Animals/Genetically Modified Animals/
Ordering name: α-Klotho KO/Jcl
klotho/Jcl is a mutant mouse of alpha-klotho so it is not null mutation actually although the alpha-klotho gene expression chance is extremely low and can be ignored as the functional point of view. In addition, the mutate expression can be back because the alpha-klotho gene expression is recovered by low phosphorus food and etc. Due to the fact that alpha-klotho mouse was created by knocking out the alpha-klotho gene because it is necessary to make null mutation mouse. (Takeshita et al., 2004)
alpha-klotho KO mouse shows the gene mutation expression as the klotho/Jcl stably except slightly better sexual gland maturation because of the C57BL/6 back ground.
This strain grows as normal as its wild type until 3 weeks but stop growing after that.
Phenotype and growth disease