani
  Maternal high-fat diet affects the contents of eggs and causes abnormal development in the medaka fish
  Endocrinology. 2024 Jan 16;165(3):bqae006. doi: 10.1210/endocr/bqae006.

• Shino Nemoto, Tetsuya Kubota, Tomoyuki Ishikura, Manabu Nakayama, Atsuo Kobayashi, Junshi Yazaki, Kazuyo Uchida, Masashi Matsuda, Takashi Kondo, O. Ohara, Haruhiko Koseki, Shigeo Koyasu, Hiroshi Ohno
  Characterization of metabolic phenotypes and distinctive genes in mice with low‐weight gain
  FASEB J. 2024 Jan;38(1):e23339. doi: 10.1096/fj.202301565R.

• Hironari Nishizawa, Mitsuyo Matsumoto, Mie Yamanaka, Riko Irikura, Kazuma Nakajima, Keisuke Tada, Yoshiaki Nakayama, Morichika Konishi, Nobuyuki Itoh, Ryo Funayama, Keiko Nakayama, Kazuhiko Igarashi
  BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion
  Cell Rep. 2024 Jul 23;43(7):114403. doi: 10.1016/j.celrep.2024.114403. Epub 2024 Jun 27.

• Shunta Yakubo, Hiroyuki Abe, Yawen Li, Marina Kudo, Atsushi Kimura, Takuya Wakabayashi, Yusuke Watanabe, Naruhiro Kimura, Toru Setsu, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Atsunori Tsuchiya, Kenya Kamimura, Shuji Terai
  Dasatinib and Quercetin as Senolytic Drugs Improve Fat Deposition and Exhibit Antifibrotic Effects in the Medaka Metabolic Dysfunction-Associated Steatotic Liver Disease Model
  Diseases. 2024 Dec 4;12(12):317. doi: 10.3390/diseases12120317.

• Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike
  Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy
  Cancer Sci. 2024 Sep 25;115(12):3846–3858. doi: 10.1111/cas.16348

• Zhe Huang, Hye Kyoung Sung, Xingqun Yan, Shiyu He, Leigang Jin, Qin Wang, Xuerui Wu, Henry H Hsu, Angelica Pignalosa, Kathryn Crawford, Gary Sweeney, Aimin Xu
  The adiponectin‐derived peptide ALY688 protects against the development of metabolic dysfunction‐associated steatohepatitis
  Clin Transl Sci. 2024 Jun 7;17(6): e13760. doi: 10.1111/cts.13760

• Sarawut Lapmanee, Sakkarin Bhubhanil, Prapimpun Wongchitrat, Natthawut Charoenphon, Anjaree Inchan, Thitaphat Ngernsutivorakul, Piroonrat Dechbumroong, Mattaka Khongkow, Katawut Namdee
  Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats
  Pharmaceutics. 2024 Apr 8;16(4):514. doi: 10.3390/pharmaceutics16040514

• Genta Kakiyama, Kei Minoiwa, Nanah Bai-Kamara, Taishi Hashiguchi, William M Pandak, Daniel Rodriguez-Agudo
  StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis
  Am J Physiol Gastrointest Liver Physiol. 2024 Jun 1;326(6):G747-G761. doi: 10.1152/ajpgi.00024.2024. Epub 2024 Apr 9.

• Shino Nemoto, Kazuyo Uchida, Hiroshi Ohno
  Implications of genetic factors underlying mouse hydronephrosis: cautionary considerations on phenotypic interpretation in genetically engineered mice
  Int J Mol Sci. 2024 Jun 29;25(13):7203. doi: 10.3390/ijms25137203

• Shota Torigoe, Douglas W Lowman, Toshihiko Sugiki, David L Williams, Sho Yamasaki
  Self‐recognition through Dectin‐1 exacerbates liver inflammation
  Genes Cells. 2024 Apr;29(4):316-327. doi: 10.1111/gtc.13106. Epub 2024 Feb 22.

• Tomoaki Yamaguchi, Keita Shibata, Keiji Hasumi, Koji Nobe
  Potent efficacy of 3-amino-4-hydroxy benzoic acid, a small molecule having anti-fibrotic activity, in a mouse model of non-alcoholic steatohepatitis
  Biol Pharm Bull. 2024;47(2):434-442. doi: 10.1248/bpb. b 23-00771.

