BALB/cAJcl-nu/nu

Animals/Immunodeficiency Models/

BALB/cAJcl-<i>nu/nu</i>

Ordering name: BALB/cAJcl-nu/nu
Nomenclature: BALB/cAJcl-Foxn1nu
Availability: Live colony

Origin

These mice were introduced by Dr. C. W. Friis (Denmark) to the Central Institute for Experimental Animals; we subsequently started their mass production and supply.

Characteristics

Because of the control from a single recessive gene nu, homozygotes (nu/nu) are anatomically athymic and are hairless in appearance (histologically, hair follicles are present and some animals have downy hair). From an immunologic perspective, they lack T-cell function. They are permanently backcrossed, and the supply of these animals is genetically and microbiologically consistent.

Use

  • Various immunology and cancer studies
  • Screening of anticancer drugs
  • Microbiological studies, etc.

Background Data (weight, blood property, blood biochemistry, organ weight)

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