SKG/Jcl
Animals/Other Disease Models and Germ-Free Animals/
Ordering name: SKG/Jcl
Nomenclature: BALB/c-Zap70m1Saka/Jcl
Availability: Live colony
Not genetically modified animal
Origin
SKG mouse (SKG/Jcl) shows natural symptom of human rheumatoid arthritis (RA)-like autoimmune arthritis, so it may be a new useful human RA animal model.
This strain was found at the BALB/c mouse colony as the one that showed joint swellings by Dr. Shimon Sakaguchi in 1994. The swellings were considered to result from a genetic mutation, so the strain was bred by sib mating and established as a human RA-like spontaneous autoimmune arthritis mutant animal model.
This strain was introduced to CLEA Japan from Kyoto University Institute for Frontier Medical Sciences in 1999 (at that time the strain was F12) and started supplying from 2006 (F21 in Dec. 2005).
Detailed Catalog (PDF)
Model Highlights & Key Findings (from PDF)
Some of the materials in the PDF document are excerpted here.
▼ Macroscopic findings of arthritis in the SKG mouse
Download Full Catalog (English PDF)
▼ For more details ▼
Related resources
◆ References
◆ Confirmation of the rheumatoid arthritis-inducing effect of mannan
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .
FAQ
What is SKG/Jcl?
SKG/Jcl is a rheumatoid arthritis (RA) model mouse that shows natural symptoms of human RA-like autoimmune arthritis. It is considered a useful animal model for studying human rheumatoid arthritis.
Is SKG/Jcl genetically modified?
No. SKG/Jcl is a Not genetically modified animal.
How was the SKG mouse established?
The SKG strain was discovered in 1994 in a BALB/c mouse colony by Dr. Shimon Sakaguchi as mice showing joint swellings. The condition was considered to result from a genetic mutation, and the strain was established through sib mating as a spontaneous autoimmune arthritis model.
When did CLEA Japan start supplying SKG/Jcl?
The strain was introduced to CLEA Japan from Kyoto University Institute for Frontier Medical Sciences in 1999 and has been supplied by CLEA Japan since 2006.
Is there evidence confirming arthritis induction in SKG mice?
Yes. The page provides confirmation data of the rheumatoid arthritis-inducing effect of mannan, as well as references and a detailed catalog describing macroscopic findings of arthritis in the SKG mouse.
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