CE-2 Academic Reference List
Research Use Snapshot
- Product type: Standard rodent diet (CE-2)
- Typical use: Baseline diet / control diet in a wide range of in vivo studies
- Evidence on this page: Publications spanning metabolism, gut function, toxicology/safety, and physiology where diet composition or standard feeding is relevant
- How to browse: Use the topic-based sections below, or jump by year in the original “References by Year” list
🩺 Metabolism, Obesity & Diabetes
Where CE-2 appears in metabolic research. The CE-2 reference list includes studies where standard diet selection or diet-related conditions are relevant to metabolic outcomes such as blood glucose, body weight, insulin resistance, and diabetic models.
- Differences in long-term effects of standard rodent diets on blood glucose and body weight of offspring. (2022) — see 2022
- Methyl dehydroabietate counters high fat diet-induced insulin resistance and hepatic steatosis by modulating PPAR signaling in mice. (2018) — see 2018
- AO-128, alpha-glucosidase inhibitor: antiobesity and antidiabetic actions in genetically obese-diabetic rats, Wistar fatty. (1995) — see 1995
- Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats. (2024) — see 2024
🦠 Gut, Nutrition Route & Intestinal Barrier
Applications related to gut structure/function, colitis, permeability and dietary components. The references include studies focusing on enteral/parenteral feeding, experimental colitis, and intestinal barrier changes driven by dietary components.
- Structural and functional alterations in the gut of parenterally or enterally fed rats. (1989) — see 1989
- Protective effect of tryptophan against dextran sulfate sodium-induced experimental colitis. (2013) — see 2013
- Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to NSAID-induced small-intestinal damage. (2019) — see 2019
🧪 Toxicology, Safety & Long-term Feeding Studies
Diet selection in toxicology/safety frameworks. The CE-2 reference list includes long-term feeding studies and toxicology-related work where standardized diets serve as controls or study variables.
🫀 Physiology (Cardio–Renal–Repro) & Systemic Effects
System-level outcomes where baseline feeding conditions matter. These references include cardio–renal physiology and systemic responses where standardized feeding supports interpretability across cohorts.
- Role of renin-angiotensin system in the pathogenesis of spontaneous myocardial fibrosis in Sprague-Dawley rats: effect of long-term administration of captopril. (1989) — see 1989
- Effect of oral-adsorbent (AST-120) in chronic renal failure (CRF) in rats. (1989) — see 1989
- Effects of long-term administration of furosemide on calcium balance, kidney and parathyroid gland. (1990) — see 1990
- Dietary intake of high-dose biotin inhibits spermatogenesis in young rats. (2015) — see 2015
🧬 Food Components, Bioactives & Drug Metabolism
Diet components and metabolism-related endpoints. These publications illustrate how diet components (e.g., cholesterol/cholic acid, specific nutrients, or bioactive food-derived substances) are used to probe metabolic pathways and pharmacokinetics.
- Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics. (2024) — see 2024
- Serum miR-29 is increased in mice with early liver fibrosis. (2024) — see 2024
- Effects of isoprothiolane and phytosterol on lipogenesis and lipolysis in adipocytes from rats of dietary fat necrosis. (1990) — see 1990
📚 Key Publications (Timeline)
Representative publications to quickly understand how CE-2 appears in research contexts. This timeline highlights a few papers across decades and links to the corresponding year sections below.
- Structural and functional alterations in the gut of parenterally or enterally fed rats. (1989) — see 1989
- AO-128, alpha-glucosidase inhibitor: antiobesity and antidiabetic actions in genetically obese-diabetic rats, Wistar fatty. (1995) — see 1995
- A 104-week feeding study of genetically modified soybeans in F344 rats. (2008) — see 2008
- Involvement of gliadin… in increased intestinal permeability… (2019) — see 2019
- Differences in long-term effects of standard rodent diets on blood glucose and body weight of offspring. (2022) — see 2022
- Induction of hepatic CYP3A4 expression by cholesterol and cholic acid… (2024) — see 2024
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References by Year
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1989
- Kawamura S.
