SKG/Jcl Academic Reference List
The SKG/Jcl Academic Reference Archive provides a curated collection of scientific publications featuring the SKG/Jcl mouse supplied by CLEA Japan.
As a spontaneous autoimmune arthritis model associated with altered T-cell signaling, SKG/Jcl has been widely utilized to investigate rheumatoid arthritis, Th17/IL-17-mediated inflammation, cytokine networks, immune cell interactions, and environmentally triggered autoimmunity.
The references collected on this page demonstrate its broad application across studies involving joint inflammation, fungal β-glucan and microbial triggers, bone and muscle complications, interstitial lung disease, and the evaluation of immunomodulatory agents and cell-based therapies. Publications are organized chronologically, allowing researchers to explore the development and expanding translational applications of this model.
For detailed information on the biological characteristics, availability, and ordering information for SKG/Jcl, please visit the corresponding product page.
Research Use Snapshot
- Model type: Spontaneous autoimmune arthritis model driven by altered T-cell signaling
- Key pathology: Th17/IL-17–associated chronic inflammation with potential multi-organ involvement
- Research focus: Autoimmune arthritis mechanisms, cytokine networks, environmental triggers, and translational interventions
- How to browse: Use the research-purpose sections below, then explore the complete reference list by year
🔬 Th17 / IL-17 Axis & Autoimmune Arthritis
Core immunopathology in SKG/Jcl. Representative studies highlight T-cell–driven autoimmune arthritis and Th17/IL-17–linked mechanisms relevant to rheumatoid arthritis research.
- Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice (2003) — see 2003
- Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice (2004) — see 2004
- T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis (2007) — see 2007
- Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model (2007) — see 2007
🧪 Cytokine Network & Immune Cell Crosstalk
Immune network regulation beyond joints. Publications include cytokine-dependent mechanisms, immune cell interactions, and inflammation phenotypes such as interstitial lung disease.
- GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice (2014) — see 2014
- CD11b+Gr-1dim Tolerogenic Dendritic Cell-Like Cells Are Expanded in Interstitial Lung Disease in SKG Mice (2017) — see 2017
- Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice (2015) — see 2015
- Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice (2019) — see 2019
🌱 Microbiome & Environmental Triggers
Trigger-driven onset and exacerbation. Representative papers include fungal β-glucan/Dectin-1 pathways and infection-related exacerbation relevant to environmentally influenced autoimmunity.
- A role for fungal ß-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice (2005) — see 2005
- Cell wall β-glucan derived from Candida albicans acts as a trigger for autoimmune arthritis in SKG mice (2007) — see 2007
- Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice (2016) — see 2016
- The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice (2018) — see 2018
🦴 Bone, Muscle & Systemic Complications
Systemic phenotypes beyond synovitis. These references include periarticular bone deterioration and inflammation-related muscle impairment reported in SKG/Jcl-associated disease settings.
- Autoimmune arthritis deteriorates bone quantity and quality of periarticular bone in a mouse model of rheumatoid arthritis (2016) — see 2016
- The l-Ser analog #290 promotes bone recovery in OP and RA mice (2011) — see 2011
- Inflammatory Cytokine-Induced Muscle Atrophy and Weakness Can Be Ameliorated by an Inhibition of TGF-β-Activated Kinase-1 (2024) — see 2024
💊 Therapeutic Modalities & Translational Intervention
Intervention studies and translational approaches. The reference list includes studies evaluating immunomodulatory agents, cell-based therapies, and drug delivery concepts in SKG/Jcl-associated phenotypes.
- Therapeutic and preventive effects of methotrexate on zymosan-induced arthritis in SKG mice (2009) — see 2009
- Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model (2010) — see 2010
- Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice (2011) — see 2011
- Local transplantation of adipose-derived stem cells has a significant therapeutic effect in a mouse model of rheumatoid arthritis (2020) — see 2020
📚 Key Publications (Timeline)
A quick timeline of representative publications. Use these key papers to understand SKG/Jcl at a glance, then jump to the full year-based list below.
