BALB/cAJcl-nu/nu
Animals/Immunodeficiency Models/
Ordering name: BALB/cAJcl-nu/nu
Nomenclature: BALB/cAJcl-Foxn1nu
Availability: Live colony
Origin
These mice were introduced by Dr. C. W. Friis (Denmark) to the Central Institute for Experimental Animals; we subsequently started their mass production and supply.
Characteristics
Because of the control from a single recessive gene nu, homozygotes (nu/nu) are anatomically athymic and are hairless in appearance (histologically, hair follicles are present and some animals have downy hair). From an immunologic perspective, they lack T-cell function. They are permanently backcrossed, and the supply of these animals is genetically and microbiologically consistent.
Use
- Various immunology and cancer studies
- Screening of anticancer drugs
- Microbiological studies, etc.