ALY/NscJcl-aly/aly
Animals/Immunodeficiency Models/
Ordering name: ALY/NscJcl-aly/aly
Nomenclature: ALY/Nsc-Map3k14aly/Jcl
Availability: Cryopreserved
Origin
Mice lacking lymph nodes and Peyer’s patches were found in a C57BL/6J mouse colony maintained at Nippon Shinyaku Co., Ltd.; it became apparent that these abnormalities were controlled by autosomal chromosome single recessive gene. This gene was named alymphoplasia and was given the gene symbol aly.
Characteristics
These mice lack lymph nodes and Peyer’s patches throughout their bodies. In these mice, immunodeficiency occurs through a mechanism by which hardly any immune response occurs in vivo, although mature T cells and B cells are present.
Use
- Various immunologic studies
- Studies using human hematopoietic cells and transplantation of human tumor cells, etc.
- Microbiologic studies, etc.
Body Weight Curve