- 2003 — ZAP-70 mutation and spontaneous autoimmune arthritis (foundational model paper) — see 2003
- 2004 — Cytokine contributions to T cell–mediated spontaneous arthritis — see 2004
- 2005 — Dectin-1 / fungal β-glucan trigger in genetically susceptible arthritis — see 2005
- 2007 — IL-17+ Th (Th17) milieu driving autoimmune arthritis — see 2007
- 2007 — CCR6/CCL20 axis in Th17 recruitment to inflamed joints — see 2007
- 2008 — Arthritis and pneumonitis driven by shared T-cell clonotypes (multi-organ relevance) — see 2008
- 2014 — GM-CSF axis in severe interstitial lung disease (SKG-ILD) — see 2014
- 2014 — Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease — see 2014
- 2015 — JAK inhibition (tofacitinib) and immunomodulation in arthritis — see 2015
- 2019 — Tofacitinib and interstitial lung disease improvement (SKG-ILD) — see 2019
- 2024 — Inflammation-induced muscle atrophy and TAK1 inhibition — see 2024
Related CLEA Japan product: SKG/Jcl
References by Year
Related CLEA Japan product: SKG/Jcl
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2001
- Yamaguchi M, Hirai K, Komiya A, Miyamasu M, Furumoto Y, Teshima R, Ohta K, Morita Y, Galli SJ, Ra C, Yamamoto K.
Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone.
Int Immunol. 2001 Jul;13(7):843-51. PMID: 11431414
2003
- Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S.
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.
Nature. 2003; 426(6965): 454-60. [PMID: 14647385]
2004
- Hata H, Sakaguchi N, Yoshitomi H, Iwakura Y, Sekikawa K, Azuma Y, Kanai C, Moriizumi E, Nomura T, Nakamura T, Sakaguchi S.
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.
J Clin Invest. 2004; 114(4): 582-8. [PMID: 15314695]
- Zhao W, Zhang L, Kobari Y, Misaki Y, Yamamoto K.
Analysis of accumulating clonotypes of T cell in joints of a spontaneous murine model of rheumatoid arthritis.
Cell Mol Immunol. 2004; 1(4): 300-3. [PMID: 16225773]
- 坂口 教子, 坂口 志文.
関節炎モデルマウスSKG とZAP-70異常.
炎症と免疫. 2004; 12(3): 345–50.
- 坂口 志文, 坂口 教子.
関節リウマチ動物モデル：自然発症 –SKGマウスとZAP-70異常.
医学のあゆみ. 2004; 209(10); 744-8.
2005
- 坂口 教子, 坂口 志文.
ZAP-70によるT細胞選択偏移と関節リウマチ.
Annual Review 免疫 2005. 2004: 1-7.
- Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S.
A role for fungal ß -glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.
J Exp Med. 2005; 201(6): 949-60. [PMID: 15781585]
- 吉富 啓之, 坂口 志文.
SKGマウス –SKG mice as a model of RA.
日本臨牀. 2005; 63(増刊1): 40-5. [PMID: 15799315]
2006
- 坂口 教子, 坂口 志文.
自己免疫疾患モデル動物から学ぶこと(SKGマウス).
medicina 2006; 43(6): 914-6.
- 田中 聡，坂口 志文.
単一遺伝子変異による自己免疫性関節炎～新しい関節リウマチモデルマウス.
実験医学. 2006; 24(10): 1540-46.
- Kobayashi K, Suda T, Nan-Ya K, Sakaguchi N, Sakaguchi S, Miki I.
Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis.
Inflamm Res. 2006; 55(8): 335-41. [PMID: 16977380]
- Shimon Sakaguchi, Noriko Sakaguchi, Hiroyuki Yoshitomi, Hiroshi Hata, Takeshi Takahashi, Takashi Nomura.
Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.
Semin Immunol. 2006,18(4):199-206. [PMID: 16713715]
2007
- Hida S, Miura NN, Adachi Y, Ohno N.
Cell wall β-glucan derived from Candida albicans acts as a trigger for autoimmune arthritis in SKG mice.
Biol Pharm Bull. 2007; 30(8): 1589-92. [PMID: 17666828]
- Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S.
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
J Exp Med. 2007; 204(1): 41-7. [PMID: 17227914]
- Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S.
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.
J Exp Med. 2007; 204(12): 2803-12. [PMID: 18025126]
2008
- Wakasa-Morimoto C, Toyosaki-Maeda T, Matsutani T, Yoshida R, Nakamura-Kikuoka S, Maeda-Tanimura M, Yoshitomi H, Hirota K, Hashimoto M, Masaki H, Fujii Y, Sakata T, Tsuruta Y, Suzuki R, Sakaguchi N, Sakaguchi S.
Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.
Int Immunol. 2008; 20(10): 1331-42. [PMID: 18711120]
2009
- Kushida T, Ueda Y, Umeda M, Oe K, Okamoto N, Iida H, Abraham NG, Gershwin ME, Ikehara S.
Allogeneic intra-bone marrow transplantation prevents rheumatoidarthritis in SKG/Jcl mice.
J Autoimmun. 2009; 32(3-4): 216-22. [PMID: 19349145]
- Nagate T, Kawai J, Nakayama J.
Therapeutic and preventive effects of methotrexate on zymosan-induced arthritis in SKG mice.
J Vet Med Sci. 2009; 71(6): 713-7. [PMID: 19578278]
2010
- Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H.
Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.
Clin Immunol. 2010; 136(2): 197-204. [PMID: 20421177]
2011
- Ichihara H, Hino M, Makizono T, Umebayashi M, Matsumoto Y, Ueoka R.
Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis.
Bioorg Med Chem Lett. 2011; 21(1): 207-10. [PMID: 21123065]
- Misaki K, Morinobu A, Saegusa J, Kasagi S, Fujita M, Miyamoto Y, Matsuki F, Kumagai S.
Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice.
Arthritis Res Ther. 2011; 13(3): R77. [PMID: 21592365]
- Bahtiar A, Nakamura T, Kishida K, Katsura J, Nitta M, Ishida-Kitagawa N, Ogawa T, Takeya T.
The l-Ser analog #290 promotes bone recovery in OP and RA mice.
Pharmacol Res. 2011 Sep;64(3):203-9. [PMID: 21605676]
2013
- Inoue K, Inoue E, Imai Y.
Female sex hormones ameliorate arthritis in SKG mice.
Biochem Biophys Res Commun. 2013 May 17;434(4):740-5. [PMID: 23583379]
2014
- Shiomi A, Usui T, Ishikawa Y, Shimizu M, Murakami K, Mimori T.
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
J Immunol. 2014 Jul 15;193(2):849-59. [PMID: 24951817]
- Murata K, Yoshitomi H, Furu M, Ishikawa M, Shibuya H, Ito H, Matsuda S.
MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK.
Arthritis Rheumatol. 2014 Mar;66(3):549-59. [PMID: 24574214]
- Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.
Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077. [PMID: 25324392]
- Li M, Guo K, Ikehara S.
Intractable diseases treated with intra-bone marrow-bone marrow transplantation
Front Cell Dev Biol. 2014 Sep 2;2:48. doi: 10.3389/fcell.2014.00048. PMCID: PMC4206987
2015
- Matsumoto Y, Ichihara H, Hino M, Umebayashi M, Ueoka R.
Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis.
Drug Deliv. 2015;22(5):619-26. [PMID: 24344811]
- Nishimura K, Saegusa J, Matsuki F, Akashi K, Kageyama G, Morinobu A.
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.
Arthritis Rheumatol. 2015 Apr;67(4):893-902. [PMID: 25545152]
2016
- Onishi S, Sakane M, Tsukanishi T, Funayama T, Ozeki E, Hara I, Yamazaki M.
Near-infrared fluorescence imaging with indocyanine green-lactosomes in a mouse model of rheumatoid arthritis.
Mod Rheumatol. 2016 May 4:1-6. [PMID: 27141810]
- Yamakawa M, Ouhara K, Kajiya M, Munenaga S, Kittaka M, Yamasaki S, Takeda K, Takeshita K, Mizuno N, Fujita T, Sugiyama E, Kurihara H.
Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.
Clin Exp Immunol. 2016 Nov;186(2):177-189. [PMID: 27465496]
- Shimizu T, Takahata M, Kimura-Suda H, Kameda Y, Endo K, Hamano H, Hiratsuka S, Ota M, Sato D, Ito T, Todoh M, Tadano S, Iwasaki N.
