F344/NJcl-rnu/rnu
Animals/Immunodeficiency Models/
Ordering name: F344/NJcl-rnu/rnu
Nomenclature: F344/NJcl.Cg-Foxn1rnu
Availability: Live colony
Not genetically modified animal
Characteristics
Because of the control of the single recessive gene rnu, homozygotes (mu/mu) are anatomically athymic and hairless in appearance (histologically, hair follicles are present and many animals have a hair coat at about 6 weeks after birth). Immunologically, they lack T-cell function. Because rats of this species are larger than nude mice, a greater quantity of tumor cells can be collected, and metastasis may occur depending on the tumor type. These rats have advantageous features that are not found in nude mice; for example, anticancer drugs can be administered via intravenous injection and the transplantation of tumor cells.
Use
- Various immunology and cancer studies
- Screening of anticancer drugs
- Microbiological studies, etc.
Background Data (weight, blood property, blood biochemistry, organ weight)
◆ F344/NJcl-rnu/+rat: 10-week data (*Japanese) 
◆ F344/NJcl-rnu/rnu rat: 10-week data (*Japanese)
Origin
These rats were discovered by chance in a colony of outbred Hooded rats at the Rowett Research Institute and were assigned to the genetic symbol rnu. The Central Institute for Experimental Medicine and Life Science introduced these rats and backcrossed them with inbred F344/N rats; we subsequently started the production and supply of these animals.
Rearing management of immunodeficiency models
Microbiological control of immunodeficiency model animals should be managed strictly because of their properties. Due caution is necessary against opportunistic infections with normal inhabitant microorganisms as well as microorganisms that are pathogenic in mice and rats.
- Requiring workers to wear specialized protective clothing that covers all exposed skin and to use respiratory filters.
- Supply of boiled and chlorine-added water and autoclaved diet (CL-2)
- Prevention of falling bacteria using filter caps and handling animals using tweezers or disposable gloves
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .