BALB/cAJcl-nu/nu Academic Reference List
The BALB/cAJcl-nu/nu Academic Reference Archive provides a curated collection of scientific publications featuring the BALB/cAJcl-nu/nu athymic nude mouse supplied by CLEA Japan.
As an immunodeficient mouse model lacking functional T lymphocytes, this strain has been widely utilized in oncology, tumor xenograft studies, regenerative medicine, cell transplantation, immunology, infectious disease research, and therapeutic evaluation. Its ability to support the engraftment of human cells and tissues has made it a valuable model for translational biomedical research.
The references collected on this page demonstrate its broad application across studies involving cancer biology, stem cell research, tissue engineering, transplantation, host–pathogen interactions, and other preclinical research fields. Publications are organized chronologically, allowing researchers to explore the historical development and expanding scientific applications of this model.
For detailed information on the biological characteristics, availability, and ordering information for BALB/cAJcl-nu/nu, please visit the corresponding product page.
Research Use Snapshot
- Product type: Athymic nude mouse with T-cell deficiency.
- Typical applications: Human tumor xenograft studies, anticancer drug evaluation, radiotherapy research, molecular imaging, cell transplantation, regenerative medicine, and immunology.
- Evidence on this page: Publications include studies on solid tumor growth and therapeutic response, radiotracer biodistribution and dosimetry, nanoparticle- and antibody-based radiosensitization, human cell engraftment, wound healing, and host metabolic or nutritional factors.
- How to browse: Explore representative publications by research purpose or browse the complete reference list organized by publication year.
🧫 Xenograft Oncology Platform
Standard xenograft platform for tumor growth and therapy response evaluation. This section highlights studies using BALB/cAJcl-nu/nu mice in solid tumor models and treatment assessments.
☢️ Radiotracer Imaging & Dosimetry
Radiotracer biodistribution, PET imaging, and dosimetry. Publications in this category demonstrate nuclear medicine–related applications evaluated in nude mice.
🥇 Nanomedicine & Radiosensitization
Advanced radiotherapy enhancement strategies. This section features studies exploring nanoparticle- and antibody-based approaches to enhance tumor control in vivo.
🩹 Regenerative Medicine & Wound Healing
Human cell–based repair under immunodeficient conditions. References here demonstrate applications in wound healing and regenerative medicine, including radiation-induced ulcer models.
🧪 Host Factors: Metabolism & Nutrition Effects
Host environment influences on biology and responses. This category includes studies examining metabolic and nutritional factors and their impact on disease-related outcomes.
- Comparison of the Effects of 3 Forms of Soluble Dietary Fiber on the Production of IgA in BALB/cAJcl and BALB/cAJcl-nu/nu Mice. (2023) — see 2023
- High glucose enhances the aggressiveness of lung adenocarcinoma via activating epidermal growth factor receptor/signal transducer and activator of transcription 3 pathways. (2023) — see 2023
📚 Key Publications (Timeline)
Representative publications that illustrate the research value of BALB/cAJcl-nu/nu mice. Use this timeline to quickly grasp how this model has been applied across different research fields, then jump to the year-based archive for full citation details.
- Fluorine-18-labeled 5-fluorouracil is a useful radiotracer for differentiation of malignant tumors from inflammatory lesions. (2008) — see 2008
- Biodistribution and radiation dosimetry of [¹⁸F]-5-fluorouracil. (2013) — see 2013
- Comparison of the Effects of 3 Forms of Soluble Dietary Fiber on the Production of IgA in BALB/cAJcl and BALB/cAJcl-nu/nu Mice. (2023) — see 2023
- High glucose enhances the aggressiveness of lung adenocarcinoma via activating epidermal growth factor receptor/signal transducer and activator of transcription 3 pathways. (2023) — see 2023
- Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo. (2023) — see 2023
- Human Adipose-Derived Endothelial Progenitor Cells Accelerate Epithelialization of Radiation Ulcers in Nude Mice. (2024) — see 2024
- Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model. (2025) — see 2025
Related CLEA Japan product: BALB/cAJcl-nu/nu
Related CLEA Japan product: BALB/cAJcl-nu/nu
For the animal, please click here↓
: https://www.clea-japan.com/en/products/immunodeficiency/item_a0010
Inquiry:
If you have any question, please feel free to contact us from here .
