NOD/ShiJic-scidJcl
Animals/Immunodeficiency Models/
Ordering name: NOD/ShiJic-scidJcl
Nomenclature: NOD.CB17-Prkdcscid/Jcl
Availability: Live colony
Not genetically modified animal
Characteristics
NOD/ShiJic-scid mice lack functional T cells and B cells and show decreased NK activity, complement activity, and macrophage function.
This strain was established by introducing the scid (Prkdcscid) mutant gene from the C.B-17-scid strain into NOD/Shi mice through 10 generations of progeny formation.
The scid mutation was originally discovered by Dr. Melvin J. Bosma at the Fox Chase Cancer Center in 1983.
NOD/Shi mice are a type 1 diabetes murine model supplied by the Central Institute for Experimental Medicine and Life Science (CIEM).
This strain was introduced to CLEA Japan, Inc. from CIEM in 2006, and production and supply as NOD/ShiJic-scidJcl began in 2007.
※The following are the formal names for each animal in our company:
*1 BALB/cAJcl-nu/nu, *2 C.B-17/Icr-scid/scidJcl, *3NOD/ShiJic-scidJcl
Background Data (weight, blood property, blood biochemistry, organ weight)
- NOD/ShiJic-scidJcl: 10-week data (*Japanese)
- NOD/ShiJic-scidJcl: Reference archive
Rearing management of immunodeficiency models
Microbiological control of immunodeficiency model animals should be managed strictly due to their susceptibility to opportunistic infections as well as pathogens affecting mice and rats.
- Workers must wear specialized protective clothing covering all exposed skin and use respiratory filters.
- Supply boiled and chlorine-added water and autoclaved diet (CL-2).
- Prevent contamination using filter caps and handle animals with tweezers or disposable gloves.
The use of a dedicated rearing room or specialized rearing device is recommended.
Detailed Catalog (PDF)
Model Highlights & Functional Characteristics
Some of the materials in the PDF document are excerpted here.
▼ NK activity
▼ Impaired macrophage function
Download Detailed Study (Japanese)
▼ For more details (*Japanese) ▼
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .
FAQ
What is NOD/ShiJic-scidJcl?
NOD/ShiJic-scidJcl is an immunodeficiency model mouse that lacks functional T cells and B cells and exhibits decreased NK activity, complement activity, and macrophage function.
Is NOD/ShiJic-scidJcl genetically modified?
No. NOD/ShiJic-scidJcl is a Not genetically modified animal.
How was NOD/ShiJic-scidJcl established?
This strain was established by introducing the scid (Prkdcscid) mutant gene from the C.B-17-scid strain into NOD/Shi mice through 10 generations of progeny formation. The scid mutation was originally discovered by Dr. Melvin J. Bosma in 1983.
When did CLEA Japan start supplying this strain?
The strain was introduced to CLEA Japan from the Central Institute for Experimental Medicine and Life Science (CIEM) in 2006, and production and supply as NOD/ShiJic-scidJcl began in 2007.
Are there special rearing requirements for NOD/ShiJic-scidJcl?
Yes. Due to their immunodeficiency, strict microbiological control is required. Protective clothing and respiratory filters should be used, boiled and chlorine-added water and autoclaved diet (CL-2) should be supplied, and contamination must be prevented using filter caps and careful handling procedures. A dedicated rearing room or specialized rearing device is recommended.
Inquiry
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