Kidney Week 2017
This page introduces a Video Poster Series archive created by CLEA Japan, based on a scientific presentation or poster.
Through this content, we share research highlights, model-related findings, and the scientific background behind the presentation in a format that is easy to explore.
Video Poster Series Archive: The SDT fatty rat Chronicles
Video Archive
Overview
This Video Poster Series is based on a scientific presentation/poster presented at Kidney Week 2017.
The presentation evaluates dapagliflozin alone or in combination with ramipril in the uni-nephrectomized SDT fatty rat, a hypertensive, obese, type 2 diabetic model that develops advanced renal complications and a marked decline in glomerular filtration rate (GFR) within 10 weeks.
After 10 weeks of treatment, dapagliflozin alone improved glycemic control and renal histopathological findings, including glomerulosclerosis, fibrosis, and inflammation, without significantly altering GFR. The combination of dapagliflozin and ramipril provided similar glycemic control while further reducing hypertension and better preventing severe GFR decline compared with dapagliflozin alone.
This content provides an overview of the study background, experimental design, and principal findings for researchers interested in diabetic kidney disease models and the preclinical evaluation of combination therapies targeting renal complications.
Poster / PDF
You can access the original presentation poster or PDF here.
[PDF link will be placed here]
Related CLEA Japan product / model
For more information about the related animal model or research resource, please visit the corresponding product or reference page.
