rasH2
Animals/Genetically Modified Animals/
Ordering name: rasH2
Nomenclature: CByB6F1-Tg(HRAS)2Jic
Common Name (Genotype): rasH2-Tg (tg/wt), rasH2-Wt (wt/wt)
Availability: Live colony
Genetically modified animal (subject to the Cartagena Protocol on Biosafety)
Origin
CB6F1-TgrasH2 mice created by Dr. Motoya Katsuki et al. with the support of Dr. Tatsuji Nomura, director of the Central Institute for Experimental Medicine and Life Science (CIEM). In 1992, development of a carcinogenicity testing system using CB6F1-TgrasH2 mice (rasH2 mice) started in CIEM. From 1997 to 2000, for four years, high reproducibility and stability of carcinogenicity evaluations using rasH2 mice validated by international collaborative research in 50 industrial, governmental and academic facilities in Europe, Japan and the USA (ILSI/HESI). From 2001, CLEA Japan, Inc. starts production and supply of rasH2 mice.
Characteristics
tumorigenicity by 34weeks of age. It is possible to evaluate carcinogenicity by starting administration of the test substance at 8 weeks of age and assessing tumorigenesis at 26 weeks
Background Data (weight, blood property, blood biochemistry, organ weight)
◆CByB6F1-Tg(HRAS)2Jic (tg/wt) 10 weeks of age data (*Japanese) 
◆CByB6F1-Tg(HRAS)2Jic (wt/wt) 10 weeks of age data (*Japanese) ◆References
Detailed Catalog (PDF)
Some of the materials in the PDF document are excerpted here.
▼ Administration of a genotoxic carcinogen
▼ For more details(*Japanese) ▼
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .