klotho/Jcl
Animals/Genetically Modified Animals/
Ordering name: klotho/Jcl
Nomenclature: C3;B6-KlTg(SLC9A1)/Jcl
Availability: Cryopreserved
Origin
klotho mouse was found among a mutant group from the mutant gene introduced chimeric mice executed by Dr. Yoichi Nabeshima. The klotho gene was then identified as a cording of new I type membrane protein with having a signal sequence at the N terminal and transmembrane domain structure at the C terminal and relating calcium controlling in vivo mainly. CLEA received the strain from Dr. Nabeshima and started its sales from 2002.
Characteristics
kl/klmouse grows normal until 3 to 4 weeks of age, then shows growth retardation after weaning, and dies around 8 to 9 weeks of age. The external appearance is normal except backward curvature. (Diet is autoclaved CE-2) The other characteristics are as below:
- Hypokinesia and dysbasia
- Thymic sexual organ and atrophy
- Arteriosclerosis
- Osteoporosis
- Ectopic calcification
- Dermatrophy
- Emphysema pulmonum
- Pituitary gland abnormality