α-Klotho KO/Jcl
Animals/Genetically Modified Animals/
Ordering name: α-Klotho KO/Jcl
Nomenclature: B6.129-Kltm1Yin/Jcl
Availability: Cryopreserved
Origin
klotho/Jcl is a mutant mouse of alpha-klotho so it is not null mutation actually although the alpha-klotho gene expression chance is extremely low and can be ignored as the functional point of view. In addition, the mutate expression can be back because the alpha-klotho gene expression is recovered by low phosphorus food and etc. Due to the fact that alpha-klotho mouse was created by knocking out the alpha-klotho gene because it is necessary to make null mutation mouse. (Takeshita et al., 2004)
alpha-klotho KO mouse shows the gene mutation expression as the klotho/Jcl stably except slightly better sexual gland maturation because of the C57BL/6 back ground.
Characteristics
This strain grows as normal as its wild type until 3 weeks but stop growing after that.
Phenotype and growth disease
Alpha-klotho mouse shows up-regulation 1 alpha-hydroxylase, makes high serum 1,25(OH)2D,FGF23 and vitamin D precursor change to active form. These characteristics are disappeared by reducing vitamin D activation up-regulation by shading and supplying vitamin D deficiency diet or mating with 1 alpha-hydroxylase (Cyp27b1)gene knockout mouse. The strain can be kept long term by supplying vitamin D deficiency diet.