Autoimmune arthritis deteriorates bone quantity and quality of periarticular bone in a mouse model of rheumatoid arthritis.
Osteoporos Int. 2016 Oct 4. [PMID: 27704183]
- Samra Sardar, Åsa Andersson.
Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development.
Immunopharmacol Immunotoxicol. 2016; 38(1):2-13. [PMID: 26769136]
2017
- Okano T, Saegusa J, Nishimura K, Takahashi S, Sendo S, Ueda Y, Morinobu A.
3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation.
Sci Rep. 2017 Feb 10;7:42412. [PMID: 28186160]
- Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A.
Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis Res Ther. 2017 Apr 11;19(1):76. [PMID: 28399896]
- Moriya N, Shibasaki S, Karasaki M, Iwasaki T.
The Impact of MicroRNA-223-3p on IL-17 Receptor D Expression in Synovial Cells.
PLoS One. 2017 Jan 5;12(1):e0169702. [PMID: 28056105]
- Jeong H, Bae EK, Kim H, Eun YH, Kim IY, Kim H, Lee J, Jeon CH, Koh EM, Cha HS.
Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model.
Arthritis Res Ther. 2017 Sep 7;19(1):198. [PMID: 28882159]
- Jeong H, Bae EK, Kim H, Lim DH, Chung TY, Lee J, Jeon CH, Koh EM, Cha HS.
Spondyloarthritis features in zymosan-induced SKG mice.
Joint Bone Spine. 2017 Nov 29. pii: S1297-319X(17)30198-7. [PMID: 29197633]
- Shimizu T, Takahata M, Kimura-Suda H, Kameda Y, Endo K, Hamano H, Hiratsuka S, Ota M, Sato D, Ito T, Todoh M, Tadano S, Iwasaki N.
Autoimmune arthritis deteriorates bone quantity and quality of periarticular bone in a mouse model of rheumatoid arthritis.
Osteoporos Int. 2017 Feb;28(2):709-718. [PMID: 27704183]
- Sendo S, Saegusa J, Okano T, Takahashi S, Akashi K, Morinobu A.
CD11b+Gr-1dim Tolerogenic Dendritic Cell-Like Cells Are Expanded in Interstitial Lung Disease in SKG Mice.
Arthritis Rheumatol. 2017 Dec;69(12):2314-2327. [PMID: 28805019]
2018
- Munenaga S, Ouhara K, Hamamoto Y, Kajiya M, Takeda K, Yamasaki S, Kawai T, Mizuno N, Fujita T, Sugiyama E, Kurihara H.
The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice.
Arthritis Res Ther. 2018 Nov 3;20(1):247. [PMID: 30390695]
- Jeong H, Bae EK, Kim H, Lim DH, Chung TY, Lee J, Jeon CH, Koh EM, Cha HS.
Spondyloarthritis features in zymosan-induced SKG mice.
Joint Bone Spine. 2018 Oct;85(5):583-591. [PMID: 29197633]
- Sato T, Konno J, Sekiguchi A, Yoneki N, Kawano K, Hayashi T, Ogawa Y, Kikitsu A, Aijima T, Hara K, Hara S, Hayashi H, Fuchigami K, Igo N, Takashima Y, Kobayashi Y, Mori M, Yamamoto K, Niwa M, Saiga K, Ichimura E.
Long-lasting immunosuppressive effects of tacrolimus-loaded micelle NK61060 in preclinical arthritis and colitis models.
Ther Deliv. 2018 Oct;9(10):711-729. [PMID: 30390695]
- M Arifur Rahman, Ranjeny Thomas.
The SKG model of spondyloarthritis.
Best Pract Res Clin Rheumatol. 2017;31(6):895-909. [PMID: 30509448]
2019
- Kustiarini DA, Nishigaki T, Kanno H, To H.
Effects of Morinda citrifolia on Rheumatoid Arthritis in SKG Mice.
Biol Pharm Bull. 2019;42(3):496-500. [PMID: 30828080]
- Sendo S, Saegusa J, Yamada H, Nishimura K, Morinobu A.
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice.