• Goro Katsuumi, Ippei Shimizu, Masayoshi Suda, Yohko Yoshida, Takaaki Furihata, Yusuke Joki, Chieh-Lun Hsiao, Liang Jiaqi, Shinya Fujiki, Manabu Abe, Masataka Sugimoto, Tomoyoshi Soga, Tohru Minamino
  SGLT2 inhibition eliminates senescent cells and alleviates pathological aging
  Nat Aging. 2024 May 30;4(7):926–938. doi: 10.1038/s43587-024-00642-y

• Katsuhiko Sato, Hayato Hikita, Minoru Shigekawa, Kazumasa Soma, Ryohei Yamauchi, Jihyun Sung, Seiya Kato, Yoichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Kumiko Shirai, Kazuhiro Murai, Yuki Tahata, Teppei Yoshioka, Akira Nishio, Yoshinobu Saito, Takahiro Kodama, Yutaka Sasaki, Tomohide Tatsumi, Tetsuo Takehara
  The serum tenascin C level is a marker of metabolic disorder-related inflammation affecting pancreatic cancer prognosis
  Sci Rep. 2024 May 26; 14:12028. doi: 10.1038/s41598-024-62498-x

• Yoshimitsu Nakanishi, Mayuko Izumi, Hiroaki Matsushita, Yoshihisa Koyama, Diego Diez, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Tomoki Mae, Yu Noda, Kamon Nakaya, Satoshi Nojima, Fuminori Sugihara, Daisuke Okuzaki, Masahito Ikawa, Shoichi Shimada, Sujin Kang, Atsushi Kumanogoh
  Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
  Neuron. 2024 Sep 4;112(17):2955-2972.e9. doi: 10.1016/j.neuron.2024.06.017. Epub 2024 Jul 12.

• Sho Wakamatsu, Teruo Jojima, Masaaki Hashiguchi, Haruka Kishi, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takahiko Kogai, Takuya Tomaru, Isao Usui, Yoshimasa Aso
  Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor
  November 2023Journal of Diabetes and its Complications 38(1):108650 DOI: 10.1016/j.jdiacomp.2023.108650

• Yung Ting Hsiao, Yohko Yoshida, Shujiro Okuda, Manabu Abe, Seiya Mizuno, Satoru Takahashi, Hironori Nakagami, Ryuichi Morishita, Kenya Kamimura, Shuji Terai, Tin May Aung, Ji Li, Takaaki Furihata, Jing Yuan Tang, Kenneth Walsh, Akihito Ishigami, Tohru Minamino & Ippei Shimizu
  PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis
  EMBO Journal 19 August 2024 DOI:10.1038/s44318-024-00196-0Corpus ID: 271907242

• Takezaki D, Morizane S, Ikeda K, Iseki M, Sakamoto Y, Kawakami Y, Hashiguchi T, Shirakata Y, Nishina S, Mukai T
  Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model
  Frontiers in Immunology, 14 Aug 2023, 14:1214623

• Hiroshi Sakai, Hideaki Uno, Harumi Yamakawa, Kaori Tanaka, Aoi Ikedo, Akiyoshi Uezumi, Yasuyuki Ohkawa, Yuuki Imai
  The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice
  Proc Natl Acad Sci USA. 2024 Sep 24;121(39):e2407768121. doi: 10.1073/pnas.2407768121. Epub 2024 Sep 18.

• Genta Kakiyama, Kei Minoiwa, Nanah Bai-Kamara, Taishi Hashiguchi, William M Pandak, Daniel Rodriguez-Agudo
  StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis
  Am J Physiol Gastrointest Liver Physiol. 2024 Jun 1;326(6): G747-G761. doi: 10.1152/ajpgi.00024.2024. Epub 2024 Apr 9.

2025

• Riku Tsudome, Yasunori Suematsu, Kohei Tashiro, Hidetaka Morita, Akihito Ideishi, Shin-ichiro Miura
  A newly developed model of atherosclerosis caused by the stress of metabolic syndrome in apolipoprotein E knockout mouse
  DOI: 10.1101/2025.03.24.645136Corpus ID: 277317819

• Rino Matsushita, Kaori Sato, Kunitoshi Uchida, Yukiko Imi, Reina Amano, Nanaho Kasahara, Yuki Kitao, Yuki Oishi, Honoka Kawaai, Chiaki Tomimoto, Yusei Hosokawa, Shigenobu Kishino, Jun Ogawa, Tetsuya Hosooka
  A Gut Microbial Metabolite HYA Ameliorates Adipocyte Hypertrophy by Activating AMP-Activated Protein Kinase
  Nutrients. 2025 Apr 21;17(8):1393. doi: 10.3390/nu17081393

• Hajime Mori, Kanako Inoue, Sho Matsui, Yasuo Oguri, Satoshi Tsuzuki, Tsutomu Sasaki
  Promotion of obesity by fibroblast growth factor 21-oxytocin system dysfunction due to sugar-specific hyperphagia
  Am J Physiol Endocrinol Metab. 2025 Jul 1;329(1): E18-E24. doi: 10.1152/ajpendo.00138.2025. Epub 2025 May 30.

• Naomi Osakabe, Hitomi Nakamura, Yamato Yoshida, Sae Katsuragawa, Naoki Iida, Yasuyuki Fujii, Ursula M. Jacob, Tilman Fritsch, Ali Abdelhameed, Vittorio Calabrese
  A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  Open Med (Wars). 2025 Mar 18;20(1):20251152. doi: 10.1515/med-2025-1152

• Mao Sato, Chiaki Sugiura, Nobuaki Okumura, Akira Terao
  Melinjo (Gnetum gnemon L.) seed extract for treatment of sleep/wake fragmentation in diet-induced obese mice
  Exp Anim. 2024 Sep 7;74(1):114–121. doi: 10.1538/expanim.24-0050

• Shino Nemoto, Kazuyo Uchida, Tetsuya Kubota, Manabu Nakayama, Yong-Woon Han, Shigeo Koyasu, Hiroshi Ohno
  Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health
  Mol Metab. 2025 Jul: 97:102168. doi: 10.1016/j.molmet.2025.102168. Epub 2025 May 12.

• Ayaka Iida, Ena Takahashi, Sachi Kuranuki, Shu Shimamoto, Tsuyoshi Nakamura, Hiroshi Kitagaki
  Water-soluble cellulose acetate changes the intestinal microbiota in mice with non-alcoholic steatohepatitis
  Nutrients. 2025 Jan 29;17(3):500. doi: 10.3390/nu17030500.

• Kenji Watanabe, Yuka Kamei, Miki Igarashi, Shuichi Shibuya, Takahiko Shimizu, Ikuo Kimura, Mitsuo Maruyama
  Impact of a water-soluble soy extract on inflammation and gut microbiota in physiologically aged mice
  Biosci Biotechnol Biochem. 2025 May 21;89(6):884-893. doi: 10.1093/bbb/zbaf032.

• YU KURODA, YOSHIYA ITO, NOBUYUKI NISHIZAWA, MINA TANABE, TAKUYA GOTO, ATSUSHI YAMASHITA, KANAKO HOSONO, MASASHI SATOH, YUSUKE KUMAMOTO, NAOKI HIKI and HIDEKI AMANO
  Activation of Invariant Natural Killer T Cells Enhances Ischemia-Reperfusion Injury in Steatotic Mouse Livers
  In Vivo. 2025 Apr 28;39(3):1355–1369. doi: 10.21873/invivo.13939

• Ruttiya Thongrung, Sarawut Lapmanee, Penjai Thongnuanjan Bray, Patlada Suthamwong, Suwaporn Deandee, Kanjana Pangjit, Chaowalit Yuajit
  Gambogic acid mitigates nephropathy by inhibiting oxidative stress and inflammation in diabetic rats
  Int J Mol Cell Med. 2025;14(1):448–461. doi: 10.22088/IJMCM.BUMS.14.1.448

• Ayano Ueki, Yukako Ito, Joe Sakamoto, Yasuhiro Kamei, Ayaka Yazawa, Shigeki Kamitani
  Effect of Porphyromonas gingivalis lipopolysaccharide administration on non-alcoholic liver disease in Medaka fish
  FEMS Microbes. 2025 Nov 7;6: xtaf 017. doi : 10.1093/femsmc/xtaf017 . eCollection 2025.

• Xi Zhang, Xiaoyun Hu, Chen Fu, Peng Yuan, Yan Yang, Jiling Ru, Yingqi Zhao, Xianglong Zhu, Xiaonan Zhang, Xianjie Liu, Li Han, Jun Li, Xue Bai, Zhe Zhang, Hong Ning, Huizhe Wu, Minjie Wei
  Novel MAFG-METTL14-SCD1 axis regulates lipid metabolism mediating choroidal melanoma distant metastasis
  Journal of experimental & clinical cancer research: CR. Nov 29, 2025. Epub Nov 29, 2025.

• Hiroyuki Sowa, Hiroki Yagi, Kazutaka Ueda, Masaki Hashimoto, Kohei Karasaki, Qing Liu, Atsumasa Kurozumi, Yusuke Adachi, Tomonobu Yanase, Shun Okamura, Bowen Zhai, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Nobuhiko Ito, Minoru Ono, Hiroshi Akazawa, Issei Komuro
  Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome
  JCI Insight. 2025 Aug 28;10(19):e184329. doi: 10.1172/jci.insight.184329. eCollection 2025 Oct 8.

• Yu Kuroda, Yoshiya Ito, Nobuyuki Nishizawa, Mina Tanabe, Atsushi Yamashita, K. Hosono, Mariko Kamata, Masashi Satoh, Yusuke Kumamoto, Naoki Hiki, H. Amano
  Inhibition of crosstalk between iNKT cells and macrophages mitigates ischemia-reperfusion injury in steatotic livers
  Exp Cell Res. 2025 Aug 15;451(2):114728. doi: 10.1016/j.yexcr.2025.114728. Epub 2025 Aug 26.

• Chiaki Sugiura, Mao Sato, Shun Tanaka, Nobuaki Okumura, Akira Terao
  Royal jelly reduced non-rapid eye movement sleep fragmentation and restored sleep stability in diet-induced obese mice
  Exp Anim. 2025 Jan 10;74(2):300–309. doi: 10.1538/expanim.24-0128

• Katarzyna Drzewicka, Katarzyna M Głuchowska, Michal Mlącki, Bartłomiej Hofman, Irina Tuszyńska, Tristram A J Ryan, Katarzyna Piwowar, Bartosz Wilczyński, Dorota Dymkowska, Marcin M Grzybowski, Barbara Dymek, Tomasz Rejczak, Kamil Lisiecki, Adam Gołębiowski, Adam Jagielski, Angelika Muchowicz, Dylan Ryan, Krzysztof Zabłocki, Luke A J O'Neill, Zbigniew Zasłona
  Chitinase-1 inhibition reverses metabolic dysregulation and restores homeostasis in MASH animal models
  Front Immunol. 2025 May 29:16:1544973. doi: 10.3389/fimmu.2025.1544973. eCollection 2025.

2026

• A Mori, Y Oguri, S Matsui, S Tsuzuki, T Sasaki
  Selective β3-adrenoceptor agonist reduces energy intake and elevates GDF15 levels in lean and diet-induced obese mice
  Endocrine Journal 73(2):217-227　DOI: 10.1507/endocrj.EJ25-0364

• Takeshi Tanoue, Manabu Nagayama, Ayumi J.A. Roochana, Samuel Zimmerman, Orr Ashenberg, Tanvi Jain, Ryo Igarashi, Satoshi Sasajima, Kozue Takeshita, Nicola Hetherington, Nobuyuki Okahashi, Masahiro Ueda, Morichika Konishi, Yoshiaki Nakayama, Aki Minoda, Ashwin N. Skelly, Yasuhiko Minokoshi, Nicholas Pucci, Daniel R. Mende, Makoto Arita, Hironori Yamamoto, Shunji Watanabe, Kouichi Miura, Scott Behie, Wataru Suda, Toshiro Sato, Koji Atarashi, Mami Matsushita, Shingo Kajimura, Damian R. Plichta, Masayuki Saito, Ramnik J. Xavier, Kenya Honda
  Microbiota-mediated induction of beige adipocytes in response to dietary cues
  Nature. 2026 Mar 4;653(8114):499–509. doi: 10.1038/s41586-026-10205-3

• An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa
  The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy
  Journal of Diabetes Investigation 17(5):719-728 DOI: 10.1111/jdi.70270

• Yoshihiro Matsuda, Shin Morizane, Daiki Takezaki, Yuma Sakamoto, Nobuyasu Baba, Masanori Iseki, Yoshio Kawakami, Tatsushi Shiomi, Tomoyuki Mukai
  Aerobic Exercise Attenuates Epidermal Hyperplasia in an Obesity-Associated Psoriasiform Dermatitis Model
  Int J Mol Sci. 2026 Feb 28;27(5):2308. doi: 10.3390/ijms27052308.

• Ryo Furuuchi, Yohko Yoshida, Goro Katsuumi, Takaaki Furihata, Yusuke Joki, Chieh-Lun Hsiao, Masayoshi Suda, Hana Saito, Tamano Kumazaki, Hidefumi Makabe, Manabu Abe, Ippei Shimizu, Tohru Minamino
  Natural senolytic activity of Rhodiola rosea extract alleviates age-associated phenotypes via paraptosis
  DOI: 10.1016/j.isci.2026.115607

• Takeshi Kondo, Yasunori Takayama, Yutaro Kumagai, Shigetsugu Hatakeyama, Makoto Tominaga, Kenta Maruyama
  Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1
  Cell Rep. 2026 Jan 27;45(1):116737. doi: 10.1016/j.celrep.2025.116737. Epub 2025 Dec 17.

• Nanoka Sakaguchi, Akari Kusamoto, Miyuki Harada, Babita Shashni, Airi Komura, Ayaka Teshima, Tsurugi Tanaka, Hiroshi Koike, Zixin Xu, Yuma Kawahara, Chihiro Tsuchida, Chisato Kunitomi, Nozomi Takahashi, Yoko Urata, Osamu Wada-Hiraike, Yasushi Hirota, Yukio Nagasaki, Yutaka Osuga
  Butyric acid-based self-assembling nanoparticles: a potential strategy to prevent development of polycystic ovary syndrome
  Molecular Human Reproduction 2026 Februrary 27