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Strain characteristic: C3H/HeJJcl・C3H/HeNJcl

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Strain characteristic: C3H/HeJJcl・C3H/HeNJcl

Profile of C3H/HeJ Jcl Mice


References

Foster et al eds., The Mouse in Biomedical Research, Volume I: 1981; Volume II: 1982; Volume III: 1983; Volume IV: 1982, Academic Press Inc. New York.

 

Biochemical and Immunological Loci

Figure-1 . Changes in body weight of male SDT fatty rats (*P<0.05, ** P<0.01)


 

 

Lifespan

  • Conventional environment:
Males: 707 days, Females: 714 days (Storer, 1966)
Males: 722 ± 30 days, Females: 683 ± 23 days (Goodrick, 1975)

  • S.P.F. environment:
Males: 629 days, Females: 719 days (Festing and Blackmore, 1971)

 

Naturally Occurring Tumors and Lesions

  • The incidence of mammary tumors in unfostered sublines was less than 1% in males, 95% in multiparous females, and 88% in nulliparous females (Heston, 1963).
  • The same incidence was 99% at 7.2 months of age (Heston & Vahaleis, 1971).
  • In the same line, latent mammary tumors developed at 276-566 days of age. Reproductive stress was suggested as a trigger (Riley, 1975).
  • The incidence of mammary tumors in fostered sublines was 37% at two years (Riley, 1975).
  • The incidence of hepatocellular carcinoma was 72-91% in males and 59% in multiparous females and 30-38% in nulliparous females at 14 months of age (Heston, 1963).
  • The incidence of pulmonary adenoma was 2-10% and leukemia was 6-30% in fostered A lines (Mühlbock & Teng-bergen, 1971).
  • In a S.P.F. environment, the incidence of naturally occurring tumors and lesions was as follows: hepatic tumors 9-23%, pulmonary tumors 2-10%, mammary tumors 21-36%, 13-26%, and ovarian cysts 13-26% (Festing & Blackmore, 1971).
  • Hepatocellular carcinoma was associated with eosinophilic cytoplasmic inclusions (Liebelt, 1971).
  • The incidence of leukemia was 17%, hepatocellular carcinoma was 14%, and lung cancer was 7% (Smith, 1973).

 

Immunological Characteristics

  • Resistant to Mouse Hepatitis virus (Bang, 1960)
  • Good immune response to Vi antigen (Gaines, 1965)
  • Responsive to sensitization with polypeptide Glu 57, Lys 38, Ala 5 (Pinchuk, 1965)
  • Good immune response to small amounts of bovine γ-globulin (Levin, 1970)
  • Weak immune response to Cholera A, B antigens (Gerny, 1970)
  • When male skin was grafted onto syngeneic females, all grafts were rejected after 100 days (Gasser, 1971)
  • Weak immune response to ovalbumin and ovomucoid (Vaz, 1971)
  • Good antibody affinity to HSA (Petty, 1972)
  • Weak immune response to bovine serum albumin (James, 1972)
  • Susceptible to Mycoplasma fermentens (Gatenby et al., 1972)
  • Resistant to LCM virus until 1970 (survival rate 76%), but currently affected (survival 3%) (Oldstone, 1973)
  • Low reactivity to specific and non-specific B cell activation by Gram-negative bacterial capsular lipopolysaccharide (LPS), while other C3H strains show high reactivity. This trait is due to a dominant gene (Watson, 1974)
  • Red blood cells exhibit strong agglutination (Rubinstein, 1974)
  • Resistant to experimental allergic encephalomyelitis induced by encephalomyelitis virus (Boucher, 1975)
  • Good immune response to Pro-Gly-Pro-ovalbumin and (Pro-Gly-Pro)n (Fuchs, 1974)
  • Resistant to Salmonella typhymurium C5 (Plant 1974, Glynn, 1976)
  • 100% infection with murine leukemia virus in three generations (Jenson et al., 1976)
  • Highly susceptible to rubella (Rager, Tisman & Uden, 1976) (Neighbour et al., 1978)
  • Deficient in LPS responsiveness (Glode, 1977)
  • B cell and macrophage (MΦ) responsiveness to LPS is linked at the same locus, and both are deficient in LPS responsiveness (Morozumi, 1981)

 

Physiological and Biochemical Characteristics

  • High serum cholesterol levels (Bruel, 1962)
  • Low serum haptoglobin levels (Pencock, 1967)
  • High hepatic tyrosin aminotransferase levels in fasted mice (Blake, 1970)
  • High erythrocyte catalase (Hoffman, 1971)
  • Fast peripheral nerve conduction velocity (Heman, 1972)
  • High porphyrin concentration in the Harderian gland (Cutroneo, 1973)
  • Low hepatic ammonia-lyase activity (Hanford, 1974)
  • Low blood pressure (Mullink, 1975)
  • High serum calcium concentration at 4 months of age (Barrett, 1975)
  • High levels of β-endorphin and ACTH secreted from the pineal gland (Crabbe, 1981)

 

Pharmacological Characteristics

  • Highly susceptible to fibroma induction by methylcholanthrene (Storong, 1952)
  • Sensitive to chloroform toxicity (Deringer, 1953, Hill, 1973)
  • Insensitive to histamine (Brown, 1965)
  • Uterus is sensitive to estrogen (Chai, 1966)
  • Short sleep time induced by hexobarbital (Vesell, 1968)
  • Liver cancer but not lung cancer is induced by administering DMBA to newborn mice (Flaks, 1968)
  • Highly susceptible to mammary cancer induction by urethane (Bentvelzen, 1970)
  • Highly susceptible to tumor induction by 3,4-benzpyrene (Liebolt, 1970 & Whitimire, 1971)
  • Prone to skin tumor induction by DMBA (Thomas, 1973)
  • Gastric cancer is highly induced by oral administration of methylcholanthrene (Akamatsu, 1974)
  • Affected by isoniazid toxicity (Taylor, 1976)

 

Anatomical Characteristics

  • Low total white blood cell count, total red blood cell count, hematocrit, and hemoglobin (Russell, 1951)
  • Few accessory spleens and many Peyer's patches (Hummel, 1966)
  • Small thymus-to-body weight ratio (Belyaev, 1970)
  • Large pituitary gland (Sinha, 1975)

※Quoted and modified from Jcl NEWS No.1, issued October 1, 1989, by CLEA Japan, Inc., Development Division.

 

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