Animals/Genetically Modified Animals/


Ordering name: rasH2
Nomenclature: CByB6F1-Tg(HRAS)2Jic
Common Name (Genotype): rasH2-Tg (tg/wt), rasH2-Wt (wt/wt)
Availability: Live colony


CB6F1-TgrasH2 mice created by Dr. Motoya Katsuki et al. with the support of Dr. Tatsuji Nomura, director of the Central Institute for Experimental Animals (CIEA). In 1992, development of a carcinogenicity testing system using CB6F1-TgrasH2 mice (rasH2 mice) started in CIEA. From 1997 to 2000, for four years, high reproducibility and stability of carcinogenicity evaluations using rasH2 mice validated by international collaborative research in 50 industrial, governmental and academic facilities in Europe, Japan and the USA (ILSI/HESI). From 2001, CLEA Japan, Inc. starts production and supply of rasH2 mice.


tumorigenicity by 34weeks of age. It is possible to evaluate carcinogenicity by starting administration of the test substance at 8 weeks of age and assessing tumorigenesis at 26 weeks