Jcl:SD Academic Reference List
This Academic Reference Archive provides a collection of representative scientific publications using Jcl:SD, CLEA Japan's Sprague-Dawley outbred rat for general biomedical and preclinical research.
The references cover a broad range of research applications, including toxicology, carcinogenesis, reproductive toxicology, pharmacokinetics, drug metabolism, ophthalmology, imaging, vaccine evaluation, and other experimental studies. Publications are organized by year to help researchers explore how Jcl:SD rats have been used across different research fields.
For detailed information on animal characteristics, specifications, and product availability, please visit the corresponding Jcl:SD product page.
Research Use Snapshot
- Product type: Sprague-Dawley outbred rat (Jcl:SD)
- Typical applications: General biomedical research, toxicology, safety evaluation, pharmacokinetics, reproductive toxicology, carcinogenesis, imaging, ophthalmology, and preclinical evaluation.
- Evidence on this page: Publications covering gastric and bladder carcinogenesis, platelet aggregation and toxicity studies, reproductive toxicology, drug metabolism, cataract induction, CT imaging, ophthalmic measurements, and vaccine safety evaluation.
- How to browse: Use the topic sections below for selected representative papers, or use the year index to access the complete list of references from 1987 through 2023.
☣️ Toxicology & Safety Evaluation
Evaluating toxicological responses and chemical safety using Jcl:SD rats. These publications demonstrate the broad application of Jcl:SD rats in toxicology, including studies of platelet function, vitamin toxicity, antioxidant safety, and systemic toxicological evaluation.
- Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin. (1991) — see 1991
- A large dose of ergocalciferol does not cause deficient blood coagulation but is extremely toxic to rats. (1993) — see 1993
- Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. (1995) — see 1995
🧬 Carcinogenesis & Experimental Oncology
Supporting cancer research through experimental carcinogenesis models. These studies utilize Jcl:SD rats to investigate gastric, bladder, skin, and mammary carcinogenesis, providing valuable models for cancer biology and toxicological pathology.
- Induction of gastric tumor and intestinal metaplasia in rats exposed to localized X-irradiation of the gastric region. (1987) — see 1987
- Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to bladder carcinogenesis. (2000) — see 2000
- Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats. (2004) — see 2004
🧫 Reproductive & Developmental Toxicology
Assessing reproductive toxicity and developmental effects in Jcl:SD rats. These publications include studies of spermatotoxicity, abnormal sperm morphology, and reproductive toxicology endpoints, supporting the use of Jcl:SD rats in safety evaluation and reproductive research.
- Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals. (2004) — see 2004
- Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male rats after treatment with 4,6-dinitro-o-cresol. (2006) — see 2006
💊 Pharmacokinetics & Drug Metabolism
Investigating strain-related drug metabolism and pharmacokinetic characteristics. These studies use Jcl:SD rats to evaluate metabolic pathways involving aldehyde oxidase, xanthine oxidase, cytochrome P450, and related in vivo–in vitro relationships in drug metabolism research.
- In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats. (2006) — see 2006
- Strain difference of oxidative metabolism of the sedative-hypnotic zaleplon by aldehyde oxidase and cytochrome P450 in vivo and in vitro in rats. (2013) — see 2013
- Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats. (2022) — see 2022
🩺 Imaging, Ophthalmology & Clinical Assessment
Supporting imaging, ophthalmic evaluation, and clinical measurement studies. Publications in this section include applications of Jcl:SD rats in cataract induction, computed tomography imaging, electroretinogram-related assessment, and other measurement-based preclinical studies.
- Rapid induction of cataract by a single intraperitoneal administration of N-methyl-N-nitrosourea in 15-day-old Sprague-Dawley (Jcl: SD) rats. (2002) — see 2002
- A comparative study for spatial resolution and subjective image characteristics of a multi-slice CT and a cone-beam CT for dental use. (2011) — see 2011
- Differences in the Effects of Pentobarbital Anesthetic and Combination of Medetomidine Hydrochloride, Midazolam, and Butorphanol Tartrate Anesthetic on Electroretinogram in Spontaneously Diabetic Torii Fatty Rats. (2022) — see 2022
🦠 Vaccine & Translational Research
Supporting translational and preclinical evaluation studies. This section includes recent applications of Jcl:SD rats in vaccine-related research and broader preclinical evaluation, demonstrating their utility in safety, immunogenicity, and efficacy assessment.
📚 Key Publications (Timeline)
Representative publications illustrating the range of Jcl:SD research applications. This timeline highlights selected studies from toxicology, carcinogenesis, reproductive toxicology, pharmacokinetics, imaging, ophthalmology, and vaccine evaluation, showing how Jcl:SD rats have been used across general biomedical and preclinical research.
- Induction of gastric tumor and intestinal metaplasia in rats exposed to localized X-irradiation of the gastric region. (1987) — see 1987
- Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin. (1991) — see 1991
- Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis. (2000) — see 2000
- Rapid induction of cataract by a single intraperitoneal administration of N-methyl-N-nitrosourea in 15-day-old Sprague-Dawley (Jcl: SD) rats. (2002) — see 2002
- Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals. (2004) — see 2004
- Strain difference of oxidative metabolism of the sedative-hypnotic zaleplon by aldehyde oxidase and cytochrome P450 in vivo and in vitro in rats. (2013) — see 2013
- Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats. (2022) — see 2022
- Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant. (2023) — see 2023
Related CLEA Japan product: Jcl:SD
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1987
- Watanabe H, Nakagawa Y, Ito A.
Induction of gastric tumor and intestinal metaplasia in rats exposed to localized X-irradiation of the gastric region
Jpn J Cancer Res. 1987 Jan;78(1):27-31. PMID: 3102435
1991
- Takahashi O.
Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin.
