F344/Jcl Academic Reference List
Research Use Snapshot
- Standard inbred background: F344/Jcl is a well-established inbred rat strain used as a reference background for comparative and baseline research.
- Toxicology & chronic studies: Commonly used in safety assessment, including long-term exposure studies where stable physiological responses are required.
- Carcinogenicity & pathology: Frequently referenced in studies evaluating tumor development and pathological outcomes under long-term experimental conditions.
- How to browse: Use the topic-based sections to find representative studies by research purpose, or use the year index to access the complete reference list.
🧪 Toxicology & Safety Assessment
Applications in toxicology and safety assessment. F344/Jcl has long been used as a reference strain in toxicological studies, providing stable and well-characterized physiological responses for evaluating chemical safety, organ toxicity, and dose-dependent effects.
- Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. (1986) — see 1986
- Possible mechanism for the anemia induced by candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, in rats. (1998) — see 1998
- Possible mechanism for testicular focal necrosis induced by hCG in rats. (2006) — see 2006
🧬 Carcinogenicity & Long-term Studies
Use in carcinogenicity and long-term exposure studies. F344/Jcl has been widely employed in studies assessing carcinogenic potential and chronic effects following long-term exposure. The references listed here demonstrate its historical significance in evaluating tumor development and long-term pathological outcomes.
- Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. (1986) — see 1986
- Coexpression of multiple Sertoli cell and Leydig cell marker genes in the spontaneous testicular tumor of F344 rat: evidence for phenotypical bifurcation of the interstitial cell tumor. (1997) — see 1997
🧠 Aging, Physiology & Baseline Biology
Baseline physiology and aging-related research. As a standard inbred strain, F344/Jcl is frequently used to characterize age-related physiological changes and baseline biological parameters. Studies in this section support its use as a comparative reference for aging and fundamental physiological research.
- Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl. (2002) — see 2002
- Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth. (2018) — see 2018
- Glucagon-like peptide-1 response to whey protein is less diminished by dipeptidyl peptidase-4 in comparison with responses to dextrin, a lipid and casein in rats. (2021) — see 2021
- Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. (2002) — see 2002
- Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats. (2002) — see 2002
- Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats. (2001) — see 2001
🧫 Disease Mechanisms & Experimental Pathology
Experimental pathology and disease-related responses. Although not a disease-specific model, F344/Jcl has been utilized to investigate pathological responses and disease mechanisms under experimental conditions. The selected publications illustrate its application in controlled pathological and mechanistic studies.
- [Spontaneous calcification in F344/Slc and F344/JCL rats]. (1986) — see 1986
- Contribution of T lymphocytes to rat renal ischemia/reperfusion injury. (2009) — see 2009
- Contribution of dipeptidyl peptidase IV to the severity of dextran sulfate sodium-induced colitis in the early phase. (2013) — see 2013
🧬 Genetic Background & Strain Characterization
Strain characteristics and genetic background. Understanding the genetic background and strain-specific characteristics of F344/Jcl is essential for experimental design and data interpretation. Publications in this section provide insights into strain definition, comparison, and long-term consistency.
📚 Key Publications (Timeline)
Key publications highlighting the scientific legacy of F344/Jcl. Use this quick timeline to jump to the year-based sections below (the original “References by Year” list remains available).
- Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. (1986) — see 1986
- Coexpression of multiple Sertoli cell and Leydig cell marker genes in the spontaneous testicular tumor of F344 rat. (1997) — see 1997
- Paradoxical increase of heat-shock response with age in a substrain of F344 rats. (2002) — see 2002
- Contribution of dipeptidyl peptidase IV to the severity of dextran sulfate sodium-induced colitis in the early phase. (2013) — see 2013
- Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth. (2018) — see 2018
- A high-quality severe combined immunodeficiency (SCID) rat bioresource. (2022) — see 2022
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References by Year
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1986
- Odagiri Y, Adachi S, Katayama H, Matsushita H, Takemoto K.
Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations.
Dev Toxicol Environ Sci. 1986; 13:291-307.
- Imai S, Morimoto J, Kiyozuka Y, Shima M, Nakamori K, Tsubura Y.
[Spontaneous calcification in F344/Slc and F344/JCL rats].
Jikken Dobutsu. 1986 Oct;35(4):521-5. doi: 10.1538/expanim1978.35.4_521.
1997
- Kondoh G, Yomogida K, Dohmae K, Nozawa M, Koga M, Nonomura N, Miki T, Okuyama A, Nishimune Y.
Coexpression of multiple Sertoli cell and Leydig cell marker genes in the spontaneous testicular tumor of F344 rat: evidence for phenotypical bifurcation of the interstitial cell tumor.
Jpn J Cancer Res. 1997 Sep;88(9):839-45. doi: 10.1111/j.1349-7006. 1997. tb00459. x.
1998
- Naeshiro I, Sato K, Chatani F, Sato S.
Possible mechanism for the anemia induced by candesartan cilexetil (TCV-116), an angiotensin II receptor antagonist, in rats.
Eur J Pharmacol. 1998 Aug 7;354(2-3):179-87. doi: 10.1016/s0014-2999(98)00451-8.
- Nagakura T, Yasuda N, Yamazaki K, Ikuta H, Yoshikawa S, Asano O, Tanaka I.
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats.
Biochem Biophys Res Commun. 2001 Jun 8;284(2):501-6. doi: 10.1006/bbrc.2001.4999.
2001
- Nagakura T, Yasuda N, Yamazaki K, Ikuta H, Yoshikawa S, Asano O, Tanaka I.
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats.
Biochem Biophys Res Commun. 2001 Jun 8;284(2):501-6. doi: 10.1006/bbrc.2001.4999.
2002
- Yasuda N, Nagakura T, Yamazaki K, Inoue T, Tanaka I.
Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats.
Life Sci. 2002 May 31;71(2):227-38. doi: 10.1016/s0024-3205(02)01637-5.
- Yasuda N, Inoue T, Nagakura T, Yamazaki K, Kira K, Saeki T, Tanaka I.
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.
Biochem Biophys Res Commun. 2002 Nov 15;298(5):779-84. doi: 10.1016/s0006-291x(02)02565-2.
- Takahashi R, Toyoda E, Aoki Y, Suzuki KT, Goto S.
Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl.
Mech Ageing Dev. 2002 Nov;123(12):1605-15. doi: 10.1016/s0047-6374(02)00096-9.
2006
- Chatani F.
Possible mechanism for testicular focal necrosis induced by hCG in rats.
J Toxicol Sci. 2006 Oct;31(4):291-303. doi: 10.2131/jts.31.291.
2009
- Noiri E, Doi K, Inagi R, Nangaku M, Fujita T.
Contribution of T lymphocytes to rat renal ischemia/reperfusion injury.
Clin Exp Nephrol. 2009 Feb;13(1):25-32. doi: 10.1007/s10157-008-0082-1. Epub 2008 Oct 1.
2013
- Iwaya H, Fujii N, Hagio M, Hara H, Ishizuka S.
Contribution of dipeptidyl peptidase IV to the severity of dextran sulfate sodium-induced colitis in the early phase.
Biosci Biotechnol Biochem. 2013;77(7):1461-6. doi: 10.1271/bbb.130105. Epub 2013 Jul 7.
2015
- Eto T.
Strain preservation of rats: vitrification of two-cell stage embryos for multiple inbred strains.
Cryo Letters. 2015 Mar-Apr;36(2):114-9.
2018
- Sato D, Takahata M, Ota M, Fukuda C, Tsuda E, Shimizu T, Okada A, Hiruma Y, Hamano H, Hiratsuka S, Fujita R, Amizuka N, Hasegawa T, Iwasaki N.
Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth.
Bone. 2018 Nov; 116:172-180. doi: 10.1016/j.bone.2018.07.026. Epub 2018 Aug 2.
2021
- Shimizu Y, Hara H, Hira T.
Glucagon-like peptide-1 response to whey protein is less diminished by dipeptidyl peptidase-4 in comparison with responses to dextrin, a lipid and casein in rats.
Br J Nutr. 2021 Feb 28;125(4):398-407. doi: 10.1017/S0007114520002834. Epub 2020 Jul 27.
2022
- Miyasaka Y, Wang J, Hattori K, Yamauchi Y, Hoshi M, Yoshimi K, Ishida S, Mashimo T.
A high-quality severe combined immunodeficiency (SCID) rat bioresource.
PLoS One. 2022 Aug 12;17(8): e0272950. doi: 10.1371/journal.pone.0272950. eCollection 2022.
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for F344/Jcl, along with a related product section and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to selected publications listed in the year-based archive.
Q: Which years are available in the References by Year index?- A: The year index on this page includes 1986, 1997, 1998, 2001, 2002, 2006, 2009, 2013, 2015, 2018, 2021, and 2022.
Q: Where can I find the related product information for F344/Jcl?- A: The related product information is provided in the "Related CLEA Japan product: F344/Jcl" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about F344/Jcl.
