B10-mdx Academic Reference List
The B10-mdx Academic Reference Archive provides a curated collection of scientific publications related to the B10-mdx mouse supplied by CLEA Japan.
As a widely used model of Duchenne muscular dystrophy, B10-mdx carries an X-linked mutation in the Dmd gene that disrupts dystrophin production and results in repeated cycles of skeletal muscle degeneration and regeneration.
The references collected on this page cover the discovery and molecular characterization of the mdx mutation, evaluation of reliable preclinical outcome measures, and the broader use of mouse models in muscular dystrophy research. Publications are organized chronologically, allowing researchers to review the scientific development and experimental applications of this model.
For detailed information on the biological characteristics, availability, and ordering information for B10-mdx, please visit the corresponding product page.
Research Use Snapshot
- Product type: Mouse model of Duchenne muscular dystrophy (DMD) carrying a spontaneous mutation in the Dmd gene.
- Typical applications: Duchenne muscular dystrophy research, skeletal muscle pathology, dystrophin biology, disease mechanism studies, and preclinical evaluation of therapeutic strategies.
- Evidence on this page: Publications include the original identification of the mdx mutation, molecular characterization of dystrophin deficiency, assessment of preclinical outcome measures, and reviews of mouse models for muscular dystrophy research.
- How to browse: Explore representative publications by research purpose or browse the complete reference list organized by publication year.
🧬 Model Discovery & Phenotype
How was the mdx mouse established as a muscular dystrophy model? The foundational publication listed on this page describes the spontaneous X-linked muscular dystrophy phenotype in the mdx mouse and its value as an experimental model of Duchenne muscular dystrophy.
🔬 Molecular Genetics & Dystrophin
Understanding the genetic basis of dystrophin deficiency. This page includes research identifying the point mutation responsible for the mdx phenotype and clarifying the molecular basis of muscular dystrophy in this model.
🧪 Preclinical Evaluation & Outcome Measures
Applications in therapeutic efficacy studies. The publications listed on this page include research evaluating reliable and sensitive functional, physiological, and pathological endpoints for preclinical drug studies using the mdx mouse.
📖 Model Comparison & Research Overview
Selecting appropriate mouse models for muscular dystrophy research. This page includes a comparative review of mouse models used to investigate muscular dystrophies, including their characteristics, strengths, limitations, and suitability for preclinical research.
- Mouse models for muscular dystrophies: an overview (2020) — see 2020
📚 Key Publications (Timeline)
Key studies in the scientific development of the mdx model. These publications provide a concise overview of the discovery, molecular characterization, preclinical evaluation, and broader positioning of the mdx mouse in muscular dystrophy research.
- X chromosome-linked muscular dystrophy (mdx) in the mouse (1984) — see 1984
- The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation (1989) — see 1989
- Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures (2009) — see 2009
- Mouse models for muscular dystrophies: an overview (2020) — see 2020
Related CLEA Japan product: B10-mdx
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: https://www.clea-japan.com/en/products/other_disease/item_a0295
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1984
- G Bulfield, W G Siller, P A Wight, K J Moore
X chromosome-linked muscular dystrophy (mdx) in the mouse.
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92. doi: 10.1073/pnas.81.4.1189.
1989
- P Sicinski, Y Geng, A S Ryder-Cook, E A Barnard, M G Darlison, P J Barnard
The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
Science. 1989 Jun 30;244(4912):1578-80. doi: 10.1126/science.2662404.
2009
- Christopher F Spurney, Heather Gordish-Dressman, Alfredo D Guerron, Arpana Sali, Gouri S Pandey, Rashmi Rawat, Jack H Van Der Meulen, Hee-Jae Cha, Emidio E Pistilli, Terence A Partridge, Eric P Hoffman, Kanneboyina Nagaraju
Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures
Muscle Nerve. 2009 May;39(5):591-602. doi: 10.1002/mus.21211.
2020
- Maaike van Putten, Erin M Lloyd, Jessica C de Greef, Vered Raz, Raffaella Willmann, Miranda D Grounds
Mouse models for muscular dystrophies: an overview
Dis Model Mech. 2020 Feb 21;13(2):dmm043562. doi: 10.1242/dmm.043562.
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for B10-mdx, along with a related product link and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Which years are included in the reference list on this page?- A: The reference list on this page includes publications from 1984, 1989, 2009, and 2020.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above provide a research-purpose view that points to the same publications listed in the year-based archive.
Q: Where can I find the product page for B10-mdx?- A: The product link is provided in the "Related CLEA Japan product: B10-mdx" section on this page.
Q: How can I contact CLEA Japan about this model?- A: The "Inquiry" section on this page includes a link to the contact form for questions about B10-mdx.