Food Chem Toxicol. 1991 Mar;29(3):173-83. doi: 10.1016/0278-6915(91)90035-6.
1993
- Takahashi O.
A large dose of ergocalciferol does not cause deficient blood coagulation but is extremely toxic to rats.
Toxicol Lett. 1993 Sep;69(3):257-72. doi: 10.1016/0378-4274(93)90031-r.
1995
- Takahashi O.
Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
Food Chem Toxicol. 1995 Feb;33(2):121-8. doi: 10.1016/0278-6915(94)00120-d.
2000
- Ota T, Asamoto M, Toriyama-Baba H, Yamamoto F, Matsuoka Y, Ochiya T, Sekiya T, Terada M, Akaza H, Tsuda H.
Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis.
Carcinogenesis. 2000 Jul;21(7):1391-6.
2002
- Kiuchi K, Yoshizawa K, Moriguchi K, Tsubura A.
Rapid induction of cataract by a single intraperitoneal administration of N-methyl-N-nitrosourea in 15-day-old Sprague-Dawley (Jcl: SD) rats.
Exp Toxicol Pathol. 2002 Nov;54(3):181-6. doi: 10.1078/0940-2993-00253.
2003
- Nakatsukasa E, Kashiwazaki N, Takizawa A, Shino M, Kitada K, Serikawa T, Hakamata Y, Kobayashi E, Takahashi R, Ueda M, Nakashima T, Nakagata N.
Cryopreservation of spermatozoa from closed colonies, and inbred, spontaneous mutant, and transgenic strains of rats.
Comp Med. 2003 Dec;53(6):639-41.
2004
- Park CB, Fukamachi K, Takasuka N, Han BS, Kim CK, Hamaguchi T, Fujita K, Ueda S, Tsuda H.
Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate.
Cancer Sci. 2004 Mar;95(3):205-10. doi: 10.1111/j.1349-7006.2004.tb02204.x.
- Takahashi KL, Hojo H, Aoyama H, Teramoto S.
Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals.
Reprod Toxicol. 2004 Jun;18(4):581-8. doi: 10.1016/j.reprotox.2004.02.009.
2006
- Takahashi KL, Takahashi N, Hojo H, Kuwahara M, Aoyama H, Teramoto S.
Pathogenetic transition in the morphology of abnormal sperm in the testes and the caput, corpus, and cauda epididymides of male rats after treatment with 4,6-dinitro-o-cresol.
Reprod Toxicol. 2006 Oct;22(3):501-7. doi: 10.1016/j.reprotox.2006.03.018. Epub 2006 May 18.
- Moriyasu A, Sugihara K, Nakatani K, Ohta S, Kitamura S.
In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats.
Drug Metab Pharmacokinet. 2006 Dec;21(6):485-91. doi: 10.2133/dmpk.21.485.
2011
- Watanabe H, Honda E, Tetsumura A, Kurabayashi T.
A comparative study for spatial resolution and subjective image characteristics of a multi-slice CT and a cone-beam CT for dental use.
Eur J Radiol. 2011 Mar;77(3):397-402. doi: 10.1016/j.ejrad.2009.09.023. Epub 2009 Oct 9.
2013
- Tanoue C, Sugihara K, Uramaru N, Watanabe Y, Tayama Y, Ohta S, Kitamura S.
Strain difference of oxidative metabolism of the sedative-hypnotic zaleplon by aldehyde oxidase and cytochrome P450 in vivo and in vitro in rats.
Drug Metab Pharmacokinet. 2013;28(3):269-73. doi: 10.2133/dmpk.dmpk-12-nt-103. Epub 2013 Jan 29.
2022
- Hasegawa T, Takagi R, Tanaka Y, Ohta T, Shinohara M, Kageyama Y, Sasase T, Muramatsu SI, Kaburaki T, Kakehashi A.
Differences in the Effects of Pentobarbital Anesthetic and Combination of Medetomidine Hydrochloride, Midazolam, and Butorphanol Tartrate Anesthetic on Electroretinogram in Spontaneously Diabetic Torii Fatty Rats.
Biomed Hub. 2022 Sep 9;7(3):106-114. doi: 10.1159/000526189. eCollection 2022 Sep-Dec.
- Tayama Y, Sugihara K, Sanoh S, Miyake K, Kitamura S, Ohta S.
Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats.
J Pharm Health Care Sci. 2022 Dec 8;8(1):31. doi: 10.1186/s40780-022-00262-x.
2023
- Phoolcharoen W, Shanmugaraj B, Khorattanakulchai N, Sunyakumthorn P, Pichyangkul S, Taepavarapruk P, Praserthsee W, Malaivijitnond S, Manopwisedjaroen S, Thitithanyanont A, Srisutthisamphan K, Jongkaewwattana A, Tomai M, Fox CB, Taychakhoonavudh S.
Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant.
Vaccine. 2023 Apr 24;41(17):2781-2792. doi: 10.1016/j.vaccine.2023.03.027. Epub 2023 Mar 21.
FAQ
- Q: What is included on this page?
- A: This page provides an academic reference list for Jcl:SD, along with a related product section and an inquiry link.
Q: How are the references organized?- A: References are presented in the original "References by Year" list. You can jump to each year using the year index on this page.
Q: Can I browse the same references by research purpose?- A: Yes. The topic-based sections above organize representative publications by research purpose and provide links to the corresponding year in the complete reference archive.
Q: Which years are available in the References by Year index?- A: The year index on this page includes publications from 1987 through 2023.
Q: Where can I find the related product information for Jcl:SD?- A: The related product information is provided in the "Related CLEA Japan product: Jcl:SD" section on this page.
Q: How can I contact CLEA Japan about Jcl:SD?- A: The "Inquiry" section on this page includes a link to the contact form for questions about Jcl:SD.
