KK-Ay/TaJcl
Animals/Diabetes Models/
Ordering name: KK-Ay/TaJcl
Nomenclature: KK.Cg-Ay/TaJcl
Availability: Live colony
Not genetically modified animal
Characteristics
KK-Ay mice are a combined model created by backcrossing the natural obesity gene Ay into KK mice. They develop obesity and hyperglycemia earlier (7-8 weeks of age) and more severely than KK mice. Females, in particular, exhibit marked obesity, exceeding the weight of males around 8 weeks of age. The Ay gene is a dominant gene located on chromosome 2 and is a natural mutation gene with pleiotropic effects, including obesity, hyperglycemia, coat color, and lethality (Ay / Ay).
Male KK-Ay mice are individually housed from 7 weeks of age to prevent fighting-related injuries.
Coat color gene ： aa BB CC DD (yellow)
Use
- Screening for anti-hyperglycemic drugs and analysis and elucidation of complications
◆References
Background Data (weight, blood property, blood biochemistry, organ weight)
◆ KK-Ay/TaJcl 10 weeks of age data (*Japanese) 
Reference
▼ KK-Ay mouse: Diabetic nephropathy model by Unilateral nephrectomy & Salt supplementation / Diet inducting (QF* and WD*)
▼ High-sucrose/high-fat diet promotes nephropathy: Introduction of obese type 2 diabetes model KK-Ay mice
Origin
Around 1910：
Mice were bred as pets in Kasukabe area, Saitama Prefecture, and strains such as KK, KA1, KB2, and KSA were established from the Kasukabe-derived mice.
1962：
Kondo et al. discovered mice exhibiting obesity and hyperglycemia within a tail-kink spontaneous mutant line (K line) of the K strain (Kasekabe) that they had been maintaining for genetic studies. This line attracted attention as a model of non-insulin-dependent diabetes. Nishimura et al. introduced the Ay gene, which exhibits multiple phenotypes such as lethality, yellow coat color, and obesity, into KK mice, creating KK- Ay mice that developed obesity and hyperglycemia earlier and more severely than KK mice.
1963：
Both KK and KK-Ay mice were introduced to Takeda Pharmaceutical Company Limited.
1990：
The mice introduced from Takeda Pharmaceutical Company Limited began to be produced and supplied as KK/TaJcl and KK-Ay/TaJcl.
PDF Catalog
*We have excerpted and included a portion of the document in the PDF.
▽ Blood glucose level
▽ Click here more details ▽
2023 Aggregate Data
Cautions for the Breeding and Experimentation of Diabetic Model Animals
- Acclimation: Please take 3-5 days of acclimation after transportation to avoid hypoglycemia caused by stress.
- Individual Housing: KK-Ay mice should be individually housed to prevent increases in blood glucose levels due to fighting when group-housed.
- Frequent Bedding Changes: Due to polyuria associated with diabetes, please increase the frequency and amount of bedding changes.
- Consistent Measurement: Blood glucose levels can fluctuate based on diet, measurement methods, and sample type (blood, serum, plasma). Please ensure consistent procedures.
Our Contract Research Services related with This Animal
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