NOD/ShiJcl
Animals/Diabetes Models/
Ordering name: NOD/ShiJcl
Nomenclature: NOD/ShiJcl
Availability: Live colony
Not genetically modified animal
Characteristics
This strain spontaneously develops insulin-dependent diabetes mellitus due to destruction of β cells by insulitis in the Langerhans islets of the pancreas.
Insulitis is a polygenic trait genetically controlled by the presence of major histocompatibility (MHC) antigen and a number of related genes. Since diabetes does not occur in NOD mice homozygously introduced with the nu gene, this characteristic is speculated to be a T cell-dependent autoimmune response.
It has been confirmed that the time of onset and the incidence of diabetes in this strain differ depending on the production lot and rearing environments.
Current production colony survey (As of 2022):
For females, the age of onset is 18 weeks and the cumulative incidence rate is 60% up to 35 weeks of age.
For males, the age of onset is 18 weeks and the cumulative incidence rate is 10% up to 35 weeks of age.
Use
- Elucidation of the etiologic mechanisms of type 1 diabetes mellitus
- Research and development of gene therapy
Background Data (weight, blood property, blood biochemistry, organ weight)
- NOD/ShiJcl 10 weeks of age data (*Japanese)
2022-2023 Aggregate Data
Incidence, age at onset, and body weight trends (2022–2023 aggregate data)
Origin
Dr. Yoshihiro Tochino and Dr. Susumu Makino identified female mice that exhibited polyuria and were highly positive for urinary glucose among cataract mice (CT strain) derived from ICR-JCL mice. Because the symptoms resembled human type 1 diabetes mellitus (insulin-dependent diabetes mellitus), the strain was named NOD (Non-Obese Diabetes).
In 1984, a contract was concluded among Shionogi Pharmaceutical Co., Ltd., the Central Institute for Experimental Medicine and Life Science (CIEM), and CLEA Japan, Inc. Production of the strain was begun by CIEM, and supply was provided by CLEA Japan.
Since January 2008, based on a contract between Shionogi Pharmaceutical Co., Ltd. and CLEA Japan, Inc., this strain has been produced as NOD/ShiJcl for sale by CLEA Japan.
“Shi” denotes the origin of the strain from Shionogi Pharmaceutical Co., Ltd.
Cautions for the Breeding and Experimentation of Diabetic Model Animals
- Acclimation: Please take 3-5 days of acclimation after transportation to avoid hypoglycemia caused by stress.
- Frequent Bedding Changes: Due to polyuria associated with diabetes, please increase the frequency and amount of bedding changes.
- Consistent Measurement: Blood glucose levels can fluctuate based on diet, measurement methods, and sample type (blood, serum, plasma). Please ensure consistent procedures.
Our Contract Research Services related with This Animal
For details on our contract research services, including cryopreserved embryos, contracted testing, and the provision of research materials such as blood and organs, please click here .
FAQ
What is NOD/ShiJcl?
NOD/ShiJcl is a type 1 diabetes model mouse that spontaneously develops insulin-dependent diabetes mellitus due to destruction of β cells by insulitis in the Langerhans islets of the pancreas.
What causes diabetes in NOD/ShiJcl mice?
Diabetes in this strain is associated with insulitis, a polygenic trait genetically controlled by major histocompatibility (MHC) antigen and related genes. The disease is considered a T cell-dependent autoimmune response, as diabetes does not occur in NOD mice homozygously introduced with the nu gene.
At what age does diabetes develop in NOD/ShiJcl?
According to the 2022 survey of the current production colony, the age of onset is 18 weeks for both females and males. The cumulative incidence rate up to 35 weeks of age is 60% in females and 10% in males.
What is NOD/ShiJcl used for?
NOD/ShiJcl is used for elucidating the etiologic mechanisms of type 1 diabetes mellitus and for research and development of gene therapy.
What is the origin of the NOD/ShiJcl strain?
The strain was identified by Dr. Yoshihiro Tochino and Dr. Susumu Makino from cataract mice (CT strain) derived from ICR-JCL mice. Because the symptoms resembled human type 1 diabetes mellitus, the strain was named NOD (Non-Obese Diabetes). It has been produced and supplied by CLEA Japan under contract since 2008.
Inquiry
▼ Please feel free to contact us
