ODS/ShiJcl-od/od
Animals/Other Disease Models and Germ-Free Animals/
Ordering name: ODS/ShiJcl-od/od
Nomenclature: ODS/ShiJcl-Gulood
Availability: Live colony
Origin
Dr. Susumu Makino and his colleagues found several animals that had gait abnormalities among Wistar-Shionogi rats that they were maintaining. They named these animals osteogenic disorder (OD) rats because they exhibited prominent bone and joint abnormalities and systemic bleeding. Subsequent studies revealed that these symptoms were derived from an ascorbic acid (vitamin C) deficiency arising from defective gulonolactone oxidase (GLO) activity. This characteristic was confirmed to be the result of a mutation involving the autosomal single recessive gene od. As part of a contract with Shionogi & Co., Ltd., the production and supply of this strain was begun. denotes the origin from Shionogi & Co., Ltd.
Characteristics
In a state of vitamin C deficiency, rats develop a gait abnormality, poor food intake, weight loss, bleeding from systemic tissue (scorbutic state), systemic dysostosis, multiple bone fractures, osteoporosis, etc., resulting in death.
Use
- Studies on metabolism and excretion of xenobiotics (various chemical substances, drugs, etc. for human) and cholesterol
- Nutritional physiological investigations of the brain
- Studies on antiviral and antitumor effects
- Studies on scurvy and various bone abnormalities
Methods of production and maintenance
The ODS/ShiJcl-od/od strain is produced by mating od/od males x females, and the ODS/ShiJcl-+/+ strain is produced by mating +/+ males x females. Breeding is performed in accordance with the method used for other inbred rat strains. These rats are given autoclaved CE-2 and water containing chlorine (4 - 6 ppm) and L-ascorbic acid (1g/500cc) ad libitum.