BKS.Cg-m +/+ Leprdb/Jcl Academic Reference List
Research Use Snapshot
BKS.Cg-m +/+ Leprdb/Jcl (db/db mouse) is a well-established obesity-associated type 2 diabetes model caused by leptin receptor deficiency, widely used for translational studies of metabolic dysregulation, diabetic complications, and therapeutic interventions.
Publications on this page demonstrate research applications spanning insulin signaling and glucose transporter regulation, diabetic wound healing and regenerative approaches, diabetic kidney dysfunction assessed by functional imaging, and systemic cardio–kidney–metabolic (CKM) comorbidities, including hepatic steatosis.
You can explore publications by research purpose below, or browse the complete reference list organized by year.
🩺 Metabolic Dysregulation & Insulin Signaling
Mechanistic insights into insulin resistance and glucose transport. This section highlights molecular pathways relevant to metabolic abnormalities in db/db mice, including insulin signaling and GLUT4 regulation.
💊 Incretin-Based & Metabolic Therapeutics
Therapeutic evaluation in obesity-associated type 2 diabetes. Publications in this category evaluate metabolic interventions, including incretin-based therapies, and their effects on pancreatic β-cells and systemic metabolic outcomes.
🩹 Diabetic Wound Healing & Regenerative Medicine
Standard model for impaired wound healing. This section highlights diabetic wound healing studies in db/db mice, supporting regenerative medicine, biomaterials, and therapeutic development for diabetic skin complications.
- A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice (2020) — see 2020
- Human cultured epidermis accelerates wound healing regardless of its viability in a diabetic mouse model. (2020) — see 2020
🫀 Diabetic Kidney Disease & Functional Imaging
Diabetic kidney dysfunction assessed with advanced techniques. References here demonstrate functional and physiological kidney assessment, including in vivo imaging approaches.
🧬 CKM Comorbidities: Liver Steatosis & Systemic Metabolism
Multi-organ metabolic comorbidities within a CKM framework. This category highlights systemic metabolic interactions associated with type 2 diabetes, including hepatic steatosis and broader cardio–kidney–metabolic (CKM) relevance.
📚 Key Publications (Timeline)
Representative publications that define the research value of the db/db mouse. Use this timeline to quickly understand how this model supports mechanistic studies, complication research, functional assessment, and therapeutic evaluation, then jump to the year-based archive for full citation details.
- Dioleoylphosphoethanolamine Retains Cell Surface GLUT4 by Inhibiting PKCα-Driven Internalization. (2018) — see 2018
- Human cultured epidermis accelerates wound healing regardless of its viability in a diabetic mouse model. (2020) — see 2020
- Sodium Magnetic Resonance Imaging Shows Impairment of the Counter-current Multiplication System in Diabetic Mice Kidney. (2023) — see 2023
- Tirzepatide, a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, exhibits favourable effects on pancreatic β-cells and hepatic steatosis in obese type 2 diabetic db/db mice (2024) — see 2024
Note: Additional wound healing data are available in the 2020 section of the archive.
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2018
- Nishizaki T.
Dioleoylphosphoethanolamine Retains Cell Surface GLUT4 by Inhibiting PKCα-Driven Internalization.
Cell Physiol Biochem. 2018;46(5):1985-1998. doi: 10.1159/000489439. PMID: 29723855
2020
- Notodihardjo SC, Morimoto N, Munisso MC, Le TM, Mitsui T, Kakudo N, Kusumoto K.
A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice
J Plast Reconstr Aesthet Surg. 2020 Aug;73(8):1547-1555. doi: 10.1016/j.bjps.2020.01.031. PMID: 32487360
- Sakamoto M, Ogino S, Shimizu Y, Inoie M, Lee S, Yamanaka H, Tsuge I, Saito S, Morimoto N.
Human cultured epidermis accelerates wound healing regardless of its viability in a diabetic mouse model.
PLoS One. 2020 Aug 21;15(8):e0237985. doi: 10.1371/journal.pone.0237985. PMID: 32822395
2023
- Nakagawa Y, Kaseda R, Suzuki Y, Watanabe H, Otsuka T, Yamamoto S, Kaneko Y, Goto S, Terada Y, Haishi T, Sasaki S, Narita I.
Sodium Magnetic Resonance Imaging Shows Impairment of the Counter-current Multiplication System in Diabetic Mice Kidney.
Kidney360. 2023 May 1;4(5):582-590. doi: 10.34067/KID.0000000000000072. PMID: 36963113
2024
- Yuichiro Iwamoto, Tomohiko Kimura, Kazunori Dan, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Masashi Shimoda, Yuki Yamasaki, Yuka Nogami, Yoshiko Shirakiya, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Tirzepatide, a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, exhibits favourable effects on pancreatic β-cells and hepatic steatosis in obese type 2 diabetic db/db mice
Diabetes Obes Metab. 2024 Dec;26(12):5982-5994. Epub 2024 Sep 30.
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for BKS.Cg-m +/+ Leprdb/Jcl (db/db), along with a related product link and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Which years are included in the reference list on this page?- A: The reference list on this page includes publications from 2018, 2020, 2023, and 2024.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to the same publications listed in the year-based archive.
Q: Where can I find the product page for BKS.Cg-m +/+ Leprdb/Jcl?- A: The product link is provided in the "Related CLEA Japan product: BKS.Cg-m +/+ Leprdb/Jcl" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about BKS.Cg-m +/+ Leprdb/Jcl.