Arthritis Res Ther. 2019 Aug 6;21(1):184. [PMID: 31387650]
- Kashiuchi S, Miyazawa R, Nagata H, Shirai M, Shimizu M, Sone H, Kamiyama S.
Effects of administration of glucosamine and chicken cartilage hydrolysate on rheumatoid arthritis in SKG mice.
Food Funct. 2019 Aug 1;10(8):5008-5017. [PMID: 31355395]
2020
- Hideki Ueyama, Tadashi Okano, Kumi Orita, Kenji Mamoto, Satoshi Sobajima, Hideki Iwaguro, Hiroaki Nakamura.
Local transplantation of adipose-derived stem cells has a significant therapeutic effect in a mouse model of rheumatoid arthritis.
Sci Rep. 2020 Feb 20;10(1):3076. [PMID: 32080313]
- Sungsin Jo, Eun Jeong Won, Moon-Ju Kim, Yu Jeong Lee, So-Hee Jin, Pu-Reum Park, Ho-Chun Song, Jahae Kim, Yoo-Duk Choi, Ji-Young Kim, Seung Cheol Shim, Sung Hoon Choi, Ye-Soo Park, Tae-Hwan Kim 1, Tae-Jong Kim.
STAT3 Phosphorylation Inhibition for Treating Inflammation and New Bone Formation in Ankylosing Spondylitis.
Rheumatology (Oxford). 2020 Nov 25;keaa846. [PMID: 33237331]
- Ueda T, Kumagai A, Iriguchi S, Yasui Y, Miyasaka T, Nakagoshi K, Nakane K, Saito K, Takahashi M, Sasaki A, Yoshida S, Takasu N, Seno H, Uemura Y, Tamada K, Nakatsura T, Kaneko S.
Non–clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell‐derived anti–glypican‐3 chimeric antigen receptor‐expressing natural killer/innate lymphoid cells
Cancer Sci. 2020 Mar 31;111(5):1478-1490. doi: 10.1111/cas.14374. PMCID: PMC7226201
2021
- Kim HJ, Kim JY, Lee SH, Yang H, Kim K.
Anti-Arthritic Effect of TLR4 Inhibitor TAK-242 Through the Inhibition of Th1 and Th17 Cell Proliferation in a Curdlan-Induced Spondyloarthritis SKG Mouse Model.
DOI: 10.21203/rs.3.rs-156812/v1. [Research Square preview]
- Kataoka T, Naoe S, Murakami K, Yukimine R, Fujimoto Y, Kanzaki N, Sakoda A, Mitsunobu F, Yamaoka K.
Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
J Clin Biochem Nutr. 2021 Nov 26;70(2):154-159. doi: 10.3164/jcbn.21-91. PMCID: PMC8921724
- Wu X, Yokoyama Y, Takahashi H, Kouda S, Yamamoto H, Wang J, Morimoto Y, Minami K, Hata T, Shamma A, Inoue A, Ohtsuka M, Shibata S, Kobayashi S, Akai S, Yamamoto H.
Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method
J Pers Med. 2021 Nov 8;11(11):1160. doi: 10.3390/jpm11111160. PMCID: PMC8623677
- Mizutani S, Nishio J, Kondo K, Motomura K, Yamada Z, Masuoka S, Yamada S, Muraoka S, Ishii N, Kuboi Y, Sendo S, Mikami T, Imai T, Nanki T.
Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice
Pharmaceuticals (Basel). 2021 May 17;14(5):474. doi: 10.3390/ph14050474. PMCID: PMC8156344
- Huffman KM, Andonian BJ, Abraham DM, Bareja A, Lee DE, Katz LH, Huebner JL, Kraus WE, White JP.
Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis
J Appl Physiol (1985). 2021 Jan 7;130(3):853-864. doi: 10.1152/japplphysiol.00576.2020. PMCID: PMC7988790
2022
- Kataoka T, Naoe S, Murakami K, Yukimine R, Fujimoto Y, Kanzaki N, Sakoda A, Mitsunobu F, Yamaoka K.
Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
J Clin Biochem Nutr. 2022 Mar;70(2):154-159. doi: 10.3164/jcbn.21-91. Epub 2021 Nov 26.