2008
- Sugae S, Suzuki A, Takahashi N, Minamimoto R, Cheng C, Theeraladanon C, Endo I, Togo S, Inoue T, Shimada H.
Fluorine-18-labeled 5-fluorouracil is a useful radiotracer for differentiation of malignant tumors from inflammatory lesions.
Ann Nucl Med. 2008 Jan;22(1):65-72. doi: 10.1007/s12149-007-0081-4.
2013
- Hino-Shishikura A, Suzuki A, Minamimoto R, Shizukuishi K, Oka T, Tateishi U, Sugae S, Ichikawa Y, Horiuchi C, Inoue T.
Biodistribution and radiation dosimetry of [¹⁸F]-5-fluorouracil.
Appl Radiat Isot. 2013 May;75:11-7. doi: 10.1016/j.apradiso.2013.01.014. Epub 2013 Jan 20.
2023
- Matsumoto K, Sawano H, Otsubo M, Yui A.
Comparison of the Effects of 3 Forms of Soluble Dietary Fiber on the Production of IgA in BALB/cAJcl and BALB/cAJcl-nu/nu Mice.
J Nutr. 2023 May;153(5):1618-1626. doi: 10.1016/j.tjnut.2023.03.037. Epub 2023 Apr 1.
- Sorin S, Zhou Y, Thithuan K, Khawkhiaw K, Zeng F, Ruangpratyakul T, Chomphoo S, Seubwai W, Wongkham S, Saengboonmee C.
High glucose enhances the aggressiveness of lung adenocarcinoma via activating epidermal growth factor receptor/signal transducer and activator of transcription 3 pathways.
J Nutr Biochem. 2023 Sep;119:109399. doi: 10.1016/j.jnutbio.2023.109399. Epub 2023 Jun 2.
- Sato T, Kakei Y, Hasegawa T, Kashin M, Teraoka S, Yamaguchi A, Sasaki R, Akashi M.
Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo.
Cancers (Basel). 2023 Dec 3;15(23):5697. doi: 10.3390/cancers15235697.
2024
- Mori M, Saito N, Shirado T, Wu Y, Asahi R, Yoshizumi K, Yamamoto Y, Zhang B, Yoshimura K.
Human Adipose-Derived Endothelial Progenitor Cells Accelerate Epithelialization of Radiation Ulcers in Nude Mice.
Plast Reconstr Surg. 2024 Mar 1;153(3):625-635. doi: 10.1097/PRS.0000000000010756. Epub 2023 May 24.
- Yamada K, Mukaimine A, Nakamura A, Kusakari Y, Pradipta AR, Chang TC, Tanaka K.
Chemistry-driven translocation of glycosylated proteins in mice
Nat Commun. 2024 Oct 2;15(1):7409. doi: 10.1038/s41467-024-51342-5. PMCID: PMC11446924
- Horiguchi M, Yoshihara K, Watanabe K, Tsurudome Y, Mizukami Y, Ushijima K.
Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus
Int J Mol Sci. 2024 Dec 6;25(23):13145. doi: 10.3390/ijms252313145. PMCID: PMC11641841
- Jeeunngoi J, Senawong G, Jogloy S, Prompipak J, Samankul A, Utaiwat S, Woranam K, Sripa B, Senawong T.
Anticancer Potential of Valencia Peanut (Arachis hypogaea L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models
Foods. 2024 Jul 26;13(15):2354. doi: 10.3390/foods13152354. PMCID: PMC11312182
- Dash S, Ueda T, Komuro A, Honda M, Sugisawa R, Okada H.
Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer
Cell Death Dis. 2024 Feb 12;15(2):131. doi: 10.1038/s41419-024-06531-x. PMCID: PMC10861559
2025
- Shan AP, Hlaing KS, Leelahavanichkul A, Amornphimoltham P.
Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model.
Eur J Oral Sci. 2025 Feb;133(1):e13034. doi: 10.1111/eos.13034. Epub 2025 Jan 8. PMID: 39780329
- Owaki R, Hosoya K, Deguchi T, Konnai S, Maekawa N, Okagawa T, Yasui H, Kim S, Sunaga T, Okumura M.
Enhancement of radio-sensitivity by inhibition of Janus kinase signaling with oclacitinib in canine tumor cell lines
Mol Ther Oncol. 2025 Feb 3;33(1):200946. doi: 10.1016/j.omton.2025.200946. eCollection 2025 Mar 20. PMID: 40051504
- Horiguchi M, Yoshihara K, Mizukami Y, Watanabe K, Tsurudome Y, Ushijima K.
The Diurnal Variation in Mitochondrial Gene in Human Type 2 Diabetic Mesenchymal Stem Cell Grafts
Int J Mol Sci. 2025 Jan 16;26(2):719. doi: 10.3390/ijms26020719. PMCID: PMC11765740
- Yamamoto M, Koyanagi K, Nishi T, Kazuno A, Shoji Y, Ninomiya Y, Kanamori K, Tajima K, Nakashima R, Mori M.
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle loss in a mouse model of esophageal squamous cell carcinoma
Ann Transl Med. 2025 Dec 19;13(6):71. doi: 10.21037/atm-25-126. PMCID: PMC12771045
- Hirasawa S, Murakami K, Kano M, Endo S, Toyozumi T, Matsumoto Y, Otsuka R, Sekino N, Shiraishi T, Ryuzaki T, Kinoshita K, Sasaki T, Matsubara H.
MSC and HUVEC co-cultured fillers overcome intractable fistula in a new mouse model
PLoS One. 2025 Aug 21;20(8):e0330478. doi: 10.1371/journal.pone.0330478. PMCID: PMC12370064
- Adachi Y, Miyake K, Ohira K, Satoh S, Masuhiro K, Edahiro R, Shirai Y, Naito M, Naito Y, Shiroyama T, Koyama S, Hirata H, Iwahori K, Nagatomo I, Takeda Y, Kumanogoh A.
Enhancing the efficacy of near-infrared photoimmunotherapy through intratumoural delivery of CD44–targeting antibody–photoabsorber conjugates
EBioMedicine. 2025 Jan 22;112:105566. doi: 10.1016/j.ebiom.2025.105566. PMCID: PMC11795636
- Namwan N, Senawong G, Phaosiri C, Kumboonma P, Somsakeesit LO, Sangchang P, Senawong T.
Curcumin Derivative CU4c Exhibits HDAC-Inhibitory and Anticancer Activities Against Human Lung Cancer Cells In Vitro and in Mouse Xenograft Models
Pharmaceuticals (Basel). 2025 Jun 26;18(7):960. doi: 10.3390/ph18070960. PMCID: PMC12297909
2026
- Kasuga H, Kataoka Y, Yamamoto F, Miyamoto R, Tsuji S, Suzuki T, Mizuarai S.
TAS3351 is a brain penetrable EGFR-TKI that overcomes T790M and C797S resistant mutations
Commun Med (Lond). 2026 Mar 25;6(1):284. doi: 10.1038/s43856-026-01546-1. PMCID: PMC13181001
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for BALB/cAJcl-nu/nu, along with a related product link and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Which years are included in the reference list on this page?- A: The reference list on this page includes publications from 2008, 2013, 2023, 2024, and 2025.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to the same publications listed in the year-based archive.
Q: Where can I find the product page for BALB/cAJcl-nu/nu?- A: The product link is provided in the "Related CLEA Japan product: BALB/cAJcl-nu/nu" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about BALB/cAJcl-nu/nu.