The effect of food consistency on conditioned avoidance response in mice and rats
Shika Kiso Igakkai Zasshi. 1989 Feb;31(1):72-82. doi: 10.2330/joralbiosci1965.31.72. PMID: 2519255
- Yoshimura S, Imai K, Hayashi Y, Hashimoto K.
Role of renin-angiotensin system in the pathogenesis of spontaneous myocardial fibrosis in Sprague-Dawley rats: effect of long-term administration of captopril.
Tohoku J Exp Med. 1989 Mar;157(3):241-9. doi: 10.1620/tjem.157.241. PMID: 2658200
- Sakai T, Kumano K, Takara S, Kuwao S, Ise M, Sugano M, Uehara Y.
Effect of oral-adsorbent (AST-120) in chronic renal failure (CRF) in rats
Nihon Jinzo Gakkai Shi. 1989 Apr;31(4):359-65. PMID: 2747009
- Hosoda N, Nishi M, Nakagawa M, Hiramatsu Y, Hioki K, Yamamoto M.
Structural and functional alterations in the gut of parenterally or enterally fed rats.
J Surg Res. 1989 Aug;47(2):129-33. doi: 10.1016/0022-4804(89)90076-0. PMID: 2547111
- Ogawa H, Nishikawa T, Fukushima S, Sasagawa S.
Studies on stroke-prone spontaneously hypertensive rats (SHRSP) fed a high-fat and high-cholesterol diet--effects of salt intake on serum lipoprotein and apolipoprotein metabolism
Nihon Eiseigaku Zasshi. 1989 Oct;44(4):911-20. doi: 10.1265/jjh.44.911. PMID: 2637385
1990
- Asano Y, Nonomura K, Koyanagi T.
Effects of long-term administration of furosemide on calcium balance, kidney and parathyroid gland
Nihon Hinyokika Gakkai Zasshi. 1990 Jan;81(1):19-24. doi: 10.5980/jpnjurol1989.81.19. PMID: 2304311
- Katamoto H, Kurihara S, Shimada Y.
Effects of isoprothiolane and phytosterol on lipogenesis and lipolysis in adipocytes from rats of dietary fat necrosis.
Nihon Juigaku Zasshi. 1990 Dec;52(6):1189-97. doi: 10.1292/jvms1939.52.1189. PMID: 2287126
1991
- Kuwao S, Sakai T, Kumano K, Ise M, Uehara Y.
Pathological study on the effect of oral adsorbent AST-120 on chronic renal failure in rats
Nihon Jinzo Gakkai Shi. 1991 Aug;33(8):731-41. PMID: 1770633
1992
- Hosokawa T.
Altered bone metabolism in db/db mice
Nihon Ronen Igakkai Zasshi. 1992 Jul-Aug;29(7-8):540-8. doi: 10.3143/geriatrics.29.540. PMID: 1434049
1993
- Takahashi A, Tanida N, Kawaura A, Nishikawa M, Shimoyama T.
Sulphated bile acid per se inhibits colonic carcinogenesis in mice.
Eur J Cancer Prev. 1993 Mar;2(2):161-7. doi: 10.1097/00008469-199303000-00009.PMID: 8461867
1994
- Yoshida T, Sakane N, Wakabayashi Y, Yoshioka K, Umekawa T, Kondo M.
The alpha/beta-adrenergic receptor blocker arotinolol activates the thermogenesis of brown adipose tissue in monosodium-L-glutamate-induced obese mice.
Int J Obes Relat Metab Disord. 1994 May;18(5):339-43. PMID: 7520314
1995
- Ikeda H, Odaka H.
AO-128, alpha-glucosidase inhibitor: antiobesity and antidiabetic actions in genetically obese-diabetic rats, Wistar fatty.
Obes Res. 1995 Nov;3 Suppl 4:617S-621S. doi: 10.1002/j.1550-8528.1995.tb00235.x. PMID: 8697066
- de Oliveira Cordeiro JG.
Experimental root surface caries in hamsters the development of the disease after inoculations of two types of cariogenic bacteria.
Bull Tokyo Med Dent Univ. 1995 Dec;42(3):83-103. PMID: 8556786
1996
- Ochiai M, Nakagama H, Watanabe M, Ishiguro Y, Sugimura T, Nagao M.
Efficient method for rapid induction of aberrant crypt foci in rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Jpn J Cancer Res. 1996 Oct;87(10):1029-33. doi: 10.1111/j.1349-7006.1996.tb03105.x. PMID: 8957059
1998
- Matsuzawa T, Saitoh H, Sano M, Tomita I, Ohkawa M, Ikekawa T.
Studies on antioxidant effects of Hypsizigus marmoreus. II. Effects of Hypsizigus marmoreus for antioxidant activities of tumor-bearing mice
Yakugaku Zasshi. 1998 Oct;118(10):476-81. doi: 10.1248/yakushi1947.118.10_476. PMID: 9800519
1999
- Rahman KM, Sugie S, Okamoto K, Watanabe T, Tanaka T, Mori H.
Modulating effects of diets high in omega-3 and omega-6 fatty acids in initiation and postinitiation stages of diethylnitrosamine-induced hepatocarcinogenesis in rats.
Jpn J Cancer Res. 1999 Jan;90(1):31-9. doi: 10.1111/j.1349-7006.1999.tb00662.x. PMID: 10076562
2000
- Sato M, Wada K, Marumo H, Nagao T, Imai K, Ono H.
Influence of corn oil and diet on reproduction and the kidney in female Sprague-Dawley rats.
Toxicol Sci. 2000 Jul;56(1):156-64. doi: 10.1093/toxsci/56.1.156. PMID: 10869464
2002
- Yamamoto N, Kabuto H, Matsumoto S, Ogawa N, Yokoi I.
alpha-Tocopheryl-L-ascorbate-2-O-phosphate diester, a hydroxyl radical scavenger, prevents the occurrence of epileptic foci in a rat model of post-traumatic epilepsy.
Pathophysiology. 2002 Jun;8(3):205-214. doi: 10.1016/s0928-4680(02)00009-3. PMID: 12039653
2003
- Sato D, Matsushima M.
Preventive effects of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rat by green tea leaves.
Int J Urol. 2003 Mar;10(3):160-6. doi: 10.1046/j.1442-2042.2003.00587.x. PMID: 12622713
2004
- Han LK, Kai F, Okuda H.
Effects of long-term administration of caffeine on fat storage in ovariectomized rats
Yakugaku Zasshi. 2004 Nov;124(11):841-6. doi: 10.1248/yakushi.124.841. PMID: 15516811
2007
- Sakamoto Y, Tada Y, Fukumori N, Tayama K, Ando H, Takahashi H, Kubo Y, Nagasawa A, Yano N, Yuzawa K, Ogata A, Kamimura H.
A 52-week feeding study of genetically modified soybeans in F344 rats
Shokuhin Eiseigaku Zasshi. 2007 Jun;48(3):41-50. doi: 10.3358/shokueishi.48.41. PMID: 17657996
2008
- Sakamoto Y, Tada Y, Fukumori N, Tayama K, Ando H, Takahashi H, Kubo Y, Nagasawa A, Yano N, Yuzawa K, Ogata A.
A 104-week feeding study of genetically modified soybeans in F344 rats
Shokuhin Eiseigaku Zasshi. 2008 Aug;49(4):272-82. doi: 10.3358/shokueishi.49.272. PMID: 18787312
- Sakurai N, Suzuki K, Sano Y, Saito T, Yoshimura H, Nishimura Y, Yano T, Sadzuka Y, Asano R.
Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma-bearing mice.
Mol Med Rep. 2008 Nov-Dec;1(6):903-7. doi: 10.3892/mmr_00000048. PMID: 21479504
2009
- Ochiai M, Matsuo T.
Prolonged swimming exercise does not affect contents and fatty acids composition of rat muscle triacylglycerol.
J Oleo Sci. 2009;58(6):313-21. doi: 10.5650/jos.58.313. PMID: 19430193
- Hiratsuka S, Koizumi K, Ooba T, Yokogoshi H.
Effects of dietary docosahexaenoic acid connecting phospholipids on the learning ability and fatty acid composition of the brain.
J Nutr Sci Vitaminol (Tokyo). 2009 Aug;55(4):374-80. doi: 10.3177/jnsv.55.374. PMID: 19763040
2010
- Zhang Y, Kouguchi T, Shimizu K, Sato M, Takahata Y, Morimatsu F.
Chicken collagen hydrolysate reduces proinflammatory cytokine production in C57BL/6.KOR-ApoEshl mice.
J Nutr Sci Vitaminol (Tokyo). 2010;56(3):208-10. doi: 10.3177/jnsv.56.208. PMID: 20651463
2011
- Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyama N.
Protective effects of Kurozu and Kurozu Moromimatsu on dextran sulfate sodium-induced experimental colitis.
Dig Dis Sci. 2011 May;56(5):1387-92. doi: 10.1007/s10620-010-1432-x. Epub 2010 Oct 9. PMID: 20936352
- Sato H, Ide Y, Nasu M, Numabe Y.
The effects of oral xylitol administration on bone density in rat femur.
Odontology. 2011 Jan;99(1):28-33. doi: 10.1007/s10266-010-0143-2. Epub 2011 Jan 27. PMID: 21271323
- Uchikawa T, Kumamoto Y, Maruyama I, Kumamoto S, Ando Y, Yasutake A.
Enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice.
J Toxicol Sci. 2011 Jan;36(1):121-6. doi: 10.2131/jts.36.121. PMID: 21297350
- Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyama N.
Protective effects of fermented rice vinegar sediment (Kurozu moromimatsu) in a diethylnitrosamine-induced hepatocellular carcinoma animal model.
J Clin Biochem Nutr. 2011 Jul;49(1):31-5. doi: 10.3164/jcbn.10-112.. Epub 2011 Jun 17. PMID: 21765604
- Shizuma T, Nagano M, Fujii A, Mori H, Fukuyama N.
Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis.
Turk J Gastroenterol. 2011 Aug;22(4):376-81. doi: 10.4318/tjg.2011.0239. PMID: 21948567
2012
- Saheki T, Inoue K, Ono H, Katsura N, Yokogawa M, Yoshidumi Y, Furuie S, Kuroda E, Ushikai M, Asakawa A, Inui A, Eto K, Kadowaki T, Sinasac DS, Yamamura K, Kobayashi K.
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
Mol Genet Metab. 2012 Nov;107(3):322-9. doi: 10.1016/j.ymgme.2012.07.021. Epub 2012 Aug 2. PMID: 22921887
2013
- Shizuma T, Mori H, Fukuyama N.
Protective effect of tryptophan against dextran sulfate sodium- induced experimental colitis.
Turk J Gastroenterol. 2013;24(1):30-5. doi: 10.4318/tjg.2013.0558. PMID: 23794341
2014
- Zidan Y, Bouderbala S, Djellouli F, Lacaille-Dubois MA, Bouchenak M.
Portulaca oleracea reduces triglyceridemia, cholesterolemia, and improves lecithin: cholesterol acyltransferase activity in rats fed enriched-cholesterol diet.
Phytomedicine. 2014 Oct 15;21(12):1504-8. doi: 10.1016/j.phymed.2014.07.010. Epub 2014 Aug 28. PMID: 25442258
2015
- Sawamura H, Ikeda C, Shimada R, Yoshii Y, Watanabe T.
Dietary intake of high-dose biotin inhibits spermatogenesis in young rats.
Congenit Anom (Kyoto). 2015 Feb;55(1):31-6. doi: 10.1111/cga.12070. PMID: 25039897
2017
- Sato W, Ishibashi KI, Yamanaka D, Adachi Y, Ohno N.
Effects of Natural and Chemically Defined Nutrients on Candida albicans Water-soluble Fraction (CAWS) Vasculitis in Mice.
Med Mycol J. 2017;58(2):E47-E62. doi: 10.3314/mmj.16-00014. PMID: 28566659
2018
- Yoshioka H, Mizuno Y, Yamaguchi T, Ichimaru Y, Takeya K, Hitotsuyanagi Y, Nonogaki T, Aoyagi Y.
Methyl dehydroabietate counters high fat diet-induced insulin resistance and hepatic steatosis by modulating peroxisome proliferator-activated receptor signaling in mice.
Biomed Pharmacother. 2018 Mar;99:214-219. doi: 10.1016/j.biopha.2018.01.064. PMID: 29334664
2019
- Shimada S, Tanigawa T, Watanabe T, Nakata A, Sugimura N, Itani S, Higashimori A, Nadatani Y, Otani K, Taira K, Hosomi S, Nagami Y, Tanaka F, Kamata N, Yamagami H, Shiba M, Fujiwara Y.
Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.
PLoS One. 2019 Feb 20;14(2):e0211436. doi: 10.1371/journal.pone.0211436. eCollection 2019. PMID: 30785904
2020
- Hotta Y, Takahashi S, Tokoro M, Naiki-Ito A, Maeda K, Kawata R, Kataoka T, Ohta Y, Hamakawa T, Takahashi S, Yasui T, Kimura K.
Anagliptin, a dipeptidyl peptidase-4 inhibitor, improved bladder function and hemodynamics in rats with bilateral internal iliac artery ligation.
Neurourol Urodyn. 2020 Sep;39(7):1922-1929. doi: 10.1002/nau.24449. Epub 2020 Jul 29. PMID: 32725853
- Nukaga S, Mori T, Miyagawa Y, Fujiwara-Tani R, Sasaki T, Fujii K, Mori S, Goto K, Kishi S, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H.
Combined administration of lauric acid and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model.
Cancer Sci. 2020 Dec;111(12):4605-4615. doi: 10.1111/cas.14656. Epub 2020 Oct 2. PMID: 32969559
2022
- Inada A, Inada O.
Differences in long-term effects of standard rodent diets on blood glucose and body weight of offspring.
Diabetol Int. 2022 Mar 24;13(4):615-623. doi: 10.1007/s13340-022-00578-x. eCollection 2022 Oct. PMID: 36117929
2024
- Yamaguchi M, Fukuyama R, Fujita M.
Effect of nattokinase on the pathological conditions in streptozotocin induced diabetic rats.
Heliyon. 2024 Mar 27;10(7):e28835. doi: 10.1016/j.heliyon.2024.e28835. eCollection 2024 Apr 15. PMID: 38586318
- Minegishi G, Kobayashi Y, Fujikura M, Sano A, Kazuki Y, Kobayashi K.
Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics.
Pharmacol Res Perspect. 2024 Jun;12(3):e1197. doi: 10.1002/prp2.1197. PMID: 38644590
- Matsumoto K, Ohsugi Y, Tayama C, Hayashi M, Kato Y, Ohashi M, Chiba M.
Serum miR-29 is increased in mice with early liver fibrosis.
Exp Ther Med. 2024 May 15;28(1):285. doi: 10.3892/etm.2024.12573. eCollection 2024 Jul. PMID: 38800048
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for CE-2, along with a related product section and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to selected publications listed in the year-based archive.
Q: Which years are available in the References by Year index?- A: The year index on this page includes 1989, 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1998, 1999, 2000, 2002, 2003, 2004, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2017, 2018, 2019, 2020, 2022, and 2024.
Q: Where can I find the related product information for CE-2?- A: The related product information is provided in the "Related CLEA Japan product: CE-2" section on this page.
Q: How can I contact CLEA Japan about CE-2?- A: The "Inquiry" section on this page includes a link to the contact form for questions about CE-2.