- Hama S, Kirimura N, Obara A, Takatsu H, Kogure K.
Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice
Molecules. 2022 Feb 20;27(4):1425. doi: 10.3390/molecules27041425. PMCID: PMC8880618
- Kataoka T, Naoe S, Murakami K, Fujimoto Y, Yukimine R, Tanaka A, Yamaoka K.
Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice
Int J Environ Res Public Health. 2022 Aug 26;19(17):10632. doi:10.3390/ijerph191710632. PMCID: PMC9518351
2023
- Jung S, Lee JS.
Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases
Mol Cells. 2023 Feb 22;46(2):120-129. doi: 10.14348/molcells.2023.0002. PMCID: PMC9982059
2024
- Kanai M, Ganbaatar B, Endo I, Ohnishi Y, Teramachi J, Tenshin H, Higa Y, Hiasa M, Mitsui Y, Hara T, Masuda S, Yamagami H, Yamaguchi Y, Aihara KI, Sebe M, Tsutsumi R, Sakaue H, Matsumoto T, Abe M.
Inflammatory Cytokine-Induced Muscle Atrophy and Weakness Can Be Ameliorated by an Inhibition of TGF-β-Activated Kinase-1.
Int J Mol Sci. 2024 May 24;25(11):5715. doi: 10.3390/ijms25115715.
- Chang SH, Jung S, Chae JJ, Kim JY, Kim SU, Choi JY, Han HJ, Kim HT, Kim HJ, Kim HJ, Park WY, Sparks JA, Lee EY, Lee JS.
Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation
EBioMedicine. 2024 Oct;108:105339. doi: 10.1016/j.ebiom.2024.105339. Epub 2024 Sep 19.PMID: 39303666
- Fujikawa Y, Sendo S, Del Peral Fanjul A, Yamada H, Uto K, Yamamoto Y, Nagamoto T, Morinobu A, Saegusa J.
Myeloid-derived suppressor cell-derived osteoclasts with bone resorption capacity in the joints of arthritic SKG mice
Front Immunol. 2024 Mar 19;15:1168323. doi: 10.3389/fimmu.2024.1168323. eCollection 2024.PMID: 38566990
2025
- Wu X, Jiang L, Cao Y, Wang P, Wang W, Zhang X.
Sex Differences and Androgen Regulation Shape Mucosal Immune Phenotype, Gut Microbiota, and Microbiota-Derived Lactate in SKG Arthritis Model
J Inflamm Res. 2025 Nov 14;18:15911-15924. doi: 10.2147/JIR.S552491. eCollection 2025.PMID: 41262153
- Kim MJ, Yoo HM, Lee YJ, Jang HH, Shim SC, Won EJ, Kim TJ.
Clonorchis sinensis excretory/secretory proteins ameliorate inflammation in rheumatoid arthritis and ankylosing spondylitis
Parasit Vectors. 2025 Mar 4;18(1):85. doi: 10.1186/s13071-025-06677-3.PMID: 40038824
- Xue J, Nian M, Liang Y, Zhu Z, Hu Z, Jia Y, Chi S, Chen J.
Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease
Respir Res. 2025 Jan 22;26(1):33. doi: 10.1186/s12931-025-03111-1.PMID: 39844268
- Yamamoto K, Kishida T, Yamamoto T, Sowa Y, Seki M, Mazda O.
Chemical direct conversion of human fibroblasts to mesenchymal stem cells that can alleviate inflammation in vivo
Stem Cell Res Ther. 2025 Oct 30;16(1):597. doi: 10.1186/s13287-025-04605-x. PMCID: PMC12574161
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for SKG/Jcl, including a related product link and publications organized by year.
Q: How are the references organized?- A: References are presented in the “References by Year” list. You can jump to each year using the year index on this page.
Q: Can I browse representative references by research purpose?- A: Yes. The research-purpose sections highlight representative publications and link to the same items within the year-based reference list.
Q: Where can I find the product page for SKG/Jcl?- A: The product link is provided in the “Related CLEA Japan product: SKG/Jcl” section on this page.
Q: How can I contact CLEA Japan about this model?- A: The “Inquiry” section on this page includes a link to the contact form for questions about SKG/Jcl.
