C.B-17/Icr-scid/scidJcl
Animals/Immunodeficiency Models/
Ordering name: C.B-17/Icr-scid/scidJcl
Nomenclature: CB17/IcrJcl-Prkdcscid
Availability: Live colony
Origin
Dr. M. J. Bosma and his colleagues at the Fox Chase Cancer Center found mutant mice that have symptoms similar to human severe combined immunodeficiency among C.B-17/lcr mice from a congenic strain of BALB/cAn with a different Igh gene locus. Because the characteristics are under the control of a single recessive gene, the gene was named scid. After establishing a contract with the Cancer Center, we started the production and supply of this species.
Characteristics
Because homozygotes (scid/scid) lack functional T cells and B cells, there is hardly any production of immunoglobulin in addition to the absence of cell immunity. These mice present with symptoms similar to those of human severe combined immunodeficiency. After judging the presence/absence of immunoglobulin production at 4 weeks after birth, we supply 5-week-old or older mice, removing Leaky mice.
Use
- Various immunology and cancer studies
- Studies using human hematopoietic cells or transplantation of human tumor cells
- Microbiological studies, etc.
