Jcl:Wistar
Animals/Outbred Strains/
Ordering name: Jcl:Wistar
Nomenclature: Jcl:Wistar
Availability: Live colony
Characteristics
A medium-sized albino rat with excellent sensitivity to various factors, particularly with superior learning ability.
Chromodacryorrhea: Jcl:Wistar rats often exhibit chromodacryorrhea, a condition characterized by red tears.
While chromodacryorrhea is not observed in mice, rabbits, or guinea pigs, it is known to occur in amphibious animals like hippos in the form of "red sweat". In rats, chromodacryorrhea can be induced within 30-40 minutes by administering acetylcholine or applying adhesive tape for physical restraint, with larger individuals showing earlier onset[1]. These red tears are composed of porphyrin derived from the Harderian gland, and their induction by experimental treatments is inhibited by atropine, suggesting a parasympathetic mechanism[2]. Although chromodacryorrhea is considered a physiological phenomenon in rats, there are strain differences in its occurrence, with Jcl:Wistar rats exhibiting the highest incidence followed by SD and F344 strains. Conversely, this suggests a higher sensitivity in Jcl:Wistar rats.
- Harkness JE, Ridgway MD. Chromodacryorrhea in laboratory rats (Rattus norvegicus): etiologic considerations. Lab Anim Sci. 1980;30(5):841-4.
- Homma et al. Studies on the secretion of red tears in rats. No.13. Proceedings of the Japan Society for Laboratory Animals, p.47, 1978
Origin
This strain is a rat strain originating from the Wistar Institute in Philadelphia (USA). The Wistar Institute was named as a memorial to the famous anatomist Professor Casper Wistar at the University of Pennsylvania. We started the production and supply of this strain after it was introduced from Carworth (UK). The name of the strain has been changed as follows.
- 1970: Animals were imported from Carworth Farms.
- 1972: After cesarean section cleaning, they were supplied as "JCL:Wistar".
- Jcl:Wistar (1981 to date); Changed according to the International Registry.
Use
These rats are used for studies in a variety of fields including behavioral pharmacology, toxicity, pharmacology, drug efficacy, and safety testing.
Background Data (weight, blood property, blood biochemistry, organ weight)
◆ Jcl:Wistar 10 weeks of age data (*Japanese)
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .