Very high reproductive brain infarction animal models
Surgical FOX CHASE SCID C.B-17/Icr-scid/scidJcl and FOX CHASE SCID C.B-17/Icr-+/+Jcl.
- BackgroundThere were basically 2 problems for traditional brain infarction models. 1) Low ischaemia place reproducibility between animals. 2) Cannot do the meaningful term study due to its low survivability. These two problems caused impossibilities for analyzing chronicity period convalescence of administrative agents and recovery of cerebral functions after a stroke.
This model was made by surgical treatment for better ischaemia place reproducibility and long life by Dr. Tomohiro Matsuyama, Hyogo College of medicine. (2019)
By using improved Tamura method, MCA of SCID(FOX CHASE SCID C.B-17/Icr-scid/scidJcl) and C.B-17(FOX CHASE SCID C.B-17/Icr-+/+Jcl) are treated an electrocoagulation directly and deligation to be a brain infarction model.
- High reproducibility
This method makes a selective cortical infarction inducement with high reproducibility in SCID and C.B-17 by direct electrocoagulation and ligation at a middle cerebral artery (MCA) distance part.
- High long-term survival rate (180 days)
This model shows high long-term survival rate with high cortical infarction reproducibility to its chronic phase. (Maximum 180 days) The survival rate after brain infarction treatment is 100% (16/16) in 90 days and 94% (15/16) in 180 days.
Due to the high reproducibility, this model can reduce the number of animals used for various test agent screening test. In addition, it is possible to conduct a treatment effect and side effect assessments at its chronicle phase due to the long term survival rate. (180 days) In this fact, this is useful as a local eternal ischemia animal model to imitate a partial human brain infarction. For using SCID mouse model, immunodeficiency animal, it is possible to conduct a treatment assessment with donor-cell hetero transplantation.
- ReferenceCatalogue (Japanese only)
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