Ordering name: BALB/cAJcl
Nomenclature: BALB/cAJcl, BALB/cByJJcl
Availability: Live colony
Albino mice maintained by Bagg were transferred to McDowell and Snell and named “BALB,” after “Bagg’s albinos.” Many sublines were produced from BALB/c mice maintained by Snell. BALB/cA mice were introduced with BALB/cA-nu from Dr. C. W. Friis (Denmark) to the Central Institute for Experimental Animals in 1973, and BALB/cA mice at F?+21 were later introduced to CLEA Japan, Inc., in 1989. In addition, BALB/c mice were brought to Bailey (BALB/cBy) and were introduced to the Jackson Laboratory in 1974 (BALB/cByJ*). BALB/cByJ mice at F156 were introduced from the Jackson Laboratory to CLEA Japan, Inc. in 1986, and production was then started.
(*This substrain is at least (a number>20 by definition) generations removed from the originating JAXⓇ Mice strain and has NOT been re-infused with pedigreed stock from The Jackson Laboratory.)
[History of cryopreservation]
BALB/cAJcl: Not applicable
BALB/cByJJcl:F166(F156+10), frozen in October 1991
[Generation number as of August 2002]
These mice are albinos (AA bb cc DD) with relatively low frequencies of various spontaneously appearing tumors. The mice exhibit white spots arising from calcification in the cardiac tissue. BALB/cByJ is the most frequently used subline in Europe.
These mice are used in the field of immunity and monoclonal antibody research, screening, etc.